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Showing 1 to 12 of 34 entries
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Characterization of monoamine oxidase activity during early stages of quail embryogenesis.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

Pintar JE, Maxwell GD, Breakefield XO.
PMID: 24875606
Int J Dev Neurosci. 1983;1(1):49-57. doi: 10.1016/0736-5748(83)90010-2.

Catecholamines and other biogenic amines may play a role in early embryogenesis in addition to functioning as neurotransmitters after neuronal differentiation. Regulation of amine levels is mediated by several different parameters including activity levels of degradative enzymes. Since monoamine...

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Pintar JE, Maxwell GD, Breakefield XO. Characterization of monoamine oxidase activity during early stages of quail embryogenesis. Int J Dev Neurosci. 1983;1(1):49-57doi: 10.1016/0736-5748(83)90010-2.
Pintar, J. E., Maxwell, G. D., & Breakefield, X. O. (1983). Characterization of monoamine oxidase activity during early stages of quail embryogenesis. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1(1), 49-57. https://doi.org/10.1016/0736-5748(83)90010-2
Pintar, J E, et al. "Characterization of monoamine oxidase activity during early stages of quail embryogenesis." International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience vol. 1,1 (1983): 49-57. doi: https://doi.org/10.1016/0736-5748(83)90010-2
Pintar JE, Maxwell GD, Breakefield XO. Characterization of monoamine oxidase activity during early stages of quail embryogenesis. Int J Dev Neurosci. 1983;1(1):49-57. doi: 10.1016/0736-5748(83)90010-2. PMID: 24875606.
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Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study.

Bioscience

Zaborowski MP, Balaj L, Breakefield XO, Lai CP.
PMID: 26955082
Bioscience. 2015 Aug 01;65(8):783-797. doi: 10.1093/biosci/biv084. Epub 2015 Jun 26.

The release of extracellular vesicles (EVs), including exosomes and microvesicles, is a phenomenon shared by many cell types as a means of communicating with other cells and also potentially removing cell contents. The cargo of EVs includes the proteins,...

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Zaborowski MP, Balaj L, Breakefield XO, et al. Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study. Bioscience. 2015;65(8):783-797doi: 10.1093/biosci/biv084.
Zaborowski, M. P., Balaj, L., Breakefield, X. O., & Lai, C. P. (2015). Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study. Bioscience, 65(8), 783-797. https://doi.org/10.1093/biosci/biv084
Zaborowski, MikoŁaj P, et al. "Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study." Bioscience vol. 65,8 (2015): 783-797. doi: https://doi.org/10.1093/biosci/biv084
Zaborowski MP, Balaj L, Breakefield XO, Lai CP. Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study. Bioscience. 2015 Aug 01;65(8):783-797. doi: 10.1093/biosci/biv084. Epub 2015 Jun 26. PMID: 26955082; PMCID: PMC4776721.
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RESPONSE: Re: Folylpolyglutamyl Synthetase Gene Transfer and Glioma Antifolate Sensitivity in Culture and In Vivo.

Journal of the National Cancer Institute

Aghi M, Kramm CM, Breakefield XO.
PMID: 10580034
J Natl Cancer Inst. 1999 Dec 01;91(23):2048-2049. doi: 10.1093/jnci/91.23.2048.

No abstract available.

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Aghi M, Kramm CM, Breakefield XO. RESPONSE: Re: Folylpolyglutamyl Synthetase Gene Transfer and Glioma Antifolate Sensitivity in Culture and In Vivo. J Natl Cancer Inst. 1999;91(23):2048-2049doi: 10.1093/jnci/91.23.2048.
Aghi, M., Kramm, C. M., & Breakefield, X. O. (1999). RESPONSE: Re: Folylpolyglutamyl Synthetase Gene Transfer and Glioma Antifolate Sensitivity in Culture and In Vivo. Journal of the National Cancer Institute, 91(23), 2048-2049. https://doi.org/10.1093/jnci/91.23.2048
Aghi, et al. "RESPONSE: Re: Folylpolyglutamyl Synthetase Gene Transfer and Glioma Antifolate Sensitivity in Culture and In Vivo." Journal of the National Cancer Institute vol. 91,23 (1999): 2048-2049. doi: https://doi.org/10.1093/jnci/91.23.2048
Aghi M, Kramm CM, Breakefield XO. RESPONSE: Re: Folylpolyglutamyl Synthetase Gene Transfer and Glioma Antifolate Sensitivity in Culture and In Vivo. J Natl Cancer Inst. 1999 Dec 01;91(23):2048-2049. doi: 10.1093/jnci/91.23.2048. PMID: 10580034.
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Cell-mediated delivery of neurotrophic factors and neuroprotection in the neostriatum and substantia nigra.

Restorative neurology and neuroscience

Isacson O, Frim DM, Galpern WR, Tatter SB, Breakefield XO, Schumacher JM.
PMID: 21551807
Restor Neurol Neurosci. 1995 Jan 01;8(1):59-61. doi: 10.3233/RNN-1995-81213.

No abstract available.

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Isacson O, Frim DM, Galpern WR, et al. Cell-mediated delivery of neurotrophic factors and neuroprotection in the neostriatum and substantia nigra. Restor Neurol Neurosci. 1995;8(1):59-61doi: 10.3233/RNN-1995-81213.
Isacson, O., Frim, D. M., Galpern, W. R., Tatter, S. B., Breakefield, X. O., & Schumacher, J. M. (1995). Cell-mediated delivery of neurotrophic factors and neuroprotection in the neostriatum and substantia nigra. Restorative neurology and neuroscience, 8(1), 59-61. https://doi.org/10.3233/RNN-1995-81213
Isacson, O, et al. "Cell-mediated delivery of neurotrophic factors and neuroprotection in the neostriatum and substantia nigra." Restorative neurology and neuroscience vol. 8,1 (1995): 59-61. doi: https://doi.org/10.3233/RNN-1995-81213
Isacson O, Frim DM, Galpern WR, Tatter SB, Breakefield XO, Schumacher JM. Cell-mediated delivery of neurotrophic factors and neuroprotection in the neostriatum and substantia nigra. Restor Neurol Neurosci. 1995 Jan 01;8(1):59-61. doi: 10.3233/RNN-1995-81213. PMID: 21551807.
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miR-1289 and "Zipcode"-like Sequence Enrich mRNAs in Microvesicles.

Molecular therapy. Nucleic acids

Bolukbasi MF, Mizrak A, Ozdener GB, Madlener S, Ströbel T, Erkan EP, Fan JB, Breakefield XO, Saydam O.
PMID: 23344721
Mol Ther Nucleic Acids. 2012 Feb 07;1:e10. doi: 10.1038/mtna.2011.2.

Despite intensive studies, the molecular mechanisms by which the genetic materials are uploaded into microvesicles (MVs) are still unknown. This is the first study describing a zipcode-like 25 nucleotide (nt) sequence in the 3'-untranslated region (3'UTR) of mRNAs, with...

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Bolukbasi MF, Mizrak A, Ozdener GB, et al. miR-1289 and "Zipcode"-like Sequence Enrich mRNAs in Microvesicles. Mol Ther Nucleic Acids. 2012;1:e10doi: 10.1038/mtna.2011.2.
Bolukbasi, M. F., Mizrak, A., Ozdener, G. B., Madlener, S., Ströbel, T., Erkan, E. P., Fan, J. B., Breakefield, X. O., & Saydam, O. (2012). miR-1289 and "Zipcode"-like Sequence Enrich mRNAs in Microvesicles. Molecular therapy. Nucleic acids, 1e10. https://doi.org/10.1038/mtna.2011.2
Bolukbasi, Mehmet Fatih, et al. "miR-1289 and "Zipcode"-like Sequence Enrich mRNAs in Microvesicles." Molecular therapy. Nucleic acids vol. 1 (2012): e10. doi: https://doi.org/10.1038/mtna.2011.2
Bolukbasi MF, Mizrak A, Ozdener GB, Madlener S, Ströbel T, Erkan EP, Fan JB, Breakefield XO, Saydam O. miR-1289 and "Zipcode"-like Sequence Enrich mRNAs in Microvesicles. Mol Ther Nucleic Acids. 2012 Feb 07;1:e10. doi: 10.1038/mtna.2011.2. PMID: 23344721; PMCID: PMC3381601.
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Role of exosomes/microvesicles in the nervous system and use in emerging therapies.

Frontiers in physiology

Lai CP, Breakefield XO.
PMID: 22754538
Front Physiol. 2012 Jun 27;3:228. doi: 10.3389/fphys.2012.00228. eCollection 2012.

Extracellular membrane vesicles (EMVs) are nanometer sized vesicles, including exosomes and microvesicles capable of transferring DNAs, mRNAs, microRNAs, non-coding RNAs, proteins, and lipids among cells without direct cell-to-cell contact, thereby representing a novel form of intercellular communication. Many cells...

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Lai CP, Breakefield XO. Role of exosomes/microvesicles in the nervous system and use in emerging therapies. Front Physiol. 2012;3:228doi: 10.3389/fphys.2012.00228.
Lai, C. P., & Breakefield, X. O. (2012). Role of exosomes/microvesicles in the nervous system and use in emerging therapies. Frontiers in physiology, 3228. https://doi.org/10.3389/fphys.2012.00228
Lai, Charles Pin-Kuang, and Breakefield, Xandra Owen. "Role of exosomes/microvesicles in the nervous system and use in emerging therapies." Frontiers in physiology vol. 3 (2012): 228. doi: https://doi.org/10.3389/fphys.2012.00228
Lai CP, Breakefield XO. Role of exosomes/microvesicles in the nervous system and use in emerging therapies. Front Physiol. 2012 Jun 27;3:228. doi: 10.3389/fphys.2012.00228. eCollection 2012. PMID: 22754538; PMCID: PMC3384085.
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Gene Delivery to the Nervous System: NINDS Workshop on Gene Delivery to the Nervous System Washington, DC, 12-13 November 2007.

Molecular therapy : the journal of the American Society of Gene Therapy

Schubert M, Breakefield X, Federoff H, Frederickson RM, Lowenstein PR.
PMID: 28178462
Mol Ther. 2008 Apr;16(4):640-646. doi: 10.1038/mt.2008.42. Epub 2016 Dec 08.

No abstract available.

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Schubert M, Breakefield X, Federoff H, et al. Gene Delivery to the Nervous System: NINDS Workshop on Gene Delivery to the Nervous System Washington, DC, 12-13 November 2007. Mol Ther. 2016;16(4):640-646doi: 10.1038/mt.2008.42.
Schubert, M., Breakefield, X., Federoff, H., Frederickson, R. M., & Lowenstein, P. R. (2008). Gene Delivery to the Nervous System: NINDS Workshop on Gene Delivery to the Nervous System Washington, DC, 12-13 November 2007. Molecular therapy : the journal of the American Society of Gene Therapy, 16(4), 640-646. https://doi.org/10.1038/mt.2008.42
Schubert, Manfred, et al. "Gene Delivery to the Nervous System: NINDS Workshop on Gene Delivery to the Nervous System Washington, DC, 12-13 November 2007." Molecular therapy : the journal of the American Society of Gene Therapy vol. 16,4 (2008): 640-646. doi: https://doi.org/10.1038/mt.2008.42
Schubert M, Breakefield X, Federoff H, Frederickson RM, Lowenstein PR. Gene Delivery to the Nervous System: NINDS Workshop on Gene Delivery to the Nervous System Washington, DC, 12-13 November 2007. Mol Ther. 2008 Apr;16(4):640-646. doi: 10.1038/mt.2008.42. Epub 2016 Dec 08. PMID: 28178462.
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Gene therapy for tuberous sclerosis complex type 2 in a mouse model by delivery of AAV9 encoding a condensed form of tuberin.

Science advances

Cheah PS, Prabhakar S, Yellen D, Beauchamp RL, Zhang X, Kasamatsu S, Bronson RT, Thiele EA, Kwiatkowski DJ, Stemmer-Rachamimov A, György B, Ling KH, Kaneki M, Tannous BA, Ramesh V, Maguire CA, Breakefield XO.
PMID: 33523984
Sci Adv. 2021 Jan 08;7(2). doi: 10.1126/sciadv.abb1703. Print 2021 Jan.

Tuberous sclerosis complex (TSC) results from loss of a tumor suppressor gene -

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Cheah PS, Prabhakar S, Yellen D, et al. Gene therapy for tuberous sclerosis complex type 2 in a mouse model by delivery of AAV9 encoding a condensed form of tuberin. Sci Adv. 2021;7(2)doi: 10.1126/sciadv.abb1703.
Cheah, P. S., Prabhakar, S., Yellen, D., Beauchamp, R. L., Zhang, X., Kasamatsu, S., Bronson, R. T., Thiele, E. A., Kwiatkowski, D. J., Stemmer-Rachamimov, A., György, B., Ling, K. H., Kaneki, M., Tannous, B. A., Ramesh, V., Maguire, C. A., & Breakefield, X. O. (2021). Gene therapy for tuberous sclerosis complex type 2 in a mouse model by delivery of AAV9 encoding a condensed form of tuberin. Science advances, 7(2), . https://doi.org/10.1126/sciadv.abb1703
Cheah, Pike-See, et al. "Gene therapy for tuberous sclerosis complex type 2 in a mouse model by delivery of AAV9 encoding a condensed form of tuberin." Science advances vol. 7,2 (2021). doi: https://doi.org/10.1126/sciadv.abb1703
Cheah PS, Prabhakar S, Yellen D, Beauchamp RL, Zhang X, Kasamatsu S, Bronson RT, Thiele EA, Kwiatkowski DJ, Stemmer-Rachamimov A, György B, Ling KH, Kaneki M, Tannous BA, Ramesh V, Maguire CA, Breakefield XO. Gene therapy for tuberous sclerosis complex type 2 in a mouse model by delivery of AAV9 encoding a condensed form of tuberin. Sci Adv. 2021 Jan 08;7(2). doi: 10.1126/sciadv.abb1703. Print 2021 Jan. PMID: 33523984; PMCID: PMC7793581.
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Discovery and Verification of Extracellular miRNA Biomarkers for Non-invasive Prediction of Pre-eclampsia in Asymptomatic Women.

Cell reports. Medicine

Srinivasan S, Treacy R, Herrero T, Olsen R, Leonardo TR, Zhang X, DeHoff P, To C, Poling LG, Fernando A, Leon-Garcia S, Knepper K, Tran V, Meads M, Tasarz J, Vuppala A, Park S, Laurent CD, Bui T, Cheah PS, Overcash RT, Ramos GA, Roeder H, Ghiran I, Parast M, Breakefield XO, Lueth AJ, Rust SR, Dufford MT, Fox AC, Hickok DE, Burchard J, Boniface JJ, Laurent LC.
PMID: 32864636
Cell Rep Med. 2020 May 19;1(2). doi: 10.1016/j.xcrm.2020.100013.

Development of effective prevention and treatment strategies for pre-eclampsia is limited by the lack of accurate methods for identification of at-risk pregnancies. We performed small RNA sequencing (RNA-seq) of maternal serum extracellular RNAs (exRNAs) to discover and verify microRNAs...

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Srinivasan S, Treacy R, Herrero T, et al. Discovery and Verification of Extracellular miRNA Biomarkers for Non-invasive Prediction of Pre-eclampsia in Asymptomatic Women. Cell Rep Med. 2020;1(2)doi: 10.1016/j.xcrm.2020.100013.
Srinivasan, S., Treacy, R., Herrero, T., Olsen, R., Leonardo, T. R., Zhang, X., DeHoff, P., To, C., Poling, L. G., Fernando, A., Leon-Garcia, S., Knepper, K., Tran, V., Meads, M., Tasarz, J., Vuppala, A., Park, S., Laurent, C. D., Bui, T., Cheah, P. S., Overcash, R. T., Ramos, G. A., Roeder, H., Ghiran, I., Parast, M., Breakefield, X. O., Lueth, A. J., Rust, S. R., Dufford, M. T., Fox, A. C., Hickok, D. E., Burchard, J., Boniface, J. J., & Laurent, L. C. (2020). Discovery and Verification of Extracellular miRNA Biomarkers for Non-invasive Prediction of Pre-eclampsia in Asymptomatic Women. Cell reports. Medicine, 1(2), . https://doi.org/10.1016/j.xcrm.2020.100013
Srinivasan, Srimeenakshi, et al. "Discovery and Verification of Extracellular miRNA Biomarkers for Non-invasive Prediction of Pre-eclampsia in Asymptomatic Women." Cell reports. Medicine vol. 1,2 (2020). doi: https://doi.org/10.1016/j.xcrm.2020.100013
Srinivasan S, Treacy R, Herrero T, Olsen R, Leonardo TR, Zhang X, DeHoff P, To C, Poling LG, Fernando A, Leon-Garcia S, Knepper K, Tran V, Meads M, Tasarz J, Vuppala A, Park S, Laurent CD, Bui T, Cheah PS, Overcash RT, Ramos GA, Roeder H, Ghiran I, Parast M, Breakefield XO, Lueth AJ, Rust SR, Dufford MT, Fox AC, Hickok DE, Burchard J, Boniface JJ, Laurent LC. Discovery and Verification of Extracellular miRNA Biomarkers for Non-invasive Prediction of Pre-eclampsia in Asymptomatic Women. Cell Rep Med. 2020 May 19;1(2). doi: 10.1016/j.xcrm.2020.100013. PMID: 32864636; PMCID: PMC7455024.
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Differences in thermal balance, body temperature and activity between non-melanic and melanic two-spot ladybird beetles (Adalia bipunctata) under controlled conditions.

The Journal of experimental biology

Jong P, Gussekloo S, Brakefield P.
PMID: 9320589
J Exp Biol. 1996;199:2655-66.

The consequences of the elytral colour difference between non-melanic (red) and melanic (black) two-spot ladybirds for their thermal properties were studied by applying and testing a biophysical model. The expected differential effects of variation in transmission through the elytra,...

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Jong P, Gussekloo S, Brakefield P. Differences in thermal balance, body temperature and activity between non-melanic and melanic two-spot ladybird beetles (Adalia bipunctata) under controlled conditions. J Exp Biol. 1996;199:2655-66
Jong, P., Gussekloo, S., & Brakefield, P. (1996). Differences in thermal balance, body temperature and activity between non-melanic and melanic two-spot ladybird beetles (Adalia bipunctata) under controlled conditions. The Journal of experimental biology, 1992655-66.
Jong, et al. "Differences in thermal balance, body temperature and activity between non-melanic and melanic two-spot ladybird beetles (Adalia bipunctata) under controlled conditions." The Journal of experimental biology vol. 199 (1996): 2655-66.
Jong P, Gussekloo S, Brakefield P. Differences in thermal balance, body temperature and activity between non-melanic and melanic two-spot ladybird beetles (Adalia bipunctata) under controlled conditions. J Exp Biol. 1996;199:2655-66. PMID: 9320589.
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CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease.

Molecular therapy. Nucleic acids

György B, Lööv C, Zaborowski MP, Takeda S, Kleinstiver BP, Commins C, Kastanenka K, Mu D, Volak A, Giedraitis V, Lannfelt L, Maguire CA, Joung JK, Hyman BT, Breakefield XO, Ingelsson M.
PMID: 29858078
Mol Ther Nucleic Acids. 2018 Jun 01;11:429-440. doi: 10.1016/j.omtn.2018.03.007. Epub 2018 Mar 16.

The APPswe (Swedish) mutation in the amyloid precursor protein (APP) gene causes dominantly inherited Alzheimer's disease (AD) as a result of increased β-secretase cleavage of the amyloid-β (Aβ) precursor protein. This leads to abnormally high Aβ levels, not only...

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György B, Lööv C, Zaborowski MP, et al. CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease. Mol Ther Nucleic Acids. 2018;11:429-440doi: 10.1016/j.omtn.2018.03.007.
György, B., Lööv, C., Zaborowski, M. P., Takeda, S., Kleinstiver, B. P., Commins, C., Kastanenka, K., Mu, D., Volak, A., Giedraitis, V., Lannfelt, L., Maguire, C. A., Joung, J. K., Hyman, B. T., Breakefield, X. O., & Ingelsson, M. (2018). CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease. Molecular therapy. Nucleic acids, 11429-440. https://doi.org/10.1016/j.omtn.2018.03.007
György, Bence, et al. "CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease." Molecular therapy. Nucleic acids vol. 11 (2018): 429-440. doi: https://doi.org/10.1016/j.omtn.2018.03.007
György B, Lööv C, Zaborowski MP, Takeda S, Kleinstiver BP, Commins C, Kastanenka K, Mu D, Volak A, Giedraitis V, Lannfelt L, Maguire CA, Joung JK, Hyman BT, Breakefield XO, Ingelsson M. CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease. Mol Ther Nucleic Acids. 2018 Jun 01;11:429-440. doi: 10.1016/j.omtn.2018.03.007. Epub 2018 Mar 16. PMID: 29858078; PMCID: PMC5992788.
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Untethering the nuclear envelope and cytoskeleton: biologically distinct dystonias arising from a common cellular dysfunction.

International journal of cell biology

Atai NA, Ryan SD, Kothary R, Breakefield XO, Nery FC.
PMID: 22611399
Int J Cell Biol. 2012;2012:634214. doi: 10.1155/2012/634214. Epub 2012 May 06.

Most cases of early onset DYT1 dystonia in humans are caused by a GAG deletion in the TOR1A gene leading to loss of a glutamic acid (ΔE) in the torsinA protein, which underlies a movement disorder associated with neuronal...

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Atai NA, Ryan SD, Kothary R, et al. Untethering the nuclear envelope and cytoskeleton: biologically distinct dystonias arising from a common cellular dysfunction. Int J Cell Biol. 2012;2012:634214doi: 10.1155/2012/634214.
Atai, N. A., Ryan, S. D., Kothary, R., Breakefield, X. O., & Nery, F. C. (2012). Untethering the nuclear envelope and cytoskeleton: biologically distinct dystonias arising from a common cellular dysfunction. International journal of cell biology, 2012634214. https://doi.org/10.1155/2012/634214
Atai, Nadia A, et al. "Untethering the nuclear envelope and cytoskeleton: biologically distinct dystonias arising from a common cellular dysfunction." International journal of cell biology vol. 2012 (2012): 634214. doi: https://doi.org/10.1155/2012/634214
Atai NA, Ryan SD, Kothary R, Breakefield XO, Nery FC. Untethering the nuclear envelope and cytoskeleton: biologically distinct dystonias arising from a common cellular dysfunction. Int J Cell Biol. 2012;2012:634214. doi: 10.1155/2012/634214. Epub 2012 May 06. PMID: 22611399; PMCID: PMC3352338.
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Showing 1 to 12 of 34 entries