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Showing 1 to 12 of 62 entries
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Dynamic Descriptions of Highly Flexible Molecules from NMR Dipolar Couplings: Physical Basis and Limitations.

Journal of the American Chemical Society

Salvi N, Salmon L, Blackledge M.
PMID: 28290683
J Am Chem Soc. 2017 Apr 12;139(14):5011-5014. doi: 10.1021/jacs.7b01566. Epub 2017 Mar 29.

Biomolecules that control physiological function by changing their conformation play key roles in biology and remain poorly characterized. NMR dipolar couplings (DCs) depend intrinsically on both molecular shape and structural fluctuations, thereby providing the enticing prospect of tracking these...

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Salvi N, Salmon L, Blackledge M. Dynamic Descriptions of Highly Flexible Molecules from NMR Dipolar Couplings: Physical Basis and Limitations. J Am Chem Soc. 2017;139(14):5011-5014doi: 10.1021/jacs.7b01566.
Salvi, N., Salmon, L., & Blackledge, M. (2017). Dynamic Descriptions of Highly Flexible Molecules from NMR Dipolar Couplings: Physical Basis and Limitations. Journal of the American Chemical Society, 139(14), 5011-5014. https://doi.org/10.1021/jacs.7b01566
Salvi, Nicola, et al. "Dynamic Descriptions of Highly Flexible Molecules from NMR Dipolar Couplings: Physical Basis and Limitations." Journal of the American Chemical Society vol. 139,14 (2017): 5011-5014. doi: https://doi.org/10.1021/jacs.7b01566
Salvi N, Salmon L, Blackledge M. Dynamic Descriptions of Highly Flexible Molecules from NMR Dipolar Couplings: Physical Basis and Limitations. J Am Chem Soc. 2017 Apr 12;139(14):5011-5014. doi: 10.1021/jacs.7b01566. Epub 2017 Mar 29. PMID: 28290683.
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A target glitter study.

Science & justice : journal of the Forensic Science Society

Aardahl K, Kirkowski S, Blackledge RD.
PMID: 15739687
Sci Justice. 2005 Jan-Mar;45(1):7-12. doi: 10.1016/S1355-0306(05)71615-4.

A target study was conducted using four different pre-selected types of commercial glitter particles. Recipient areas in the general environment around San Diego, California were tested. Glitter particles were recovered using double-sided tape affixed to square plastic Petri dishes....

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Aardahl K, Kirkowski S, Blackledge RD. A target glitter study. Sci Justice. 2005;45(1):7-12doi: 10.1016/S1355-0306(05)71615-4.
Aardahl, K., Kirkowski, S., & Blackledge, R. D. (2005). A target glitter study. Science & justice : journal of the Forensic Science Society, 45(1), 7-12. https://doi.org/10.1016/S1355-0306(05)71615-4
Aardahl, K, et al. "A target glitter study." Science & justice : journal of the Forensic Science Society vol. 45,1 (2005): 7-12. doi: https://doi.org/10.1016/S1355-0306(05)71615-4
Aardahl K, Kirkowski S, Blackledge RD. A target glitter study. Sci Justice. 2005 Jan-Mar;45(1):7-12. doi: 10.1016/S1355-0306(05)71615-4. PMID: 15739687.
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Hygroscopic compounds in spider aggregate glue remove interfacial water to maintain adhesion in humid conditions.

Nature communications

Singla S, Amarpuri G, Dhopatkar N, Blackledge TA, Dhinojwala A.
PMID: 29789602
Nat Commun. 2018 May 22;9(1):1890. doi: 10.1038/s41467-018-04263-z.

Adhesion in humid environments is fundamentally challenging because of the presence of interfacial bound water. Spiders often hunt in wet habitats and overcome this challenge using sticky aggregate glue droplets whose adhesion is resistant to interfacial failure under humid...

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Singla S, Amarpuri G, Dhopatkar N, et al. Hygroscopic compounds in spider aggregate glue remove interfacial water to maintain adhesion in humid conditions. Nat Commun. 2018;9(1):1890doi: 10.1038/s41467-018-04263-z.
Singla, S., Amarpuri, G., Dhopatkar, N., Blackledge, T. A., & Dhinojwala, A. (2018). Hygroscopic compounds in spider aggregate glue remove interfacial water to maintain adhesion in humid conditions. Nature communications, 9(1), 1890. https://doi.org/10.1038/s41467-018-04263-z
Singla, Saranshu, et al. "Hygroscopic compounds in spider aggregate glue remove interfacial water to maintain adhesion in humid conditions." Nature communications vol. 9,1 (2018): 1890. doi: https://doi.org/10.1038/s41467-018-04263-z
Singla S, Amarpuri G, Dhopatkar N, Blackledge TA, Dhinojwala A. Hygroscopic compounds in spider aggregate glue remove interfacial water to maintain adhesion in humid conditions. Nat Commun. 2018 May 22;9(1):1890. doi: 10.1038/s41467-018-04263-z. PMID: 29789602; PMCID: PMC5964112.
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Automatic Segmentation of Pelvic Cancers Using Deep Learning: State-of-the-Art Approaches and Challenges.

Diagnostics (Basel, Switzerland)

Kalantar R, Lin G, Winfield JM, Messiou C, Lalondrelle S, Blackledge MD, Koh DM.
PMID: 34829310
Diagnostics (Basel). 2021 Oct 22;11(11). doi: 10.3390/diagnostics11111964.

The recent rise of deep learning (DL) and its promising capabilities in capturing non-explicit detail from large datasets have attracted substantial research attention in the field of medical image processing. DL provides grounds for technological development of computer-aided diagnosis...

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Kalantar R, Lin G, Winfield JM, et al. Automatic Segmentation of Pelvic Cancers Using Deep Learning: State-of-the-Art Approaches and Challenges. Diagnostics (Basel). 2021;11(11)doi: 10.3390/diagnostics11111964.
Kalantar, R., Lin, G., Winfield, J. M., Messiou, C., Lalondrelle, S., Blackledge, M. D., & Koh, D. M. (2021). Automatic Segmentation of Pelvic Cancers Using Deep Learning: State-of-the-Art Approaches and Challenges. Diagnostics (Basel, Switzerland), 11(11), . https://doi.org/10.3390/diagnostics11111964
Kalantar, Reza, et al. "Automatic Segmentation of Pelvic Cancers Using Deep Learning: State-of-the-Art Approaches and Challenges." Diagnostics (Basel, Switzerland) vol. 11,11 (2021). doi: https://doi.org/10.3390/diagnostics11111964
Kalantar R, Lin G, Winfield JM, Messiou C, Lalondrelle S, Blackledge MD, Koh DM. Automatic Segmentation of Pelvic Cancers Using Deep Learning: State-of-the-Art Approaches and Challenges. Diagnostics (Basel). 2021 Oct 22;11(11). doi: 10.3390/diagnostics11111964. PMID: 34829310; PMCID: PMC8625809.
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Intrinsically Disordered Tardigrade Proteins Self-Assemble into Fibrous Gels in Response to Environmental Stress.

Angewandte Chemie (International ed. in English)

Malki A, Teulon JM, Camacho-Zarco AR, Chen SW, Adamski W, Maurin D, Salvi N, Pellequer JL, Blackledge M.
PMID: 34750927
Angew Chem Int Ed Engl. 2022 Jan 03;61(1):e202109961. doi: 10.1002/anie.202109961. Epub 2021 Nov 25.

Tardigrades are remarkable for their ability to survive harsh stress conditions as diverse as extreme temperature and desiccation. The molecular mechanisms that confer this unusual resistance to physical stress remain unknown. Recently, tardigrade-unique intrinsically disordered proteins have been shown...

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Malki A, Teulon JM, Camacho-Zarco AR, et al. Intrinsically Disordered Tardigrade Proteins Self-Assemble into Fibrous Gels in Response to Environmental Stress. Angew Chem Int Ed Engl. 2021;61(1):e202109961doi: 10.1002/anie.202109961.
Malki, A., Teulon, J. M., Camacho-Zarco, A. R., Chen, S. W., Adamski, W., Maurin, D., Salvi, N., Pellequer, J. L., & Blackledge, M. (2022). Intrinsically Disordered Tardigrade Proteins Self-Assemble into Fibrous Gels in Response to Environmental Stress. Angewandte Chemie (International ed. in English), 61(1), e202109961. https://doi.org/10.1002/anie.202109961
Malki, Anas, et al. "Intrinsically Disordered Tardigrade Proteins Self-Assemble into Fibrous Gels in Response to Environmental Stress." Angewandte Chemie (International ed. in English) vol. 61,1 (2022): e202109961. doi: https://doi.org/10.1002/anie.202109961
Malki A, Teulon JM, Camacho-Zarco AR, Chen SW, Adamski W, Maurin D, Salvi N, Pellequer JL, Blackledge M. Intrinsically Disordered Tardigrade Proteins Self-Assemble into Fibrous Gels in Response to Environmental Stress. Angew Chem Int Ed Engl. 2022 Jan 03;61(1):e202109961. doi: 10.1002/anie.202109961. Epub 2021 Nov 25. PMID: 34750927.
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The Influence of Journal Self-Citations on Impact Factors in Obstetrics and Gynecology.

American journal of obstetrics and gynecology

Blackledge KT, Ananth CV, Brandt JS.
PMID: 34968457
Am J Obstet Gynecol. 2021 Dec 27; doi: 10.1016/j.ajog.2021.12.036. Epub 2021 Dec 27.

No abstract available.

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Blackledge KT, Ananth CV, Brandt JS. The Influence of Journal Self-Citations on Impact Factors in Obstetrics and Gynecology. Am J Obstet Gynecol. 2021;doi: 10.1016/j.ajog.2021.12.036.
Blackledge, K. T., Ananth, C. V., & Brandt, J. S. (2021). The Influence of Journal Self-Citations on Impact Factors in Obstetrics and Gynecology. American journal of obstetrics and gynecology, . https://doi.org/10.1016/j.ajog.2021.12.036
Blackledge, Kristin T, et al. "The Influence of Journal Self-Citations on Impact Factors in Obstetrics and Gynecology." American journal of obstetrics and gynecology vol. (2021). doi: https://doi.org/10.1016/j.ajog.2021.12.036
Blackledge KT, Ananth CV, Brandt JS. The Influence of Journal Self-Citations on Impact Factors in Obstetrics and Gynecology. Am J Obstet Gynecol. 2021 Dec 27; doi: 10.1016/j.ajog.2021.12.036. Epub 2021 Dec 27. PMID: 34968457.
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Evaluation of small molecule kinase inhibitors as novel antimicrobial and antibiofilm agents.

Chemical biology & drug design

King A, Blackledge MS.
PMID: 34581492
Chem Biol Drug Des. 2021 Dec;98(6):1038-1064. doi: 10.1111/cbdd.13962. Epub 2021 Oct 04.

Antibiotic resistance is a global and pressing concern. Our current therapeutic arsenal is increasingly limited as bacteria are developing resistance at a rate that far outpaces our ability to create new treatments. Novel approaches to treating and curing bacterial...

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King A, Blackledge MS. Evaluation of small molecule kinase inhibitors as novel antimicrobial and antibiofilm agents. Chem Biol Drug Des. 2021;98(6):1038-1064doi: 10.1111/cbdd.13962.
King, A., & Blackledge, M. S. (2021). Evaluation of small molecule kinase inhibitors as novel antimicrobial and antibiofilm agents. Chemical biology & drug design, 98(6), 1038-1064. https://doi.org/10.1111/cbdd.13962
King, Ashley, and Blackledge, Meghan S. "Evaluation of small molecule kinase inhibitors as novel antimicrobial and antibiofilm agents." Chemical biology & drug design vol. 98,6 (2021): 1038-1064. doi: https://doi.org/10.1111/cbdd.13962
King A, Blackledge MS. Evaluation of small molecule kinase inhibitors as novel antimicrobial and antibiofilm agents. Chem Biol Drug Des. 2021 Dec;98(6):1038-1064. doi: 10.1111/cbdd.13962. Epub 2021 Oct 04. PMID: 34581492; PMCID: PMC8616828.
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Noise-Corrected, Exponentially Weighted, Diffusion-Weighted MRI (niceDWI) Improves Image Signal Uniformity in Whole-Body Imaging of Metastatic Prostate Cancer.

Frontiers in oncology

Blackledge MD, Tunariu N, Zungi F, Holbrey R, Orton MR, Ribeiro A, Hughes JC, Scurr ED, Collins DJ, Leach MO, Koh DM.
PMID: 32457842
Front Oncol. 2020 May 08;10:704. doi: 10.3389/fonc.2020.00704. eCollection 2020.

No abstract available.

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Blackledge MD, Tunariu N, Zungi F, et al. Noise-Corrected, Exponentially Weighted, Diffusion-Weighted MRI (niceDWI) Improves Image Signal Uniformity in Whole-Body Imaging of Metastatic Prostate Cancer. Front Oncol. 2020;10:704doi: 10.3389/fonc.2020.00704.
Blackledge, M. D., Tunariu, N., Zungi, F., Holbrey, R., Orton, M. R., Ribeiro, A., Hughes, J. C., Scurr, E. D., Collins, D. J., Leach, M. O., & Koh, D. M. (2020). Noise-Corrected, Exponentially Weighted, Diffusion-Weighted MRI (niceDWI) Improves Image Signal Uniformity in Whole-Body Imaging of Metastatic Prostate Cancer. Frontiers in oncology, 10704. https://doi.org/10.3389/fonc.2020.00704
Blackledge, Matthew D, et al. "Noise-Corrected, Exponentially Weighted, Diffusion-Weighted MRI (niceDWI) Improves Image Signal Uniformity in Whole-Body Imaging of Metastatic Prostate Cancer." Frontiers in oncology vol. 10 (2020): 704. doi: https://doi.org/10.3389/fonc.2020.00704
Blackledge MD, Tunariu N, Zungi F, Holbrey R, Orton MR, Ribeiro A, Hughes JC, Scurr ED, Collins DJ, Leach MO, Koh DM. Noise-Corrected, Exponentially Weighted, Diffusion-Weighted MRI (niceDWI) Improves Image Signal Uniformity in Whole-Body Imaging of Metastatic Prostate Cancer. Front Oncol. 2020 May 08;10:704. doi: 10.3389/fonc.2020.00704. eCollection 2020. PMID: 32457842; PMCID: PMC7225292.
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Anti-EGF receptor therapy.

Prostate cancer and prostatic diseases

Blackledge G, Averbuch S, Kay A, Barton J.
PMID: 12497082
Prostate Cancer Prostatic Dis. 2000 Dec;3(4):296-302. doi: 10.1038/sj.pcan.4500488.

The epidermal growth factor receptor (EGFR) signalling pathway contributes to a number of processes important to tumour progression, including cell proliferation, apoptosis, angiogenesis and metastatic spread. EGFR signalling is thought to be an important cell survival mechanism in hormone-resistant...

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Blackledge G, Averbuch S, Kay A, et al. Anti-EGF receptor therapy. Prostate Cancer Prostatic Dis. 2000;3(4):296-302doi: 10.1038/sj.pcan.4500488.
Blackledge, G., Averbuch, S., Kay, A., & Barton, J. (2000). Anti-EGF receptor therapy. Prostate cancer and prostatic diseases, 3(4), 296-302. https://doi.org/10.1038/sj.pcan.4500488
Blackledge, G, et al. "Anti-EGF receptor therapy." Prostate cancer and prostatic diseases vol. 3,4 (2000): 296-302. doi: https://doi.org/10.1038/sj.pcan.4500488
Blackledge G, Averbuch S, Kay A, Barton J. Anti-EGF receptor therapy. Prostate Cancer Prostatic Dis. 2000 Dec;3(4):296-302. doi: 10.1038/sj.pcan.4500488. PMID: 12497082.
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Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors.

ACS medicinal chemistry letters

Su DS, Qu J, Schulz M, Blackledge CW, Yu H, Zeng J, Burgess J, Reif A, Stern M, Nagarajan R, Pappalardi MB, Wong K, Graves AP, Bonnette W, Wang L, Elkins P, Knapp-Reed B, Carson JD, McHugh C, Mohammad H, Kruger R, Luengo J, Heerding DA, Creasy CL.
PMID: 32071679
ACS Med Chem Lett. 2019 Dec 27;11(2):133-140. doi: 10.1021/acsmedchemlett.9b00493. eCollection 2020 Feb 13.

We report herein the discovery of isoxazole amides as potent and selective SET and MYND Domain-Containing Protein 3 (SMYD3) inhibitors. Elucidation of the structure-activity relationship of the high-throughput screening (HTS) lead compound

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Su DS, Qu J, Schulz M, et al. Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors. ACS Med Chem Lett. 2019;11(2):133-140doi: 10.1021/acsmedchemlett.9b00493.
Su, D. S., Qu, J., Schulz, M., Blackledge, C. W., Yu, H., Zeng, J., Burgess, J., Reif, A., Stern, M., Nagarajan, R., Pappalardi, M. B., Wong, K., Graves, A. P., Bonnette, W., Wang, L., Elkins, P., Knapp-Reed, B., Carson, J. D., McHugh, C., Mohammad, H., Kruger, R., Luengo, J., Heerding, D. A., & Creasy, C. L. (2020). Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors. ACS medicinal chemistry letters, 11(2), 133-140. https://doi.org/10.1021/acsmedchemlett.9b00493
Su, Dai-Shi, et al. "Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors." ACS medicinal chemistry letters vol. 11,2 (2020): 133-140. doi: https://doi.org/10.1021/acsmedchemlett.9b00493
Su DS, Qu J, Schulz M, Blackledge CW, Yu H, Zeng J, Burgess J, Reif A, Stern M, Nagarajan R, Pappalardi MB, Wong K, Graves AP, Bonnette W, Wang L, Elkins P, Knapp-Reed B, Carson JD, McHugh C, Mohammad H, Kruger R, Luengo J, Heerding DA, Creasy CL. Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors. ACS Med Chem Lett. 2019 Dec 27;11(2):133-140. doi: 10.1021/acsmedchemlett.9b00493. eCollection 2020 Feb 13. PMID: 32071679; PMCID: PMC7025381.
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Silk structure rather than tensile mechanics explains web performance in the moth-specialized spider, Cyrtarachne.

Journal of experimental zoology. Part A, Ecological and integrative physiology

Diaz C, Tanikawa A, Miyashita T, Dhinojwala A, Blackledge TA.
PMID: 29992763
J Exp Zool A Ecol Integr Physiol. 2018 Jul 10; doi: 10.1002/jez.2212. Epub 2018 Jul 10.

Orb webs intercept and retain prey so spiders may subdue them. Orb webs are composed of sticky, compliant spirals of capture silk spun across strong, stiff major ampullate silk threads. Interplay between differences in the mechanical properties of these...

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Diaz C, Tanikawa A, Miyashita T, et al. Silk structure rather than tensile mechanics explains web performance in the moth-specialized spider, Cyrtarachne. J Exp Zool A Ecol Integr Physiol. 2018;doi: 10.1002/jez.2212.
Diaz, C., Tanikawa, A., Miyashita, T., Dhinojwala, A., & Blackledge, T. A. (2018). Silk structure rather than tensile mechanics explains web performance in the moth-specialized spider, Cyrtarachne. Journal of experimental zoology. Part A, Ecological and integrative physiology, . https://doi.org/10.1002/jez.2212
Diaz, Candido, et al. "Silk structure rather than tensile mechanics explains web performance in the moth-specialized spider, Cyrtarachne." Journal of experimental zoology. Part A, Ecological and integrative physiology vol. (2018). doi: https://doi.org/10.1002/jez.2212
Diaz C, Tanikawa A, Miyashita T, Dhinojwala A, Blackledge TA. Silk structure rather than tensile mechanics explains web performance in the moth-specialized spider, Cyrtarachne. J Exp Zool A Ecol Integr Physiol. 2018 Jul 10; doi: 10.1002/jez.2212. Epub 2018 Jul 10. PMID: 29992763.
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Resensitization of methicillin-resistant .

Heliyon

Wilson TJ, Blackledge MS, Vigueira PA.
PMID: 29349359
Heliyon. 2018 Jan 12;4(1):e00501. doi: 10.1016/j.heliyon.2017.e00501. eCollection 2018 Jan.

The rapid increase in bacterial resistance to antibiotics is a global healthcare crisis. Non-antibiotic pharmaceuticals that have attained approval by the United States Food and Drug Administration have the potential to be repurposed as bacterial resistance-modifying agents and therefore...

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Wilson TJ, Blackledge MS, Vigueira PA. Resensitization of methicillin-resistant . Heliyon. 2018;4(1):e00501doi: 10.1016/j.heliyon.2017.e00501.
Wilson, T. J., Blackledge, M. S., & Vigueira, P. A. (2018). Resensitization of methicillin-resistant . Heliyon, 4(1), e00501. https://doi.org/10.1016/j.heliyon.2017.e00501
Wilson, Tyler J, et al. "Resensitization of methicillin-resistant ." Heliyon vol. 4,1 (2018): e00501. doi: https://doi.org/10.1016/j.heliyon.2017.e00501
Wilson TJ, Blackledge MS, Vigueira PA. Resensitization of methicillin-resistant . Heliyon. 2018 Jan 12;4(1):e00501. doi: 10.1016/j.heliyon.2017.e00501. eCollection 2018 Jan. PMID: 29349359; PMCID: PMC5767979.
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Showing 1 to 12 of 62 entries