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Showing 1 to 12 of 32 entries
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Germline whole exome sequencing and large-scale replication identifies .

Oncotarget

Dicks E, Song H, Ramus SJ, Oudenhove EV, Tyrer JP, Intermaggio MP, Kar S, Harrington P, Bowtell DD, Group AS, Cicek MS, Cunningham JM, Fridley BL, Alsop J, Jimenez-Linan M, Piskorz A, Goranova T, Kent E, Siddiqui N, Paul J, Crawford R, Poblete S, Lele S, Sucheston-Campbell L, Moysich KB, Sieh W, McGuire V, Lester J, Odunsi K, Whittemore AS, Bogdanova N, Dürst M, Hillemanns P, Karlan BY, Gentry-Maharaj A, Menon U, Tischkowitz M, Levine D, Brenton JD, Dörk T, Goode EL, Gayther SA, Pharoah DPP.
PMID: 28881617
Oncotarget. 2017 Mar 03;8(31):50930-50940. doi: 10.18632/oncotarget.15871. eCollection 2017 Aug 01.

We analyzed whole exome sequencing data in germline DNA from 412 high grade serous ovarian cancer (HGSOC) cases from The Cancer Genome Atlas Project and identified 5,517 genes harboring a predicted deleterious germline coding mutation in at least one...

Acquired .

Cancer research

Nesic K, Kondrashova O, Hurley RM, McGehee CD, Vandenberg CJ, Ho GY, Lieschke E, Dall G, Bound N, Shield-Artin K, Radke M, Musafer A, Chai ZQ, Ghamsari MRE, Harrell MI, Kee D, Olesen I, McNally O, Traficante N, Australian Ovarian Cancer Study, DeFazio A, Bowtell DDL, Swisher EM, Weroha SJ, Nones K, Waddell N, Kaufmann SH, Dobrovic A, Wakefield MJ, Scott CL.
PMID: 34321239
Cancer Res. 2021 Sep 15;81(18):4709-4722. doi: 10.1158/0008-5472.CAN-21-0774. Epub 2021 Jul 28.

In high-grade serous ovarian carcinoma (HGSC), deleterious mutations in DNA repair gene

Use, Practices and Attitudes of Elite and Sub-Elite Athletes towards Tart Cherry Supplementation.

Sports (Basel, Switzerland)

Wangdi JT, Sabou V, O'Leary MF, Kelly VG, Bowtell JL.
PMID: 33807198
Sports (Basel). 2021 Mar 31;9(4). doi: 10.3390/sports9040049.

Tart cherry (TC) supplementation can improve exercise recovery and performance; and may also improve sleep duration and quality. This study investigated the use and knowledge of TC supplementation by athletes of all competitive levels. Eighty participants (52.5% elite (international,...

Synergistic targeting of BRCA1 mutated breast cancers with PARP and CDK2 inhibition.

NPJ breast cancer

Aziz D, Portman N, Fernandez KJ, Lee C, Alexandrou S, Llop-Guevara A, Phan Z, Yong A, Wilkinson A, Sergio CM, Ferraro D, Etemadmoghadam D, Bowtell DD, Serra V, Waring P, Lim E, Caldon CE.
PMID: 34465787
NPJ Breast Cancer. 2021 Aug 31;7(1):111. doi: 10.1038/s41523-021-00312-x.

Basal-like breast cancers (BLBC) are aggressive breast cancers that respond poorly to targeted therapies and chemotherapies. In order to define therapeutically targetable subsets of BLBC we examined two markers: cyclin E1 and BRCA1 loss. In high grade serous ovarian...

Tart Cherry Supplement Enhances Skeletal Muscle Glutathione Peroxidase Expression and Functional Recovery after Muscle Damage.

Medicine and science in sports and exercise

Wangdi JT, O'Leary MF, Kelly VG, Jackman SR, Tang JCY, Dutton J, Bowtell JL.
PMID: 34772901
Med Sci Sports Exerc. 2021 Nov 10; doi: 10.1249/MSS.0000000000002827. Epub 2021 Nov 10.

INTRODUCTION: Montmorency cherry concentrate (MCC) supplementation enhances functional recovery from exercise, potentially due to antioxidant and anti-inflammatory effects. However, to date, supporting empirical evidence for these mechanistic hypotheses is reliant on indirect blood biomarkers. This study is the first...

Direct contact ultrasound for fouling control and flux enhancement in air-gap membrane distillation.

Ultrasonics sonochemistry

Naji O, Al-Juboori RA, Bowtell L, Alpatova A, Ghaffour N.
PMID: 31669841
Ultrason Sonochem. 2020 Mar;61:104816. doi: 10.1016/j.ultsonch.2019.104816. Epub 2019 Sep 30.

Air Gap Membrane distillation (AGMD) is a thermally driven separation process capable of treating challenging water types, but its low productivity is a major drawback. Membrane fouling is a common problem in many membrane treatment systems, which exacerbates AGMD's...

Signal Transduction Pathway Activity in High-Grade, Serous Ovarian Carcinoma Reveals a More Favorable Prognosis in Tumors with Low PI3K and High NF-κB Pathway Activity: A Novel Approach to a Long-Standing Enigma.

Cancers

van Lieshout L, van de Stolpe A, van der Ploeg P, Bowtell D, de Hullu J, Piek J.
PMID: 32961868
Cancers (Basel). 2020 Sep 18;12(9). doi: 10.3390/cancers12092660.

We investigated signal transduction pathway (STP) activity in high-grade serous ovarian carcinoma (HGSC) in relation to progression-free survival (PFS) and overall survival (OS). We made use of signal transduction pathway activity analysis (STA analysis), a novel method to quantify...

Genomic Analysis Using Regularized Regression in High-Grade Serous Ovarian Cancer.

Cancer informatics

Natanzon Y, Earp M, Cunningham JM, Kalli KR, Wang C, Armasu SM, Larson MC, Bowtell DD, Garsed DW, Fridley BL, Winham SJ, Goode EL.
PMID: 29434467
Cancer Inform. 2018 Feb 01;17:1176935118755341. doi: 10.1177/1176935118755341. eCollection 2018.

High-grade serous ovarian cancer (HGSOC) is a complex disease in which initiation and progression have been associated with copy number alterations, epigenetic processes, and, to a lesser extent, germline variation. We hypothesized that, when summarized at the gene level,...

A dual role for Caspase8 and NF-.

Cell death discovery

Hernandez L, Kim MK, Noonan AM, Sagher E, Kohlhammer H, Wright G, Lyle LT, Steeg PS, Anver M, Bowtell DD, Annunziata CM.
PMID: 28179987
Cell Death Discov. 2015 Dec 14;1:15053. doi: 10.1038/cddiscovery.2015.53. eCollection 2015.

Ovarian cancer is a deadly disease characterized by primary and acquired resistance to chemotherapy. We previously associated NF-

Lower Body Acceleration and Muscular Responses to Rotational and Vertical Whole-Body Vibration at Different Frequencies and Amplitudes.

Dose-response : a publication of International Hormesis Society

Zaidell LN, Pollock RD, James DC, Bowtell JL, Newham DJ, Sumners DP, Mileva KN.
PMID: 30670936
Dose Response. 2019 Jan 06;17(1):1559325818819946. doi: 10.1177/1559325818819946. eCollection 2019.

AIM: The aim of this study was to characterize acceleration transmission and neuromuscular responses to rotational vibration (RV) and vertical vibration (VV) at different frequencies and amplitudes.METHODS: Twelve healthy males completed 2 experimental trials (RV vs VV) during which...

Correction: The Subclonal Architecture of Metastatic Breast Cancer: Results from a Prospective Community-Based Rapid Autopsy Program "CASCADE".

PLoS medicine

Savas P, Teo ZL, Lefevre C, Flensburg C, Caramia F, Alsop K, Mansour M, Francis PA, Thorne HA, Silva MJ, Kanu N, Dietzen M, Rowan A, Kschischo M, Fox S, Bowtell DD, Dawson SJ, Speed TP, Swanton C, Loi S.
PMID: 28430777
PLoS Med. 2017 Apr 21;14(4):e1002302. doi: 10.1371/journal.pmed.1002302. eCollection 2017 Apr.

[This corrects the article DOI: 10.1371/journal.pmed.1002204.].

No evidence for PALB2 methylation in high-grade serous ovarian cancer.

Journal of ovarian research

Mikeska T, Alsop K, Mitchell G, Bowtell DD, Dobrovic A.
PMID: 23587053
J Ovarian Res. 2013 Apr 12;6(1):26. doi: 10.1186/1757-2215-6-26.

BACKGROUND: High-grade serous ovarian cancers are a distinct histological subtype of ovarian cancer often characterised by a dysfunctional BRCA/Fanconi anaemia (BRCA/FA) pathway, which is critical to the homologous recombination DNA repair machinery. An impaired BRCA/FA pathway sensitises tumours to...

Showing 1 to 12 of 32 entries