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Showing 1 to 12 of 64 entries
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Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS.

Neuron

Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ.
PMID: 27151643
Neuron. 2016 May 04;90(3):662. doi: 10.1016/j.neuron.2016.04.025.

No abstract available.

Nicotine and coronary heart disease.

Trends in cardiovascular medicine

Benowitz NL.
PMID: 21239286
Trends Cardiovasc Med. 1991 Dec;1(8):315-21. doi: 10.1016/1050-1738(91)90068-P.

Nicotine may contribute to accelerated atherogenesis by inducing hyperlipidemia, injuring endothelial cells, and/or promoting thrombosis, although the evidence is not conclusive. Nicotine is likely to contribute to acute ischemic events in people who already have coronary heart disease via...

Multi-Omic Analyses of Growth Cones at Different Developmental Stages Provides Insight into Pathways in Adult Neuroregeneration.

iScience

Chauhan MZ, Arcuri J, Park KK, Zafar MK, Fatmi R, Hackam AS, Yin Y, Benowitz L, Goldberg JL, Samarah M, Bhattacharya SK.
PMID: 32058951
iScience. 2020 Feb 21;23(2):100836. doi: 10.1016/j.isci.2020.100836. Epub 2020 Jan 14.

Growth cones (GCs) are structures associated with growing neurons. GC membrane expansion, which necessitates protein-lipid interactions, is critical to axonal elongation in development and in adult neuritogenesis. We present a multi-omic analysis that integrates proteomics and lipidomics data for...

Balfour et al. Respond.

American journal of public health

Balfour DJK, Benowitz NL, Colby SM, Hatsukami DK, Lando HA, Leischow SJ, Lerman C, Mermelstein RJ, Niaura R, Perkins KA, Pomerleau OF, Rigotti NA, Swan GE, Warner KE, West R.
PMID: 34936414
Am J Public Health. 2022 Jan;112(1):e5-e6. doi: 10.2105/AJPH.2021.306570.

No abstract available.

A Phenotypic Approach for the Identification of New Molecules for Targeted Protein Degradation Applications.

SLAS discovery : advancing life sciences R & D

Stacey P, Lithgow H, Lewell X, Konopacka A, Besley S, Green G, Whatling R, Law R, Röth S, Sapkota GP, Smith IED, Burley GA, Harling J, Benowitz AB, Queisser MA, Muelbaier M.
PMID: 34041938
SLAS Discov. 2021 Aug;26(7):885-895. doi: 10.1177/24725552211017517. Epub 2021 May 27.

Targeted protein degradation is an emerging new strategy for the modulation of intracellular protein levels with applications in chemical biology and drug discovery. One approach to enable this strategy is to redirect the ubiquitin-proteasome system to mark and degrade...

Balfour et al. Respond.

American journal of public health

Balfour DJK, Benowitz NL, Colby SM, Hatsukami DK, Lando HA, Leischow SJ, Lerman C, Mermelstein RJ, Niaura R, Perkins KA, Pomerleau OF, Rigotti NA, Swan GE, Warner KE, West R.
PMID: 34936419
Am J Public Health. 2022 Jan;112(1):e2-e3. doi: 10.2105/AJPH.2021.306555.

No abstract available.

A mixed effects model for analyzing area under the curve of longitudinally measured biomarkers with missing data.

Pharmaceutical statistics

Shi L, Hatsukami DK, Koopmeiners JS, Le CT, Benowitz NL, Donny EC, Luo X.
PMID: 34151513
Pharm Stat. 2021 Nov;20(6):1249-1264. doi: 10.1002/pst.2146. Epub 2021 Jun 20.

A simple approach for analyzing longitudinally measured biomarkers is to calculate summary measures such as the area under the curve (AUC) for each individual and then compare the mean AUC between treatment groups using methods such as t test....

Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes.

Clinical and translational science

El-Boraie A, Tanner JA, Zhu AZX, Claw KG, Prasad B, Schuetz EG, Thummel KE, Fukunaga K, Mushiroda T, Kubo M, Benowitz NL, Lerman C, Tyndale RF.
PMID: 34476898
Clin Transl Sci. 2022 Jan;15(1):204-220. doi: 10.1111/cts.13135. Epub 2021 Sep 25.

CYP2A6 activity, phenotyped by the nicotine metabolite ratio (NMR), is a predictor of several smoking behaviors, including cessation and smoking-related disease risk. The heritability of the NMR is 60-80%, yet weighted genetic risk scores (wGRSs) based on common variants...

Biparental care is predominant and beneficial to parents in the burying beetle .

Biological journal of the Linnean Society. Linnean Society of London

Benowitz KM, Moore AJ.
PMID: 28025585
Biol J Linn Soc Lond. 2016 Dec;119(4):1082-1088. doi: 10.1111/bij.12830. Epub 2016 May 26.

Parenting strategies can be flexible within a species, and may have varying fitness effects. Understanding this flexibility and its fitness consequences is important for understanding why parenting strategies evolve. Here, we investigate the fitness consequences of flexible parenting in...

Difference in parenting in two species of burying beetle, .

Journal of ethology

Benowitz KM, McKinney EC, Moore AJ.
PMID: 27917015
J Ethol. 2016 Sep;34(3):315-319. doi: 10.1007/s10164-016-0477-5. Epub 2016 Jun 28.

Burying beetles (

Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes.

Clinical and translational science

El-Boraie A, Tanner JA, Zhu AZX, Claw KG, Prasad B, Schuetz EG, Thummel KE, Fukunaga K, Mushiroda T, Kubo M, Benowitz NL, Lerman C, Tyndale RF.
PMID: 34476898
Clin Transl Sci. 2022 Jan;15(1):204-220. doi: 10.1111/cts.13135. Epub 2021 Sep 25.

CYP2A6 activity, phenotyped by the nicotine metabolite ratio (NMR), is a predictor of several smoking behaviors, including cessation and smoking-related disease risk. The heritability of the NMR is 60-80%, yet weighted genetic risk scores (wGRSs) based on common variants...

Big business: when Wall Street and cancer research collide.

Journal of the National Cancer Institute

Benowitz S.
PMID: 12237278
J Natl Cancer Inst. 2002 Sep 18;94(18):1352-3. doi: 10.1093/jnci/94.18.1352.

No abstract available.

Showing 1 to 12 of 64 entries