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Showing 1 to 12 of 13 entries
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Localization of epileptic seizure focus by computerized analysis of fMRI recordings.

Brain informatics

Hekmati R, Azencott R, Zhang W, Chu ZD, Paldino MJ.
PMID: 33128629
Brain Inform. 2020 Oct 31;7(1):13. doi: 10.1186/s40708-020-00114-0.

By computerized analysis of cortical activity recorded via fMRI for pediatric epilepsy patients, we implement algorithmic localization of epileptic seizure focus within one of eight cortical lobes. Our innovative machine learning techniques involve intensive analysis of large matrices of...

Nonlinear post-selection inference for genome-wide association studies.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

Slim L, Chatelain C, Azencott CA.
PMID: 34890162
Pac Symp Biocomput. 2022;27:349-360.

To address the lack of statistical power and interpretability of genome-wide association studies (GWAS), gene-level analyses combine the p-values of individual single nucleotide polymorphisms (SNPs) into gene statistics. However, using all SNPs mapped to a gene, including those with...

Genome-wide perturbations by miRNAs map onto functional cellular pathways, identifying regulators of chromatin modifiers.

NPJ systems biology and applications

Moss TJ, Luo Z, Seviour EG, Sehgal V, Lu Y, Hill SM, Rupaimoole R, Lee JS, Rodriguez-Aguayo C, Lopez-Berestein G, Sood AK, Azencott R, Gray JW, Mukherjee S, Mills GB, Ram PT.
PMID: 28725457
NPJ Syst Biol Appl. 2015 Sep 28;1:15001. doi: 10.1038/npjsba.2015.1. eCollection 2015.

BACKGROUND: Regulation of gene expression by microRNAs (miRNAs) is critical for determining cellular fate and function. Dysregulation of miRNA expression contributes to the development and progression of multiple diseases. miRNA can target multiple mRNAs, making deconvolution of the effects...

Multitask group Lasso for Genome Wide association Studies in diverse populations.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

Nouira A, Azencott CA.
PMID: 34890146
Pac Symp Biocomput. 2022;27:163-174.

Genome-Wide Association Studies, or GWAS, aim at finding Single Nucleotide Polymorphisms (SNPs) that are associated with a phenotype of interest. GWAS are known to suffer from the large dimensionality of the data with respect to the number of available...

Functional Thin Films on Surfaces.

IEEE transactions on visualization and computer graphics

Vantzos O, Azencot O, Wardeztky M, Rumpf M, Ben-Chen M.
PMID: 28113979
IEEE Trans Vis Comput Graph. 2017 Mar;23(3):1179-1192. doi: 10.1109/TVCG.2016.2605083. Epub 2016 Sep 01.

The motion of a thin viscous film of fluid on a curved surface exhibits many intricate visual phenomena, which are challenging to simulate using existing techniques. A possible alternative is to use a reduced model, involving only the temporal...

Binary Markov Random Fields and interpretable mass spectra discrimination.

Statistical applications in genetics and molecular biology

Kong A, Azencott R.
PMID: 28475101
Stat Appl Genet Mol Biol. 2017 Feb 11; doi: 10.1515/sagmb-2016-0019. Epub 2017 Feb 11.

For mass spectra acquired from cancer patients by MALDI or SELDI techniques, automated discrimination between cancer types or stages has often been implemented by machine learning algorithms. Nevertheless, these techniques typically lack interpretability in terms of biomarkers. In this...

Erratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Nature communications

Sieberts SK, Zhu F, García-García J, Stahl E, Pratap A, Pandey G, Pappas D, Aguilar D, Anton B, Bonet J, Eksi R, Fornés O, Guney E, Li H, Marín MA, Panwar B, Planas-Iglesias J, Poglayen D, Cui J, Falcao AO, Suver C, Hoff B, Balagurusamy VSK, Dillenberger D, Neto EC, Norman T, Aittokallio T, Ammad-Ud-Din M, Azencott CA, Bellón V, Boeva V, Bunte K, Chheda H, Cheng L, Corander J, Dumontier M, Goldenberg A, Gopalacharyulu P, Hajiloo M, Hidru D, Jaiswal A, Kaski S, Khalfaoui B, Khan SA, Kramer ER, Marttinen P, Mezlini AM, Molparia B, Pirinen M, Saarela J, Samwald M, Stoven V, Tang H, Tang J, Torkamani A, Vert JP, Wang B, Wang T, Wennerberg K, Wineinger NE, Xiao G, Xie Y, Yeung R, Zhan X, Zhao C, Greenberg J, Kremer J, Michaud K, Barton A, Coenen M, Mariette X, Miceli C, Shadick N, Weinblatt M, de Vries N, Tak PP, Gerlag D, Huizinga TWJ, Kurreeman F, Allaart CF, Bridges SL, Criswell L, Moreland L, Klareskog L, Saevarsdottir S, Padyukov L, Gregersen PK, Friend S, Plenge R, Stolovitzky G, Oliva B, Guan Y, Mangravite LM.
PMID: 27721464
Nat Commun. 2016 Oct 10;7:13205. doi: 10.1038/ncomms13205.

No abstract available.

Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer.

Oncogene

Seviour EG, Sehgal V, Lu Y, Luo Z, Moss T, Zhang F, Hill SM, Liu W, Maiti SN, Cooper L, Azencot R, Lopez-Berestein G, Rodriguez-Aguayo C, Roopaimoole R, Pecot CV, Sood AK, Mukherjee S, Gray JW, Mills GB, Ram PT.
PMID: 26865225
Oncogene. 2016 Feb 11;35(6):801. doi: 10.1038/onc.2015.177.

No abstract available.

Multitask group Lasso for Genome Wide association Studies in diverse populations.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

Nouira A, Azencott CA.
PMID: 34890146
Pac Symp Biocomput. 2022;27:163-174.

Genome-Wide Association Studies, or GWAS, aim at finding Single Nucleotide Polymorphisms (SNPs) that are associated with a phenotype of interest. GWAS are known to suffer from the large dimensionality of the data with respect to the number of available...

Where Do We Stand in Regularization for Life Science Studies?.

Journal of computational biology : a journal of computational molecular cell biology

Tozzo V, Azencott CA, Fiorini S, Fava E, Trucco A, Barla A.
PMID: 33926217
J Comput Biol. 2021 Apr 29; doi: 10.1089/cmb.2019.0371. Epub 2021 Apr 29.

More and more biologists and bioinformaticians turn to machine learning to analyze large amounts of data. In this context, it is crucial to understand which is the most suitable data analysis pipeline for achieving reliable results. This process may...

Nonlinear post-selection inference for genome-wide association studies.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

Slim L, Chatelain C, Azencott CA.
PMID: 34890162
Pac Symp Biocomput. 2022;27:349-360.

To address the lack of statistical power and interpretability of genome-wide association studies (GWAS), gene-level analyses combine the p-values of individual single nucleotide polymorphisms (SNPs) into gene statistics. However, using all SNPs mapped to a gene, including those with...

Nonlinear post-selection inference for genome-wide association studies.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

Slim L, Chatelain C, Azencott CA.
PMID: 34890162
Pac Symp Biocomput. 2022;27:349-360.

To address the lack of statistical power and interpretability of genome-wide association studies (GWAS), gene-level analyses combine the p-values of individual single nucleotide polymorphisms (SNPs) into gene statistics. However, using all SNPs mapped to a gene, including those with...

Showing 1 to 12 of 13 entries