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Showing 1 to 12 of 32 entries
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Proinflammatory high-density lipoprotein results from oxidized lipid mediators in the pathogenesis of both idiopathic and associated types of pulmonary arterial hypertension.

Pulmonary circulation

Ross DJ, Hough G, Hama S, Aboulhosn J, Belperio JA, Saggar R, Van Lenten BJ, Ardehali A, Eghbali M, Reddy S, Fogelman AM, Navab M.
PMID: 26697171
Pulm Circ. 2015 Dec;5(4):640-8. doi: 10.1086/683695.

Pulmonary arterial hypertension (PAH) is characterized by abnormal elaboration of vasoactive peptides, endothelial cell dysfunction, vascular remodeling, and inflammation, which collectively contribute to its pathogenesis. We investigated the potential for high-density lipoprotein (HDL) dysfunction (i.e., proinflammatory effects) and abnormal...

CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection.

Journal of inflammation (London, England)

Londhe VA, Belperio JA, Keane MP, Burdick MD, Xue YY, Strieter RM.
PMID: 15921526
J Inflamm (Lond). 2005 May 28;2(1):4. doi: 10.1186/1476-9255-2-4.

BACKGROUND: Respiratory viral infections are characterized by the infiltration of leukocytes, including activated neutrophils into the lung that can lead to sustained lung injury and potentially contribute to chronic lung disease. Specific mechanisms recruiting neutrophils to the lung during...

Preoperative cardiac variables of diastolic dysfunction and clinical outcomes in lung transplant recipients.

Journal of transplantation

Yadlapati A, Lynch JP, Saggar R, Ross D, Belperio JA, Weigt S, Ardehali A, Grogan T, Yang EH, Aboulhosn J.
PMID: 24163757
J Transplant. 2013;2013:391620. doi: 10.1155/2013/391620. Epub 2013 Sep 12.

Background. Orthotopic lung transplantation is now widely performed in patients with advanced lung disease. Patients with moderate or severe ventricular systolic dysfunction are typically excluded from lung transplantation; however, there is a paucity of data regarding the prognostic significance...

Occult Colonic Perforation in a Patient With Coronavirus Disease 2019 After Interleukin-6 Receptor Antagonist Therapy.

Open forum infectious diseases

Schwab K, Hamidi S, Chung A, Lim RJ, Khanlou N, Hoesterey D, Dumitras C, Adeyiga OB, Phan-Tang M, Wang TS, Saggar R, Goldstein J, Belperio JA, Dubinett SM, Kim JT, Salehi-Rad R.
PMID: 33204749
Open Forum Infect Dis. 2020 Sep 12;7(11):ofaa424. doi: 10.1093/ofid/ofaa424. eCollection 2020 Nov.

BACKGROUND: Interleukin-6 blockade (IL-6) has become a focus of therapeutic investigation for the coronavirus disease 2019 (COVID-19).METHODS: We report a case of a 34-year-old with COVID-19 pneumonia receiving an IL-6 receptor antagonist (IL-6Ra) who developed spontaneous colonic perforation. This...

Use of Immunodeficient Mice for the Evaluation of CXC Chemokines in the Regulation of Tumor-associated Angiogenesis.

ILAR journal

Strieter RM, Addison CL, Ehlert JE, Keane MP, Belperio JA, Burdick MD, Arenberg DA.
PMID: 11406696
ILAR J. 1999 Sep;40(4):175-182. doi: 10.1093/ilar.40.4.175.

Angiogenesis, defined as the growth of new capillaries from pre-existing vessels, is a pervasive biological phenomenon that is at the core of many physiologic and pathologic processes such as tumor growth. The use of human tumor xenografts in immunodeficient...

The Effect of Monthly Anti-CD25.

International journal of organ transplantation medicine

Ross DJ, Belperio J, Natori C, Ardehali A.
PMID: 32913585
Int J Organ Transplant Med. 2020;11(3):101-106.

BACKGROUND: Chronic renal dysfunction (CRD), as predominantly related to calcineurin-inhibitor (CNI) nephrotoxicity, is associated with increased morbidity and mortality after lung transplantation (LTx). Basiliximab (BSX), a recombinant chimeric monoclonal antibody against CD25OBJECTIVE: To determine the effect of monthly anti-CD25METHODS:...

The State of Hepatitis C Care in the VA.

Federal practitioner : for the health care professionals of the VA, DoD, and PHS

Belperio PS, Fox RK, Backus LI.
PMID: 30766108
Fed Pract. 2015 Feb;32:20S-24S.

Primary care providers are increasingly important in the treatment of patients with the hepatitis C virus, especially for the large cohort of veterans born between 1945 and 1965.

Outcome and prognostic indicators of patients with hematopoietic stem cell transplants admitted to the intensive care unit.

Journal of transplantation

Huynh TN, Weigt SS, Belperio JA, Territo M, Keane MP.
PMID: 20130763
J Transplant. 2009;2009:917294. doi: 10.1155/2009/917294. Epub 2009 Sep 15.

The prognosis of patients with hematopoietic stem cell transplants (HSCTs) who require admission to the intensive care unit (ICU) has been regarded as extremely poor. We sought to re-evaluate recent outcomes and predictive factors in a retrospective cohort study....

Delphi Consensus Recommendations on Management of Dosing, Adverse Events, and Comorbidities in the Treatment of Idiopathic Pulmonary Fibrosis with Nintedanib.

Clinical medicine insights. Circulatory, respiratory and pulmonary medicine

Rahaghi F, Belperio JA, Fitzgerald J, Gulati M, Hallowell R, Highland KB, Huie TJ, Kim HJ, Kolb M, Lasky JA, Southern BD, Swigris JJ, de Andrade JA.
PMID: 33854398
Clin Med Insights Circ Respir Pulm Med. 2021 Mar 30;15:11795484211006050. doi: 10.1177/11795484211006050. eCollection 2021.

PURPOSE: Nintedanib is an approved treatment for idiopathic pulmonary fibrosis (IPF), which slows disease progression. Management of patients with IPF receiving nintedanib can be complicated by tolerability issues, comorbidities, and concomitant medications. We developed consensus recommendations on the management...

Advanced competence in intensive care unit: expectations, role ambiguity between physicians and nurses in intensive care units. Multi - method survey.

Acta bio-medica : Atenei Parmensis

Carbone R, Ferrari S, Belperio S, Bravi S, Mancinelli C, Soave E, Di Bartolomeo M, Andreassi L, Perondi L, Tamba M, Astolfi M, Artioli G, Sarli L.
PMID: 35037632
Acta Biomed. 2022 Jan 17;92:e2021332. doi: 10.23750/abm.v92iS2.12670.

BACKGROUND AND AIM: The roles of physicians and nurses have undergone profound changes in recent years, becoming more complex and creating, at times, overlapping competencies with consequent negative repercussions in terms of problems related to autonomy and inter-professional collaboration....

Lung Transplantation: Controversies and Evolving Concepts.

Seminars in respiratory and critical care medicine

Belperio JA, Palmer SM.
PMID: 34030196
Semin Respir Crit Care Med. 2021 Jun;42(3):327-328. doi: 10.1055/s-0041-1728793. Epub 2021 May 24.

No abstract available.

Sweet's Syndrome: A First in Human Lung Transplantation.

Chest

Ramsey AL, Wallace WD, Abtin F, Suh JD, Liang LL, Shah S, Lynch JP, Belperio J, Derhovanessian A, Britton I, Sayah DM, Shino MY, Weigt SS, Saggar R.
PMID: 34366039
Chest. 2021 Aug;160(2):e173-e176. doi: 10.1016/j.chest.2021.04.018.

Sweet's Syndrome (SS), also known as acute febrile neutrophilic dermatosis, is one of several cutaneous inflammatory disorders classified as neutrophilic dermatoses. Respiratory complications are described inĀ 

Showing 1 to 12 of 32 entries