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Showing 1 to 7 of 7 entries
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Production of anti TNF-α antibodies in eukaryotic cells using different combinations of vectors carrying heavy and light chains.

Cytotechnology

Balabashin D, Kovalenko E, Toporova V, Aliev T, Panina A, Svirshchevskaya E, Dolgikh D, Kirpichnikov M.
PMID: 24939591
Cytotechnology. 2015 Oct;67(5):761-72. doi: 10.1007/s10616-014-9714-3. Epub 2014 Jun 18.

Tumor necrosis factor-α (TNF-α) plays a key role in rheumatoid arthritis and some other autoimmune diseases. Therapy with anti-TNF-α recombinant antibodies (Ab) appears to be highly effective. Production of new hyper-producing eukaryotic cell lines can decrease the treatment cost,...

Recombinant Bispecific Antibodies to the Human ErbB2 Receptor and Interferon-Beta.

Acta naturae

Panina AA, Rybchenko VS, Solopova ON, Balabashin DS, Yakimov SA, Aliev TK, Dolgikh DA, Sveshnikov PG, Kirpichnikov MP.
PMID: 32742732
Acta Naturae. 2020 Apr-Jun;12(2):95-104. doi: 10.32607/actanaturae.10903.

The development of and research into new therapies that can selectively and effectively destroy tumor cells that overexpress the ErbB2 receptor is a pressing task. Recently, research into the use of type I interferons in the treatment of cancer...

Bispecific Antibodies for IFN-β Delivery to ErbB2.

Biomolecules

Rybchenko VS, Panina AA, Aliev TK, Solopova ON, Balabashin DS, Novoseletsky VN, Dolgikh DA, Sveshnikov PG, Kirpichnikov MP.
PMID: 34944558
Biomolecules. 2021 Dec 20;11(12). doi: 10.3390/biom11121915.

The main aim of our work was to create a full-length bispecific antibody (BsAb) as a vehicle for the targeted delivery of interferon-beta (IFN-β) to ErbB2

Bispecific Antibodies for IFN-β Delivery to ErbB2.

Biomolecules

Rybchenko VS, Panina AA, Aliev TK, Solopova ON, Balabashin DS, Novoseletsky VN, Dolgikh DA, Sveshnikov PG, Kirpichnikov MP.
PMID: 34944558
Biomolecules. 2021 Dec 20;11(12). doi: 10.3390/biom11121915.

The main aim of our work was to create a full-length bispecific antibody (BsAb) as a vehicle for the targeted delivery of interferon-beta (IFN-β) to ErbB2

Recombinant Antibodies to the Ebola Virus Glycoprotein.

Acta naturae

Panina AA, Dementieva IG, Aliev TK, Toporova VA, Balabashin DS, Bokov MN, Pozdnyakova LP, Shchemchukova OB, Dolgikh DA, Sveshnikov PG, Kirpichnikov MP.
PMID: 29340221
Acta Naturae. 2017 Oct-Dec;9(4):84-91.

Currently, there are no approved therapies for targeted prevention and treatment of Ebola hemorrhagic fever. In the present work, we describe the development of a eukaryotic expression system for the production of three full-length chimeric antibodies (IgG1-kappa isotypes) GPE118,...

Targeting Extracellular Vesicles to Dendritic Cells and Macrophages.

Acta naturae

Ovchinnikova LA, Filimonova IN, Zakharova MY, Balabashin DS, Aliev TK, Lomakin YA, Gabibov AG.
PMID: 34707904
Acta Naturae. 2021 Jul-Sep;13(3):114-121. doi: 10.32607/actanaturae.11478.

Targeting protein therapeutics to specific cells and tissues is a major challenge in modern medicine. Improving the specificity of protein therapeutic delivery will significantly enhance efficiency in drug development. One of the promising tools for protein delivery is extracellular...

Bispecific Antibodies for IFN-β Delivery to ErbB2.

Biomolecules

Rybchenko VS, Panina AA, Aliev TK, Solopova ON, Balabashin DS, Novoseletsky VN, Dolgikh DA, Sveshnikov PG, Kirpichnikov MP.
PMID: 34944558
Biomolecules. 2021 Dec 20;11(12). doi: 10.3390/biom11121915.

The main aim of our work was to create a full-length bispecific antibody (BsAb) as a vehicle for the targeted delivery of interferon-beta (IFN-β) to ErbB2

Showing 1 to 7 of 7 entries