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Showing 1 to 12 of 34 entries
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Diversifying Biomedical Training: A Synergistic Intervention.

Journal of women and minorities in science and engineering

Gibau GS, Foertsch J, Blum J, Brutkiewicz R, Queener S, Roman A, Rhodes S, Sturek M, Wilkes D, Broxmeyer H.
PMID: 21796238
J Women Minor Sci Eng. 2010;16(3):215-235. doi: 10.1615/JWomenMinorScienEng.v16.i3.20.

For over three decades, the scientific community has expressed concern over the paucity of African American, Latino and Native American researchers in the biomedical training pipeline. Concern has been expressed regarding what is forecasted as a shortage of these...

MiR-9 Controls Chemotactic Activity of Cord Blood CD34⁺ Cells by Repressing CXCR4 Expression.

International journal of stem cells

Ha TW, Kang HS, Kim TH, Kwon JH, Kim HK, Ryu A, Jeon H, Han J, Broxmeyer HE, Hwang Y, Lee YK, Lee MR.
PMID: 30343551
Int J Stem Cells. 2018 Nov 30;11(2):187-195. doi: 10.15283/ijsc18057.

Improved approaches for promoting umbilical cord blood (CB) hematopoietic stem cell (HSC) homing are clinically important to enhance engraftment of CB-HSCs. Clinical transplantation of CB-HSCs is used to treat a wide range of disorders. However, an improved understanding of...

Retraction: Interferon-inducible protein 10 and macrophage inflammatory protein-1α inhibit growth factor stimulation of Raf-1 kinase activity and protein synthesis in a human growth factor-dependent hematopoietic cell line. VOLUME 270 (1995) PAGES 21998-22007.

The Journal of biological chemistry

Aronica SM, Mantel C, Gonin R, Marshall MS, Sarris A, Cooper S, Hague N, Zhang XF, Broxmeyer HE.
PMID: 33725802
J Biol Chem. 2006 Jun 23;281(25):17540. doi: 10.1016/S0021-9258(20)55783-9. Epub 2020 Oct 07.

No abstract available.

Players in Drug-Resistant Leukemia Stem/Initiating Cells and Immunity in Patients with CML in Context of Oxygen Levels: Would Collecting/Processing Cells in Hypoxia Offer Additional Information? A Next Frontier of Investigation.

Blood cancer discovery

Broxmeyer H.
PMID: 34661136
Blood Cancer Discov. 2020 Jun 22;1(1):13-15. doi: 10.1158/2643-3249.BCD-20-0034. eCollection 2020 Jul.

Chronic myelogenous leukemia (CML) is a stem cell disorder once considered an eventual death sentence upon progression to the terminal acute/blastic cell phase, a terrible clinical outcome that has improved with the introduction of tyrosine kinase inhibitors. A major...

Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil.

Current stem cell reports

Huang X, Trinh T, Aljoufi A, Broxmeyer HE.
PMID: 31275803
Curr Stem Cell Rep. 2018 Jun;4(2):149-157. doi: 10.1007/s40778-018-0127-7. Epub 2018 Apr 30.

PURPOSE OF REVIEW: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell systems. Stem cells...

Leukocytosis and Mobilization of CD34+ Hematopoietic Progenitor Cells by AMD3100, a CXCR4 Antagonist.

Supportive cancer therapy

Hübel K, Liles WC, Broxmeyer HE, Rodger E, Wood B, Cooper S, Hangoc G, Macfarland R, Bridger GJ, Henson GW, Calandra G, Dale DC.
PMID: 18628138
Support Cancer Ther. 2004 Apr 01;1(3):165-72. doi: 10.3816/SCT.2004.n.008.

Stromal cell-derived factor-1 (SDF-1/CXCL12) plays a key regulatory role in the trafficking of hematopoietic cells. AMD3100 is a specific antagonist of the binding of SDF-1 to its receptor, CXCR4. This phase I study assessed the hematological effects, pharmacokinetics, and...

Measurement of Long-Range Angular Correlation and Quadrupole Anisotropy of Pions and (Anti)Protons in Central d+Au Collisions at sqrt[s_{NN}]=200 GeV.

Physical review letters

Adare A, Aidala C, Ajitanand NN, Akiba Y, Akimoto R, Al-Bataineh H, Al-Ta'ani H, Alexander J, Andrews KR, Angerami A, Aoki K, Apadula N, Appelt E, Aramaki Y, Armendariz R, Aschenauer EC, Atomssa ET, Averbeck R, Awes TC, Azmoun B, Babintsev V, Bai M, Baksay G, Baksay L, Bannier B, Barish KN, Bassalleck B, Basye AT, Bathe S, Baublis V, Baumann C, Bazilevsky A, Belikov S, Belmont R, Ben-Benjamin J, Bennett R, Bhom JH, Blau DS, Bok JS, Boyle K, Brooks ML, Broxmeyer D, Buesching H, Bumazhnov V, Bunce G, Butsyk S, Campbell S, Caringi A, Castera P, Chen CH, Chi CY, Chiu M, Choi IJ, Choi JB, Choudhury RK, Christiansen P, Chujo T, Chung P, Chvala O, Cianciolo V, Citron Z, Cole BA, Conesa Del Valle Z, Connors M, Csanád M, Csörgő T, Dahms T, Dairaku S, Danchev I, Das K, Datta A, David G, Dayananda MK, Denisov A, Deshpande A, Desmond EJ, Dharmawardane KV, Dietzsch O, Dion A, Donadelli M, Drapier O, Drees A, Drees KA, Durham JM, Durum A, Dutta D, D'Orazio L, Edwards S, Efremenko YV, Ellinghaus F, Engelmore T, Enokizono A, En'yo H, Esumi S, Fadem B, Fields DE, Finger M, Finger M, Fleuret F, Fokin SL, Fraenkel Z, Frantz JE, Franz A, Frawley AD, Fujiwara K, Fukao Y, Fusayasu T, Gal C, Garishvili I, Glenn A, Gong H, Gong X, Gonin M, Goto Y, Granier de Cassagnac R, Grau N, Greene SV, Grim G, Grosse Perdekamp M, Gunji T, Guo L, Gustafsson HÅ, Haggerty JS, Hahn KI, Hamagaki H, Hamblen J, Han R, Hanks J, Harper C, Hashimoto K, Haslum E, Hayano R, He X, Heffner M, Hemmick TK, Hester T, Hill JC, Hohlmann M, Hollis RS, Holzmann W, Homma K, Hong B, Horaguchi T, Hori Y, Hornback D, Huang S, Ichihara T, Ichimiya R, Iinuma H, Ikeda Y, Imai K, Inaba M, Iordanova A, Isenhower D, Ishihara M, Issah M, Ivanischev D, Iwanaga Y, Jacak BV, Jia J, Jiang X, Jin J, John D, Johnson BM, Jones T, Joo KS, Jouan D, Jumper DS, Kajihara F, Kamin J, Kaneti S, Kang BH, Kang JH, Kang JS, Kapustinsky J, Karatsu K, Kasai M, Kawall D, Kawashima M, Kazantsev AV, Kempel T, Khanzadeev A, Kijima KM, Kikuchi J, Kim A, Kim BI, Kim DJ, Kim EJ, Kim YJ, Kim YK, Kinney E, Kiss Á, Kistenev E, Kleinjan D, Kline P, Kochenda L, Komkov B, Konno M, Koster J, Kotov D, Král A, Kravitz A, Kunde GJ, Kurita K, Kurosawa M, Kwon Y, Kyle GS, Lacey R, Lai YS, Lajoie JG, Lebedev A, Lee DM, Lee J, Lee KB, Lee KS, Lee SH, Lee SR, Leitch MJ, Leite MA, Li X, Lichtenwalner P, Liebing P, Lim SH, Linden Levy LA, Liška T, Liu H, Liu MX, Love B, Lynch D, Maguire CF, Makdisi YI, Malik MD, Manion A, Manko VI, Mannel E, Mao Y, Masui H, Matathias F, McCumber M, McGaughey PL, McGlinchey D, McKinney C, Means N, Mendoza M, Meredith B, Miake Y, Mibe T, Mignerey AC, Miki K, Milov A, Mitchell JT, Miyachi Y, Mohanty AK, Moon HJ, Morino Y, Morreale A, Morrison DP, Motschwiller S, Moukhanova TV, Murakami T, Murata J, Nagamiya S, Nagle JL, Naglis M, Nagy MI, Nakagawa I, Nakamiya Y, Nakamura KR, Nakamura T, Nakano K, Nam S, Newby J, Nguyen M, Nihashi M, Nouicer R, Nyanin AS, Oakley C, O'Brien E, Oda SX, Ogilvie CA, Oka M, Okada K, Onuki Y, Oskarsson A, Ouchida M, Ozawa K, Pak R, Pantuev V, Papavassiliou V, Park BH, Park IH, Park SK, Park WJ, Pate SF, Patel L, Pei H, Peng JC, Pereira H, Peressounko DY, Petti R, Pinkenburg C, Pisani RP, Proissl M, Purschke ML, Qu H, Rak J, Ravinovich I, Read KF, Rembeczki S, Reygers K, Riabov V, Riabov Y, Richardson E, Roach D, Roche G, Rolnick SD, Rosati M, Rosen CA, Rosendahl SS, Ružička P, Sahlmueller B, Saito N, Sakaguchi T, Sakashita K, Samsonov V, Sano S, Sarsour M, Sato T, Savastio M, Sawada S, Sedgwick K, Seele J, Seidl R, Seto R, Sharma D, Shein I, Shibata TA, Shigaki K, Shim HH, Shimomura M, Shoji K, Shukla P, Sickles A, Silva CL, Silvermyr D, Silvestre C, Sim KS, Singh BK, Singh CP, Singh V, Slunečka M, Sodre T, Soltz RA, Sondheim WE, Sorensen SP, Sourikova IV, Stankus PW, Stenlund E, Stoll SP, Sugitate T, Sukhanov A, Sun J, Sziklai J, Takagui EM, Takahara A, Taketani A, Tanabe R, Tanaka Y, Taneja S, Tanida K, Tannenbaum MJ, Tarafdar S, Taranenko A, Tennant E, Themann H, Thomas D, Thomas TL, Togawa M, Toia A, Tomášek L, Tomášek M, Torii H, Towell RS, Tserruya I, Tsuchimoto Y, Utsunomiya K, Vale C, Valle H, van Hecke HW, Vazquez-Zambrano E, Veicht A, Velkovska J, Vértesi R, Virius M, Vossen A, Vrba V, Vznuzdaev E, Wang XR, Watanabe D, Watanabe K, Watanabe Y, Watanabe YS, Wei F, Wei R, Wessels J, White SN, Winter D, Woody CL, Wright RM, Wysocki M, Yamaguchi YL, Yamaura K, Yang R, Yanovich A, Ying J, Yokkaichi S, Yoo JS, You Z, Young GR, Younus I, Yushmanov IE, Zajc WA, Zelenski A, Zhou S.
PMID: 26024164
Phys Rev Lett. 2015 May 15;114(19):192301. doi: 10.1103/PhysRevLett.114.192301. Epub 2015 May 12.

We present azimuthal angular correlations between charged hadrons and energy deposited in calorimeter towers in central d+Au and minimum bias p+p collisions at sqrt[s_{NN}]=200 GeV. The charged hadron is measured at midrapidity |η|

ADGRG1 enriches for functional human hematopoietic stem cells following ex vivo expansion-induced mitochondrial oxidative stress.

The Journal of clinical investigation

Chen Y, Fang S, Ding Q, Jiang R, He J, Wang Q, Jin Y, Huang X, Liu S, Capitano ML, Trinh T, Teng Y, Meng Q, Wan J, Broxmeyer HE, Guo B.
PMID: 34464351
J Clin Invest. 2021 Oct 15;131(20). doi: 10.1172/JCI148329.

The heterogeneity of human hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) under stress conditions such as ex vivo expansion is poorly understood. Here, we report that the frequencies of SCID-repopulating cells were greatly decreased in cord blood...

Chromatin remodeling subunit BRM and valine regulate hematopoietic stem/progenitor cell function and self-renewal via intrinsic and extrinsic effects.

Leukemia

Naidu SR, Capitano M, Ropa J, Cooper S, Huang X, Broxmeyer HE.
PMID: 34599272
Leukemia. 2021 Oct 01; doi: 10.1038/s41375-021-01426-8. Epub 2021 Oct 01.

Little is known of hematopoietic stem (HSC) and progenitor (HPC) cell self-renewal. The role of Brahma (BRM), a chromatin remodeler, in HSC function is unknown. Bone marrow (BM) from Brm

CXCL15/Lungkine has suppressive activity on proliferation and expansion of multi-potential, erythroid, granulocyte and macrophage progenitors in S-phase specific manner.

Blood cells, molecules & diseases

Broxmeyer HE, Cooper SH, Ropa J.
PMID: 34520986
Blood Cells Mol Dis. 2021 Nov;91:102594. doi: 10.1016/j.bcmd.2021.102594. Epub 2021 Jul 03.

Cytokines/chemokines regulate hematopoiesis, most having multiple cell actions. Numerous but not all chemokine family members act as negative regulators of hematopoietic progenitor cell (HPC) proliferation, but very little is known about such effects of the chemokine, CXCL15/Lungkine. We found...

Associated guilt: radiation/bystanders.

Blood

Broxmeyer HE.
PMID: 34137845
Blood. 2021 Jun 17;137(24):3314-3316. doi: 10.1182/blood.2021011360.

No abstract available.

Role for Leptin and Leptin Receptors in Stem Cells During Health and Diseases.

Stem cell reviews and reports

Trinh T, Broxmeyer HE.
PMID: 33598894
Stem Cell Rev Rep. 2021 Apr;17(2):511-522. doi: 10.1007/s12015-021-10132-y. Epub 2021 Feb 17.

Hematopoietic stem cells (HSCs) give rise to all blood and immune cells in the body. These rare cells reside in the hypoxic niche of the bone marrow (BM) where they are subjected to a complex network of regulatory factors...

Showing 1 to 12 of 34 entries