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Showing 1 to 9 of 9 entries
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Epigenome-Wide Analysis of Methylation Changes in the Sequence of Gallstone Disease, Dysplasia, and Gallbladder Cancer.

Hepatology (Baltimore, Md.)

Brägelmann J, Barahona Ponce C, Marcelain K, Roessler S, Goeppert B, Gallegos I, Colombo A, Sanhueza V, Morales E, Rivera MT, de Toro G, Ortega A, Müller B, Gabler F, Scherer D, Waldenberger M, Reischl E, Boekstegers F, Garate-Calderon V, Umu SU, Rounge TB, Popanda O, Lorenzo Bermejo J.
PMID: 33020926
Hepatology. 2021 Jun;73(6):2293-2310. doi: 10.1002/hep.31585. Epub 2021 Jun 15.

BACKGROUND AND AIMS: Gallbladder cancer (GBC) is a highly aggressive malignancy of the biliary tract. Most cases of GBC are diagnosed in low-income and middle-income countries, and research into this disease has long been limited. In this study we...

Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data.

Hepatology (Baltimore, Md.)

Barahona Ponce C, Scherer D, Brinster R, Boekstegers F, Marcelain K, Gárate-Calderón V, Müller B, de Toro G, Retamales J, Barajas O, Ahumada M, Morales E, Rojas A, Sanhueza V, Loader D, Rivera MT, Gutiérrez L, Bernal G, Ortega A, Montalvo D, Portiño S, Bertrán ME, Gabler F, Spencer L, Olloquequi J, Fischer C, Jenab M, Aleksandrova K, Katzke V, Weiderpass E, Bonet C, Moradi T, Fischer K, Bossers W, Brenner H, Hveem K, Eklund N, Völker U, Waldenberger M, Fuentes Guajardo M, Gonzalez-Jose R, Bedoya G, Bortolini MC, Canizales-Quinteros S, Gallo C, Ruiz-Linares A, Rothhammer F, Lorenzo Bermejo J.
PMID: 32893372
Hepatology. 2021 May;73(5):1783-1796. doi: 10.1002/hep.31537.

BACKGROUND AND AIMS: Gallbladder cancer (GBC) is a neglected disease with substantial geographical variability: Chile shows the highest incidence worldwide, while GBC is relatively rare in Europe. Here, we investigate the causal effects of risk factors considered in current...

Epigenome-Wide Analysis of Methylation Changes in the Sequence of Gallstone Disease, Dysplasia, and Gallbladder Cancer.

Hepatology (Baltimore, Md.)

Brägelmann J, Barahona Ponce C, Marcelain K, Roessler S, Goeppert B, Gallegos I, Colombo A, Sanhueza V, Morales E, Rivera MT, de Toro G, Ortega A, Müller B, Gabler F, Scherer D, Waldenberger M, Reischl E, Boekstegers F, Garate-Calderon V, Umu SU, Rounge TB, Popanda O, Lorenzo Bermejo J.
PMID: 33020926
Hepatology. 2021 Jun;73(6):2293-2310. doi: 10.1002/hep.31585. Epub 2021 Jun 15.

BACKGROUND AND AIMS: Gallbladder cancer (GBC) is a highly aggressive malignancy of the biliary tract. Most cases of GBC are diagnosed in low-income and middle-income countries, and research into this disease has long been limited. In this study we...

Cardioprotective Potential of Thymosin s4 in a Preclinical Pig Model of Ischemia/Reperfusion Injury.

Journal of stem cells & regenerative medicine

Hinkel R, Aouni CE, Bock-Marquette I, Hatzopoulos A, Boekstegers P, Kupatt C.
PMID: 24692928
J Stem Cells Regen Med. 2007 May 16;2(1):98-9. eCollection 2007.

No abstract available.

Corticoperipheral neuromuscular disconnection in obstructive sleep apnoea.

Brain communications

Gouveris H, Bahr K, Schmitt E, Abriani A, Boekstegers T, Fassnacht S, Huppertz T, Groppa S, Muthuraman M.
PMID: 32954306
Brain Commun. 2020 May 11;2(1):fcaa056. doi: 10.1093/braincomms/fcaa056. eCollection 2020.

The roles of central nervous mechanisms and cortical output in obstructive sleep apnoea remain unclear. We addressed corticomuscular coupling between cortical sensorimotor areas and lower facial motor units as a mechanistic pathway and as a possible surrogate marker of...

Amerindian Ancestry Influences Genetic Susceptibility to Chronic Obstructive Pulmonary Disease.

Journal of personalized medicine

Díaz-Peña R, Boekstegers F, Silva RS, Jaime S, Hosgood Iii HD, Miravitlles M, Agustí À, Lorenzo Bermejo J, Olloquequi J.
PMID: 32824824
J Pers Med. 2020 Aug 18;10(3). doi: 10.3390/jpm10030093.

The contribution of genetic ancestry on chronic obstructive pulmonary disease (COPD) predisposition remains unclear. To explore this relationship, we analyzed the associations between 754,159 single nucleotide polymorphisms (SNPs) and risk of COPD (

Comparison of a Pure Plug-Based versus a Primary Suture-Based Vascular Closure Device Strategy for Transfemoral Transcatheter Aortic Valve Replacement: The CHOICE-CLOSURE Randomized Clinical Trial.

Circulation

Abdel-Wahab M, Hartung P, Dumpies O, Obradovic D, Wilde J, Majunke N, Boekstegers P, Müller R, Seyfarth M, Vorpahl M, Kiefer P, Noack T, Leontyev S, Sandri M, Rotta Detto Loria J, Kitamura M, Borger MA, Funkat AK, Hohenstein S, Desch S, Holzhey D, Thiele H.
PMID: 34738828
Circulation. 2021 Nov 05; doi: 10.1161/CIRCULATIONAHA.121.057856. Epub 2021 Nov 05.

No abstract available.

Inbreeding, native American ancestry and child mortality: Linking human selection and paediatric medicine.

Human molecular genetics

Koenigstein F, Boekstegers F, Wilson JF, Fuentes-Guajardo M, Gonzalez-Jose R, Bedoya G, Bortolini MC, Acuña-Alonzo V, Gallo C, Linares AR, Rothhammer F, Bermejo JL.
PMID: 34673976
Hum Mol Genet. 2021 Oct 21; doi: 10.1093/hmg/ddab302. Epub 2021 Oct 21.

The children of related parents show increased risk of early mortality. The Native American genome typically exhibits long stretches of homozygosity, and Latin Americans are highly heterogeneous regarding the individual burden of homozygosity, the proportion, and the type of...

Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data.

Hepatology (Baltimore, Md.)

Barahona Ponce C, Scherer D, Brinster R, Boekstegers F, Marcelain K, Gárate-Calderón V, Müller B, de Toro G, Retamales J, Barajas O, Ahumada M, Morales E, Rojas A, Sanhueza V, Loader D, Rivera MT, Gutiérrez L, Bernal G, Ortega A, Montalvo D, Portiño S, Bertrán ME, Gabler F, Spencer L, Olloquequi J, Fischer C, Jenab M, Aleksandrova K, Katzke V, Weiderpass E, Bonet C, Moradi T, Fischer K, Bossers W, Brenner H, Hveem K, Eklund N, Völker U, Waldenberger M, Fuentes Guajardo M, Gonzalez-Jose R, Bedoya G, Bortolini MC, Canizales-Quinteros S, Gallo C, Ruiz-Linares A, Rothhammer F, Lorenzo Bermejo J.
PMID: 32893372
Hepatology. 2021 May;73(5):1783-1796. doi: 10.1002/hep.31537.

BACKGROUND AND AIMS: Gallbladder cancer (GBC) is a neglected disease with substantial geographical variability: Chile shows the highest incidence worldwide, while GBC is relatively rare in Europe. Here, we investigate the causal effects of risk factors considered in current...

Showing 1 to 9 of 9 entries