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Amplifying undetectable NMR signals to study host-guest interactions and exchange.

Chemical science

Avram L, Iron MA, Bar-Shir A.
PMID: 28567261
Chem Sci. 2016 Dec 01;7(12):6905-6909. doi: 10.1039/c6sc04083g. Epub 2016 Oct 05.

The characteristics of host-guest systems, such as molecular recognition, complexation, encapsulation, guest composition, and dynamic exchange, are manifested by changes in the chemical shifts (Δ

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Avram L, Iron MA, Bar-Shir A. Amplifying undetectable NMR signals to study host-guest interactions and exchange. Chem Sci. 2016;7(12):6905-6909doi: 10.1039/c6sc04083g.
Avram, L., Iron, M. A., & Bar-Shir, A. (2016). Amplifying undetectable NMR signals to study host-guest interactions and exchange. Chemical science, 7(12), 6905-6909. https://doi.org/10.1039/c6sc04083g
Avram, Liat, et al. "Amplifying undetectable NMR signals to study host-guest interactions and exchange." Chemical science vol. 7,12 (2016): 6905-6909. doi: https://doi.org/10.1039/c6sc04083g
Avram L, Iron MA, Bar-Shir A. Amplifying undetectable NMR signals to study host-guest interactions and exchange. Chem Sci. 2016 Dec 01;7(12):6905-6909. doi: 10.1039/c6sc04083g. Epub 2016 Oct 05. PMID: 28567261; PMCID: PMC5450594.
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Cation-Ligand Complexation Mediates the Temporal Evolution of Colloidal Fluoride Nanocrystals through Transient Aggregation.

Nano letters

Mashiach R, Weissman H, Avram L, Houben L, Diskin-Posner Y, Arunachalam V, Leskes M, Rybtchinski B, Bar-Shir A.
PMID: 34813333
Nano Lett. 2021 Dec 08;21(23):9916-9921. doi: 10.1021/acs.nanolett.1c03131. Epub 2021 Nov 23.

Colloidal inorganic nanofluorides have aroused great interest for various applications with their development greatly accelerated thanks to advanced synthetic approaches. Nevertheless, understanding their colloidal evolution and the factors that affect their dispersion could improve the ability to rationally design...

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Mashiach R, Weissman H, Avram L, et al. Cation-Ligand Complexation Mediates the Temporal Evolution of Colloidal Fluoride Nanocrystals through Transient Aggregation. Nano Lett. 2021;21(23):9916-9921doi: 10.1021/acs.nanolett.1c03131.
Mashiach, R., Weissman, H., Avram, L., Houben, L., Diskin-Posner, Y., Arunachalam, V., Leskes, M., Rybtchinski, B., & Bar-Shir, A. (2021). Cation-Ligand Complexation Mediates the Temporal Evolution of Colloidal Fluoride Nanocrystals through Transient Aggregation. Nano letters, 21(23), 9916-9921. https://doi.org/10.1021/acs.nanolett.1c03131
Mashiach, Reut, et al. "Cation-Ligand Complexation Mediates the Temporal Evolution of Colloidal Fluoride Nanocrystals through Transient Aggregation." Nano letters vol. 21,23 (2021): 9916-9921. doi: https://doi.org/10.1021/acs.nanolett.1c03131
Mashiach R, Weissman H, Avram L, Houben L, Diskin-Posner Y, Arunachalam V, Leskes M, Rybtchinski B, Bar-Shir A. Cation-Ligand Complexation Mediates the Temporal Evolution of Colloidal Fluoride Nanocrystals through Transient Aggregation. Nano Lett. 2021 Dec 08;21(23):9916-9921. doi: 10.1021/acs.nanolett.1c03131. Epub 2021 Nov 23. PMID: 34813333; PMCID: PMC8662719.
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Calcium Fluoride Nanocrystals: Tracers for In Vivo .

Angewandte Chemie (International ed. in English)

Ashur I, Allouche-Arnon H, Bar-Shir A.
PMID: 29518272
Angew Chem Int Ed Engl. 2018 Jun 18;57(25):7478-7482. doi: 10.1002/anie.201800838. Epub 2018 Mar 30.

Inorganic nanocrystals (NCs) have been extensively developed for a variety of uses. The ability to obtain high-resolution NMR signals from the core nuclei of NCs in solution could offer new opportunities in materials sciences and MR imaging. Herein, we...

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Ashur I, Allouche-Arnon H, Bar-Shir A. Calcium Fluoride Nanocrystals: Tracers for In Vivo . Angew Chem Int Ed Engl. 2018;57(25):7478-7482doi: 10.1002/anie.201800838.
Ashur, I., Allouche-Arnon, H., & Bar-Shir, A. (2018). Calcium Fluoride Nanocrystals: Tracers for In Vivo . Angewandte Chemie (International ed. in English), 57(25), 7478-7482. https://doi.org/10.1002/anie.201800838
Ashur, Idan, et al. "Calcium Fluoride Nanocrystals: Tracers for In Vivo ." Angewandte Chemie (International ed. in English) vol. 57,25 (2018): 7478-7482. doi: https://doi.org/10.1002/anie.201800838
Ashur I, Allouche-Arnon H, Bar-Shir A. Calcium Fluoride Nanocrystals: Tracers for In Vivo . Angew Chem Int Ed Engl. 2018 Jun 18;57(25):7478-7482. doi: 10.1002/anie.201800838. Epub 2018 Mar 30. PMID: 29518272.
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GBA mutations are associated with Rapid Eye Movement Sleep Behavior Disorder.

Annals of clinical and translational neurology

Gan-Or Z, Mirelman A, Postuma RB, Arnulf I, Bar-Shira A, Dauvilliers Y, Desautels A, Gagnon JF, Leblond CS, Frauscher B, Alcalay RN, Saunders-Pullman R, Bressman SB, Marder K, Monaca C, Högl B, Orr-Urtreger A, Dion PA, Montplaisir JY, Giladi N, Rouleau GA.
PMID: 26401515
Ann Clin Transl Neurol. 2015 Sep;2(9):941-5. doi: 10.1002/acn3.228. Epub 2015 Jul 31.

Rapid eye movement sleep behavior disorder and GBA mutations are both associated with Parkinson's disease. The GBA gene was sequenced in idiopathic rapid eye movement sleep behavior disorder patients (n = 265), and compared to controls (n = 2240)....

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Gan-Or Z, Mirelman A, Postuma RB, et al. GBA mutations are associated with Rapid Eye Movement Sleep Behavior Disorder. Ann Clin Transl Neurol. 2015;2(9):941-5doi: 10.1002/acn3.228.
Gan-Or, Z., Mirelman, A., Postuma, R. B., Arnulf, I., Bar-Shira, A., Dauvilliers, Y., Desautels, A., Gagnon, J. F., Leblond, C. S., Frauscher, B., Alcalay, R. N., Saunders-Pullman, R., Bressman, S. B., Marder, K., Monaca, C., Högl, B., Orr-Urtreger, A., Dion, P. A., Montplaisir, J. Y., Giladi, N., & Rouleau, G. A. (2015). GBA mutations are associated with Rapid Eye Movement Sleep Behavior Disorder. Annals of clinical and translational neurology, 2(9), 941-5. https://doi.org/10.1002/acn3.228
Gan-Or, Ziv, et al. "GBA mutations are associated with Rapid Eye Movement Sleep Behavior Disorder." Annals of clinical and translational neurology vol. 2,9 (2015): 941-5. doi: https://doi.org/10.1002/acn3.228
Gan-Or Z, Mirelman A, Postuma RB, Arnulf I, Bar-Shira A, Dauvilliers Y, Desautels A, Gagnon JF, Leblond CS, Frauscher B, Alcalay RN, Saunders-Pullman R, Bressman SB, Marder K, Monaca C, Högl B, Orr-Urtreger A, Dion PA, Montplaisir JY, Giladi N, Rouleau GA. GBA mutations are associated with Rapid Eye Movement Sleep Behavior Disorder. Ann Clin Transl Neurol. 2015 Sep;2(9):941-5. doi: 10.1002/acn3.228. Epub 2015 Jul 31. PMID: 26401515; PMCID: PMC4574811.
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Deletion in COL4A2 is associated with a three-generation variable phenotype: from fetal to adult manifestations.

European journal of human genetics : EJHG

Hausman-Kedem M, Ben-Sira L, Kidron D, Ben-Shachar S, Straussberg R, Marom D, Ponger P, Bar-Shira A, Malinger G, Fattal-Valevski A.
PMID: 33837277
Eur J Hum Genet. 2021 Nov;29(11):1654-1662. doi: 10.1038/s41431-021-00880-3. Epub 2021 Apr 09.

Genetic alterations in COL4A2 are less common than those of COL4A1 and their fetal phenotype has not been described to date. We describe a three-generation family with an intragenic deletion in COL4A2 associated with a prenatal diagnosis of recurrent...

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Hausman-Kedem M, Ben-Sira L, Kidron D, et al. Deletion in COL4A2 is associated with a three-generation variable phenotype: from fetal to adult manifestations. Eur J Hum Genet. 2021;29(11):1654-1662doi: 10.1038/s41431-021-00880-3.
Hausman-Kedem, M., Ben-Sira, L., Kidron, D., Ben-Shachar, S., Straussberg, R., Marom, D., Ponger, P., Bar-Shira, A., Malinger, G., & Fattal-Valevski, A. (2021). Deletion in COL4A2 is associated with a three-generation variable phenotype: from fetal to adult manifestations. European journal of human genetics : EJHG, 29(11), 1654-1662. https://doi.org/10.1038/s41431-021-00880-3
Hausman-Kedem, Moran, et al. "Deletion in COL4A2 is associated with a three-generation variable phenotype: from fetal to adult manifestations." European journal of human genetics : EJHG vol. 29,11 (2021): 1654-1662. doi: https://doi.org/10.1038/s41431-021-00880-3
Hausman-Kedem M, Ben-Sira L, Kidron D, Ben-Shachar S, Straussberg R, Marom D, Ponger P, Bar-Shira A, Malinger G, Fattal-Valevski A. Deletion in COL4A2 is associated with a three-generation variable phenotype: from fetal to adult manifestations. Eur J Hum Genet. 2021 Nov;29(11):1654-1662. doi: 10.1038/s41431-021-00880-3. Epub 2021 Apr 09. PMID: 33837277; PMCID: PMC8560832.
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Versatile non-luminescent color palette based on guest exchange dynamics in paramagnetic cavitands.

Nature communications

Goren E, Avram L, Bar-Shir A.
PMID: 34031377
Nat Commun. 2021 May 24;12(1):3072. doi: 10.1038/s41467-021-23179-9.

Multicolor luminescent portrayal of complexed arrays is indispensable for many aspects of science and technology. Nevertheless, challenges such as inaccessible readouts from opaque objects, a limited visible-light spectrum and restricted spectral resolution call for alternative approaches for multicolor representation....

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Goren E, Avram L, Bar-Shir A. Versatile non-luminescent color palette based on guest exchange dynamics in paramagnetic cavitands. Nat Commun. 2021;12(1):3072doi: 10.1038/s41467-021-23179-9.
Goren, E., Avram, L., & Bar-Shir, A. (2021). Versatile non-luminescent color palette based on guest exchange dynamics in paramagnetic cavitands. Nature communications, 12(1), 3072. https://doi.org/10.1038/s41467-021-23179-9
Goren, Elad, et al. "Versatile non-luminescent color palette based on guest exchange dynamics in paramagnetic cavitands." Nature communications vol. 12,1 (2021): 3072. doi: https://doi.org/10.1038/s41467-021-23179-9
Goren E, Avram L, Bar-Shir A. Versatile non-luminescent color palette based on guest exchange dynamics in paramagnetic cavitands. Nat Commun. 2021 May 24;12(1):3072. doi: 10.1038/s41467-021-23179-9. PMID: 34031377; PMCID: PMC8144181.
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Decreased expression of B cell related genes in leukocytes of women with Parkinson's disease.

Molecular neurodegeneration

Kedmi M, Bar-Shira A, Gurevich T, Giladi N, Orr-Urtreger A.
PMID: 21943286
Mol Neurodegener. 2011 Sep 23;6:66. doi: 10.1186/1750-1326-6-66.

BACKGROUND: Parkinson's disease (PD) is a complex disorder caused by genetic, environmental and age-related factors, and it is more prevalent in men. We aimed to identify differentially expressed genes in peripheral blood leukocytes (PBLs) that might be involved in...

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Kedmi M, Bar-Shira A, Gurevich T, et al. Decreased expression of B cell related genes in leukocytes of women with Parkinson's disease. Mol Neurodegener. 2011;6:66doi: 10.1186/1750-1326-6-66.
Kedmi, M., Bar-Shira, A., Gurevich, T., Giladi, N., & Orr-Urtreger, A. (2011). Decreased expression of B cell related genes in leukocytes of women with Parkinson's disease. Molecular neurodegeneration, 666. https://doi.org/10.1186/1750-1326-6-66
Kedmi, Merav, et al. "Decreased expression of B cell related genes in leukocytes of women with Parkinson's disease." Molecular neurodegeneration vol. 6 (2011): 66. doi: https://doi.org/10.1186/1750-1326-6-66
Kedmi M, Bar-Shira A, Gurevich T, Giladi N, Orr-Urtreger A. Decreased expression of B cell related genes in leukocytes of women with Parkinson's disease. Mol Neurodegener. 2011 Sep 23;6:66. doi: 10.1186/1750-1326-6-66. PMID: 21943286; PMCID: PMC3189133.
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Glucocerebrosidase Activity is not Associated with Parkinson's Disease Risk or Severity.

Movement disorders : official journal of the Movement Disorder Society

Omer N, Giladi N, Gurevich T, Bar-Shira A, Gana-Weisz M, Glinka T, Goldstein O, Kestenbaum M, Cedarbaum JM, Mabrouk OS, Fraser KB, Shirvan JC, Orr-Urtreger A, Mirelman A, Thaler A.
PMID: 34550621
Mov Disord. 2021 Sep 22; doi: 10.1002/mds.28792. Epub 2021 Sep 22.

BACKGROUND: Mutations in the GBA gene, which encodes the lysosomal enzyme glucocerebrosidase (GCase), are risk factors for Parkinson's disease (PD).OBJECTIVE: To explore the association between GCase activity, PD phenotype, and probability for prodromal PD among carriers of mutations in...

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Omer N, Giladi N, Gurevich T, et al. Glucocerebrosidase Activity is not Associated with Parkinson's Disease Risk or Severity. Mov Disord. 2021;doi: 10.1002/mds.28792.
Omer, N., Giladi, N., Gurevich, T., Bar-Shira, A., Gana-Weisz, M., Glinka, T., Goldstein, O., Kestenbaum, M., Cedarbaum, J. M., Mabrouk, O. S., Fraser, K. B., Shirvan, J. C., Orr-Urtreger, A., Mirelman, A., & Thaler, A. (2021). Glucocerebrosidase Activity is not Associated with Parkinson's Disease Risk or Severity. Movement disorders : official journal of the Movement Disorder Society, . https://doi.org/10.1002/mds.28792
Omer, Nurit, et al. "Glucocerebrosidase Activity is not Associated with Parkinson's Disease Risk or Severity." Movement disorders : official journal of the Movement Disorder Society vol. (2021). doi: https://doi.org/10.1002/mds.28792
Omer N, Giladi N, Gurevich T, Bar-Shira A, Gana-Weisz M, Glinka T, Goldstein O, Kestenbaum M, Cedarbaum JM, Mabrouk OS, Fraser KB, Shirvan JC, Orr-Urtreger A, Mirelman A, Thaler A. Glucocerebrosidase Activity is not Associated with Parkinson's Disease Risk or Severity. Mov Disord. 2021 Sep 22; doi: 10.1002/mds.28792. Epub 2021 Sep 22. PMID: 34550621.
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Quantifying Guest Exchange in Supramolecular Systems.

Angewandte Chemie (International ed. in English)

Avram L, Wishard AD, Gibb BC, Bar-Shir A.
PMID: 28972281
Angew Chem Int Ed Engl. 2017 Nov 27;56(48):15314-15318. doi: 10.1002/anie.201708726. Epub 2017 Oct 20.

The ability to accurately determine and quantitatively evaluate kinetic phenomena associated with supramolecular assemblies, in real time, is key to a better understanding of their defined architectures and diverse functionalities. Therefore, analytical tools that can precisely assess a wide...

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Avram L, Wishard AD, Gibb BC, et al. Quantifying Guest Exchange in Supramolecular Systems. Angew Chem Int Ed Engl. 2017;56(48):15314-15318doi: 10.1002/anie.201708726.
Avram, L., Wishard, A. D., Gibb, B. C., & Bar-Shir, A. (2017). Quantifying Guest Exchange in Supramolecular Systems. Angewandte Chemie (International ed. in English), 56(48), 15314-15318. https://doi.org/10.1002/anie.201708726
Avram, Liat, et al. "Quantifying Guest Exchange in Supramolecular Systems." Angewandte Chemie (International ed. in English) vol. 56,48 (2017): 15314-15318. doi: https://doi.org/10.1002/anie.201708726
Avram L, Wishard AD, Gibb BC, Bar-Shir A. Quantifying Guest Exchange in Supramolecular Systems. Angew Chem Int Ed Engl. 2017 Nov 27;56(48):15314-15318. doi: 10.1002/anie.201708726. Epub 2017 Oct 20. PMID: 28972281.
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Dynamic Interactions in Synthetic Receptors: A Guest Exchange Saturation Transfer Study.

Chemistry (Weinheim an der Bergstrasse, Germany)

Avram L, Havel V, Shusterman-Krush R, Iron MA, Zaiss M, Šindelář V, Bar-Shir A.
PMID: 30548679
Chemistry. 2019 Feb 01;25(7):1687-1690. doi: 10.1002/chem.201805973. Epub 2019 Jan 07.

The accumulated knowledge regarding molecular architectures is based on established, reliable, and accessible analytical tools that provide robust structural and functional information on assemblies. However, both the dynamicity and low population of noncovalently interacting moieties within studied molecular systems...

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Avram L, Havel V, Shusterman-Krush R, et al. Dynamic Interactions in Synthetic Receptors: A Guest Exchange Saturation Transfer Study. Chemistry. 2019;25(7):1687-1690doi: 10.1002/chem.201805973.
Avram, L., Havel, V., Shusterman-Krush, R., Iron, M. A., Zaiss, M., Šindelář, V., & Bar-Shir, A. (2019). Dynamic Interactions in Synthetic Receptors: A Guest Exchange Saturation Transfer Study. Chemistry (Weinheim an der Bergstrasse, Germany), 25(7), 1687-1690. https://doi.org/10.1002/chem.201805973
Avram, Liat, et al. "Dynamic Interactions in Synthetic Receptors: A Guest Exchange Saturation Transfer Study." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 25,7 (2019): 1687-1690. doi: https://doi.org/10.1002/chem.201805973
Avram L, Havel V, Shusterman-Krush R, Iron MA, Zaiss M, Šindelář V, Bar-Shir A. Dynamic Interactions in Synthetic Receptors: A Guest Exchange Saturation Transfer Study. Chemistry. 2019 Feb 01;25(7):1687-1690. doi: 10.1002/chem.201805973. Epub 2019 Jan 07. PMID: 30548679.
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In situ NMR reveals real-time nanocrystal growth evolution via monomer-attachment or particle-coalescence.

Nature communications

Mashiach R, Weissman H, Avram L, Houben L, Brontvein O, Lavie A, Arunachalam V, Leskes M, Rybtchinski B, Bar-Shir A.
PMID: 33431908
Nat Commun. 2021 Jan 11;12(1):229. doi: 10.1038/s41467-020-20512-6.

Understanding inorganic nanocrystal (NC) growth dynamic pathways under their native fabrication environment remains a central goal of science, as it is crucial for rationalizing novel nanoformulations with desired architectures and functionalities. We here present an in-situ method for quantifying,...

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Mashiach R, Weissman H, Avram L, et al. In situ NMR reveals real-time nanocrystal growth evolution via monomer-attachment or particle-coalescence. Nat Commun. 2021;12(1):229doi: 10.1038/s41467-020-20512-6.
Mashiach, R., Weissman, H., Avram, L., Houben, L., Brontvein, O., Lavie, A., Arunachalam, V., Leskes, M., Rybtchinski, B., & Bar-Shir, A. (2021). In situ NMR reveals real-time nanocrystal growth evolution via monomer-attachment or particle-coalescence. Nature communications, 12(1), 229. https://doi.org/10.1038/s41467-020-20512-6
Mashiach, Reut, et al. "In situ NMR reveals real-time nanocrystal growth evolution via monomer-attachment or particle-coalescence." Nature communications vol. 12,1 (2021): 229. doi: https://doi.org/10.1038/s41467-020-20512-6
Mashiach R, Weissman H, Avram L, Houben L, Brontvein O, Lavie A, Arunachalam V, Leskes M, Rybtchinski B, Bar-Shir A. In situ NMR reveals real-time nanocrystal growth evolution via monomer-attachment or particle-coalescence. Nat Commun. 2021 Jan 11;12(1):229. doi: 10.1038/s41467-020-20512-6. PMID: 33431908; PMCID: PMC7801738.
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Single Fluorinated Agent for Multiplexed .

Angewandte Chemie (International ed. in English)

Shusterman-Krush R, Tirukoti ND, Bandela AK, Avram L, Allouche-Arnon H, Cai X, Gibb BC, Bar-Shir A.
PMID: 33856080
Angew Chem Int Ed Engl. 2021 Jul 05;60(28):15405-15411. doi: 10.1002/anie.202100427. Epub 2021 Jun 04.

The weak thermal polarization of nuclear spins limits the sensitivity of MRI, even for MR-sensitive nuclei as fluorine-19. Therefore, despite being the source of inspiration for the development of background-free MRI for various applications, including for multiplexed imaging, the...

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Shusterman-Krush R, Tirukoti ND, Bandela AK, et al. Single Fluorinated Agent for Multiplexed . Angew Chem Int Ed Engl. 2021;60(28):15405-15411doi: 10.1002/anie.202100427.
Shusterman-Krush, R., Tirukoti, N. D., Bandela, A. K., Avram, L., Allouche-Arnon, H., Cai, X., Gibb, B. C., & Bar-Shir, A. (2021). Single Fluorinated Agent for Multiplexed . Angewandte Chemie (International ed. in English), 60(28), 15405-15411. https://doi.org/10.1002/anie.202100427
Shusterman-Krush, Ronit, et al. "Single Fluorinated Agent for Multiplexed ." Angewandte Chemie (International ed. in English) vol. 60,28 (2021): 15405-15411. doi: https://doi.org/10.1002/anie.202100427
Shusterman-Krush R, Tirukoti ND, Bandela AK, Avram L, Allouche-Arnon H, Cai X, Gibb BC, Bar-Shir A. Single Fluorinated Agent for Multiplexed . Angew Chem Int Ed Engl. 2021 Jul 05;60(28):15405-15411. doi: 10.1002/anie.202100427. Epub 2021 Jun 04. PMID: 33856080.
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