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Showing 1 to 12 of 44 entries
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Who is being referred to cancer genetic counseling? Characteristics of counselees and their referral.

Journal of community genetics

van Riel E, van Dulmen S, Ausems MG.
PMID: 22426886
J Community Genet. 2012 Oct;3(4):265-74. doi: 10.1007/s12687-012-0090-4. Epub 2012 Mar 17.

Both physician and patient play a role in the referral process for cancer genetic counseling. Access to such counseling is not optimal because some eligible patients are not being reached by current referral practice. We aimed to identify factors...

Glycogen storage disease type II: birth prevalence agrees with predicted genotype frequency.

Community genetics

Ausems MG, ten Berg K, Kroos MA, van Diggelen OP, Wevers RA, Poorthuis BJ, Niezen-Koning KE, van der Ploeg AT, Beemer FA, Reuser AJ, Sandkuijl LA, Wokke JH.
PMID: 15181339
Community Genet. 1999;2(2):91-6. doi: 10.1159/000016192.

OBJECTIVES: To compare the overall birth prevalence of diagnosed glycogen storage disease type II (GSD II) with the predicted frequency based on mutation screening, in order to determine whether GSD II is an underdiagnosed condition, and to analyze which...

Referral to cancer genetic counseling: do migrant status and patients' educational background matter?.

Journal of community genetics

van der Giessen JAM, van Riel E, Velthuizen ME, van Dulmen AM, Ausems MGEM.
PMID: 28868568
J Community Genet. 2017 Oct;8(4):303-310. doi: 10.1007/s12687-017-0326-4. Epub 2017 Sep 04.

Participation rates in cancer genetic counseling differ among populations, as patients with a lower educational background and migrant patients seem to have poorer access to it. We conducted a study to determine the present-day educational level and migrant status...

Breast cancer genetic counseling among Dutch patients from Turkish and Moroccan descent: participation determinants and perspectives of patients and healthcare professionals.

Journal of community genetics

Baars JE, van Dulmen AM, Velthuizen ME, van Riel E, Ausems MG.
PMID: 28083845
J Community Genet. 2017 Apr;8(2):97-108. doi: 10.1007/s12687-016-0290-4. Epub 2017 Jan 12.

Lower participation rates in cancer genetic counseling are observed among different ethnic minorities. The goal of our study is to gain insight into determinants of Turkish and Moroccan patients' participation in breast cancer genetic counseling and DNA testing, from...

Long-Term Morbidity and Health After Early Menopause Due to Oophorectomy in Women at Increased Risk of Ovarian Cancer: Protocol for a Nationwide Cross-Sectional Study With Prospective Follow-Up (HARMOny Study).

JMIR research protocols

Terra L, Hooning MJ, Heemskerk-Gerritsen BAM, van Beurden M, Roeters van Lennep JE, van Doorn HC, de Hullu JA, Mom C, van Dorst EBL, Mourits MJE, Slangen BFM, Gaarenstroom KN, Zillikens MC, Leiner T, van der Kolk L, Collee M, Wevers M, Ausems MGEM, van Engelen K, Berger LP, van Asperen CJ, Gomez-Garcia EB, van de Beek I, Rookus MA, Hauptmann M, Bleiker EM, Schagen SB, Aaronson NK, Maas AHEM, van Leeuwen FE.
PMID: 33480862
JMIR Res Protoc. 2021 Jan 22;10(1):e24414. doi: 10.2196/24414.

BACKGROUND: BRCA1/2 mutation carriers are recommended to undergo risk-reducing salpingo-oophorectomy (RRSO) at 35 to 45 years of age. RRSO substantially decreases ovarian cancer risk, but at the cost of immediate menopause. Knowledge about the potential adverse effects of premenopausal...

Effects of chemotherapy on contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers: A nationwide cohort study.

Breast (Edinburgh, Scotland)

Akdeniz D, van Barele M, Heemskerk-Gerritsen BAM, Steyerberg EW, Hauptmann M, van de Beek I, van Engelen K, Wevers MR, Gómez García EB, Ausems MGEM, Berger LPV, van Asperen CJ, Adank MA, Collée MJ, Stommel-Jenner DJ, Jager A, Schmidt MK, Hooning MJ.
PMID: 34929424
Breast. 2021 Dec 14;61:98-107. doi: 10.1016/j.breast.2021.12.007. Epub 2021 Dec 14.

AIM: BRCA1/2 mutation carriers with primary breast cancer (PBC) are at high risk of contralateral breast cancer (CBC). In a nationwide cohort, we investigated the effects of chemotherapeutic agents given for PBC on CBC risk separately in BRCA1 and...

The tumor microenvironment and radiotherapy response; a central role for cancer-associated fibroblasts.

Clinical and translational radiation oncology

Ansems M, Span PN.
PMID: 32337377
Clin Transl Radiat Oncol. 2020 Apr 13;22:90-97. doi: 10.1016/j.ctro.2020.04.001. eCollection 2020 May.

Tumor growth is not only dictated by events involving tumor cells, but also by the environment they reside in, the so-called tumor microenvironment (TME). In the TME, cancer-associated fibroblasts (CAFs) are often the predominant cell type. CAFs were long...

Genotyping and Characterization of HPV Status, Hypoxia, and Radiosensitivity in 22 Head and Neck Cancer Cell Lines.

Cancers

Göttgens EL, Ansems M, Leenders WPJ, Bussink J, Span PN.
PMID: 33802339
Cancers (Basel). 2021 Mar 03;13(5). doi: 10.3390/cancers13051069.

To study head and neck squamous cell carcinomas (HNSCC) in vitro, a large variety of HNSCC cell lines have been developed. Here, we characterize a panel of 22 HNSCC cell lines, thereby providing a tool for research into tumor-specific...

Reproductive decision-making in the context of hereditary cancer: the effects of an online decision aid on informed decision-making.

Journal of community genetics

Reumkens K, Tummers MHE, Severijns Y, Gietel-Habets JJG, van Kuijk SMJ, Aalfs CM, van Asperen CJ, Ausems MGEM, Collée M, Dommering CJ, Kets M, van der Kolk LE, Oosterwijk JC, Tjan-Heijnen VCG, van der Weijden T, de Die-Smulders CEM, van Osch LADM.
PMID: 32880035
J Community Genet. 2021 Jan;12(1):101-110. doi: 10.1007/s12687-020-00484-2. Epub 2020 Sep 02.

Individuals having a genetic predisposition to cancer and their partners face challenging decisions regarding their wish to have children. This study aimed to determine the effects of an online decision aid to support couples in making an informed decision...

European experts consensus: BRCA/homologous recombination deficiency testing in first-line ovarian cancer.

Annals of oncology : official journal of the European Society for Medical Oncology

Vergote I, González-Martín A, Ray-Coquard I, Harter P, Colombo N, Pujol P, Lorusso D, Mirza MR, Brasiuniene B, Madry R, Brenton JD, Ausems MGEM, Büttner R, Lambrechts D.
PMID: 34861371
Ann Oncol. 2021 Dec 01; doi: 10.1016/j.annonc.2021.11.013. Epub 2021 Dec 01.

BACKGROUND: Homologous recombination repair (HRR) enables fault-free repair of double-stranded DNA breaks. HRR deficiency is predicted to occur in around half of high-grade serous ovarian carcinomas. Ovarian cancers harbouring HRR deficiency typically exhibit sensitivity to poly-ADP ribose polymerase inhibitors...

Timeline of development of pancreatic cancer and implications for successful early detection in high-risk individuals.

Gastroenterology

Overbeek KA, Goggins MG, Dbouk M, Levink IJM, Koopmann BDM, Chuidian M, Konings ICAW, Paiella S, Earl J, Fockens P, Gress TM, Ausems MGEM, Poley JW, Thosani NC, Half E, Lachter J, Stoffel EM, Kwon RS, Stoita A, Kastrinos F, Lucas AL, Syngal S, Brand RE, Chak A, Carrato A, Vleggaar FP, Bartsch DK, van Hooft JE, Cahen DL, Canto MI, Bruno MJ.
PMID: 34678218
Gastroenterology. 2021 Oct 19; doi: 10.1053/j.gastro.2021.10.014. Epub 2021 Oct 19.

BACKGROUND AND AIMS: To successfully implement imaging-based pancreatic cancer (PC) surveillance, it is key to understand the timeline and morphological features of neoplastic progression. We aimed to investigate the progression to neoplasia from serial prediagnostic pancreatic imaging tests in...

Effects of chemotherapy on contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers: A nationwide cohort study.

Breast (Edinburgh, Scotland)

Akdeniz D, van Barele M, Heemskerk-Gerritsen BAM, Steyerberg EW, Hauptmann M, van de Beek I, van Engelen K, Wevers MR, Gómez García EB, Ausems MGEM, Berger LPV, van Asperen CJ, Adank MA, Collée MJ, Stommel-Jenner DJ, Jager A, Schmidt MK, Hooning MJ.
PMID: 34929424
Breast. 2021 Dec 14;61:98-107. doi: 10.1016/j.breast.2021.12.007. Epub 2021 Dec 14.

AIM: BRCA1/2 mutation carriers with primary breast cancer (PBC) are at high risk of contralateral breast cancer (CBC). In a nationwide cohort, we investigated the effects of chemotherapeutic agents given for PBC on CBC risk separately in BRCA1 and...

Showing 1 to 12 of 44 entries