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Showing 1 to 12 of 42 entries
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Arc Interacts with the Integral Endoplasmic Reticulum Protein, Calnexin.

Frontiers in cellular neuroscience

Myrum C, Soulé J, Bittins M, Cavagnini K, Goff K, Ziemek SK, Eriksen MS, Patil S, Szum A, Nair RR, Bramham CR.
PMID: 28979192
Front Cell Neurosci. 2017 Sep 20;11:294. doi: 10.3389/fncel.2017.00294. eCollection 2017.

Activity-regulated cytoskeleton-associated protein, Arc, is a major regulator of long-term synaptic plasticity and memory formation. Here we reveal a novel interaction partner of Arc, a resident endoplasmic reticulum transmembrane protein, calnexin. We show an interaction between recombinantly-expressed GST-tagged Arc...

Axillary surgery in women with sentinel node-positive operable breast cancer: a systematic review with meta-analyses.

SpringerPlus

Schmidt-Hansen M, Bromham N, Hasler E, Reed MW.
PMID: 26848425
Springerplus. 2016 Jan 27;5:85. doi: 10.1186/s40064-016-1712-9. eCollection 2016.

Traditionally, women with node-positive operable breast cancer have received complete axillary lymph node dissection (ALND), which is associated with significant morbidity, but recently less invasive alternatives have been explored. We conducted a systematic review of randomised controlled trials assessing...

Social Defeat during Adolescence and Adulthood Differentially Induce BDNF-Regulated Immediate Early Genes.

Frontiers in behavioral neuroscience

Coppens CM, Siripornmongcolchai T, Wibrand K, Alme MN, Buwalda B, de Boer SF, Koolhaas JM, Bramham CR.
PMID: 22065953
Front Behav Neurosci. 2011 Nov 02;5:72. doi: 10.3389/fnbeh.2011.00072. eCollection 2011.

Stressful life events generally enhance the vulnerability for the development of human psychopathologies such as anxiety disorders and depression. The incidence rates of adult mental disorders steeply rises during adolescence in parallel with a structural and functional reorganization of...

Hormetic Effects of Early Juvenile Radiation Exposure on Adult Reproduction and Offspring Performance in the Cricket (.

Dose-response : a publication of International Hormesis Society

Shephard AM, Aksenov V, Tran J, Nelson CJ, Boreham DR, Rollo CD.
PMID: 30210269
Dose Response. 2018 Sep 06;16(3):1559325818797499. doi: 10.1177/1559325818797499. eCollection 2018.

Exposure to low-dose ionizing radiation can have positive impacts on biological performance-a concept known as hormesis. Although radiation hormesis is well-documented, the predominant focus has been medical. In comparison, little research has examined potential effects of early life radiation...

Dynamic Arc SUMOylation and Selective Interaction with F-Actin-Binding Protein Drebrin A in LTP Consolidation .

Frontiers in synaptic neuroscience

Nair RR, Patil S, Tiron A, Kanhema T, Panja D, Schiro L, Parobczak K, Wilczynski G, Bramham CR.
PMID: 28553222
Front Synaptic Neurosci. 2017 May 10;9:8. doi: 10.3389/fnsyn.2017.00008. eCollection 2017.

Activity-regulatedcytoskeleton-associated protein (Arc) protein is implicated as a master regulator of long-term forms of synaptic plasticity and memory formation, but the mechanisms controlling Arc protein function are little known. Post-translation modification by small ubiquitin-like modifier (SUMO) proteins has emerged...

Parasites and politics: why cross-cultural studies must control for relatedness, proximity and covariation.

Royal Society open science

Bromham L, Hua X, Cardillo M, Schneemann H, Greenhill SJ.
PMID: 30225088
R Soc Open Sci. 2018 Aug 29;5(8):181100. doi: 10.1098/rsos.181100. eCollection 2018 Aug.

A growing number of studies seek to identify predictors of broad-scale patterns in human cultural diversity, but three sources of non-independence in human cultural variables can bias the results of cross-cultural studies. First, related cultures tend to have many...

Bidirectional Dysregulation of AMPA Receptor-Mediated Synaptic Transmission and Plasticity in Brain Disorders.

Frontiers in synaptic neuroscience

Zhang H, Bramham CR.
PMID: 32754026
Front Synaptic Neurosci. 2020 Jul 10;12:26. doi: 10.3389/fnsyn.2020.00026. eCollection 2020.

AMPA receptors (AMPARs) are glutamate-gated ion channels that mediate the majority of fast excitatory synaptic transmission throughout the brain. Changes in the properties and postsynaptic abundance of AMPARs are pivotal mechanisms in synaptic plasticity, such as long-term potentiation (LTP)...

Molecular dating when rates vary.

Trends in ecology & evolution

Welch JJ, Bromham L.
PMID: 16701388
Trends Ecol Evol. 2005 Jun;20(6):320-7. doi: 10.1016/j.tree.2005.02.007.

Molecular-dating techniques potentially enable us to estimate the time of origin of any biological lineage. Such techniques were originally premised on the assumption of a 'molecular clock'; that is, the assumption that genetic change accumulated steadily over time. However,...

Human Health and the Biological Effects of Tritium in Drinking Water: Prudent Policy Through Science - Addressing the ODWAC New Recommendation.

Dose-response : a publication of International Hormesis Society

Dingwall S, Mills CE, Phan N, Taylor K, Boreham DR.
PMID: 21431084
Dose Response. 2011 Feb 22;9(1):6-31. doi: 10.2203/dose-response.10-048.Boreham.

Tritium is a radioactive form of hydrogen and is a by-product of energy production in Canadian Deuterium Uranium (CANDU) reactors. The release of this radioisotope into the environment is carefully managed at CANDU facilities in order to minimize radiation...

Biological Response of Positron Emission Tomography Scan Exposure and Adaptive Response in Humans.

Dose-response : a publication of International Hormesis Society

Schnarr K, Carter TF, Gillis D, Webber C, Lemon JA, Dayes I, Dolling JA, Gulenchyn K, Boreham DR.
PMID: 26740810
Dose Response. 2015 Nov 19;13(4):1559325815611904. doi: 10.1177/1559325815611904. eCollection 2015.

The biological effects of exposure to radioactive fluorodeoxyglucose ((18)F-FDG) were investigated in the lymphocytes of patients undergoing positron emission tomography (PET) procedures. Low-dose, radiation-induced cellular responses were measured using 3 different end points: (1) apoptosis; (2) chromosome aberrations; and...

Lasting Effects of Low to Non-Lethal Radiation Exposure during Late Gestation on Offspring's Cardiac Metabolism and Oxidative Stress.

Antioxidants (Basel, Switzerland)

Nemec-Bakk AS, Niccoli S, Davidson C, Roy D, Stoa L, Sreetharan S, Simard A, Boreham DR, Wilson JY, Tai TC, Lees SJ, Khaper N.
PMID: 34065524
Antioxidants (Basel). 2021 May 20;10(5). doi: 10.3390/antiox10050816.

Ionizing radiation (IR) is known to cause fetal programming, but the physiological effects of low-dose IR are not fully understood. This study examined the effect of low (50 mGy) to non-lethal (300 and 1000 mGy) radiation exposure during late...

Colorectal cancer: summary of NICE guidance.

BMJ (Clinical research ed.)

Bromham N, Kallioinen M, Hoskin P, Davies RJ.
PMID: 32122877
BMJ. 2020 Mar 02;368:m461. doi: 10.1136/bmj.m461.

No abstract available.

Showing 1 to 12 of 42 entries