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Showing 1 to 12 of 77 entries
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Using PAT to accelerate the transition to continuous API manufacturing.

Analytical and bioanalytical chemistry

Gouveia FF, Rahbek JP, Mortensen AR, Pedersen MT, Felizardo PM, Bro R, Mealy MJ.
PMID: 27515798
Anal Bioanal Chem. 2017 Jan;409(3):821-832. doi: 10.1007/s00216-016-9834-z. Epub 2016 Aug 11.

Significant improvements can be realized by converting conventional batch processes into continuous ones. The main drivers include reduction of cost and waste, increased safety, and simpler scale-up and tech transfer activities. Re-designing the process layout offers the opportunity to...

Toward Highlighting the Ultrafast Electron Transfer Dynamics at the Optically Dark Sites of Photocatalysts.

The journal of physical chemistry letters

Canton SE, Zhang X, Zhang J, van Driel TB, Kjaer KS, Haldrup K, Chabera P, Harlang T, Suarez-Alcantara K, Liu Y, Pérez J, Bordage A, Pápai M, Vankó G, Jennings G, Kurtz CA, Rovezzi M, Glatzel P, Smolentsev G, Uhlig J, Dohn AO, Christensen M, Galler A, Gawelda W, Bressler C, Lemke HT, Møller KB, Nielsen MM, Lomoth R, Wärnmark K, Sundström V.
PMID: 26283136
J Phys Chem Lett. 2013 Jun 06;4(11):1972-6. doi: 10.1021/jz401016h. Epub 2013 May 28.

Building a detailed understanding of the structure-function relationship is a crucial step in the optimization of molecular photocatalysts employed in water splitting schemes. The optically dark nature of their active sites usually prevents a complete mapping of the photoinduced...

Femtosecond X-Ray Scattering Study of Ultrafast Photoinduced Structural Dynamics in Solvated [Co(terpy)_{2}]^{2+}.

Physical review letters

Biasin E, van Driel TB, Kjær KS, Dohn AO, Christensen M, Harlang T, Chabera P, Liu Y, Uhlig J, Pápai M, Németh Z, Hartsock R, Liang W, Zhang J, Alonso-Mori R, Chollet M, Glownia JM, Nelson S, Sokaras D, Assefa TA, Britz A, Galler A, Gawelda W, Bressler C, Gaffney KJ, Lemke HT, Møller KB, Nielsen MM, Sundström V, Vankó G, Wärnmark K, Canton SE, Haldrup K.
PMID: 27419566
Phys Rev Lett. 2016 Jul 01;117(1):013002. doi: 10.1103/PhysRevLett.117.013002. Epub 2016 Jun 30.

We study the structural dynamics of photoexcited [Co(terpy)_{2}]^{2+} in an aqueous solution with ultrafast x-ray diffuse scattering experiments conducted at the Linac Coherent Light Source. Through direct comparisons with density functional theory calculations, our analysis shows that the photoexcitation...

Trace elements determination in seawater by ICP-MS with on-line pre-concentration on a Chelex-100 column using a 'standard' instrument setup.

MethodsX

Søndergaard J, Asmund G, Larsen MM.
PMID: 26258050
MethodsX. 2015 Jun 18;2:323-30. doi: 10.1016/j.mex.2015.06.003. eCollection 2015.

Trace element determination in seawater is analytically challenging due to the typically very low concentrations of the trace elements and the potential interference of the salt matrix. A common way to address the challenge is to pre-concentrate the trace...

Increased mid-infrared supercontinuum bandwidth and average power by tapering large-mode-area chalcogenide photonic crystal fibers.

Optics express

Petersen CR, Engelsholm RD, Markos C, Brilland L, Caillaud C, Trolès J, Bang O.
PMID: 28788961
Opt Express. 2017 Jun 26;25(13):15336-15348. doi: 10.1364/OE.25.015336.

The trade-off between the spectral bandwidth and average output power from chalcogenide fiber-based mid-infrared supercontinuum sources is one of the major challenges towards practical application of the technology. In this paper we address this challenge through tapering of large-mode-area...

[Invasive sinonasal papilloma with intracranial invasion: Case report and bibliographic review].

Surgical neurology international

Di Pietrantonio A, Asmus H, Ingratta C, Brennan W, Schulz J, Carballo L.
PMID: 29430328
Surg Neurol Int. 2018 Jan 22;9:S29-S35. doi: 10.4103/sni.sni_370_17. eCollection 2018.

INTRODUCTION: Inverted papilloma is a locally-aggressive benign neoplasm of the paranasal sinuses with a high potential for recurrence and malignancy. Intracranial extension is infrequent, and dural penetration even more so, typically associated with recurrence of the disease or its...

Finding intersections between electronic excited state potential energy surfaces with simultaneous ultrafast X-ray scattering and spectroscopy.

Chemical science

Kjær KS, Van Driel TB, Harlang TCB, Kunnus K, Biasin E, Ledbetter K, Hartsock RW, Reinhard ME, Koroidov S, Li L, Laursen MG, Hansen FB, Vester P, Christensen M, Haldrup K, Nielsen MM, Dohn AO, Pápai MI, Møller KB, Chabera P, Liu Y, Tatsuno H, Timm C, Jarenmark M, Uhlig J, Sundstöm V, Wärnmark K, Persson P, Németh Z, Szemes DS, Bajnóczi É, Vankó G, Alonso-Mori R, Glownia JM, Nelson S, Sikorski M, Sokaras D, Canton SE, Lemke HT, Gaffney KJ.
PMID: 31293761
Chem Sci. 2019 Apr 22;10(22):5749-5760. doi: 10.1039/c8sc04023k. eCollection 2019 Jun 14.

Light-driven molecular reactions are dictated by the excited state potential energy landscape, depending critically on the location of conical intersections and intersystem crossing points between potential surfaces where non-adiabatic effects govern transition probabilities between distinct electronic states. While ultrafast...

Effectiveness of a Decentralized Hub and Spoke Model for the Treatment of Hepatitis C Virus in a Federally Qualified Health Center.

Hepatology communications

Rojas SA, Godino JG, Northrup A, Khasira M, Tam A, Asmus L, Frenette C, Ramers CB.
PMID: 33681676
Hepatol Commun. 2020 Dec 21;5(3):412-423. doi: 10.1002/hep4.1617. eCollection 2021 Mar.

Hepatitis C virus (HCV) is a major cause of cirrhosis, liver cancer, and mortality in the United States. We assessed the effectiveness of decentralized HCV treatment delivered by nurse practitioners (NPs), primary care physicians (PMDs), or an infectious disease...

A microdosing framework for absolute bioavailability assessment of poorly soluble drugs: A case study on cold-labeled venetoclax, from chemistry to the clinic.

Clinical and translational science

Alaarg A, Menon R, Rizzo D, Liu Y, Bien J, Elkinton T, Grieme T, Asmus LR, Salem AH.
PMID: 34416076
Clin Transl Sci. 2022 Jan;15(1):244-254. doi: 10.1111/cts.13144. Epub 2021 Oct 27.

This work presents an end-to-end approach for assessing the absolute bioavailability of highly hydrophobic, poorly water-soluble compounds that exhibit high nonspecific binding using venetoclax as a model drug. The approach utilizes a stable labeled i.v. microdose and requires fewer...

Effects of weak intermolecular interactions on the molecular isomerism of tricobalt metal chains.

Journal of the American Chemical Society

Poulsen RD, Overgaard J, Schulman A, Østergaard C, Murillo CA, Spackman MA, Iversen BB.
PMID: 19438202
J Am Chem Soc. 2009 Jun 10;131(22):7580-91. doi: 10.1021/ja8091032.

Depending on the number of interstitial solvent molecules, n, crystals of the linear chain compound Co(3)(dipyridylamide)(4)Cl(2) x nCH(2)Cl(2) adopt either symmetrical or unsymmetrical metal chain structures. We explore here the possible reasons for such behavior using Hirshfeld surface analysis...

Early dismantling of the polyethylene liner in the Arpe® trapezial cup: a report of two cases.

The Journal of hand surgery, European volume

Thorkildsen RD, Reigstad O, Røkkum M.
PMID: 33926280
J Hand Surg Eur Vol. 2021 Nov;46(9):1008-1009. doi: 10.1177/17531934211012203. Epub 2021 Apr 29.

No abstract available.

Ultra-flat, low-noise, and linearly polarized fiber supercontinuum source covering 670-1390  nm.

Optics letters

Genier E, Grelet S, Engelsholm RD, Bowen P, Moselund PM, Bang O, Dudley JM, Sylvestre T.
PMID: 33857078
Opt Lett. 2021 Apr 15;46(8):1820-1823. doi: 10.1364/OL.420676.

We report an octave-spanning coherent supercontinuum (SC) fiber laser with excellent noise and polarization properties. This was achieved by pumping a highly birefringent all-normal dispersion photonic crystal fiber with a compact high-power ytterbium femtosecond laser at 1049 nm. This...

Showing 1 to 12 of 77 entries