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[Quality assurance in surgery].

Zentralblatt fur Chirurgie

Brockmüller U.
PMID: 9012241
Zentralbl Chir. 1996;121(9):801.

No abstract available.

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Brockmüller U. Qualitätssicherung in der Chirurgie. [Quality assurance in surgery]. Zentralbl Chir. 1996;121(9):801
Brockmüller, U. (1996). Qualitätssicherung in der Chirurgie. [Quality assurance in surgery]. Zentralblatt fur Chirurgie, 121(9), 801.
Brockmüller, U. "Qualitätssicherung in der Chirurgie." [Quality assurance in surgery]. Zentralblatt fur Chirurgie vol. 121,9 (1996): 801.
Brockmüller U. Qualitätssicherung in der Chirurgie. [Quality assurance in surgery]. Zentralbl Chir. 1996;121(9):801. German. PMID: 9012241.
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The CYP2C9 polymorphism: from enzyme kinetics to clinical dose recommendations.

Personalized medicine

Kirchheiner J, Tsahuridu M, Jabrane W, Roots I, Brockmöller J.
PMID: 29793229
Per Med. 2004 Dec;1(1):63-84. doi: 10.1517/17410541.1.1.63.

CYP2C9 is the major human enzyme of the cytochrome P450 2C subfamily and metabolizes approximately 10% of all therapeutically relevant drugs. Two inherited SNPs termed CYP2C9*2 (Arg144Cys) and *3 (Ile359Leu) are known to affect catalytic function. Numerous rare or...

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Kirchheiner J, Tsahuridu M, Jabrane W, et al. The CYP2C9 polymorphism: from enzyme kinetics to clinical dose recommendations. Per Med. 2004;1(1):63-84doi: 10.1517/17410541.1.1.63.
Kirchheiner, J., Tsahuridu, M., Jabrane, W., Roots, I., & Brockmöller, J. (2004). The CYP2C9 polymorphism: from enzyme kinetics to clinical dose recommendations. Personalized medicine, 1(1), 63-84. https://doi.org/10.1517/17410541.1.1.63
Kirchheiner, Julia, et al. "The CYP2C9 polymorphism: from enzyme kinetics to clinical dose recommendations." Personalized medicine vol. 1,1 (2004): 63-84. doi: https://doi.org/10.1517/17410541.1.1.63
Kirchheiner J, Tsahuridu M, Jabrane W, Roots I, Brockmöller J. The CYP2C9 polymorphism: from enzyme kinetics to clinical dose recommendations. Per Med. 2004 Dec;1(1):63-84. doi: 10.1517/17410541.1.1.63. PMID: 29793229.
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Cellular Uptake of Psychostimulants - Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers?.

Frontiers in pharmacology

Jensen O, Rafehi M, Gebauer L, Brockmöller J.
PMID: 33551812
Front Pharmacol. 2021 Jan 20;11:609811. doi: 10.3389/fphar.2020.609811. eCollection 2020.

Psychostimulants are used therapeutically and for illegal recreational purposes. Many of these are inhibitors of the presynaptic noradrenaline, dopamine, and serotonin transporters (NET, DAT, and SERT). According to their physicochemical properties, some might also be substrates of polyspecific organic...

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Jensen O, Rafehi M, Gebauer L, et al. Cellular Uptake of Psychostimulants - Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers?. Front Pharmacol. 2021;11:609811doi: 10.3389/fphar.2020.609811.
Jensen, O., Rafehi, M., Gebauer, L., & Brockmöller, J. (2020). Cellular Uptake of Psychostimulants - Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers?. Frontiers in pharmacology, 11609811. https://doi.org/10.3389/fphar.2020.609811
Jensen, Ole, et al. "Cellular Uptake of Psychostimulants - Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers?." Frontiers in pharmacology vol. 11 (2020): 609811. doi: https://doi.org/10.3389/fphar.2020.609811
Jensen O, Rafehi M, Gebauer L, Brockmöller J. Cellular Uptake of Psychostimulants - Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers?. Front Pharmacol. 2021 Jan 20;11:609811. doi: 10.3389/fphar.2020.609811. eCollection 2020. PMID: 33551812; PMCID: PMC7854383.
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The roles of caffeine and corticosteroids in modulating cortical excitability after paired associative stimulation (PAS) and transcranial alternating current stimulation (tACS) in caffeine-naïve and caffeine-adapted subjects.

Psychoneuroendocrinology

Zulkifly MFM, Merkohitaj O, Paulus W, Brockmöller J.
PMID: 33740589
Psychoneuroendocrinology. 2021 May;127:105201. doi: 10.1016/j.psyneuen.2021.105201. Epub 2021 Mar 15.

The modulatory effects of non-invasive brain stimulation (NIBS) are highly variable between subjects. This variability may be due to uncontrolled caffeine consumption and circadian rhythms. Therefore, here we studied if caffeine consumption, systemically available caffeine measured in saliva, and...

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Zulkifly MFM, Merkohitaj O, Paulus W, et al. The roles of caffeine and corticosteroids in modulating cortical excitability after paired associative stimulation (PAS) and transcranial alternating current stimulation (tACS) in caffeine-naïve and caffeine-adapted subjects. Psychoneuroendocrinology. 2021;127:105201doi: 10.1016/j.psyneuen.2021.105201.
Zulkifly, M. F. M., Merkohitaj, O., Paulus, W., & Brockmöller, J. (2021). The roles of caffeine and corticosteroids in modulating cortical excitability after paired associative stimulation (PAS) and transcranial alternating current stimulation (tACS) in caffeine-naïve and caffeine-adapted subjects. Psychoneuroendocrinology, 127105201. https://doi.org/10.1016/j.psyneuen.2021.105201
Zulkifly, Mohd Faizal Mohd, et al. "The roles of caffeine and corticosteroids in modulating cortical excitability after paired associative stimulation (PAS) and transcranial alternating current stimulation (tACS) in caffeine-naïve and caffeine-adapted subjects." Psychoneuroendocrinology vol. 127 (2021): 105201. doi: https://doi.org/10.1016/j.psyneuen.2021.105201
Zulkifly MFM, Merkohitaj O, Paulus W, Brockmöller J. The roles of caffeine and corticosteroids in modulating cortical excitability after paired associative stimulation (PAS) and transcranial alternating current stimulation (tACS) in caffeine-naïve and caffeine-adapted subjects. Psychoneuroendocrinology. 2021 May;127:105201. doi: 10.1016/j.psyneuen.2021.105201. Epub 2021 Mar 15. PMID: 33740589.
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Overlap and Specificity in the Substrate Spectra of Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3.

International journal of molecular sciences

Gebauer L, Jensen O, Neif M, Brockmöller J, Dücker C.
PMID: 34884618
Int J Mol Sci. 2021 Nov 26;22(23). doi: 10.3390/ijms222312816.

Human monoamine transporters (MATs) are cation transporters critically involved in neuronal signal transmission. While inhibitors of MATs have been intensively studied, their substrate spectra have received far less attention. Polyspecific organic cation transporters (OCTs), predominantly known for their role...

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Gebauer L, Jensen O, Neif M, et al. Overlap and Specificity in the Substrate Spectra of Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3. Int J Mol Sci. 2021;22(23)doi: 10.3390/ijms222312816.
Gebauer, L., Jensen, O., Neif, M., Brockmöller, J., & Dücker, C. (2021). Overlap and Specificity in the Substrate Spectra of Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3. International journal of molecular sciences, 22(23), . https://doi.org/10.3390/ijms222312816
Gebauer, Lukas, et al. "Overlap and Specificity in the Substrate Spectra of Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3." International journal of molecular sciences vol. 22,23 (2021). doi: https://doi.org/10.3390/ijms222312816
Gebauer L, Jensen O, Neif M, Brockmöller J, Dücker C. Overlap and Specificity in the Substrate Spectra of Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3. Int J Mol Sci. 2021 Nov 26;22(23). doi: 10.3390/ijms222312816. PMID: 34884618; PMCID: PMC8657982.
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Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2.

Biochemical pharmacology

Gebauer L, Arul Murugan N, Jensen O, Brockmöller J, Rafehi M.
PMID: 34902340
Biochem Pharmacol. 2021 Dec 10;197:114871. doi: 10.1016/j.bcp.2021.114871. Epub 2021 Dec 10.

Stereoselectivity is important in many pharmacological processes but its impact on drug membrane transport is scarcely understood. Recent studies showed strong stereoselective effects in the cellular uptake of fenoterol by the organic cation transporters OCT1 and OCT2. To provide...

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Gebauer L, Arul Murugan N, Jensen O, et al. Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2. Biochem Pharmacol. 2021;197:114871doi: 10.1016/j.bcp.2021.114871.
Gebauer, L., Arul Murugan, N., Jensen, O., Brockmöller, J., & Rafehi, M. (2021). Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2. Biochemical pharmacology, 197114871. https://doi.org/10.1016/j.bcp.2021.114871
Gebauer, Lukas, et al. "Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2." Biochemical pharmacology vol. 197 (2021): 114871. doi: https://doi.org/10.1016/j.bcp.2021.114871
Gebauer L, Arul Murugan N, Jensen O, Brockmöller J, Rafehi M. Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2. Biochem Pharmacol. 2021 Dec 10;197:114871. doi: 10.1016/j.bcp.2021.114871. Epub 2021 Dec 10. PMID: 34902340.
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Functional and Pharmacological Comparison of Human and Mouse Na.

SLAS discovery : advancing life sciences R & D

Floerl S, Kuehne A, Geyer J, Brockmoeller J, Tzvetkov MV, Hagos Y.
PMID: 34060352
SLAS Discov. 2021 Sep;26(8):1055-1064. doi: 10.1177/24725552211017500. Epub 2021 Jun 01.

The Na

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Floerl S, Kuehne A, Geyer J, et al. Functional and Pharmacological Comparison of Human and Mouse Na. SLAS Discov. 2021;26(8):1055-1064doi: 10.1177/24725552211017500.
Floerl, S., Kuehne, A., Geyer, J., Brockmoeller, J., Tzvetkov, M. V., & Hagos, Y. (2021). Functional and Pharmacological Comparison of Human and Mouse Na. SLAS discovery : advancing life sciences R & D, 26(8), 1055-1064. https://doi.org/10.1177/24725552211017500
Floerl, Saskia, et al. "Functional and Pharmacological Comparison of Human and Mouse Na." SLAS discovery : advancing life sciences R & D vol. 26,8 (2021): 1055-1064. doi: https://doi.org/10.1177/24725552211017500
Floerl S, Kuehne A, Geyer J, Brockmoeller J, Tzvetkov MV, Hagos Y. Functional and Pharmacological Comparison of Human and Mouse Na. SLAS Discov. 2021 Sep;26(8):1055-1064. doi: 10.1177/24725552211017500. Epub 2021 Jun 01. PMID: 34060352.
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Chromosome-scale reference genome assembly of a diploid potato clone derived from an elite variety.

G3 (Bethesda, Md.)

Freire R, Weisweiler M, Guerreiro R, Baig N, Hüttel B, Obeng-Hinneh E, Renner J, Hartje S, Muders K, Truberg B, Rosen A, Prigge V, Bruckmüller J, Lübeck J, Stich B.
PMID: 34534288
G3 (Bethesda). 2021 Dec 08;11(12). doi: 10.1093/g3journal/jkab330.

Potato (Solanum tuberosum L.) is one of the most important crops with a worldwide production of 370 million metric tons. The objectives of this study were (1) to create a high-quality consensus sequence across the two haplotypes of a...

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Freire R, Weisweiler M, Guerreiro R, et al. Chromosome-scale reference genome assembly of a diploid potato clone derived from an elite variety. G3 (Bethesda). 2021;11(12)doi: 10.1093/g3journal/jkab330.
Freire, R., Weisweiler, M., Guerreiro, R., Baig, N., Hüttel, B., Obeng-Hinneh, E., Renner, J., Hartje, S., Muders, K., Truberg, B., Rosen, A., Prigge, V., Bruckmüller, J., Lübeck, J., & Stich, B. (2021). Chromosome-scale reference genome assembly of a diploid potato clone derived from an elite variety. G3 (Bethesda, Md.), 11(12), . https://doi.org/10.1093/g3journal/jkab330
Freire, Ruth, et al. "Chromosome-scale reference genome assembly of a diploid potato clone derived from an elite variety." G3 (Bethesda, Md.) vol. 11,12 (2021). doi: https://doi.org/10.1093/g3journal/jkab330
Freire R, Weisweiler M, Guerreiro R, Baig N, Hüttel B, Obeng-Hinneh E, Renner J, Hartje S, Muders K, Truberg B, Rosen A, Prigge V, Bruckmüller J, Lübeck J, Stich B. Chromosome-scale reference genome assembly of a diploid potato clone derived from an elite variety. G3 (Bethesda). 2021 Dec 08;11(12). doi: 10.1093/g3journal/jkab330. PMID: 34534288; PMCID: PMC8664475.
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The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response.

Translational psychiatry

Biernacka JM, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Baune BT, Kato M, Liu YL, Praphanphoj V, Stingl JC, Tsai SJ, Kubo M, Klein TE, Weinshilboum R.
PMID: 27801898
Transl Psychiatry. 2016 Nov 01;6(11):e937. doi: 10.1038/tp.2016.187.

No abstract available.

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Biernacka JM, Sangkuhl K, Jenkins G, et al. The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response. Transl Psychiatry. 2016;6(11):e937doi: 10.1038/tp.2016.187.
Biernacka, J. M., Sangkuhl, K., Jenkins, G., Whaley, R. M., Barman, P., Batzler, A., Altman, R. B., Arolt, V., Brockmöller, J., Chen, C. H., Domschke, K., Hall-Flavin, D. K., Hong, C. J., Illi, A., Ji, Y., Kampman, O., Kinoshita, T., Leinonen, E., Liou, Y. J., Mushiroda, T., Nonen, S., Skime, M. K., Wang, L., Baune, B. T., Kato, M., Liu, Y. L., Praphanphoj, V., Stingl, J. C., Tsai, S. J., Kubo, M., Klein, T. E., & Weinshilboum, R. (2016). The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response. Translational psychiatry, 6(11), e937. https://doi.org/10.1038/tp.2016.187
Biernacka, J M, et al. "The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response." Translational psychiatry vol. 6,11 (2016): e937. doi: https://doi.org/10.1038/tp.2016.187
Biernacka JM, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Baune BT, Kato M, Liu YL, Praphanphoj V, Stingl JC, Tsai SJ, Kubo M, Klein TE, Weinshilboum R. The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response. Transl Psychiatry. 2016 Nov 01;6(11):e937. doi: 10.1038/tp.2016.187. PMID: 27801898; PMCID: PMC5314112.
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Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2.

Biochemical pharmacology

Gebauer L, Arul Murugan N, Jensen O, Brockmöller J, Rafehi M.
PMID: 34902340
Biochem Pharmacol. 2021 Dec 10;197:114871. doi: 10.1016/j.bcp.2021.114871. Epub 2021 Dec 10.

Stereoselectivity is important in many pharmacological processes but its impact on drug membrane transport is scarcely understood. Recent studies showed strong stereoselective effects in the cellular uptake of fenoterol by the organic cation transporters OCT1 and OCT2. To provide...

Cite
Gebauer L, Arul Murugan N, Jensen O, et al. Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2. Biochem Pharmacol. 2021;197:114871doi: 10.1016/j.bcp.2021.114871.
Gebauer, L., Arul Murugan, N., Jensen, O., Brockmöller, J., & Rafehi, M. (2021). Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2. Biochemical pharmacology, 197114871. https://doi.org/10.1016/j.bcp.2021.114871
Gebauer, Lukas, et al. "Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2." Biochemical pharmacology vol. 197 (2021): 114871. doi: https://doi.org/10.1016/j.bcp.2021.114871
Gebauer L, Arul Murugan N, Jensen O, Brockmöller J, Rafehi M. Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2. Biochem Pharmacol. 2021 Dec 10;197:114871. doi: 10.1016/j.bcp.2021.114871. Epub 2021 Dec 10. PMID: 34902340.
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Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder.

Frontiers in psychiatry

Amare AT, Schubert KO, Tekola-Ayele F, Hsu YH, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Kato M, Liu YL, Praphanphoj V, Stingl JC, Bobo WV, Tsai SJ, Kubo M, Klein TE, Weinshilboum RM, Biernacka JM, Baune BT.
PMID: 29559929
Front Psychiatry. 2018 Mar 06;9:65. doi: 10.3389/fpsyt.2018.00065. eCollection 2018.

Studies reported a strong genetic correlation between the Big Five personality traits and major depressive disorder (MDD). Moreover, personality traits are thought to be associated with response to antidepressants treatment that might partly be mediated by genetic factors. In...

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Amare AT, Schubert KO, Tekola-Ayele F, et al. Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder. Front Psychiatry. 2018;9:65doi: 10.3389/fpsyt.2018.00065.
Amare, A. T., Schubert, K. O., Tekola-Ayele, F., Hsu, Y. H., Sangkuhl, K., Jenkins, G., Whaley, R. M., Barman, P., Batzler, A., Altman, R. B., Arolt, V., Brockmöller, J., Chen, C. H., Domschke, K., Hall-Flavin, D. K., Hong, C. J., Illi, A., Ji, Y., Kampman, O., Kinoshita, T., Leinonen, E., Liou, Y. J., Mushiroda, T., Nonen, S., Skime, M. K., Wang, L., Kato, M., Liu, Y. L., Praphanphoj, V., Stingl, J. C., Bobo, W. V., Tsai, S. J., Kubo, M., Klein, T. E., Weinshilboum, R. M., Biernacka, J. M., & Baune, B. T. (2018). Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder. Frontiers in psychiatry, 965. https://doi.org/10.3389/fpsyt.2018.00065
Amare, Azmeraw T, et al. "Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder." Frontiers in psychiatry vol. 9 (2018): 65. doi: https://doi.org/10.3389/fpsyt.2018.00065
Amare AT, Schubert KO, Tekola-Ayele F, Hsu YH, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Kato M, Liu YL, Praphanphoj V, Stingl JC, Bobo WV, Tsai SJ, Kubo M, Klein TE, Weinshilboum RM, Biernacka JM, Baune BT. Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder. Front Psychiatry. 2018 Mar 06;9:65. doi: 10.3389/fpsyt.2018.00065. eCollection 2018. PMID: 29559929; PMCID: PMC5845551.
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CYP2D6 and CYP2C19 in Papua New Guinea: High frequency of previously uncharacterized CYP2D6 alleles and heterozygote excess.

International journal of molecular epidemiology and genetics

von Ahsen N, Tzvetkov M, Karunajeewa HA, Gomorrai S, Ura A, Brockmöller J, Davis TM, Mueller I, Ilett KF, Oellerich M.
PMID: 21532842
Int J Mol Epidemiol Genet. 2010 Aug 18;1(4):310-9.

PURPOSE: A high frequency of previously unknown CYP2D6 alleles have been reported in Oceania populations. Genetic and functional properties of these alleles remain unknown.METHODS: We performed analyses of the genetic variability of CYP2D6 and CYP2C19 genes using AmpliChip genotyping...

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von Ahsen N, Tzvetkov M, Karunajeewa HA, et al. CYP2D6 and CYP2C19 in Papua New Guinea: High frequency of previously uncharacterized CYP2D6 alleles and heterozygote excess. Int J Mol Epidemiol Genet. 2010;1(4):310-9
von Ahsen, N., Tzvetkov, M., Karunajeewa, H. A., Gomorrai, S., Ura, A., Brockmöller, J., Davis, T. M., Mueller, I., Ilett, K. F., & Oellerich, M. (2010). CYP2D6 and CYP2C19 in Papua New Guinea: High frequency of previously uncharacterized CYP2D6 alleles and heterozygote excess. International journal of molecular epidemiology and genetics, 1(4), 310-9.
von Ahsen, Nicolas, et al. "CYP2D6 and CYP2C19 in Papua New Guinea: High frequency of previously uncharacterized CYP2D6 alleles and heterozygote excess." International journal of molecular epidemiology and genetics vol. 1,4 (2010): 310-9.
von Ahsen N, Tzvetkov M, Karunajeewa HA, Gomorrai S, Ura A, Brockmöller J, Davis TM, Mueller I, Ilett KF, Oellerich M. CYP2D6 and CYP2C19 in Papua New Guinea: High frequency of previously uncharacterized CYP2D6 alleles and heterozygote excess. Int J Mol Epidemiol Genet. 2010 Aug 18;1(4):310-9. PMID: 21532842; PMCID: PMC3076784.
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