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Showing 1 to 12 of 78 entries
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LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor.

Pathobiology of aging & age related diseases

de Laat R, Meabon JS, Wiley JC, Hudson MP, Montine TJ, Bothwell M.
PMID: 25758563
Pathobiol Aging Age Relat Dis. 2015 Mar 09;5:25796. doi: 10.3402/pba.v5.25796. eCollection 2015.

Sequential proteolytic cleavages of amyloid-β protein precursor (AβPP) by β-secretase and γ-secretase generate amyloid β (Aβ) peptides, which are thought to contribute to Alzheimer's disease (AD). Much of this processing occurs in endosomes following endocytosis of AβPP from the...

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de Laat R, Meabon JS, Wiley JC, et al. LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor. Pathobiol Aging Age Relat Dis. 2015;5:25796doi: 10.3402/pba.v5.25796.
de Laat, R., Meabon, J. S., Wiley, J. C., Hudson, M. P., Montine, T. J., & Bothwell, M. (2015). LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor. Pathobiology of aging & age related diseases, 525796. https://doi.org/10.3402/pba.v5.25796
de Laat, Rian, et al. "LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor." Pathobiology of aging & age related diseases vol. 5 (2015): 25796. doi: https://doi.org/10.3402/pba.v5.25796
de Laat R, Meabon JS, Wiley JC, Hudson MP, Montine TJ, Bothwell M. LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor. Pathobiol Aging Age Relat Dis. 2015 Mar 09;5:25796. doi: 10.3402/pba.v5.25796. eCollection 2015. PMID: 25758563; PMCID: PMC4355507.
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The Origin of Invasive Microorganisms Matters for Science, Policy, and Management: The Case of .

Bioscience

Taylor BW, Bothwell ML.
PMID: 26955071
Bioscience. 2014 Jun 01;64(6):531-538. doi: 10.1093/biosci/biu060. Epub 2014 May 06.

The value of distinguishing native from nonnative invasive species has recently been questioned. However, this dichotomy is important for understanding whether a species' successful dominance is caused by introductions, changing environmental conditions that facilitate an existing population, or both...

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Taylor BW, Bothwell ML. The Origin of Invasive Microorganisms Matters for Science, Policy, and Management: The Case of . Bioscience. 2014;64(6):531-538doi: 10.1093/biosci/biu060.
Taylor, B. W., & Bothwell, M. L. (2014). The Origin of Invasive Microorganisms Matters for Science, Policy, and Management: The Case of . Bioscience, 64(6), 531-538. https://doi.org/10.1093/biosci/biu060
Taylor, Brad W, and Bothwell, Max L. "The Origin of Invasive Microorganisms Matters for Science, Policy, and Management: The Case of ." Bioscience vol. 64,6 (2014): 531-538. doi: https://doi.org/10.1093/biosci/biu060
Taylor BW, Bothwell ML. The Origin of Invasive Microorganisms Matters for Science, Policy, and Management: The Case of . Bioscience. 2014 Jun 01;64(6):531-538. doi: 10.1093/biosci/biu060. Epub 2014 May 06. PMID: 26955071; PMCID: PMC4776677.
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Applications of bismuth(III) compounds in organic synthesis.

Chemical Society reviews

Bothwell JM, Krabbe SW, Mohan RS.
PMID: 21589974
Chem Soc Rev. 2011 Sep;40(9):4649-707. doi: 10.1039/c0cs00206b. Epub 2011 May 17.

This review article summarizes the applications of bismuth(III) compounds in organic synthesis since 2002. Although there are an increasing number of reports on applications of bismuth(III) salts in polymerization reactions, and their importance is acknowledged, they are not included...

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Bothwell JM, Krabbe SW, Mohan RS. Applications of bismuth(III) compounds in organic synthesis. Chem Soc Rev. 2011;40(9):4649-707doi: 10.1039/c0cs00206b.
Bothwell, J. M., Krabbe, S. W., & Mohan, R. S. (2011). Applications of bismuth(III) compounds in organic synthesis. Chemical Society reviews, 40(9), 4649-707. https://doi.org/10.1039/c0cs00206b
Bothwell, Jason M, et al. "Applications of bismuth(III) compounds in organic synthesis." Chemical Society reviews vol. 40,9 (2011): 4649-707. doi: https://doi.org/10.1039/c0cs00206b
Bothwell JM, Krabbe SW, Mohan RS. Applications of bismuth(III) compounds in organic synthesis. Chem Soc Rev. 2011 Sep;40(9):4649-707. doi: 10.1039/c0cs00206b. Epub 2011 May 17. PMID: 21589974.
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Comparison of trihalomethane levels and other water quality parameters for three treatment plants on the Ottawa River.

Environmental science & technology

Otson R, Williams DT, Bothwell PD, Quon TK.
PMID: 22284113
Environ Sci Technol. 1981 Sep 01;15(9):1075-80. doi: 10.1021/es00091a008.

No abstract available.

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Otson R, Williams DT, Bothwell PD, et al. Comparison of trihalomethane levels and other water quality parameters for three treatment plants on the Ottawa River. Environ Sci Technol. 1981;15(9):1075-80doi: 10.1021/es00091a008.
Otson, R., Williams, D. T., Bothwell, P. D., & Quon, T. K. (1981). Comparison of trihalomethane levels and other water quality parameters for three treatment plants on the Ottawa River. Environmental science & technology, 15(9), 1075-80. https://doi.org/10.1021/es00091a008
Otson, R, et al. "Comparison of trihalomethane levels and other water quality parameters for three treatment plants on the Ottawa River." Environmental science & technology vol. 15,9 (1981): 1075-80. doi: https://doi.org/10.1021/es00091a008
Otson R, Williams DT, Bothwell PD, Quon TK. Comparison of trihalomethane levels and other water quality parameters for three treatment plants on the Ottawa River. Environ Sci Technol. 1981 Sep 01;15(9):1075-80. doi: 10.1021/es00091a008. PMID: 22284113.
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A Mechanistic Approach to Modeling Single Protein Adsorption at Solid-Water Interfaces.

Journal of colloid and interface science

Bothwell MK, Lee WK, McGuire J.
PMID: 10191030
J Colloid Interface Sci. 1999 May 01;213(1):265-267. doi: 10.1006/jcis.1999.6135.

A kinetic model for single component protein adsorption which can be readily extended to adsorption from multi-protein solutions was developed, and used to simulate adsorption of site-directed, structural stability mutants of bacteriophage T4 lysozyme. The model allows for two...

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Bothwell MK, Lee WK, McGuire J. A Mechanistic Approach to Modeling Single Protein Adsorption at Solid-Water Interfaces. J Colloid Interface Sci. 1999;213(1):265-267doi: 10.1006/jcis.1999.6135.
Bothwell, M. K., Lee, W. K., & McGuire, J. (1999). A Mechanistic Approach to Modeling Single Protein Adsorption at Solid-Water Interfaces. Journal of colloid and interface science, 213(1), 265-267. https://doi.org/10.1006/jcis.1999.6135
Bothwell, et al. "A Mechanistic Approach to Modeling Single Protein Adsorption at Solid-Water Interfaces." Journal of colloid and interface science vol. 213,1 (1999): 265-267. doi: https://doi.org/10.1006/jcis.1999.6135
Bothwell MK, Lee WK, McGuire J. A Mechanistic Approach to Modeling Single Protein Adsorption at Solid-Water Interfaces. J Colloid Interface Sci. 1999 May 01;213(1):265-267. doi: 10.1006/jcis.1999.6135. PMID: 10191030.
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THE RELATIONSHIP BETWEEN PRE-OPERATIVE AND TWELVE-WEEK POST-OPERATIVE Y-BALANCE AND QUADRICEPS STRENGTH IN ATHLETES WITH AN ANTERIOR CRUCIATE LIGAMENT TEAR.

International journal of sports physical therapy

Hallagin C, Garrison JC, Creed K, Bothwell JM, Goto S, Hannon J.
PMID: 29158959
Int J Sports Phys Ther. 2017 Nov;12(6):986-993.

BACKGROUND: Pre-operative quadriceps strength may have a positive influence on post-operative function and outcomes at time of return to sport. Little consideration has been given to quadriceps strength during the early post-operative timeframes. Twelve-week post-operative anterior cruciate ligament reconstruction...

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Hallagin C, Garrison JC, Creed K, et al. THE RELATIONSHIP BETWEEN PRE-OPERATIVE AND TWELVE-WEEK POST-OPERATIVE Y-BALANCE AND QUADRICEPS STRENGTH IN ATHLETES WITH AN ANTERIOR CRUCIATE LIGAMENT TEAR. Int J Sports Phys Ther. 2017;12(6):986-993
Hallagin, C., Garrison, J. C., Creed, K., Bothwell, J. M., Goto, S., & Hannon, J. (2017). THE RELATIONSHIP BETWEEN PRE-OPERATIVE AND TWELVE-WEEK POST-OPERATIVE Y-BALANCE AND QUADRICEPS STRENGTH IN ATHLETES WITH AN ANTERIOR CRUCIATE LIGAMENT TEAR. International journal of sports physical therapy, 12(6), 986-993.
Hallagin, Cassidy, et al. "THE RELATIONSHIP BETWEEN PRE-OPERATIVE AND TWELVE-WEEK POST-OPERATIVE Y-BALANCE AND QUADRICEPS STRENGTH IN ATHLETES WITH AN ANTERIOR CRUCIATE LIGAMENT TEAR." International journal of sports physical therapy vol. 12,6 (2017): 986-993.
Hallagin C, Garrison JC, Creed K, Bothwell JM, Goto S, Hannon J. THE RELATIONSHIP BETWEEN PRE-OPERATIVE AND TWELVE-WEEK POST-OPERATIVE Y-BALANCE AND QUADRICEPS STRENGTH IN ATHLETES WITH AN ANTERIOR CRUCIATE LIGAMENT TEAR. Int J Sports Phys Ther. 2017 Nov;12(6):986-993. PMID: 29158959; PMCID: PMC5675374.
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Do Muscle Strength Deficits of the Uninvolved Hip and Knee Exist in Young Athletes Before Anterior Cruciate Ligament Reconstruction?.

Orthopaedic journal of sports medicine

Hannon J, Wang-Price S, Goto S, Garrison JC, Bothwell JM.
PMID: 28203600
Orthop J Sports Med. 2017 Jan 26;5(1):2325967116683941. doi: 10.1177/2325967116683941. eCollection 2017 Jan.

BACKGROUND: Muscle strength of the involved limb is known to be decreased after injury. Comparison with the uninvolved limb has become standard of practice to measure progress and for calculation of limb symmetry indices (LSIs) to determine readiness to...

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Hannon J, Wang-Price S, Goto S, et al. Do Muscle Strength Deficits of the Uninvolved Hip and Knee Exist in Young Athletes Before Anterior Cruciate Ligament Reconstruction?. Orthop J Sports Med. 2017;5(1):2325967116683941doi: 10.1177/2325967116683941.
Hannon, J., Wang-Price, S., Goto, S., Garrison, J. C., & Bothwell, J. M. (2017). Do Muscle Strength Deficits of the Uninvolved Hip and Knee Exist in Young Athletes Before Anterior Cruciate Ligament Reconstruction?. Orthopaedic journal of sports medicine, 5(1), 2325967116683941. https://doi.org/10.1177/2325967116683941
Hannon, Joseph, et al. "Do Muscle Strength Deficits of the Uninvolved Hip and Knee Exist in Young Athletes Before Anterior Cruciate Ligament Reconstruction?." Orthopaedic journal of sports medicine vol. 5,1 (2017): 2325967116683941. doi: https://doi.org/10.1177/2325967116683941
Hannon J, Wang-Price S, Goto S, Garrison JC, Bothwell JM. Do Muscle Strength Deficits of the Uninvolved Hip and Knee Exist in Young Athletes Before Anterior Cruciate Ligament Reconstruction?. Orthop J Sports Med. 2017 Jan 26;5(1):2325967116683941. doi: 10.1177/2325967116683941. eCollection 2017 Jan. PMID: 28203600; PMCID: PMC5298463.
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Simulated Angioedema in a Fresh Frozen Cadaver: A Novel Teaching Model for Airway Training.

Simulation in healthcare : journal of the Society for Simulation in Healthcare

Walsh RM, Bothwell JD.
PMID: 26335563
Simul Healthc. 2015 Dec;10(6):378-380. doi: 10.1097/SIH.0000000000000102.

INTRODUCTION: As educators, we are charged with preparing emergency medicine residents for successfully intubating patients with even the most troublesome anatomy. This situation is encountered during the intubation of patients with angioedema. These patients are uncommon in the emergency...

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Walsh RM, Bothwell JD. Simulated Angioedema in a Fresh Frozen Cadaver: A Novel Teaching Model for Airway Training. Simul Healthc. 2015;10(6):378-380doi: 10.1097/SIH.0000000000000102.
Walsh, R. M., & Bothwell, J. D. (2015). Simulated Angioedema in a Fresh Frozen Cadaver: A Novel Teaching Model for Airway Training. Simulation in healthcare : journal of the Society for Simulation in Healthcare, 10(6), 378-380. https://doi.org/10.1097/SIH.0000000000000102
Walsh, Ryan M, and Bothwell, Jason D. "Simulated Angioedema in a Fresh Frozen Cadaver: A Novel Teaching Model for Airway Training." Simulation in healthcare : journal of the Society for Simulation in Healthcare vol. 10,6 (2015): 378-380. doi: https://doi.org/10.1097/SIH.0000000000000102
Walsh RM, Bothwell JD. Simulated Angioedema in a Fresh Frozen Cadaver: A Novel Teaching Model for Airway Training. Simul Healthc. 2015 Dec;10(6):378-380. doi: 10.1097/SIH.0000000000000102. PMID: 26335563.
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Demonstration of a Timescale Based on a Stable Optical Carrier.

Physical review letters

Milner WR, Robinson JM, Kennedy CJ, Bothwell T, Kedar D, Matei DG, Legero T, Sterr U, Riehle F, Leopardi H, Fortier TM, Sherman JA, Levine J, Yao J, Ye J, Oelker E.
PMID: 31702265
Phys Rev Lett. 2019 Oct 25;123(17):173201. doi: 10.1103/PhysRevLett.123.173201.

We report on the first timescale based entirely on optical technology. Existing timescales, including those incorporating optical frequency standards, rely exclusively on microwave local oscillators owing to the lack of an optical oscillator with the required frequency predictability and...

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Milner WR, Robinson JM, Kennedy CJ, et al. Demonstration of a Timescale Based on a Stable Optical Carrier. Phys Rev Lett. 2019;123(17):173201doi: 10.1103/PhysRevLett.123.173201.
Milner, W. R., Robinson, J. M., Kennedy, C. J., Bothwell, T., Kedar, D., Matei, D. G., Legero, T., Sterr, U., Riehle, F., Leopardi, H., Fortier, T. M., Sherman, J. A., Levine, J., Yao, J., Ye, J., & Oelker, E. (2019). Demonstration of a Timescale Based on a Stable Optical Carrier. Physical review letters, 123(17), 173201. https://doi.org/10.1103/PhysRevLett.123.173201
Milner, William R, et al. "Demonstration of a Timescale Based on a Stable Optical Carrier." Physical review letters vol. 123,17 (2019): 173201. doi: https://doi.org/10.1103/PhysRevLett.123.173201
Milner WR, Robinson JM, Kennedy CJ, Bothwell T, Kedar D, Matei DG, Legero T, Sterr U, Riehle F, Leopardi H, Fortier TM, Sherman JA, Levine J, Yao J, Ye J, Oelker E. Demonstration of a Timescale Based on a Stable Optical Carrier. Phys Rev Lett. 2019 Oct 25;123(17):173201. doi: 10.1103/PhysRevLett.123.173201. PMID: 31702265.
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Probing the Origin of the Open Circuit Voltage in Perovskite Quantum Dot Photovoltaics.

ACS nano

Wieliczka BM, Márquez JA, Bothwell AM, Zhao Q, Moot T, VanSant KT, Ferguson AJ, Unold T, Kuciauskas D, Luther JM.
PMID: 34859993
ACS Nano. 2021 Dec 03; doi: 10.1021/acsnano.1c05642. Epub 2021 Dec 03.

Perovskite quantum dots (PQDs) have many properties that make them attractive for optoelectronic applications, including expanded compositional tunability and crystallographic stabilization. While they have not achieved the same photovoltaic (PV) efficiencies of top-performing perovskite thin films, they do reproducibly...

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Wieliczka BM, Márquez JA, Bothwell AM, et al. Probing the Origin of the Open Circuit Voltage in Perovskite Quantum Dot Photovoltaics. ACS Nano. 2021;doi: 10.1021/acsnano.1c05642.
Wieliczka, B. M., Márquez, J. A., Bothwell, A. M., Zhao, Q., Moot, T., VanSant, K. T., Ferguson, A. J., Unold, T., Kuciauskas, D., & Luther, J. M. (2021). Probing the Origin of the Open Circuit Voltage in Perovskite Quantum Dot Photovoltaics. ACS nano, . https://doi.org/10.1021/acsnano.1c05642
Wieliczka, Brian M, et al. "Probing the Origin of the Open Circuit Voltage in Perovskite Quantum Dot Photovoltaics." ACS nano vol. (2021). doi: https://doi.org/10.1021/acsnano.1c05642
Wieliczka BM, Márquez JA, Bothwell AM, Zhao Q, Moot T, VanSant KT, Ferguson AJ, Unold T, Kuciauskas D, Luther JM. Probing the Origin of the Open Circuit Voltage in Perovskite Quantum Dot Photovoltaics. ACS Nano. 2021 Dec 03; doi: 10.1021/acsnano.1c05642. Epub 2021 Dec 03. PMID: 34859993.
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HDAC6 Inhibition Corrects Electrophysiological and Axonal Transport Deficits in a Human Stem Cell-Based Model of Charcot-Marie-Tooth Disease (Type 2D).

Advanced biology

Smith AST, Kim JH, Chun C, Gharai A, Moon HW, Kim EY, Nam SH, Ha N, Song JY, Chung KW, Doo HM, Hesson J, Mathieu J, Bothwell M, Choi BO, Kim DH.
PMID: 34958183
Adv Biol (Weinh). 2021 Dec 26;e2101308. doi: 10.1002/adbi.202101308. Epub 2021 Dec 26.

Charcot-Marie-Tooth disease type 2D (CMT2D), is a hereditary peripheral neuropathy caused by mutations in the gene encoding glycyl-tRNA synthetase (GARS1). Here, human induced pluripotent stem cell (hiPSC)-based models of CMT2D bearing mutations in GARS1 and their use for the...

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Smith AST, Kim JH, Chun C, et al. HDAC6 Inhibition Corrects Electrophysiological and Axonal Transport Deficits in a Human Stem Cell-Based Model of Charcot-Marie-Tooth Disease (Type 2D). Adv Biol (Weinh). 2021;e2101308doi: 10.1002/adbi.202101308.
Smith, A. S. T., Kim, J. H., Chun, C., Gharai, A., Moon, H. W., Kim, E. Y., Nam, S. H., Ha, N., Song, J. Y., Chung, K. W., Doo, H. M., Hesson, J., Mathieu, J., Bothwell, M., Choi, B. O., & Kim, D. H. (2021). HDAC6 Inhibition Corrects Electrophysiological and Axonal Transport Deficits in a Human Stem Cell-Based Model of Charcot-Marie-Tooth Disease (Type 2D). Advanced biology, e2101308. https://doi.org/10.1002/adbi.202101308
Smith, Alec S T, et al. "HDAC6 Inhibition Corrects Electrophysiological and Axonal Transport Deficits in a Human Stem Cell-Based Model of Charcot-Marie-Tooth Disease (Type 2D)." Advanced biology vol. (2021): e2101308. doi: https://doi.org/10.1002/adbi.202101308
Smith AST, Kim JH, Chun C, Gharai A, Moon HW, Kim EY, Nam SH, Ha N, Song JY, Chung KW, Doo HM, Hesson J, Mathieu J, Bothwell M, Choi BO, Kim DH. HDAC6 Inhibition Corrects Electrophysiological and Axonal Transport Deficits in a Human Stem Cell-Based Model of Charcot-Marie-Tooth Disease (Type 2D). Adv Biol (Weinh). 2021 Dec 26;e2101308. doi: 10.1002/adbi.202101308. Epub 2021 Dec 26. PMID: 34958183.
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Human Induced Pluripotent Stem Cell-Derived TDP-43 Mutant Neurons Exhibit Consistent Functional Phenotypes Across Multiple Gene Edited Lines Despite Transcriptomic and Splicing Discrepancies.

Frontiers in cell and developmental biology

Smith AST, Chun C, Hesson J, Mathieu J, Valdmanis PN, Mack DL, Choi BO, Kim DH, Bothwell M.
PMID: 34660586
Front Cell Dev Biol. 2021 Sep 29;9:728707. doi: 10.3389/fcell.2021.728707. eCollection 2021.

Gene editing technologies hold great potential to enhance our ability to model inheritable neurodegenerative diseases. Specifically, engineering multiple amyotrophic lateral sclerosis (ALS) mutations into isogenic cell populations facilitates determination of whether different causal mutations cause pathology

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Smith AST, Chun C, Hesson J, et al. Human Induced Pluripotent Stem Cell-Derived TDP-43 Mutant Neurons Exhibit Consistent Functional Phenotypes Across Multiple Gene Edited Lines Despite Transcriptomic and Splicing Discrepancies. Front Cell Dev Biol. 2021;9:728707doi: 10.3389/fcell.2021.728707.
Smith, A. S. T., Chun, C., Hesson, J., Mathieu, J., Valdmanis, P. N., Mack, D. L., Choi, B. O., Kim, D. H., & Bothwell, M. (2021). Human Induced Pluripotent Stem Cell-Derived TDP-43 Mutant Neurons Exhibit Consistent Functional Phenotypes Across Multiple Gene Edited Lines Despite Transcriptomic and Splicing Discrepancies. Frontiers in cell and developmental biology, 9728707. https://doi.org/10.3389/fcell.2021.728707
Smith, Alec S T, et al. "Human Induced Pluripotent Stem Cell-Derived TDP-43 Mutant Neurons Exhibit Consistent Functional Phenotypes Across Multiple Gene Edited Lines Despite Transcriptomic and Splicing Discrepancies." Frontiers in cell and developmental biology vol. 9 (2021): 728707. doi: https://doi.org/10.3389/fcell.2021.728707
Smith AST, Chun C, Hesson J, Mathieu J, Valdmanis PN, Mack DL, Choi BO, Kim DH, Bothwell M. Human Induced Pluripotent Stem Cell-Derived TDP-43 Mutant Neurons Exhibit Consistent Functional Phenotypes Across Multiple Gene Edited Lines Despite Transcriptomic and Splicing Discrepancies. Front Cell Dev Biol. 2021 Sep 29;9:728707. doi: 10.3389/fcell.2021.728707. eCollection 2021. PMID: 34660586; PMCID: PMC8511491.
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Showing 1 to 12 of 78 entries