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Showing 1 to 10 of 10 entries
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Mechanisms of perivascular adipose tissue dysfunction in obesity.

International journal of endocrinology

Fernández-Alfonso MS, Gil-Ortega M, García-Prieto CF, Aranguez I, Ruiz-Gayo M, Somoza B.
PMID: 24307898
Int J Endocrinol. 2013;2013:402053. doi: 10.1155/2013/402053. Epub 2013 Nov 07.

Most blood vessels are surrounded by adipose tissue. Similarly to the adventitia, perivascular adipose tissue (PVAT) was considered only as a passive structural support for the vasculature, and it was routinely removed for isolated blood vessel studies. In 1991,...

Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells.

Frontiers in cellular neuroscience

Quintanilla RA, Tapia-Monsalves C, Vergara EH, Pérez MJ, Aranguiz A.
PMID: 32848607
Front Cell Neurosci. 2020 Jul 30;14:175. doi: 10.3389/fncel.2020.00175. eCollection 2020.

Mitochondria are highly specialized organelles essential for the synapse, and their impairment contributes to the neurodegeneration in Alzheimer's disease (AD). Previously, we studied the role of caspase-3-cleaved tau in mitochondrial dysfunction in AD. In neurons, the presence of this...

Assessment of the main factors affecting the dynamics of nutrients in two rainfed cereal watersheds.

The Science of the total environment

Hernández-García I, Merchán D, Aranguren I, Casalí J, Giménez R, Campo-Bescós MA, Del Valle de Lersundi J.
PMID: 32450378
Sci Total Environ. 2020 Sep 01;733:139177. doi: 10.1016/j.scitotenv.2020.139177. Epub 2020 May 05.

Nutrient dynamics and factors that control nutrient exports were observed in two watersheds, namely Latxaga and La Tejería, with similar climatic and management characteristics throughout 10 years (2007-2016). Similar patterns were observed in intra-annual and inter-annual dynamics with higher...

Anticontractile Effect of Perivascular Adipose Tissue and Leptin are Reduced in Hypertension.

Frontiers in pharmacology

Gálvez-Prieto B, Somoza B, Gil-Ortega M, García-Prieto CF, de Las Heras AI, González MC, Arribas S, Aranguez I, Bolbrinker J, Kreutz R, Ruiz-Gayo M, Fernández-Alfonso MS.
PMID: 22679436
Front Pharmacol. 2012 Jun 05;3:103. doi: 10.3389/fphar.2012.00103. eCollection 2012.

Leptin causes vasodilatation both by endothelium-dependent and -independent mechanisms. Leptin is synthesized by perivascular adipose tissue (PVAT). The hypothesis of this study is that a decrease of leptin production in PVAT of spontaneously hypertensive rats (SHR) might contribute to...

Non-zoonotic Pasteurella multocida Infection as a Cause of Septic Shock in a Patient with Liver Cirrhosis: A Case Report and Review of the Literature.

Journal of global infectious diseases

Orsini J, Perez R, Llosa A, Araguez N.
PMID: 24672181
J Glob Infect Dis. 2013 Oct;5(4):176-8. doi: 10.4103/0974-777X.122016.

Pasteurella multocida is a Gram-negative organism characterized morphologically as coccobacillus. It is the commonest organism infecting pet bites. However, severe infections may occur in the absence of animal bites or scratches. Pasteurella multocida serves as an opportunistic pathogen in...

Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases.

Brain : a journal of neurology

Legaz A, Abrevaya S, Dottori M, Campo CG, Birba A, Caro MM, Aguirre J, Slachevsky A, Aranguiz R, Serrano C, Gillan CM, Leroi I, García AM, Fittipaldi S, Ibañez A.
PMID: 34529034
Brain. 2021 Sep 16; doi: 10.1093/brain/awab345. Epub 2021 Sep 16.

Social feedback can selectively enhance learning in diverse domains. Relevant neurocognitive mechanisms have been studied mainly in healthy persons, yielding correlational findings. Neurodegenerative lesion models, coupled with multimodal brain measures, can complement standard approaches by revealing direct multidimensional correlates...

Remodeling of energy metabolism and absence of electrophysiological changes in the heart of obese hyperleptinemic mice. New insights into the pleiotropic role of leptin.

Frontiers in endocrinology

Guzmán-Ruiz R, Gómez-Hurtado N, Gil-Ortega M, Somoza B, González MC, Aránguez I, Martín-Ramos M, González-Martín C, Delgado C, Fernández-Alfonso M, Ruiz-Gayo M.
PMID: 24298268
Front Endocrinol (Lausanne). 2013 Nov 15;4:175. doi: 10.3389/fendo.2013.00175. eCollection 2013.

Dietary treatment with high-fat diets (HFD) triggers diabetes and hyperleptinemia, concomitantly with a partial state of leptin resistance that affects hepatic and adipose tissue but not the heart. In this context, characterized by widespread steatosis, cardiac lipid content remains...

Tsunami detection by GPS-derived ionospheric total electron content.

Scientific reports

Shrivastava MN, Maurya AK, Gonzalez G, Sunil PS, Gonzalez J, Salazar P, Aranguiz R.
PMID: 34155312
Sci Rep. 2021 Jun 21;11(1):12978. doi: 10.1038/s41598-021-92479-3.

To unravel the relationship between earthquake and tsunami using ionospheric total electron content (TEC) changes, we analyzed two Chilean tsunamigenic subduction earthquakes: the 2014 Pisagua M

The Functional Topography of the Arabidopsis Genome Is Organized in a Reduced Number of Linear Motifs of Chromatin States.

The Plant cell

Sequeira-Mendes J, Aragüez I, Peiró R, Mendez-Giraldez R, Zhang X, Jacobsen SE, Bastolla U, Gutierrez C.
PMID: 24934173
Plant Cell. 2014 Jun;26(6):2351-2366. doi: 10.1105/tpc.114.124578. Epub 2014 Jun 16.

Chromatin is of major relevance for gene expression, cell division, and differentiation. Here, we determined the landscape of Arabidopsis thaliana chromatin states using 16 features, including DNA sequence, CG methylation, histone variants, and modifications. The combinatorial complexity of chromatin...

Beneficial Effect of Bariatric Surgery on Abnormal MMP-9 and AMPK Activities: Potential Markers of Obesity-Related CV Risk.

Frontiers in physiology

García-Prieto CF, Gil-Ortega M, Vega-Martín E, Ramiro-Cortijo D, Martín-Ramos M, Bordiú E, Sanchez-Pernaute A, Torres A, Aránguez I, Fernández-Alfonso M, Rubio MA, Somoza B.
PMID: 31133882
Front Physiol. 2019 May 08;10:553. doi: 10.3389/fphys.2019.00553. eCollection 2019.

Bariatric surgery (BS) results in sustained weight loss and may reverse inflammation, metabolic alterations, extracellular matrix remodeling and arterial stiffness. We hypothesize that increased stiffening in omental arteries from obese patients might be associated with an increase in MMP...

Showing 1 to 10 of 10 entries