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Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4.

ACS medicinal chemistry letters

Lim J, Altman MD, Baker J, Brubaker JD, Chen H, Chen Y, Fischmann T, Gibeau C, Kleinschek MA, Leccese E, Lesburg C, Maclean JK, Moy LY, Mulrooney EF, Presland J, Rakhilina L, Smith GF, Steinhuebel D, Yang R.
PMID: 26101574
ACS Med Chem Lett. 2015 Apr 20;6(6):683-8. doi: 10.1021/acsmedchemlett.5b00107. eCollection 2015 Jun 11.

Interleukin-1 receptor associated kinase 4 (IRAK4) is an essential signal transducer downstream of the IL-1R and TLR superfamily, and selective inhibition of the kinase activity of the protein represents an attractive target for the treatment of inflammatory diseases. A...

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Lim J, Altman MD, Baker J, et al. Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4. ACS Med Chem Lett. 2015;6(6):683-8doi: 10.1021/acsmedchemlett.5b00107.
Lim, J., Altman, M. D., Baker, J., Brubaker, J. D., Chen, H., Chen, Y., Fischmann, T., Gibeau, C., Kleinschek, M. A., Leccese, E., Lesburg, C., Maclean, J. K., Moy, L. Y., Mulrooney, E. F., Presland, J., Rakhilina, L., Smith, G. F., Steinhuebel, D., & Yang, R. (2015). Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4. ACS medicinal chemistry letters, 6(6), 683-8. https://doi.org/10.1021/acsmedchemlett.5b00107
Lim, Jongwon, et al. "Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4." ACS medicinal chemistry letters vol. 6,6 (2015): 683-8. doi: https://doi.org/10.1021/acsmedchemlett.5b00107
Lim J, Altman MD, Baker J, Brubaker JD, Chen H, Chen Y, Fischmann T, Gibeau C, Kleinschek MA, Leccese E, Lesburg C, Maclean JK, Moy LY, Mulrooney EF, Presland J, Rakhilina L, Smith GF, Steinhuebel D, Yang R. Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4. ACS Med Chem Lett. 2015 Apr 20;6(6):683-8. doi: 10.1021/acsmedchemlett.5b00107. eCollection 2015 Jun 11. PMID: 26101574; PMCID: PMC4468400.
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One-step synthesis of low polydispersity, biotinylated poly(N-isopropylacrylamide) by ATRP.

Chemical communications (Cambridge, England)

Bontempo D, Li RC, Ly T, Brubaker CE, Maynard HD.
PMID: 16175298
Chem Commun (Camb). 2005 Oct 07;(37):4702-4. doi: 10.1039/b507912h. Epub 2005 Aug 22.

Low polydispersity poly(N-isopropylacrylamide) with a biotin end-group was obtained in one step from a biotinylated initiator for atom transfer radical polymerization and interacted with streptavidin to generate the thermosensitive polymer-protein conjugate.

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Bontempo D, Li RC, Ly T, et al. One-step synthesis of low polydispersity, biotinylated poly(N-isopropylacrylamide) by ATRP. Chem Commun (Camb). 2005;(37):4702-4doi: 10.1039/b507912h.
Bontempo, D., Li, R. C., Ly, T., Brubaker, C. E., & Maynard, H. D. (2005). One-step synthesis of low polydispersity, biotinylated poly(N-isopropylacrylamide) by ATRP. Chemical communications (Cambridge, England), (37), 4702-4. https://doi.org/10.1039/b507912h
Bontempo, Debora, et al. "One-step synthesis of low polydispersity, biotinylated poly(N-isopropylacrylamide) by ATRP." Chemical communications (Cambridge, England) vol. ,37 (2005): 4702-4. doi: https://doi.org/10.1039/b507912h
Bontempo D, Li RC, Ly T, Brubaker CE, Maynard HD. One-step synthesis of low polydispersity, biotinylated poly(N-isopropylacrylamide) by ATRP. Chem Commun (Camb). 2005 Oct 07;(37):4702-4. doi: 10.1039/b507912h. Epub 2005 Aug 22. PMID: 16175298.
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Dysregulation of neutrophil CXCR2 and pulmonary endothelial icam-1 promotes age-related pulmonary inflammation.

Aging and disease

Nomellini V, Brubaker AL, Mahbub S, Palmer JL, Gomez CR, Kovacs EJ.
PMID: 22724082
Aging Dis. 2012 Jun;3(3):234-47. Epub 2012 Feb 28.

We have previously demonstrated that aging is associated with prolonged pulmonary inflammation in a murine model of thermal injury. To further investigate these observations, we examined lung congestion, markers of neutrophil chemotaxis and adhesion, and lung endothelia responses in...

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Nomellini V, Brubaker AL, Mahbub S, et al. Dysregulation of neutrophil CXCR2 and pulmonary endothelial icam-1 promotes age-related pulmonary inflammation. Aging Dis. 2012;3(3):234-47
Nomellini, V., Brubaker, A. L., Mahbub, S., Palmer, J. L., Gomez, C. R., & Kovacs, E. J. (2012). Dysregulation of neutrophil CXCR2 and pulmonary endothelial icam-1 promotes age-related pulmonary inflammation. Aging and disease, 3(3), 234-47.
Nomellini, Vanessa, et al. "Dysregulation of neutrophil CXCR2 and pulmonary endothelial icam-1 promotes age-related pulmonary inflammation." Aging and disease vol. 3,3 (2012): 234-47.
Nomellini V, Brubaker AL, Mahbub S, Palmer JL, Gomez CR, Kovacs EJ. Dysregulation of neutrophil CXCR2 and pulmonary endothelial icam-1 promotes age-related pulmonary inflammation. Aging Dis. 2012 Jun;3(3):234-47. Epub 2012 Feb 28. PMID: 22724082; PMCID: PMC3375080.
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Behavioral contracting in the treatment of eating disorders.

The Physician and sportsmedicine

Brubaker DA, Leddy JJ.
PMID: 20086487
Phys Sportsmed. 2003 Sep;31(9):15-26. doi: 10.3810/psm.2003.09.481.

Team physicians frequently encounter athletes who have eating disorders. Behavioral contracting may be an effective tool for motivating these patients to implement nutritional changes. An effective contract must be built on five important principles: a collaborative physician-athlete relationship developed...

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Brubaker DA, Leddy JJ. Behavioral contracting in the treatment of eating disorders. Phys Sportsmed. 2003;31(9):15-26doi: 10.3810/psm.2003.09.481.
Brubaker, D. A., & Leddy, J. J. (2003). Behavioral contracting in the treatment of eating disorders. The Physician and sportsmedicine, 31(9), 15-26. https://doi.org/10.3810/psm.2003.09.481
Brubaker, David A, and Leddy, John J. "Behavioral contracting in the treatment of eating disorders." The Physician and sportsmedicine vol. 31,9 (2003): 15-26. doi: https://doi.org/10.3810/psm.2003.09.481
Brubaker DA, Leddy JJ. Behavioral contracting in the treatment of eating disorders. Phys Sportsmed. 2003 Sep;31(9):15-26. doi: 10.3810/psm.2003.09.481. PMID: 20086487.
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Light sources for fluorescein fluorophotometry: erratum.

Applied optics

McLaren JW, Brubaker RF.
PMID: 20407545
Appl Opt. 1984 Jan 15;23(2):199. doi: 10.1364/AO.23.000199.

No abstract available.

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McLaren JW, Brubaker RF. Light sources for fluorescein fluorophotometry: erratum. Appl Opt. 1984;23(2):199doi: 10.1364/AO.23.000199.
McLaren, J. W., & Brubaker, R. F. (1984). Light sources for fluorescein fluorophotometry: erratum. Applied optics, 23(2), 199. https://doi.org/10.1364/AO.23.000199
McLaren, J W, and Brubaker, R F. "Light sources for fluorescein fluorophotometry: erratum." Applied optics vol. 23,2 (1984): 199. doi: https://doi.org/10.1364/AO.23.000199
McLaren JW, Brubaker RF. Light sources for fluorescein fluorophotometry: erratum. Appl Opt. 1984 Jan 15;23(2):199. doi: 10.1364/AO.23.000199. PMID: 20407545.
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Synthesis and secretion of glucagon-like peptide-1 by fetal rat intestinal cells in culture.

Endocrine

Jackson Huang TH, Brubaker PL.
PMID: 21153205
Endocrine. 1995 Jul;3(7):499-503. doi: 10.1007/BF02738824.

Secretion of the intestinal proglucagon-derived peptides (PGDPs) including the incretin glucagon-like peptide-1 (GLP-1) is regulated, at least in part, by the duodenal hormone glucose-dependent insulinotropic peptide (GIP) through a protein kinase (PK) A-dependent pathway. It has been demonstrated that...

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Jackson Huang TH, Brubaker PL. Synthesis and secretion of glucagon-like peptide-1 by fetal rat intestinal cells in culture. Endocrine. 1995;3(7):499-503doi: 10.1007/BF02738824.
Jackson Huang, T. H., & Brubaker, P. L. (1995). Synthesis and secretion of glucagon-like peptide-1 by fetal rat intestinal cells in culture. Endocrine, 3(7), 499-503. https://doi.org/10.1007/BF02738824
Jackson Huang, T H, and Brubaker, P L. "Synthesis and secretion of glucagon-like peptide-1 by fetal rat intestinal cells in culture." Endocrine vol. 3,7 (1995): 499-503. doi: https://doi.org/10.1007/BF02738824
Jackson Huang TH, Brubaker PL. Synthesis and secretion of glucagon-like peptide-1 by fetal rat intestinal cells in culture. Endocrine. 1995 Jul;3(7):499-503. doi: 10.1007/BF02738824. PMID: 21153205.
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Temperature dependence of the magnetoresistance of sputtered Fe/Cr superlattices.

Physical review. B, Condensed matter

Bader SD, Brubaker ME, Conover M, Mattson JE, Qiu Z, Sowers CH.
PMID: 9998919
Phys Rev B Condens Matter. 1991 Nov 01;44(17):9378-9384. doi: 10.1103/physrevb.44.9378.

No abstract available.

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Bader SD, Brubaker ME, Conover M, et al. Temperature dependence of the magnetoresistance of sputtered Fe/Cr superlattices. Phys Rev B Condens Matter. 1991;44(17):9378-9384doi: 10.1103/physrevb.44.9378.
Bader, S. D., Brubaker, M. E., Conover, M., Mattson, J. E., Qiu, Z., & Sowers, C. H. (1991). Temperature dependence of the magnetoresistance of sputtered Fe/Cr superlattices. Physical review. B, Condensed matter, 44(17), 9378-9384. https://doi.org/10.1103/physrevb.44.9378
Bader, et al. "Temperature dependence of the magnetoresistance of sputtered Fe/Cr superlattices." Physical review. B, Condensed matter vol. 44,17 (1991): 9378-9384. doi: https://doi.org/10.1103/physrevb.44.9378
Bader SD, Brubaker ME, Conover M, Mattson JE, Qiu Z, Sowers CH. Temperature dependence of the magnetoresistance of sputtered Fe/Cr superlattices. Phys Rev B Condens Matter. 1991 Nov 01;44(17):9378-9384. doi: 10.1103/physrevb.44.9378. PMID: 9998919.
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Contemporary Approaches to Prescribing Exercise in Coronary Artery Disease Patients.

American journal of lifestyle medicine

Brubaker PH, Ross JH, Joo KC.
PMID: 30202385
Am J Lifestyle Med. 2016 Jan 19;12(2):130-139. doi: 10.1177/1559827615625482. eCollection 2018.

Health care professionals engaged in the management of coronary artery disease (CAD) patients, both in primary and secondary prevention settings, should possess the knowledge to develop and modify both aerobic exercise as well as musculoskeletal resistance exercise training programs....

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Brubaker PH, Ross JH, Joo KC. Contemporary Approaches to Prescribing Exercise in Coronary Artery Disease Patients. Am J Lifestyle Med. 2016;12(2):130-139doi: 10.1177/1559827615625482.
Brubaker, P. H., Ross, J. H., & Joo, K. C. (2018). Contemporary Approaches to Prescribing Exercise in Coronary Artery Disease Patients. American journal of lifestyle medicine, 12(2), 130-139. https://doi.org/10.1177/1559827615625482
Brubaker, Peter H, et al. "Contemporary Approaches to Prescribing Exercise in Coronary Artery Disease Patients." American journal of lifestyle medicine vol. 12,2 (2018): 130-139. doi: https://doi.org/10.1177/1559827615625482
Brubaker PH, Ross JH, Joo KC. Contemporary Approaches to Prescribing Exercise in Coronary Artery Disease Patients. Am J Lifestyle Med. 2016 Jan 19;12(2):130-139. doi: 10.1177/1559827615625482. eCollection 2018. PMID: 30202385; PMCID: PMC6124989.
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Closure in the Time of COVID-19.

The western journal of emergency medicine

Brubaker MA.
PMID: 32726237
West J Emerg Med. 2020 May 22;21(4):759. doi: 10.5811/westjem.2020.5.48050.

No abstract available.

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Brubaker MA. Closure in the Time of COVID-19. West J Emerg Med. 2020;21(4):759doi: 10.5811/westjem.2020.5.48050.
Brubaker, M. A. (2020). Closure in the Time of COVID-19. The western journal of emergency medicine, 21(4), 759. https://doi.org/10.5811/westjem.2020.5.48050
Brubaker, Mark A. "Closure in the Time of COVID-19." The western journal of emergency medicine vol. 21,4 (2020): 759. doi: https://doi.org/10.5811/westjem.2020.5.48050
Brubaker MA. Closure in the Time of COVID-19. West J Emerg Med. 2020 May 22;21(4):759. doi: 10.5811/westjem.2020.5.48050. PMID: 32726237; PMCID: PMC7390575.
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A quantum enhanced search for dark matter axions.

Nature

Backes KM, Palken DA, Kenany SA, Brubaker BM, Cahn SB, Droster A, Hilton GC, Ghosh S, Jackson H, Lamoreaux SK, Leder AF, Lehnert KW, Lewis SM, Malnou M, Maruyama RH, Rapidis NM, Simanovskaia M, Singh S, Speller DH, Urdinaran I, Vale LR, van Assendelft EC, van Bibber K, Wang H.
PMID: 33568823
Nature. 2021 Feb;590(7845):238-242. doi: 10.1038/s41586-021-03226-7. Epub 2021 Feb 10.

The manipulation of quantum states of light

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Backes KM, Palken DA, Kenany SA, et al. A quantum enhanced search for dark matter axions. Nature. 2021;590(7845):238-242doi: 10.1038/s41586-021-03226-7.
Backes, K. M., Palken, D. A., Kenany, S. A., Brubaker, B. M., Cahn, S. B., Droster, A., Hilton, G. C., Ghosh, S., Jackson, H., Lamoreaux, S. K., Leder, A. F., Lehnert, K. W., Lewis, S. M., Malnou, M., Maruyama, R. H., Rapidis, N. M., Simanovskaia, M., Singh, S., Speller, D. H., Urdinaran, I., Vale, L. R., van Assendelft, E. C., van Bibber, K., & Wang, H. (2021). A quantum enhanced search for dark matter axions. Nature, 590(7845), 238-242. https://doi.org/10.1038/s41586-021-03226-7
Backes, K M, et al. "A quantum enhanced search for dark matter axions." Nature vol. 590,7845 (2021): 238-242. doi: https://doi.org/10.1038/s41586-021-03226-7
Backes KM, Palken DA, Kenany SA, Brubaker BM, Cahn SB, Droster A, Hilton GC, Ghosh S, Jackson H, Lamoreaux SK, Leder AF, Lehnert KW, Lewis SM, Malnou M, Maruyama RH, Rapidis NM, Simanovskaia M, Singh S, Speller DH, Urdinaran I, Vale LR, van Assendelft EC, van Bibber K, Wang H. A quantum enhanced search for dark matter axions. Nature. 2021 Feb;590(7845):238-242. doi: 10.1038/s41586-021-03226-7. Epub 2021 Feb 10. PMID: 33568823.
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Evaluation of a blood-based geroscience biomarker index in a randomized trial of caloric restriction and exercise in older adults with heart failure with preserved ejection fraction.

GeroScience

Justice JN, Pajewski NM, Espeland MA, Brubaker P, Houston DK, Marcovina S, Nicklas BJ, Kritchevsky SB, Kitzman DW.
PMID: 35013909
Geroscience. 2022 Jan 10; doi: 10.1007/s11357-021-00509-9. Epub 2022 Jan 10.

Intermediate endpoints are needed to evaluate the effect of interventions targeting the biology of aging in clinical trials. A working group identified five blood-based biomarkers that may serve such a purpose as an integrated index. We evaluated the responsiveness...

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Justice JN, Pajewski NM, Espeland MA, et al. Evaluation of a blood-based geroscience biomarker index in a randomized trial of caloric restriction and exercise in older adults with heart failure with preserved ejection fraction. Geroscience. 2022;doi: 10.1007/s11357-021-00509-9.
Justice, J. N., Pajewski, N. M., Espeland, M. A., Brubaker, P., Houston, D. K., Marcovina, S., Nicklas, B. J., Kritchevsky, S. B., & Kitzman, D. W. (2022). Evaluation of a blood-based geroscience biomarker index in a randomized trial of caloric restriction and exercise in older adults with heart failure with preserved ejection fraction. GeroScience, . https://doi.org/10.1007/s11357-021-00509-9
Justice, Jamie N, et al. "Evaluation of a blood-based geroscience biomarker index in a randomized trial of caloric restriction and exercise in older adults with heart failure with preserved ejection fraction." GeroScience vol. (2022). doi: https://doi.org/10.1007/s11357-021-00509-9
Justice JN, Pajewski NM, Espeland MA, Brubaker P, Houston DK, Marcovina S, Nicklas BJ, Kritchevsky SB, Kitzman DW. Evaluation of a blood-based geroscience biomarker index in a randomized trial of caloric restriction and exercise in older adults with heart failure with preserved ejection fraction. Geroscience. 2022 Jan 10; doi: 10.1007/s11357-021-00509-9. Epub 2022 Jan 10. PMID: 35013909.
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Relationship of end-tidal oxygen partial pressure to the determinants of anaerobic threshold in post-myocardial infarction patients.

Heart and vessels

Ogura A, Izawa KP, Sato S, Tawa H, Kureha F, Wada M, Kanai M, Kubo I, Brubaker PH, Yoshikawa R, Matsuda Y.
PMID: 33990894
Heart Vessels. 2021 Dec;36(12):1811-1817. doi: 10.1007/s00380-021-01870-7. Epub 2021 May 14.

The anaerobic threshold (AT), obtained during cardiopulmonary exercise testing (CPET), is an important prognostic measure and can be used to develop an exercise prescription in patients after a myocardial infarction (post-MI). The purpose of this study was to examine...

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Ogura A, Izawa KP, Sato S, et al. Relationship of end-tidal oxygen partial pressure to the determinants of anaerobic threshold in post-myocardial infarction patients. Heart Vessels. 2021;36(12):1811-1817doi: 10.1007/s00380-021-01870-7.
Ogura, A., Izawa, K. P., Sato, S., Tawa, H., Kureha, F., Wada, M., Kanai, M., Kubo, I., Brubaker, P. H., Yoshikawa, R., & Matsuda, Y. (2021). Relationship of end-tidal oxygen partial pressure to the determinants of anaerobic threshold in post-myocardial infarction patients. Heart and vessels, 36(12), 1811-1817. https://doi.org/10.1007/s00380-021-01870-7
Ogura, Asami, et al. "Relationship of end-tidal oxygen partial pressure to the determinants of anaerobic threshold in post-myocardial infarction patients." Heart and vessels vol. 36,12 (2021): 1811-1817. doi: https://doi.org/10.1007/s00380-021-01870-7
Ogura A, Izawa KP, Sato S, Tawa H, Kureha F, Wada M, Kanai M, Kubo I, Brubaker PH, Yoshikawa R, Matsuda Y. Relationship of end-tidal oxygen partial pressure to the determinants of anaerobic threshold in post-myocardial infarction patients. Heart Vessels. 2021 Dec;36(12):1811-1817. doi: 10.1007/s00380-021-01870-7. Epub 2021 May 14. PMID: 33990894.
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Showing 1 to 12 of 89 entries