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Showing 1 to 12 of 43 entries
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Perceived supports and evidence-based teaching in college STEM

STEM training programs

Aragón OR, Bathgate ME.
GSID: 3o96UI2QkWMJ
ME Bathgate, OR Aragón… - … of STEM …, 2019 - stemeducationjournal.springeropen …

… training efforts, we suggest that the identification of supports be included and amplified during the EBT training at programs … Incorporating the new ideas introduced during such trainings …

Disentangling intensity from breadth of science interest: What predicts learning behaviors?

after-school settings

Bathgate M, Schunn C.
GSID: -uf4GiLX5KYJ
M Bathgate, C Schunn - Instructional Science, 2016 - Springer

Overall interest in science has been argued to drive learner participation and engagement. However, there are other important aspects of interest such as breadth of interest within a …

Measuring choice to participate in optional science learning experiences during early adolescence

after-school settings

Schunn C, Bathgate M.
GSID: xntCqyHbAMQJ
L Sha, C Schunn, M Bathgate - Journal of research in science …, 2015 - Wiley Online Library

… Cumulatively, participation in optional science learning experiences in school, after school, at … learning, such as participating in various after school clubs, weekend classes, or summer … Also, given the diversity in content that could be accessed in...

Families support their children's success in science learning by influencing interest and self‐efficacy

after-school settings

Bathgate M, Schunn C.
GSID: PoyvjOxEzlIJ
L Sha, C Schunn, M Bathgate… - Journal of Research in …, 2016 - Wiley Online Library

How is a child's successful participation in science learning shaped by their family's support? We focus on the critical time period of early adolescents, testing (i) whether the …

Benefits of a college STEM faculty development initiative: Instructors report increased and sustained implementation of research-based instructional strategies

science instructors

Aragón OR, Bathgate ME.
GSID: 9x3Rsej2eVgJ
MF Durham, OR Aragón, ME Bathgate… - … of Microbiology & …, 2020 - Am Soc Microbiol

… ) is a faculty development workshop in which science, technology, engineering, and mathematics (STEM) instructors, particularly from biology, are … However, instructors reported implementation gains for some practices more than others. The practices with the highest gains were...

Synthesis of fluorescent analogs of relaxin family peptides and their preliminary in vitro and in vivo characterization.

Frontiers in chemistry

Chan LJ, Smith CM, Chua BE, Lin F, Bathgate RA, Separovic F, Gundlach AL, Hossain MA, Wade JD.
PMID: 24790958
Front Chem. 2013 Dec 06;1:30. doi: 10.3389/fchem.2013.00030. eCollection 2013.

Relaxin, a heterodimeric polypeptide hormone, is a key regulator of collagen metabolism and multiple vascular control pathways in humans and rodents. Its actions are mediated via its cognate G-protein-coupled receptor, RXFP1 although it also "pharmacologically" activates RXFP2, the receptor...

Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290.

Frontiers in endocrinology

Huang Z, Myhr C, Bathgate RA, Ho BA, Bueno A, Hu X, Xiao J, Southall N, Barnaeva E, Agoulnik IU, Marugan JJ, Ferrer M, Agoulnik AI.
PMID: 26347712
Front Endocrinol (Lausanne). 2015 Aug 17;6:128. doi: 10.3389/fendo.2015.00128. eCollection 2015.

Relaxin peptide (RLN), which signals through the relaxin family peptide 1 (RXFP1) GPCR receptor, has shown therapeutic effects in an acute heart failure clinical trial. We have identified a small-molecule agonist of human RXFP1, ML290; however, it does not...

Gram scale preparation of clozapine .

MethodsX

van der Peet PL, Gunawan C, Abdul-Ridha A, Ma S, Scott DJ, Gundlach AL, Bathgate RAD, White JM, Williams SJ.
PMID: 30038895
MethodsX. 2018 Mar 23;5:257-267. doi: 10.1016/j.mex.2018.03.003. eCollection 2018.

Chemogenetics uses engineered proteins that are controlled by small molecule actuators, allowing

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1.

Chemical science

Hossain MA, Kocan M, Yao ST, Royce SG, Nair VB, Siwek C, Patil NA, Harrison IP, Rosengren KJ, Selemidis S, Summers RJ, Wade JD, Bathgate RAD, Samuel CS.
PMID: 30155023
Chem Sci. 2016 Jun 01;7(6):3805-3819. doi: 10.1039/c5sc04754d. Epub 2016 Feb 26.

Human gene-2 relaxin (H2 relaxin) is a pleiotropic hormone with powerful vasodilatory and anti-fibrotic properties which has led to its clinical evaluation and provisional FDA approval as a treatment for acute heart failure. The diverse effects of H2 relaxin...

High-Throughput Screening Campaign Identified a Potential Small Molecule RXFP3/4 Agonist.

Molecules (Basel, Switzerland)

Lin G, Feng Y, Cai X, Zhou C, Shao L, Chen Y, Chen L, Liu Q, Zhou Q, Bathgate RAD, Yang D, Wang MW.
PMID: 34946593
Molecules. 2021 Dec 11;26(24). doi: 10.3390/molecules26247511.

Relaxin/insulin-like family peptide receptor 3 (RXFP3) belongs to class A G protein-coupled receptor family. RXFP3 and its endogenous ligand relaxin-3 are mainly expressed in the brain with important roles in the regulation of appetite, energy metabolism, endocrine homeostasis and...

Conformational Changes in Tyrosine 11 of Neurotensin Are Required to Activate the Neurotensin Receptor 1.

ACS pharmacology & translational science

Bumbak F, Thomas T, Noonan-Williams BJ, Vaid TM, Yan F, Whitehead AR, Bruell S, Kocan M, Tan X, Johnson MA, Bathgate RAD, Chalmers DK, Gooley PR, Scott DJ.
PMID: 32832871
ACS Pharmacol Transl Sci. 2020 Apr 29;3(4):690-705. doi: 10.1021/acsptsci.0c00026. eCollection 2020 Aug 14.

Cell-cell communication via endogenous peptides and their receptors is vital for controlling all aspects of human physiology and most peptides signal through G protein-coupled receptors (GPCRs). Disordered peptides bind GPCRs through complex modes for which there are few representative...

Impact of daytime sleepiness and insomnia on simple and complex cognitive task performances.

Sleep medicine

Edinger JD, Bathgate CJ, Tsai S, Khassawneh B.
PMID: 34509774
Sleep Med. 2021 Nov;87:46-55. doi: 10.1016/j.sleep.2021.08.004. Epub 2021 Aug 12.

OBJECTIVE: To examine the individual and combined effects of daytime sleepiness and insomnia disorder (ID) on measures of cognitive functioning.DESIGN AND SETTING: This study was conducted at a medical center using a cross-sectional research design.PARTICIPANTS: 35 persons with ID...

Showing 1 to 12 of 43 entries