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Showing 1 to 12 of 43 entries
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Increasing Frequencies of Antibiotic Resistant Non-typhoidal .

Frontiers in medicine

Mukherjee S, Anderson CM, Mosci RE, Newton DW, Lephart P, Salimnia H, Khalife W, Rudrik JT, Manning SD.
PMID: 31781566
Front Med (Lausanne). 2019 Nov 08;6:250. doi: 10.3389/fmed.2019.00250. eCollection 2019.

Non-typhoidal

On the cusp of cures: Breakthroughs in Batten disease research.

Current opinion in neurobiology

Brudvig JJ, Weimer JM.
PMID: 34571324
Curr Opin Neurobiol. 2021 Sep 24;72:48-54. doi: 10.1016/j.conb.2021.08.003. Epub 2021 Sep 24.

Batten disease is a family of rare, lysosomal disorders caused by mutations in one of at least 13 genes, which encode a diverse set of lysosomal and extralysosomal proteins. Despite decades of research, the development of effective therapies has...

Increased divergence but reduced variation on the Z chromosome relative to autosomes in Ficedula flycatchers: differential introgression or the faster-Z effect?.

Ecology and evolution

Hogner S, Sæther SA, Borge T, Bruvik T, Johnsen A, Sætre GP.
PMID: 22423331
Ecol Evol. 2012 Feb;2(2):379-96. doi: 10.1002/ece3.92.

Recent multilocus studies of congeneric birds have shown a pattern of elevated interspecific divergence on the Z chromosome compared to the autosomes. In contrast, intraspecifically, birds exhibit less polymorphism on the Z chromosome relative to the autosomes. We show...

Increased divergence but reduced variation on the Z chromosome relative to autosomes in Ficedula flycatchers: differential introgression or the faster-Z effect?.

Ecology and evolution

Hogner S, Sæther SA, Borge T, Bruvik T, Johnsen A, Sætre GP.
PMID: 22423331
Ecol Evol. 2012 Feb;2(2):379-96. doi: 10.1002/ece3.92.

Recent multilocus studies of congeneric birds have shown a pattern of elevated interspecific divergence on the Z chromosome compared to the autosomes. In contrast, intraspecifically, birds exhibit less polymorphism on the Z chromosome relative to the autosomes. We show...

X MARCKS the spot: myristoylated alanine-rich C kinase substrate in neuronal function and disease.

Frontiers in cellular neuroscience

Brudvig JJ, Weimer JM.
PMID: 26528135
Front Cell Neurosci. 2015 Oct 13;9:407. doi: 10.3389/fncel.2015.00407. eCollection 2015.

Intracellular protein-protein interactions are dynamic events requiring tightly regulated spatial and temporal checkpoints. But how are these spatial and temporal cues integrated to produce highly specific molecular response patterns? A helpful analogy to this process is that of a...

Measurement of Compton scattering from the deuteron and an improved extraction of the neutron electromagnetic polarizabilities.

Physical review letters

Myers LS, Annand JR, Brudvik J, Feldman G, Fissum KG, Grießhammer HW, Hansen K, Henshaw SS, Isaksson L, Jebali R, Kovash MA, Lundin M, McGovern JA, Middleton DG, Nathan AM, Phillips DR, Schröder B, Stave SC.
PMID: 25615318
Phys Rev Lett. 2014 Dec 31;113(26):262506. doi: 10.1103/PhysRevLett.113.262506. Epub 2014 Dec 31.

The electromagnetic polarizabilities of the nucleon are fundamental properties that describe its response to external electric and magnetic fields. They can be extracted from Compton-scattering data-and have been, with good accuracy, in the case of the proton. In contradistinction,...

Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum.

Traffic (Copenhagen, Denmark)

Lu CL, Ortmeier S, Brudvig J, Moretti T, Cain J, Boyadjiev SA, Weimer JM, Kim J.
PMID: 34761479
Traffic. 2022 Jan;23(1):81-93. doi: 10.1111/tra.12826. Epub 2021 Nov 22.

SEC24 is mainly involved in cargo sorting during COPII vesicle assembly. There are four SEC24 paralogs (A-D) in vertebrates, which are classified into two subgroups (SEC24A/B and SEC24C/D). Pathological mutations in SEC24D cause osteogenesis imperfecta with craniofacial dysplasia in...

On the cusp of cures: Breakthroughs in Batten disease research.

Current opinion in neurobiology

Brudvig JJ, Weimer JM.
PMID: 34571324
Curr Opin Neurobiol. 2021 Sep 24;72:48-54. doi: 10.1016/j.conb.2021.08.003. Epub 2021 Sep 24.

Batten disease is a family of rare, lysosomal disorders caused by mutations in one of at least 13 genes, which encode a diverse set of lysosomal and extralysosomal proteins. Despite decades of research, the development of effective therapies has...

De novo transcriptomic subtyping of colorectal cancer liver metastases in the context of tumor heterogeneity.

Genome medicine

Moosavi SH, Eide PW, Eilertsen IA, Brunsell TH, Berg KCG, Røsok BI, Brudvik KW, Bjørnbeth BA, Guren MG, Nesbakken A, Lothe RA, Sveen A.
PMID: 34470666
Genome Med. 2021 Sep 01;13(1):143. doi: 10.1186/s13073-021-00956-1.

BACKGROUND: Gene expression-based subtyping has the potential to form a new paradigm for stratified treatment of colorectal cancer. However, current frameworks are based on the transcriptomic profiles of primary tumors, and metastatic heterogeneity is a challenge. Here we aimed...

Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum.

Traffic (Copenhagen, Denmark)

Lu CL, Ortmeier S, Brudvig J, Moretti T, Cain J, Boyadjiev SA, Weimer JM, Kim J.
PMID: 34761479
Traffic. 2021 Nov 11; doi: 10.1111/tra.12826. Epub 2021 Nov 11.

SEC24 is mainly involved in cargo sorting during COPII vesicle assembly. There are four SEC24 paralogs (A-D) in vertebrates, which are classified into two subgroups (SEC24A/B and SEC24C/D). Pathological mutations in SEC24D cause osteogenesis imperfecta with craniofacial dysplasia in...

Population structure and genetic diversity of non-O157 Shiga toxin-producing Escherichia coli (STEC) clinical isolates from Michigan.

Scientific reports

Blankenship HM, Mosci RE, Dietrich S, Burgess E, Wholehan J, McWilliams K, Pietrzen K, Benko S, Gatesy T, Rudrik JT, Soehnlen M, Manning SD.
PMID: 33627701
Sci Rep. 2021 Feb 24;11(1):4461. doi: 10.1038/s41598-021-83775-z.

Non-O157 STEC are increasingly linked to foodborne infections, yet little is known about the diversity and molecular epidemiology across locations. Herein, we used whole genome sequencing to examine genetic variation in 894 isolates collected from Michigan patients between 2001...

Neuronal Ceroid Lipofuscinosis Type 6 (CLN6) clinical findings and molecular diagnosis: Costa Rica's experience.

Orphanet journal of rare diseases

Badilla-Porras R, Echeverri-McCandless A, Weimer JM, Ulate-Campos A, Soto-Rodríguez A, Gutiérrez-Mata A, Hernández-Con L, Bogantes-Ledezma S, Balmaceda-Meza A, Brudvig J, Sanabria-Castro A.
PMID: 35012600
Orphanet J Rare Dis. 2022 Jan 10;17(1):13. doi: 10.1186/s13023-021-02162-z.

BACKGROUND: Commonly known as Batten disease, the neuronal ceroid lipofuscinoses (NCLs) are a genetically heterogeneous group of rare pediatric lysosomal storage disorders characterized by the intracellular accumulation of autofluorescent material (known as lipofuscin), progressive neurodegeneration, and neurological symptoms. In...

Showing 1 to 12 of 43 entries