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Immunomodulatory Properties of Cucumariosides from the Edible Far-Eastern Holothurian Cucumaria japonica.

Journal of medicinal food

Aminin DL, Agafonova IG, Berdyshev EV, Isachenko EG, Avilov SA, Stonik VA.
PMID: 12639406
J Med Food. 2001;4(3):127-135. doi: 10.1089/109662001753165701.

Holothurian triterpene glycosides (cucumariosides) are known to possess multiple biological activities. Here we show that cucumariosides from the Far Eastern edible holothurian (sea cucumber), Cucumaria japonica, and their semisynthetic derivatives possess potent immunomodulatory properties. Intraperitoneal injection of cucumariosides (0.2-20...

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Aminin DL, Agafonova IG, Berdyshev EV, et al. Immunomodulatory Properties of Cucumariosides from the Edible Far-Eastern Holothurian Cucumaria japonica. J Med Food. 2001;4(3):127-135doi: 10.1089/109662001753165701.
Aminin, D. L., Agafonova, I. G., Berdyshev, E. V., Isachenko, E. G., Avilov, S. A., & Stonik, V. A. (2001). Immunomodulatory Properties of Cucumariosides from the Edible Far-Eastern Holothurian Cucumaria japonica. Journal of medicinal food, 4(3), 127-135. https://doi.org/10.1089/109662001753165701
Aminin, D. L., et al. "Immunomodulatory Properties of Cucumariosides from the Edible Far-Eastern Holothurian Cucumaria japonica." Journal of medicinal food vol. 4,3 (2001): 127-135. doi: https://doi.org/10.1089/109662001753165701
Aminin DL, Agafonova IG, Berdyshev EV, Isachenko EG, Avilov SA, Stonik VA. Immunomodulatory Properties of Cucumariosides from the Edible Far-Eastern Holothurian Cucumaria japonica. J Med Food. 2001;4(3):127-135. doi: 10.1089/109662001753165701. PMID: 12639406.
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Phosphodiesterase 4 inhibitors and db-cAMP inhibit TNF-alpha release from human mononuclear cells. Effects of cAMP and cGMP-dependent protein kinase inhibitors.

Mediators of inflammation

Hichami A, Boichot E, Germain N, Berdyshev E, Coqueret O, Lagente V.
PMID: 18475747
Mediators Inflamm. 1996;5(6):425-8. doi: 10.1155/S0962935196000580.

We investigated the effects of specific inhibitors of cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG) on the inhibitory activity of phosphodiesterase (PDE) type 4 inhibitors and of the cell permeable analogue of cAMP, db-cAMP on LPS-induced TNF-alpha...

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Hichami A, Boichot E, Germain N, et al. Phosphodiesterase 4 inhibitors and db-cAMP inhibit TNF-alpha release from human mononuclear cells. Effects of cAMP and cGMP-dependent protein kinase inhibitors. Mediators Inflamm. 1996;5(6):425-8doi: 10.1155/S0962935196000580.
Hichami, A., Boichot, E., Germain, N., Berdyshev, E., Coqueret, O., & Lagente, V. (1996). Phosphodiesterase 4 inhibitors and db-cAMP inhibit TNF-alpha release from human mononuclear cells. Effects of cAMP and cGMP-dependent protein kinase inhibitors. Mediators of inflammation, 5(6), 425-8. https://doi.org/10.1155/S0962935196000580
Hichami, A, et al. "Phosphodiesterase 4 inhibitors and db-cAMP inhibit TNF-alpha release from human mononuclear cells. Effects of cAMP and cGMP-dependent protein kinase inhibitors." Mediators of inflammation vol. 5,6 (1996): 425-8. doi: https://doi.org/10.1155/S0962935196000580
Hichami A, Boichot E, Germain N, Berdyshev E, Coqueret O, Lagente V. Phosphodiesterase 4 inhibitors and db-cAMP inhibit TNF-alpha release from human mononuclear cells. Effects of cAMP and cGMP-dependent protein kinase inhibitors. Mediators Inflamm. 1996;5(6):425-8. doi: 10.1155/S0962935196000580. PMID: 18475747; PMCID: PMC2365824.
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Ceramide and sphingosine-1 phosphate in COPD lungs.

Thorax

Berdyshev EV, Serban KA, Schweitzer KS, Bronova IA, Mikosz A, Petrache I.
PMID: 33514670
Thorax. 2021 Jan 29; doi: 10.1136/thoraxjnl-2020-215892. Epub 2021 Jan 29.

Studies of chronic obstructive pulmonary disease (COPD) using animal models and patient plasma indicate dysregulation of sphingolipid metabolism, but data in COPD lungs are sparse. Mass spectrometric and immunostaining measurements of lungs from 69 COPD, 16 smokers without COPD...

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Berdyshev EV, Serban KA, Schweitzer KS, et al. Ceramide and sphingosine-1 phosphate in COPD lungs. Thorax. 2021;doi: 10.1136/thoraxjnl-2020-215892.
Berdyshev, E. V., Serban, K. A., Schweitzer, K. S., Bronova, I. A., Mikosz, A., & Petrache, I. (2021). Ceramide and sphingosine-1 phosphate in COPD lungs. Thorax, . https://doi.org/10.1136/thoraxjnl-2020-215892
Berdyshev, Evgeny V, et al. "Ceramide and sphingosine-1 phosphate in COPD lungs." Thorax vol. (2021). doi: https://doi.org/10.1136/thoraxjnl-2020-215892
Berdyshev EV, Serban KA, Schweitzer KS, Bronova IA, Mikosz A, Petrache I. Ceramide and sphingosine-1 phosphate in COPD lungs. Thorax. 2021 Jan 29; doi: 10.1136/thoraxjnl-2020-215892. Epub 2021 Jan 29. PMID: 33514670.
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Particulate matter causes skin barrier dysfunction.

JCI insight

Kim BE, Kim J, Goleva E, Berdyshev E, Lee J, Vang KA, Lee UH, Han S, Leung S, Hall CF, Kim NR, Bronova I, Lee EJ, Yang HR, Leung DY, Ahn K.
PMID: 33497363
JCI Insight. 2021 Mar 08;6(5). doi: 10.1172/jci.insight.145185.

The molecular mechanisms that underlie the detrimental effects of particulate matter (PM) on skin barrier function are poorly understood. In this study, the effects of PM2.5 on filaggrin (FLG) and skin barrier function were investigated in vitro and in...

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Kim BE, Kim J, Goleva E, et al. Particulate matter causes skin barrier dysfunction. JCI Insight. 2021;6(5)doi: 10.1172/jci.insight.145185.
Kim, B. E., Kim, J., Goleva, E., Berdyshev, E., Lee, J., Vang, K. A., Lee, U. H., Han, S., Leung, S., Hall, C. F., Kim, N. R., Bronova, I., Lee, E. J., Yang, H. R., Leung, D. Y., & Ahn, K. (2021). Particulate matter causes skin barrier dysfunction. JCI insight, 6(5), . https://doi.org/10.1172/jci.insight.145185
Kim, Byung Eui, et al. "Particulate matter causes skin barrier dysfunction." JCI insight vol. 6,5 (2021). doi: https://doi.org/10.1172/jci.insight.145185
Kim BE, Kim J, Goleva E, Berdyshev E, Lee J, Vang KA, Lee UH, Han S, Leung S, Hall CF, Kim NR, Bronova I, Lee EJ, Yang HR, Leung DY, Ahn K. Particulate matter causes skin barrier dysfunction. JCI Insight. 2021 Mar 08;6(5). doi: 10.1172/jci.insight.145185. PMID: 33497363; PMCID: PMC8021104.
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Methodological Considerations for Lipid and Polar Component Analyses in Human Skin Stratum Corneum.

Cell biochemistry and biophysics

Berdyshev E, Bronova I, Leung DYM, Goleva E.
PMID: 34264438
Cell Biochem Biophys. 2021 Sep;79(3):659-668. doi: 10.1007/s12013-021-01016-6. Epub 2021 Jul 15.

Collection of skin very top layer, called stratum corneum, by tape stripping and the analysis of stratum corneum components by mass spectrometry provides multiple advantages for clinical studies that aim to understand the origins of allergic skin diseases and...

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Berdyshev E, Bronova I, Leung DYM, et al. Methodological Considerations for Lipid and Polar Component Analyses in Human Skin Stratum Corneum. Cell Biochem Biophys. 2021;79(3):659-668doi: 10.1007/s12013-021-01016-6.
Berdyshev, E., Bronova, I., Leung, D. Y. M., & Goleva, E. (2021). Methodological Considerations for Lipid and Polar Component Analyses in Human Skin Stratum Corneum. Cell biochemistry and biophysics, 79(3), 659-668. https://doi.org/10.1007/s12013-021-01016-6
Berdyshev, E, et al. "Methodological Considerations for Lipid and Polar Component Analyses in Human Skin Stratum Corneum." Cell biochemistry and biophysics vol. 79,3 (2021): 659-668. doi: https://doi.org/10.1007/s12013-021-01016-6
Berdyshev E, Bronova I, Leung DYM, Goleva E. Methodological Considerations for Lipid and Polar Component Analyses in Human Skin Stratum Corneum. Cell Biochem Biophys. 2021 Sep;79(3):659-668. doi: 10.1007/s12013-021-01016-6. Epub 2021 Jul 15. PMID: 34264438; PMCID: PMC8551066.
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The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells.

Biomolecules

Tonelli F, Alossaimi M, Natarajan V, Gorshkova I, Berdyshev E, Bittman R, Watson DG, Pyne S, Pyne NJ.
PMID: 24970170
Biomolecules. 2013 Jun 10;3(2):316-33. doi: 10.3390/biom3020316.

We have previously shown that treatment of androgen-sensitive LNCaP cells with the sphingosine kinase (SK) inhibitor SKi (2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole) induces the proteasomal degradation of two N-terminal variants of SK1 (SK1a and SK1b), increases C22:0-ceramide and diadenosine 5',5'''-P1,P3-triphosphate (Ap3A) and reduces...

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Tonelli F, Alossaimi M, Natarajan V, et al. The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells. Biomolecules. 2013;3(2):316-33doi: 10.3390/biom3020316.
Tonelli, F., Alossaimi, M., Natarajan, V., Gorshkova, I., Berdyshev, E., Bittman, R., Watson, D. G., Pyne, S., & Pyne, N. J. (2013). The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells. Biomolecules, 3(2), 316-33. https://doi.org/10.3390/biom3020316
Tonelli, Francesca, et al. "The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells." Biomolecules vol. 3,2 (2013): 316-33. doi: https://doi.org/10.3390/biom3020316
Tonelli F, Alossaimi M, Natarajan V, Gorshkova I, Berdyshev E, Bittman R, Watson DG, Pyne S, Pyne NJ. The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells. Biomolecules. 2013 Jun 10;3(2):316-33. doi: 10.3390/biom3020316. PMID: 24970170; PMCID: PMC4030851.
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Nuclear Sphingosine-1-phosphate Lyase Generated ∆2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells.

Cell biochemistry and biophysics

Ebenezer DL, Ramchandran R, Fu P, Mangio LA, Suryadevara V, Ha AW, Berdyshev E, Van Veldhoven PP, Kron SJ, Schumacher F, Kleuser B, Natarajan V.
PMID: 34085165
Cell Biochem Biophys. 2021 Sep;79(3):575-592. doi: 10.1007/s12013-021-01005-9. Epub 2021 Jun 03.

Sphingosine-1-phosphate (S1P), a bioactive lipid mediator, is generated from sphingosine by sphingosine kinases (SPHKs) 1 and 2 and is metabolized to ∆2-hexadecenal (∆2-HDE) and ethanolamine phosphate by S1P lyase (S1PL) in mammalian cells. We have recently demonstrated the activation...

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Ebenezer DL, Ramchandran R, Fu P, et al. Nuclear Sphingosine-1-phosphate Lyase Generated ∆2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells. Cell Biochem Biophys. 2021;79(3):575-592doi: 10.1007/s12013-021-01005-9.
Ebenezer, D. L., Ramchandran, R., Fu, P., Mangio, L. A., Suryadevara, V., Ha, A. W., Berdyshev, E., Van Veldhoven, P. P., Kron, S. J., Schumacher, F., Kleuser, B., & Natarajan, V. (2021). Nuclear Sphingosine-1-phosphate Lyase Generated ∆2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells. Cell biochemistry and biophysics, 79(3), 575-592. https://doi.org/10.1007/s12013-021-01005-9
Ebenezer, David L, et al. "Nuclear Sphingosine-1-phosphate Lyase Generated ∆2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells." Cell biochemistry and biophysics vol. 79,3 (2021): 575-592. doi: https://doi.org/10.1007/s12013-021-01005-9
Ebenezer DL, Ramchandran R, Fu P, Mangio LA, Suryadevara V, Ha AW, Berdyshev E, Van Veldhoven PP, Kron SJ, Schumacher F, Kleuser B, Natarajan V. Nuclear Sphingosine-1-phosphate Lyase Generated ∆2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells. Cell Biochem Biophys. 2021 Sep;79(3):575-592. doi: 10.1007/s12013-021-01005-9. Epub 2021 Jun 03. PMID: 34085165.
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Peculiarity of changes of peripheral blood hematological indices in rats under N-stearoilethanolamine administration conditioned by combined effects of ionizing radiation and stress.

Problemy radiatsiinoi medytsyny ta radiobiolohii

Rоdionova NK, Аtаmaniuk NP, Dеrevyanko LP, Talko VV, Yanina AM, Shelkovskiy MV, Kosyakova GV, Mehed OP, Berdyshev AG, Gula NM, Chumak AA.
PMID: 25536581
Probl Radiac Med Radiobiol. 2014 Sep;19:441-9.

UNLABELLED: Objective - to investigate the peculiarities of peripheral blood indices changes in rats under the N-stearoiletanolamine treatment before and after combined effects of ionizing radiation and stress.METHODS: hematological, statistical.RESULTS: Per oral administration of NSE (10,0 mg / kg)...

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Rоdionova NK, Аtаmaniuk NP, Dеrevyanko LP, et al. Osoblyvosti zmin gematologichnyh pokaznykiv peryferychnoi' krovi shhuriv pry vvedenni N-stearoi'letanolaminu za umov kombinovanoi' dii' ionizujuchogo vyprominjuvannja ta stresu. Peculiarity of changes of peripheral blood hematological indices in rats under N-stearoilethanolamine administration conditioned by combined effects of ionizing radiation and stress. Probl Radiac Med Radiobiol. 2014;19:441-9
Rоdionova, N. K., Аtаmaniuk, N. P., Dеrevyanko, L. P., Talko, V. V., Yanina, A. M., Shelkovskiy, M. V., Kosyakova, G. V., Mehed, O. P., Berdyshev, A. G., Gula, N. M., & Chumak, A. A. (2014). Osoblyvosti zmin gematologichnyh pokaznykiv peryferychnoi' krovi shhuriv pry vvedenni N-stearoi'letanolaminu za umov kombinovanoi' dii' ionizujuchogo vyprominjuvannja ta stresu. Peculiarity of changes of peripheral blood hematological indices in rats under N-stearoilethanolamine administration conditioned by combined effects of ionizing radiation and stress. Problemy radiatsiinoi medytsyny ta radiobiolohii, 19441-9.
Rоdionova, N K, et al. "Osoblyvosti zmin gematologichnyh pokaznykiv peryferychnoi' krovi shhuriv pry vvedenni N-stearoi'letanolaminu za umov kombinovanoi' dii' ionizujuchogo vyprominjuvannja ta stresu." Peculiarity of changes of peripheral blood hematological indices in rats under N-stearoilethanolamine administration conditioned by combined effects of ionizing radiation and stress. Problemy radiatsiinoi medytsyny ta radiobiolohii vol. 19 (2014): 441-9.
Rоdionova NK, Аtаmaniuk NP, Dеrevyanko LP, Talko VV, Yanina AM, Shelkovskiy MV, Kosyakova GV, Mehed OP, Berdyshev AG, Gula NM, Chumak AA. Osoblyvosti zmin gematologichnyh pokaznykiv peryferychnoi' krovi shhuriv pry vvedenni N-stearoi'letanolaminu za umov kombinovanoi' dii' ionizujuchogo vyprominjuvannja ta stresu. Peculiarity of changes of peripheral blood hematological indices in rats under N-stearoilethanolamine administration conditioned by combined effects of ionizing radiation and stress. Probl Radiac Med Radiobiol. 2014 Sep;19:441-9. Ukrainian. PMID: 25536581.
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Potential use of N-stearoylethanolamine in radiation medicine.

Problemy radiatsiinoi medytsyny ta radiobiolohii

Chumak AA, Berdyshev AG, Kosyakova GV, Talko VV, Gula NM.
PMID: 26695898
Probl Radiac Med Radiobiol. 2015 Dec;20:137-46.

A new class of biologically active compounds N-acylethanolamines with properties of endogenous cannabinoids are considered in the terms of promising use in radiation medicine both in the acute phase for the prevention and treatment of ionizing radiation damage and...

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Chumak AA, Berdyshev AG, Kosyakova GV, et al. POTENTsIYNI MOZhLYVOSTI VYKORYSTANNIa N-STEAROILETANOLAMINU V RADIATsIYNIY MEDYTsYNI. Potential use of N-stearoylethanolamine in radiation medicine. Probl Radiac Med Radiobiol. 2015;20:137-46
Chumak, A. A., Berdyshev, A. G., Kosyakova, G. V., Talko, V. V., & Gula, N. M. (2015). POTENTsIYNI MOZhLYVOSTI VYKORYSTANNIa N-STEAROILETANOLAMINU V RADIATsIYNIY MEDYTsYNI. Potential use of N-stearoylethanolamine in radiation medicine. Problemy radiatsiinoi medytsyny ta radiobiolohii, 20137-46.
Chumak, A A, et al. "POTENTsIYNI MOZhLYVOSTI VYKORYSTANNIa N-STEAROILETANOLAMINU V RADIATsIYNIY MEDYTsYNI." Potential use of N-stearoylethanolamine in radiation medicine. Problemy radiatsiinoi medytsyny ta radiobiolohii vol. 20 (2015): 137-46.
Chumak AA, Berdyshev AG, Kosyakova GV, Talko VV, Gula NM. POTENTsIYNI MOZhLYVOSTI VYKORYSTANNIa N-STEAROILETANOLAMINU V RADIATsIYNIY MEDYTsYNI. Potential use of N-stearoylethanolamine in radiation medicine. Probl Radiac Med Radiobiol. 2015 Dec;20:137-46. Ukrainian. PMID: 26695898.
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Showing 1 to 9 of 9 entries