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Showing 1 to 7 of 7 entries
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The Importance of Oxidation or Glycosylation of Low-density Lipoproteins in Relation to Platelet Activation.

Platelets

Meraji S, Moore CE, Skinner VO, Bruckdorfer KR.
PMID: 21043908
Platelets. 1992;3(3):155-62. doi: 10.3109/09537109209013176.

Low-density lipoproteins (LDL) are thought to influence directly the sensitivity of platelets, but this may only be the case when the LDL are modified by oxidation. In diabetes, LDL are known to be modified by non-enzymatic glycosylation, especially when...

Modulation of fibrosis in systemic sclerosis by nitric oxide and antioxidants.

Cardiology research and practice

Dooley A, Bruckdorfer KR, Abraham DJ.
PMID: 22111028
Cardiol Res Pract. 2012;2012:521958. doi: 10.1155/2012/521958. Epub 2011 Oct 31.

SYSTEMIC SCLEROSIS (SCLERODERMA: SSc) is a multisystem, connective tissue disease of unknown aetiology characterized by vascular dysfunction, autoimmunity, and enhanced fibroblast activity resulting in fibrosis of the skin, heart, and lungs, and ultimately internal organ failure, and death. One...

Differential effects of native and oxidatively modified low-density lipoproteins on platelet function.

Platelets

Naseem KM, Goodall AH, Bruckdorfer KR.
PMID: 20297939
Platelets. 1997;8(2):163-73. doi: 10.1080/09537109709169333.

Low-density lipoproteins (LDL) have been various reported to induce platelet aggregation independently and/or sensitise platelets to other agonists. In these earlier studies the extent of oxidation of LDL was not always reported or addressed. We have now investigated the...

Detection of a Protein in Human Platelet Membranes which Binds Low-density Lipoproteins.

Platelets

Hassall DG, Desai K, Owen JS, Bruckdorfer KR.
PMID: 21043983
Platelets. 1990;1(1):29-35. doi: 10.3109/09537109009009193.

Sensitisation of human blood platelets by plasma low-density lipoproteins (LDL) is thought to involve an initial interaction between LDL and the platelet surface membrane. When washed, fully responsive platelets were incubated with radio-iodinated LDL, two phases of binding were...

The influence of organic peroxides on platelet aggregation and sensitivity to nitric oxide.

Platelets

Naseem KM, Bruckdorfer KR.
PMID: 16801085
Platelets. 1999;10(2):146-52. doi: 10.1080/09537109976220.

The effects of oxidative stress, induced by water-soluble and lipid peroxides, on platelet reactivity and platelet sensitivity to nitric oxide were investigated. Hydrogen peroxide and cumene hydroperoxide potentiated thrombin-induced platelet aggregation. In contrast, 15(S)-hydroperoxyeicosatetraenoic acid had no such effect,...

Interactions between Platelets and Human Hepatoma Cell Lines: The Influence of Endothelial Cells.

Platelets

Skinner VO, Bruckdorfer KR.
PMID: 21043959
Platelets. 1991;2(1):31-9. doi: 10.3109/09537109109005500.

The properties of human hepatoma cell lines in relation to their ability to aggregate isolated human platelets were investigated because of the possible relevance to tumour metastasis. Mahlavu, HepG2 and SK55 cells were all able to aggregate platelets irreversibly,...

3-Nitrotyrosine in the proteins of human plasma determined by an ELISA method .

The Biochemical journal

Khan J, Brennand DM, Bradley N, Gao B, Bruckdorfer R, Jacobs M.
PMID: 9622476
Biochem J. 1998 Jun 15;332:807-8. doi: 10.1042/bj3320807v.
Free PMC Article

No abstract available.

Showing 1 to 7 of 7 entries