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Showing 1 to 12 of 14 entries
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Influencing factors of early cognitive deficits after ambulatory anesthesia.

Saudi journal of anaesthesia

Metterlein T, Wobbe T, Brede EM, Vogtner A, Krannich J, Eichelbrönner O, Broscheit J.
PMID: 34188628
Saudi J Anaesth. 2021 Apr-Jun;15(2):123-126. doi: 10.4103/sja.sja_967_20. Epub 2021 Apr 01.

BACKGROUND: Anesthesia has an influence on early postoperative cognitive function. This is specifically relevant in ambulatory surgery. At discharge, patients must return to their normal life and manage simple tasks. Goal was to detect influencing factors of early postoperative...

Novel Approach for Characterizing Propofol Binding Affinities to Serum Albumins from Different Species.

ACS omega

Shityakov S, Fischer A, Su KP, Hussein AA, Dandekar T, Broscheit J.
PMID: 33073080
ACS Omega. 2020 Sep 30;5(40):25543-25551. doi: 10.1021/acsomega.0c01295. eCollection 2020 Oct 13.

The interaction between the main carrier (serum albumin, SA) of endogenous and exogenous compounds in the bloodstream of different species (human, bovine, canine, rat, rabbit, and sheep) and a general anesthetic agent (propofol, PR) was investigated using an experimental...

Mesenchymal stromal cells mitigate liver damage after extended resection in the pig by modulating thrombospondin-1/TGF-β.

NPJ Regenerative medicine

Nickel S, Vlaic S, Christ M, Schubert K, Henschler R, Tautenhahn F, Burger C, Kühne H, Erler S, Roth A, Wild C, Brach J, Hammad S, Gittel C, Baunack M, Lange U, Broschewitz J, Stock P, Metelmann I, Bartels M, Pietsch UC, Krämer S, Eichfeld U, von Bergen M, Dooley S, Tautenhahn HM, Christ B.
PMID: 34862411
NPJ Regen Med. 2021 Dec 03;6(1):84. doi: 10.1038/s41536-021-00194-4.

Post-surgery liver failure is a serious complication for patients after extended partial hepatectomies (ePHx). Previously, we demonstrated in the pig model that transplantation of mesenchymal stromal cells (MSC) improved circulatory maintenance and supported multi-organ functions after 70% liver resection....

[Thoracic Surgery Without Chest Tube: The Current Situation in Germany].

Zentralblatt fur Chirurgie

Broschewitz J, Metelmann I, Steinert M, Krämer S.
PMID: 34225380
Zentralbl Chir. 2021 Jul 05; doi: 10.1055/a-1502-8210. Epub 2021 Jul 05.

BACKGROUND: Over the last decades, several techniques have been implemented to reduce the invasiveness of thoracic surgery. Omitting chest tubes can lead to less postoperative pain and a shorter length of hospital stay. This study examines the extent to...

Prognostic Factors for Iatrogenic Tracheal Rupture: A Single-Center Retrospective Cohort Study.

Journal of clinical medicine

Krämer S, Broschewitz J, Kirsten H, Sell C, Eichfeld U, Struck MF.
PMID: 32024043
J Clin Med. 2020 Feb 01;9(2). doi: 10.3390/jcm9020382.

Iatrogenic tracheal ruptures are rare but severe complications of medical interventions. The main goal of this study was to explore prognostic factors for all-cause mortality and rupture-related (adjusted) mortality. We retrospectively analyzed patients admitted to an academic referral center...

Mesenchymal stromal cells mitigate liver damage after extended resection in the pig by modulating thrombospondin-1/TGF-β.

NPJ Regenerative medicine

Nickel S, Vlaic S, Christ M, Schubert K, Henschler R, Tautenhahn F, Burger C, Kühne H, Erler S, Roth A, Wild C, Brach J, Hammad S, Gittel C, Baunack M, Lange U, Broschewitz J, Stock P, Metelmann I, Bartels M, Pietsch UC, Krämer S, Eichfeld U, von Bergen M, Dooley S, Tautenhahn HM, Christ B.
PMID: 34862411
NPJ Regen Med. 2021 Dec 03;6(1):84. doi: 10.1038/s41536-021-00194-4.

Post-surgery liver failure is a serious complication for patients after extended partial hepatectomies (ePHx). Previously, we demonstrated in the pig model that transplantation of mesenchymal stromal cells (MSC) improved circulatory maintenance and supported multi-organ functions after 70% liver resection....

The role of virtual reality simulation in surgical training in the light of COVID-19 pandemic: Visual spatial ability as a predictor for improved surgical performance: a randomized trial.

Medicine

Sommer GM, Broschewitz J, Huppert S, Sommer CG, Jahn N, Jansen-Winkeln B, Gockel I, Hau HM.
PMID: 34918632
Medicine (Baltimore). 2021 Dec 17;100(50):e27844. doi: 10.1097/MD.0000000000027844.

INTRODUCTION: Due to the current COVID-19 pandemic, surgical training has become increasingly challenging due to required social distancing. Therefore, the use of virtual reality (VR)-simulation could be a helpful tool for imparting surgical skills, especially in minimally invasive environments....

The role of virtual reality simulation in surgical training in the light of COVID-19 pandemic: Visual spatial ability as a predictor for improved surgical performance: a randomized trial.

Medicine

Sommer GM, Broschewitz J, Huppert S, Sommer CG, Jahn N, Jansen-Winkeln B, Gockel I, Hau HM.
PMID: 34918632
Medicine (Baltimore). 2021 Dec 17;100(50):e27844. doi: 10.1097/MD.0000000000027844.

INTRODUCTION: Due to the current COVID-19 pandemic, surgical training has become increasingly challenging due to required social distancing. Therefore, the use of virtual reality (VR)-simulation could be a helpful tool for imparting surgical skills, especially in minimally invasive environments....

Three-dimensional quantitative structure-activity relationship and docking studies in a series of anthocyanin derivatives as cytochrome P450 3A4 inhibitors.

Advances and applications in bioinformatics and chemistry : AABC

Shityakov S, Puskás I, Roewer N, Förster C, Broscheit J.
PMID: 24741320
Adv Appl Bioinform Chem. 2014 Mar 25;7:11-21. doi: 10.2147/AABC.S56478. eCollection 2014.

The cytochrome P450 (CYP)3A4 enzyme affects the metabolism of most drug-like substances, and its inhibition may influence drug safety. Modulation of CYP3A4 by flavonoids, such as anthocyanins, has been shown to inhibit the mutagenic activity of mammalian cells. Considering...

Human tissue cultures of lung cancer predict patient susceptibility to immune-checkpoint inhibition.

Cell death discovery

Junk D, Krämer S, Broschewitz J, Laura H, Massa C, Moulla Y, Hoang NA, Monecke A, Eichfeld U, Bechmann I, Lordick F, Seliger B, Kallendrusch S.
PMID: 34564709
Cell Death Discov. 2021 Sep 25;7(1):264. doi: 10.1038/s41420-021-00651-5.

Despite novel immunotherapies being approved and established for the treatment of non-small cell lung cancer (NSCLC), ex vivo models predicting individual patients' responses to immunotherapies are missing. Especially immune modulating therapies with moderate response rates urge for biomarkers and/or...

The role of virtual reality simulation in surgical training in the light of COVID-19 pandemic: Visual spatial ability as a predictor for improved surgical performance: a randomized trial.

Medicine

Sommer GM, Broschewitz J, Huppert S, Sommer CG, Jahn N, Jansen-Winkeln B, Gockel I, Hau HM.
PMID: 34918632
Medicine (Baltimore). 2021 Dec 17;100(50):e27844. doi: 10.1097/MD.0000000000027844.

INTRODUCTION: Due to the current COVID-19 pandemic, surgical training has become increasingly challenging due to required social distancing. Therefore, the use of virtual reality (VR)-simulation could be a helpful tool for imparting surgical skills, especially in minimally invasive environments....

Procedural times in early non-intubated VATS program - a propensity score analysis.

BMC anesthesiology

Metelmann I, Broschewitz J, Pietsch UC, Huschak G, Eichfeld U, Bercker S, Kraemer S.
PMID: 33573604
BMC Anesthesiol. 2021 Feb 11;21(1):44. doi: 10.1186/s12871-021-01270-4.

BACKGROUND: Non-intubated video-assisted thoracic surgery (NiVATS) has been introduced to surgical medicine in order to reduce the invasiveness of anesthetic procedures and avoid adverse effects of intubation and one-lung ventilation (OLV). The aim of this study is to determine...

Showing 1 to 12 of 14 entries