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Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4.

ACS medicinal chemistry letters

Lim J, Altman MD, Baker J, Brubaker JD, Chen H, Chen Y, Fischmann T, Gibeau C, Kleinschek MA, Leccese E, Lesburg C, Maclean JK, Moy LY, Mulrooney EF, Presland J, Rakhilina L, Smith GF, Steinhuebel D, Yang R.
PMID: 26101574
ACS Med Chem Lett. 2015 Apr 20;6(6):683-8. doi: 10.1021/acsmedchemlett.5b00107. eCollection 2015 Jun 11.

Interleukin-1 receptor associated kinase 4 (IRAK4) is an essential signal transducer downstream of the IL-1R and TLR superfamily, and selective inhibition of the kinase activity of the protein represents an attractive target for the treatment of inflammatory diseases. A...

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Lim J, Altman MD, Baker J, et al. Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4. ACS Med Chem Lett. 2015;6(6):683-8doi: 10.1021/acsmedchemlett.5b00107.
Lim, J., Altman, M. D., Baker, J., Brubaker, J. D., Chen, H., Chen, Y., Fischmann, T., Gibeau, C., Kleinschek, M. A., Leccese, E., Lesburg, C., Maclean, J. K., Moy, L. Y., Mulrooney, E. F., Presland, J., Rakhilina, L., Smith, G. F., Steinhuebel, D., & Yang, R. (2015). Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4. ACS medicinal chemistry letters, 6(6), 683-8. https://doi.org/10.1021/acsmedchemlett.5b00107
Lim, Jongwon, et al. "Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4." ACS medicinal chemistry letters vol. 6,6 (2015): 683-8. doi: https://doi.org/10.1021/acsmedchemlett.5b00107
Lim J, Altman MD, Baker J, Brubaker JD, Chen H, Chen Y, Fischmann T, Gibeau C, Kleinschek MA, Leccese E, Lesburg C, Maclean JK, Moy LY, Mulrooney EF, Presland J, Rakhilina L, Smith GF, Steinhuebel D, Yang R. Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4. ACS Med Chem Lett. 2015 Apr 20;6(6):683-8. doi: 10.1021/acsmedchemlett.5b00107. eCollection 2015 Jun 11. PMID: 26101574; PMCID: PMC4468400.
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Mutations Influencing the Assimilation of Nitrogen by Yersinia pestis.

Infection and immunity

Brubaker RR, Sulen A.
PMID: 16558021
Infect Immun. 1971 Apr;3(4):580-8. doi: 10.1128/iai.3.4.580-588.1971.

Cells of 20 isolates of Yersinia (Pasteurella) pestis exhibited an unusual nutritional requirement which could be fulfilled by glycine or l-threonine. Meiotrophic mutants which required neither of these amino acids (Gly/Thr(+)) were isolated from cultures of all 20 strains...

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Brubaker RR, Sulen A. Mutations Influencing the Assimilation of Nitrogen by Yersinia pestis. Infect Immun. 1971;3(4):580-8doi: 10.1128/iai.3.4.580-588.1971.
Brubaker, R. R., & Sulen, A. (1971). Mutations Influencing the Assimilation of Nitrogen by Yersinia pestis. Infection and immunity, 3(4), 580-8. https://doi.org/10.1128/iai.3.4.580-588.1971
Brubaker, R R, and Sulen, A. "Mutations Influencing the Assimilation of Nitrogen by Yersinia pestis." Infection and immunity vol. 3,4 (1971): 580-8. doi: https://doi.org/10.1128/iai.3.4.580-588.1971
Brubaker RR, Sulen A. Mutations Influencing the Assimilation of Nitrogen by Yersinia pestis. Infect Immun. 1971 Apr;3(4):580-8. doi: 10.1128/iai.3.4.580-588.1971. PMID: 16558021; PMCID: PMC416200.
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One-step synthesis of low polydispersity, biotinylated poly(N-isopropylacrylamide) by ATRP.

Chemical communications (Cambridge, England)

Bontempo D, Li RC, Ly T, Brubaker CE, Maynard HD.
PMID: 16175298
Chem Commun (Camb). 2005 Oct 07;(37):4702-4. doi: 10.1039/b507912h. Epub 2005 Aug 22.

Low polydispersity poly(N-isopropylacrylamide) with a biotin end-group was obtained in one step from a biotinylated initiator for atom transfer radical polymerization and interacted with streptavidin to generate the thermosensitive polymer-protein conjugate.

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Bontempo D, Li RC, Ly T, et al. One-step synthesis of low polydispersity, biotinylated poly(N-isopropylacrylamide) by ATRP. Chem Commun (Camb). 2005;(37):4702-4doi: 10.1039/b507912h.
Bontempo, D., Li, R. C., Ly, T., Brubaker, C. E., & Maynard, H. D. (2005). One-step synthesis of low polydispersity, biotinylated poly(N-isopropylacrylamide) by ATRP. Chemical communications (Cambridge, England), (37), 4702-4. https://doi.org/10.1039/b507912h
Bontempo, Debora, et al. "One-step synthesis of low polydispersity, biotinylated poly(N-isopropylacrylamide) by ATRP." Chemical communications (Cambridge, England) vol. ,37 (2005): 4702-4. doi: https://doi.org/10.1039/b507912h
Bontempo D, Li RC, Ly T, Brubaker CE, Maynard HD. One-step synthesis of low polydispersity, biotinylated poly(N-isopropylacrylamide) by ATRP. Chem Commun (Camb). 2005 Oct 07;(37):4702-4. doi: 10.1039/b507912h. Epub 2005 Aug 22. PMID: 16175298.
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Photorefractive phase shift induced by nonlinear electronic transport.

Optics letters

Wang QN, Brubaker RM, Nolte DD.
PMID: 19844457
Opt Lett. 1994 Jun 01;19(11):822-4. doi: 10.1364/ol.19.000822.

A photorefractive phase shift can be generated under dc applied fields if the dominant photocarriers have a nonlinear velocity-field dependence with a vanishing differential mobility. Phase shifts as large as pi/2 are possible when velocity saturation disables dielectric relaxation...

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Wang QN, Brubaker RM, Nolte DD. Photorefractive phase shift induced by nonlinear electronic transport. Opt Lett. 1994;19(11):822-4doi: 10.1364/ol.19.000822.
Wang, Q. N., Brubaker, R. M., & Nolte, D. D. (1994). Photorefractive phase shift induced by nonlinear electronic transport. Optics letters, 19(11), 822-4. https://doi.org/10.1364/ol.19.000822
Wang, Q N, et al. "Photorefractive phase shift induced by nonlinear electronic transport." Optics letters vol. 19,11 (1994): 822-4. doi: https://doi.org/10.1364/ol.19.000822
Wang QN, Brubaker RM, Nolte DD. Photorefractive phase shift induced by nonlinear electronic transport. Opt Lett. 1994 Jun 01;19(11):822-4. doi: 10.1364/ol.19.000822. PMID: 19844457.
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Dysregulation of neutrophil CXCR2 and pulmonary endothelial icam-1 promotes age-related pulmonary inflammation.

Aging and disease

Nomellini V, Brubaker AL, Mahbub S, Palmer JL, Gomez CR, Kovacs EJ.
PMID: 22724082
Aging Dis. 2012 Jun;3(3):234-47. Epub 2012 Feb 28.

We have previously demonstrated that aging is associated with prolonged pulmonary inflammation in a murine model of thermal injury. To further investigate these observations, we examined lung congestion, markers of neutrophil chemotaxis and adhesion, and lung endothelia responses in...

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Nomellini V, Brubaker AL, Mahbub S, et al. Dysregulation of neutrophil CXCR2 and pulmonary endothelial icam-1 promotes age-related pulmonary inflammation. Aging Dis. 2012;3(3):234-47
Nomellini, V., Brubaker, A. L., Mahbub, S., Palmer, J. L., Gomez, C. R., & Kovacs, E. J. (2012). Dysregulation of neutrophil CXCR2 and pulmonary endothelial icam-1 promotes age-related pulmonary inflammation. Aging and disease, 3(3), 234-47.
Nomellini, Vanessa, et al. "Dysregulation of neutrophil CXCR2 and pulmonary endothelial icam-1 promotes age-related pulmonary inflammation." Aging and disease vol. 3,3 (2012): 234-47.
Nomellini V, Brubaker AL, Mahbub S, Palmer JL, Gomez CR, Kovacs EJ. Dysregulation of neutrophil CXCR2 and pulmonary endothelial icam-1 promotes age-related pulmonary inflammation. Aging Dis. 2012 Jun;3(3):234-47. Epub 2012 Feb 28. PMID: 22724082; PMCID: PMC3375080.
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Behavioral contracting in the treatment of eating disorders.

The Physician and sportsmedicine

Brubaker DA, Leddy JJ.
PMID: 20086487
Phys Sportsmed. 2003 Sep;31(9):15-26. doi: 10.3810/psm.2003.09.481.

Team physicians frequently encounter athletes who have eating disorders. Behavioral contracting may be an effective tool for motivating these patients to implement nutritional changes. An effective contract must be built on five important principles: a collaborative physician-athlete relationship developed...

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Brubaker DA, Leddy JJ. Behavioral contracting in the treatment of eating disorders. Phys Sportsmed. 2003;31(9):15-26doi: 10.3810/psm.2003.09.481.
Brubaker, D. A., & Leddy, J. J. (2003). Behavioral contracting in the treatment of eating disorders. The Physician and sportsmedicine, 31(9), 15-26. https://doi.org/10.3810/psm.2003.09.481
Brubaker, David A, and Leddy, John J. "Behavioral contracting in the treatment of eating disorders." The Physician and sportsmedicine vol. 31,9 (2003): 15-26. doi: https://doi.org/10.3810/psm.2003.09.481
Brubaker DA, Leddy JJ. Behavioral contracting in the treatment of eating disorders. Phys Sportsmed. 2003 Sep;31(9):15-26. doi: 10.3810/psm.2003.09.481. PMID: 20086487.
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Light sources for fluorescein fluorophotometry: erratum.

Applied optics

McLaren JW, Brubaker RF.
PMID: 20407545
Appl Opt. 1984 Jan 15;23(2):199. doi: 10.1364/AO.23.000199.

No abstract available.

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McLaren JW, Brubaker RF. Light sources for fluorescein fluorophotometry: erratum. Appl Opt. 1984;23(2):199doi: 10.1364/AO.23.000199.
McLaren, J. W., & Brubaker, R. F. (1984). Light sources for fluorescein fluorophotometry: erratum. Applied optics, 23(2), 199. https://doi.org/10.1364/AO.23.000199
McLaren, J W, and Brubaker, R F. "Light sources for fluorescein fluorophotometry: erratum." Applied optics vol. 23,2 (1984): 199. doi: https://doi.org/10.1364/AO.23.000199
McLaren JW, Brubaker RF. Light sources for fluorescein fluorophotometry: erratum. Appl Opt. 1984 Jan 15;23(2):199. doi: 10.1364/AO.23.000199. PMID: 20407545.
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Synthesis and secretion of glucagon-like peptide-1 by fetal rat intestinal cells in culture.

Endocrine

Jackson Huang TH, Brubaker PL.
PMID: 21153205
Endocrine. 1995 Jul;3(7):499-503. doi: 10.1007/BF02738824.

Secretion of the intestinal proglucagon-derived peptides (PGDPs) including the incretin glucagon-like peptide-1 (GLP-1) is regulated, at least in part, by the duodenal hormone glucose-dependent insulinotropic peptide (GIP) through a protein kinase (PK) A-dependent pathway. It has been demonstrated that...

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Jackson Huang TH, Brubaker PL. Synthesis and secretion of glucagon-like peptide-1 by fetal rat intestinal cells in culture. Endocrine. 1995;3(7):499-503doi: 10.1007/BF02738824.
Jackson Huang, T. H., & Brubaker, P. L. (1995). Synthesis and secretion of glucagon-like peptide-1 by fetal rat intestinal cells in culture. Endocrine, 3(7), 499-503. https://doi.org/10.1007/BF02738824
Jackson Huang, T H, and Brubaker, P L. "Synthesis and secretion of glucagon-like peptide-1 by fetal rat intestinal cells in culture." Endocrine vol. 3,7 (1995): 499-503. doi: https://doi.org/10.1007/BF02738824
Jackson Huang TH, Brubaker PL. Synthesis and secretion of glucagon-like peptide-1 by fetal rat intestinal cells in culture. Endocrine. 1995 Jul;3(7):499-503. doi: 10.1007/BF02738824. PMID: 21153205.
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Temperature dependence of the magnetoresistance of sputtered Fe/Cr superlattices.

Physical review. B, Condensed matter

Bader SD, Brubaker ME, Conover M, Mattson JE, Qiu Z, Sowers CH.
PMID: 9998919
Phys Rev B Condens Matter. 1991 Nov 01;44(17):9378-9384. doi: 10.1103/physrevb.44.9378.

No abstract available.

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Bader SD, Brubaker ME, Conover M, et al. Temperature dependence of the magnetoresistance of sputtered Fe/Cr superlattices. Phys Rev B Condens Matter. 1991;44(17):9378-9384doi: 10.1103/physrevb.44.9378.
Bader, S. D., Brubaker, M. E., Conover, M., Mattson, J. E., Qiu, Z., & Sowers, C. H. (1991). Temperature dependence of the magnetoresistance of sputtered Fe/Cr superlattices. Physical review. B, Condensed matter, 44(17), 9378-9384. https://doi.org/10.1103/physrevb.44.9378
Bader, et al. "Temperature dependence of the magnetoresistance of sputtered Fe/Cr superlattices." Physical review. B, Condensed matter vol. 44,17 (1991): 9378-9384. doi: https://doi.org/10.1103/physrevb.44.9378
Bader SD, Brubaker ME, Conover M, Mattson JE, Qiu Z, Sowers CH. Temperature dependence of the magnetoresistance of sputtered Fe/Cr superlattices. Phys Rev B Condens Matter. 1991 Nov 01;44(17):9378-9384. doi: 10.1103/physrevb.44.9378. PMID: 9998919.
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Contemporary Approaches to Prescribing Exercise in Coronary Artery Disease Patients.

American journal of lifestyle medicine

Brubaker PH, Ross JH, Joo KC.
PMID: 30202385
Am J Lifestyle Med. 2016 Jan 19;12(2):130-139. doi: 10.1177/1559827615625482. eCollection 2018.

Health care professionals engaged in the management of coronary artery disease (CAD) patients, both in primary and secondary prevention settings, should possess the knowledge to develop and modify both aerobic exercise as well as musculoskeletal resistance exercise training programs....

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Brubaker PH, Ross JH, Joo KC. Contemporary Approaches to Prescribing Exercise in Coronary Artery Disease Patients. Am J Lifestyle Med. 2016;12(2):130-139doi: 10.1177/1559827615625482.
Brubaker, P. H., Ross, J. H., & Joo, K. C. (2018). Contemporary Approaches to Prescribing Exercise in Coronary Artery Disease Patients. American journal of lifestyle medicine, 12(2), 130-139. https://doi.org/10.1177/1559827615625482
Brubaker, Peter H, et al. "Contemporary Approaches to Prescribing Exercise in Coronary Artery Disease Patients." American journal of lifestyle medicine vol. 12,2 (2018): 130-139. doi: https://doi.org/10.1177/1559827615625482
Brubaker PH, Ross JH, Joo KC. Contemporary Approaches to Prescribing Exercise in Coronary Artery Disease Patients. Am J Lifestyle Med. 2016 Jan 19;12(2):130-139. doi: 10.1177/1559827615625482. eCollection 2018. PMID: 30202385; PMCID: PMC6124989.
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Closure in the Time of COVID-19.

The western journal of emergency medicine

Brubaker MA.
PMID: 32726237
West J Emerg Med. 2020 May 22;21(4):759. doi: 10.5811/westjem.2020.5.48050.

No abstract available.

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Brubaker MA. Closure in the Time of COVID-19. West J Emerg Med. 2020;21(4):759doi: 10.5811/westjem.2020.5.48050.
Brubaker, M. A. (2020). Closure in the Time of COVID-19. The western journal of emergency medicine, 21(4), 759. https://doi.org/10.5811/westjem.2020.5.48050
Brubaker, Mark A. "Closure in the Time of COVID-19." The western journal of emergency medicine vol. 21,4 (2020): 759. doi: https://doi.org/10.5811/westjem.2020.5.48050
Brubaker MA. Closure in the Time of COVID-19. West J Emerg Med. 2020 May 22;21(4):759. doi: 10.5811/westjem.2020.5.48050. PMID: 32726237; PMCID: PMC7390575.
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A quantum enhanced search for dark matter axions.

Nature

Backes KM, Palken DA, Kenany SA, Brubaker BM, Cahn SB, Droster A, Hilton GC, Ghosh S, Jackson H, Lamoreaux SK, Leder AF, Lehnert KW, Lewis SM, Malnou M, Maruyama RH, Rapidis NM, Simanovskaia M, Singh S, Speller DH, Urdinaran I, Vale LR, van Assendelft EC, van Bibber K, Wang H.
PMID: 33568823
Nature. 2021 Feb;590(7845):238-242. doi: 10.1038/s41586-021-03226-7. Epub 2021 Feb 10.

The manipulation of quantum states of light

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Backes KM, Palken DA, Kenany SA, et al. A quantum enhanced search for dark matter axions. Nature. 2021;590(7845):238-242doi: 10.1038/s41586-021-03226-7.
Backes, K. M., Palken, D. A., Kenany, S. A., Brubaker, B. M., Cahn, S. B., Droster, A., Hilton, G. C., Ghosh, S., Jackson, H., Lamoreaux, S. K., Leder, A. F., Lehnert, K. W., Lewis, S. M., Malnou, M., Maruyama, R. H., Rapidis, N. M., Simanovskaia, M., Singh, S., Speller, D. H., Urdinaran, I., Vale, L. R., van Assendelft, E. C., van Bibber, K., & Wang, H. (2021). A quantum enhanced search for dark matter axions. Nature, 590(7845), 238-242. https://doi.org/10.1038/s41586-021-03226-7
Backes, K M, et al. "A quantum enhanced search for dark matter axions." Nature vol. 590,7845 (2021): 238-242. doi: https://doi.org/10.1038/s41586-021-03226-7
Backes KM, Palken DA, Kenany SA, Brubaker BM, Cahn SB, Droster A, Hilton GC, Ghosh S, Jackson H, Lamoreaux SK, Leder AF, Lehnert KW, Lewis SM, Malnou M, Maruyama RH, Rapidis NM, Simanovskaia M, Singh S, Speller DH, Urdinaran I, Vale LR, van Assendelft EC, van Bibber K, Wang H. A quantum enhanced search for dark matter axions. Nature. 2021 Feb;590(7845):238-242. doi: 10.1038/s41586-021-03226-7. Epub 2021 Feb 10. PMID: 33568823.
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Showing 1 to 12 of 97 entries