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Showing 1 to 12 of 37 entries
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Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer.

ACS medicinal chemistry letters

Balog A, Rampulla R, Martin GS, Krystek SR, Attar R, Dell-John J, DiMarco JD, Fairfax D, Gougoutas J, Holst CL, Nation A, Rizzo C, Rossiter LM, Schweizer L, Shan W, Spergel S, Spires T, Cornelius G, Gottardis M, Trainor G, Vite GD, Salvati ME.
PMID: 26288692
ACS Med Chem Lett. 2015 Jun 19;6(8):908-12. doi: 10.1021/acsmedchemlett.5b00173. eCollection 2015 Aug 13.

BMS-641988 (23) is a novel, nonsteroidal androgen receptor antagonist designed for the treatment of prostate cancer. The compound has high binding affinity for the AR and acts as a functional antagonist in vitro. BMS-641988 is efficacious in multiple human...

The role of natriuretic peptides in cardiovascular disorders and human cardiac allografts (Review).

International journal of molecular medicine

Ationu A, Boateng S.
PMID: 9855695
Int J Mol Med. 1998 Aug;2(2):235-239. doi: 10.3892/ijmm.2.2.235.

The human myocardium is composed of a variety of cardiac cell types that synthesise cardioactive factors with autocrine, paracrine and endocrine functions. These cardioactive factors include a family of structurally and functionally related peptides, natriuretic peptides (NPs), that act...

Prevention of Mother-to-Child HIV Transmission in Nigeria: Six Years Experience from a Tertiary Institution.

Current HIV research

Jalo RI, Amole T, Dongarwar D, Abdullahi H, Tsiga-Ahmed FI, Gaya SA, Bello MM, Bashir U, Aminu A, Kwaku A, Aliyu M, Salihu H, Galadanci H.
PMID: 34109911
Curr HIV Res. 2021 Jun 07; doi: 10.2174/1570162X19666210607113153. Epub 2021 Jun 07.

BACKGROUND: In line with global standards and progress made in Prevention of Mother-to-Child Transmission (PMTCT), an assessment of the outcome of Early Infant Diagnosis in northern Nigeria is necessary to evaluate progress towards a zero Human immunodeficiency Virus (HIV)...

Symptom burden, quality of life, functioning and emotional distress in survivors of human papillomavirus associated oropharyngeal cancer: An Australian cohort.

Oral oncology

McDowell L, Casswell G, Bressel M, Drosdowsky A, Rischin D, Coleman A, Shrestha S, D'Costa I, Fua T, Tiong A, Liu C, Gough K.
PMID: 34653749
Oral Oncol. 2021 Nov;122:105560. doi: 10.1016/j.oraloncology.2021.105560. Epub 2021 Oct 13.

BACKGROUND: This cross-sectional study examines patient-reported outcomes and functioning-based subgroups in human papillomavirus-associated oropharyngeal cancer survivors treated with chemoradiotherapy ≥12 months prior.METHOD: Survivors completed EORTC QLQ-C30, MDASI-HN and PROMIS-Emotional distress questionnaires. Subgroups were identified via two-step clustering of QLQ-C30...

Author Correction: The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density.

Nature communications

Slater HC, Ross A, Felger I, Hofmann NE, Robinson L, Cook J, Gonçalves BP, Björkman A, Ouedraogo AL, Morris U, Msellem M, Koepfli C, Mueller I, Tadesse F, Gadisa E, Das S, Domingo G, Kapulu M, Midega J, Owusu-Agyei S, Nabet C, Piarroux R, Doumbo O, Doumbo SN, Koram K, Lucchi N, Udhayakumar V, Mosha J, Tiono A, Chandramohan D, Gosling R, Mwingira F, Sauerwein R, Paul R, Riley EM, White NJ, Nosten F, Imwong M, Bousema T, Drakeley C, Okell LC.
PMID: 31186429
Nat Commun. 2019 Jun 11;10(1):2644. doi: 10.1038/s41467-019-10790-0.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

African journal of laboratory medicine

Sanon S, Gansane A, Ouattara LP, Traore A, Ouedraogo IN, Tiono A, Taramelli D, Basilico N, Sirima SB.
PMID: 29043169
Afr J Lab Med. 2013 Mar 08;2(1):81. doi: 10.4102/ajlm.v2i1.81. eCollection 2013.

BACKGROUND: Resistance of malaria parasites to existing drugs complicates treatment, but an antimalarial vaccine that could protect against this disease is not yet available. It is therefore necessary to find new effective and affordable medicines. Medicinal plants could be...

Effects of motor control exercise and patient education program in the management of chronic low back pain among community-dwelling adults in rural Nigeria: a study protocol for a randomized clinical trial.

Integrative medicine research

Ibrahim AA, Akindele MO, Ganiyu SO, Bello B.
PMID: 31080731
Integr Med Res. 2019 Jun;8(2):71-81. doi: 10.1016/j.imr.2019.02.001. Epub 2019 Feb 21.

BACKGROUND: The impact of chronic low back pain (CLBP) is disproportionally higher in rural Nigeria than in urban areas but lack access to rehabilitation. While exercise and education are commonly advocated interventions for the rehabilitation of CLBP, there is...

Effects of spinal stabilization exercise with real-time ultrasound imaging biofeedback in individuals with chronic nonspecific low back pain: a pilot study.

Journal of exercise rehabilitation

Sarafadeen R, Ganiyu SO, Ibrahim AA.
PMID: 32724788
J Exerc Rehabil. 2020 Jun 30;16(3):293-299. doi: 10.12965/jer.2040380.190. eCollection 2020 Jun.

The use of real-time ultrasound imaging (RUSI) as biofeedback to enhance the performance of spinal stabilization exercise and recovery from low back pain has been a recent trend in musculoskeletal rehabilitation. The aim of this pilot study was to...

Fructose-1,6-bisphosphatase deficiency causes fatty liver disease and requires long-term hepatic follow-up.

Journal of inherited metabolic disease

Gorce M, Lebigot E, Arion A, Brassier A, Cano A, De Lonlay P, Feillet F, Gay C, Labarthe F, Nassogne MC, Roche S, Roubertie A, Sacaze E, Touati G, Broué P.
PMID: 34687058
J Inherit Metab Dis. 2021 Oct 23; doi: 10.1002/jimd.12452. Epub 2021 Oct 23.

Liver disease, occurring during pediatric or adult age, is often of undetermined cause. Some cases are probably related to undiagnosed inherited metabolic disorders. Hepatic disorders associated with fructose-1,6-bisphosphatase deficiency, a gluconeogenesis defect, are not reported in the literature. These...

The antimicrobial resistance landscape of .

Microbial genomics

Straub C, Thirkell C, Tiong A, Woodhouse R, Szeto J, Dyet KH.
PMID: 34755593
Microb Genom. 2021 Nov;7(11). doi: 10.1099/mgen.0.000701.

No abstract available.

Effectiveness of lumbar stabilization exercise with real-time ultrasound imaging biofeedback on lumbar multifidus muscle cross-sectional area in individuals with non-specific chronic low back pain: a study protocol for a randomized controlled trial.

Trials

Sarafadeen R, Ganiyu SO, Ibrahim AA, Ismail A, Akindele MO, Kaka B, Awotidebe AW.
PMID: 34991706
Trials. 2022 Jan 06;23(1):20. doi: 10.1186/s13063-021-05952-9.

BACKGROUND: Structural impairment of the lumbar multifidus muscle, such as reduced cross-sectional area, is evident among individuals with chronic low back pain. Real-time ultrasound imaging (RUSI) biofeedback has been reported to improve preferential activation of as well as retention...

High Systolic Blood Pressure, Anterior Segment Changes and Visual Impairment Independently Predict Sickle Cell Retinopathy.

Hemoglobin

Idris IM, Yusuf AA, Gwarzo DH, Kurawa MS, Shuaib A, Galadanci AA, Ibrahim H, Borodo AM, Jobbi YD, Danagundi MB, Borodo SB, Mohammed IY, Galadanci NA, Kuliya-Gwarzo A.
PMID: 34353203
Hemoglobin. 2021 Jul;45(4):228-233. doi: 10.1080/03630269.2021.1957927. Epub 2021 Aug 06.

Sickle cell disease is often complicated by retinopathy, which can be proliferative or non proliferative. Proliferative sickle cell retinopathy potentially leads to blindness. There is a paucity of data on sickle cell disease-related retinopathy from Africa, where the disease...

Showing 1 to 12 of 37 entries