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Further exploration of the heterocyclic diversity accessible from the allylation chemistry of indigo.

Beilstein journal of organic chemistry

Shakoori A, Bremner JB, Abdel-Hamid MK, Willis AC, Haritakun R, Keller PA.
PMID: 25977722
Beilstein J Org Chem. 2015 Apr 15;11:481-92. doi: 10.3762/bjoc.11.54. eCollection 2015.

Diversity-directed synthesis based on the cascade allylation chemistry of indigo, with its embedded 2,2'-diindolic core, has resulted in rapid access to new examples of the hydroxy-8a,13-dihydroazepino[1,2-a:3,4-b']diindol-14(8H)-one skeleton in up to 51% yield. Additionally a derivative of the novel bridged...

Health care costs for prostate cancer patients receiving androgen deprivation therapy: treatment and adverse events.

Current oncology (Toronto, Ont.)

Krahn MD, Bremner KE, Luo J, Alibhai SM.
PMID: 24940106
Curr Oncol. 2014 Jun;21(3):e457-65. doi: 10.3747/co.21.1865.

BACKGROUND: Serious adverse events have been associated with androgen deprivation therapy (adt) for prostate cancer (pca), but few studies address the costs of those events.METHODS: All pca patients (ICD-9-CM 185) in Ontario who started 90 days or more of...

Practical scheme for quantum computation with any two-qubit entangling gate.

Physical review letters

Bremner MJ, Dawson CM, Dodd JL, Gilchrist A, Harrow AW, Mortimer D, Nielsen MA, Osborne TJ.
PMID: 12484981
Phys Rev Lett. 2002 Dec 09;89(24):247902. doi: 10.1103/PhysRevLett.89.247902. Epub 2002 Nov 25.

Which gates are universal for quantum computation? Although it is well known that certain gates on two-level quantum systems (qubits), such as the controlled-not, are universal when assisted by arbitrary one-qubit gates, it has only recently become clear precisely...

New molecular perovskites: cubic C(4)N(2)H(12).NH(4)Cl(3).H(2)O and 2-H hexagonal C(6)N(2)H(14).NH(4)Cl(3).

Journal of the American Chemical Society

Bremner CA, Simpson M, Harrison WT.
PMID: 12224926
J Am Chem Soc. 2002 Sep 18;124(37):10960-1. doi: 10.1021/ja027484e.

The room-temperature syntheses and single-crystal structures of C(4)N(2)H(12).NH(4)Cl(3).H(2)O and C(6)N(2)H(14).NH(4)Cl(3) are reported. These novel molecular perovskites contain vertex-sharing octahedral (NH(4))Cl(6) arrays which replicate the octahedral packing in the cubic (SrTiO(3)) and 2-H hexagonal (BaNiO(3)) perovskite structures, respectively. The structures...

Regulation of assimilatory nitrate reductase activity in soil by microbial assimilation of ammonium.

Proceedings of the National Academy of Sciences of the United States of America

McCarty GW, Bremner JM.
PMID: 11607250
Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):453-6. doi: 10.1073/pnas.89.2.453.

It is well established that assimilatory nitrate reductase (ANR) activity in soil is inhibited by ammonium (NH4+). To elucidate the mechanism of this inhibition, we studied the effect of L-methionine sulfoximine (MSX), an inhibitor of NH4+ assimilation by microorganisms,...

A combined manipulandum-reinforcement arrangement.

Journal of the experimental analysis of behavior

BREMNER FJ, TROWILL JA.
PMID: 13872796
J Exp Anal Behav. 1962 Jul;5:339-40. doi: 10.1901/jeab.1962.5-339.

No abstract available.

Structural changes in the brain in depression and relationship to symptom recurrence.

CNS spectrums

Bremner JD.
PMID: 15220855
CNS Spectr. 2002 Feb;7(2):129-30, 135-9. doi: 10.1017/s1092852900017442.

Depression is an important public health problem affecting about 15% of the general population; however, little is known about possible changes in the brain that might underlie the disorder. Neuroimaging has been a powerful tool to map actual changes...

Evidence that the adverse effect of urea fertilizer on seed germination in soil is due to ammonia formed through hydrolysis of urea by soil urease.

Proceedings of the National Academy of Sciences of the United States of America

Bremner JM, Krogmeier MJ.
PMID: 16594076
Proc Natl Acad Sci U S A. 1989 Nov;86(21):8185-8. doi: 10.1073/pnas.86.21.8185.

Studies using seeds of wheat (Triticum aestivum L.), rye (Secale cereale L.), barley (Hordeum vulgare L.), and corn (Zea mays L.) indicated that the adverse effect of urea fertilizer on seed germination in soil is due to ammonia formed...

Production of nitrous oxide by ammonia-oxidizing chemoautotrophic microorganisms in soil.

Applied and environmental microbiology

Blackmer AM, Bremner JM, Schmidt EL.
PMID: 16345670
Appl Environ Microbiol. 1980 Dec;40(6):1060-6. doi: 10.1128/aem.40.6.1060-1066.1980.

Gas chromatographic studies showed that nitrous oxide was produced in each instance when sterilized (autoclaved) soil was incubated after treatment with ammonium sulfate and inoculation with pure cultures of ammonia-oxidizing chemoautotrophic microorganisms (strains of Nitrosomonas, Nitrosospira, and Nitrosolobus). Production...

Androgen receptor gene expression in the rat central nervous system: Evidence for two mRNA transcripts.

Molecular and cellular neurosciences

McLachlan RI, Tempel BL, Miller MA, Bicknell JN, Bremner WJ, Dorsa DM.
PMID: 19912789
Mol Cell Neurosci. 1991 Apr;2(2):117-22. doi: 10.1016/1044-7431(91)90003-7.

Androgen receptor (AR) gene expression in the central nervous system (CNS) and peripheral tissues of male rats was examined using cDNA probes to measure AR mRNA by RNA (Northern) blot analysis and by in situ hybridization. Using a probe...

A new palladium-mediated approach to 4-N-arylamino-1-butanols from peroxidic tetrahydrofuran and primary aromatic amines.

Tetrahedron letters

Russell HF, Bremner JB, Bushelle-Edghill J, Lewis MR, Thomas SR, Bates F.
PMID: 18071580
Tetrahedron Lett. 2007 Feb 26;48(9):1637-1639. doi: 10.1016/j.tetlet.2006.12.136.

Reaction of primary aromatic amines with peroxidic tetrahydrofuran (THF) in the presence of hydrogen and 10% palladium on carbon catalyst results in THF ring opening to give 4-N-arylamino-1-butanols in good yield. The reaction mechanism is believed to involve a...

Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations.

Beilstein journal of organic chemistry

Bremner JB, Keller PA, Pyne SG, Robertson MJ, Sakthivel K, Somphol K, Baylis D, Coates JA, Deadman J, Jeevarajah D, Rhodes DI.
PMID: 23019457
Beilstein J Org Chem. 2012;8:1265-70. doi: 10.3762/bjoc.8.142. Epub 2012 Aug 09.

The facile synthesis of seven new dicationic tripeptide benzyl ester derivatives, with hydrophobic group variations in the C-terminal amino acid component, is described. Moderate to good activity was seen against Gram-positive bacteria in vitro. One cyclohexyl-substituted compound 2c was...

Showing 1 to 12 of 118 entries