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Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins.

Frontiers in immunology

Fishman D, Kisand K, Hertel C, Rothe M, Remm A, Pihlap M, Adler P, Vilo J, Peet A, Meloni A, Podkrajsek KT, Battelino T, Bruserud Ø, Wolff ASB, Husebye ES, Kluger N, Krohn K, Ranki A, Peterson H, Hayday A, Peterson P.
PMID: 28861084
Front Immunol. 2017 Aug 16;8:976. doi: 10.3389/fimmu.2017.00976. eCollection 2017.

High titer autoantibodies produced by B lymphocytes are clinically important features of many common autoimmune diseases. APECED patients with deficient autoimmune regulator (AIRE) gene collectively display a broad repertoire of high titer autoantibodies, including some which are pathognomonic for...

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Fishman D, Kisand K, Hertel C, et al. Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins. Front Immunol. 2017;8:976doi: 10.3389/fimmu.2017.00976.
Fishman, D., Kisand, K., Hertel, C., Rothe, M., Remm, A., Pihlap, M., Adler, P., Vilo, J., Peet, A., Meloni, A., Podkrajsek, K. T., Battelino, T., Bruserud, �. �., Wolff, A. S. B., Husebye, E. S., Kluger, N., Krohn, K., Ranki, A., Peterson, H., Hayday, A., & Peterson, P. (2017). Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins. Frontiers in immunology, 8976. https://doi.org/10.3389/fimmu.2017.00976
Fishman, Dmytro, et al. "Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins." Frontiers in immunology vol. 8 (2017): 976. doi: https://doi.org/10.3389/fimmu.2017.00976
Fishman D, Kisand K, Hertel C, Rothe M, Remm A, Pihlap M, Adler P, Vilo J, Peet A, Meloni A, Podkrajsek KT, Battelino T, Bruserud Ø, Wolff ASB, Husebye ES, Kluger N, Krohn K, Ranki A, Peterson H, Hayday A, Peterson P. Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins. Front Immunol. 2017 Aug 16;8:976. doi: 10.3389/fimmu.2017.00976. eCollection 2017. PMID: 28861084; PMCID: PMC5561390.
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Effects of acute myelogenous leukemia blasts on platelet release of soluble P-selectin and platelet-derived growth factor.

Platelets

Bruserud Ø, Foss B, Ulvestad E, Hervig T.
PMID: 16793718
Platelets. 1998;9(6):352-8. doi: 10.1080/09537109876410.

Complex interactions occur between platelets and normal as well as leukemic myeloid cells. In vitro co-culture of platelets and acute myelogenous leukemia (AML) blasts with allogeneic platelets enhances blast proliferation and constitutive cytokine secretion. In the present study the...

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Bruserud Ø, Foss B, Ulvestad E, et al. Effects of acute myelogenous leukemia blasts on platelet release of soluble P-selectin and platelet-derived growth factor. Platelets. 1998;9(6):352-8doi: 10.1080/09537109876410.
Bruserud, �. �., Foss, B., Ulvestad, E., & Hervig, T. (1998). Effects of acute myelogenous leukemia blasts on platelet release of soluble P-selectin and platelet-derived growth factor. Platelets, 9(6), 352-8. https://doi.org/10.1080/09537109876410
Bruserud, Ø, et al. "Effects of acute myelogenous leukemia blasts on platelet release of soluble P-selectin and platelet-derived growth factor." Platelets vol. 9,6 (1998): 352-8. doi: https://doi.org/10.1080/09537109876410
Bruserud Ø, Foss B, Ulvestad E, Hervig T. Effects of acute myelogenous leukemia blasts on platelet release of soluble P-selectin and platelet-derived growth factor. Platelets. 1998;9(6):352-8. doi: 10.1080/09537109876410. PMID: 16793718.
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Selecting Sample Preparation Workflows for Mass Spectrometry-Based Proteomic and Phosphoproteomic Analysis of Patient Samples with Acute Myeloid Leukemia.

Proteomes

Hernandez-Valladares M, Aasebø E, Selheim F, Berven FS, Bruserud Ø.
PMID: 28248234
Proteomes. 2016 Aug 22;4(3). doi: 10.3390/proteomes4030024.

Global mass spectrometry (MS)-based proteomic and phosphoproteomic studies of acute myeloid leukemia (AML) biomarkers represent a powerful strategy to identify and confirm proteins and their phosphorylated modifications that could be applied in diagnosis and prognosis, as a support for...

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Hernandez-Valladares M, Aasebø E, Selheim F, et al. Selecting Sample Preparation Workflows for Mass Spectrometry-Based Proteomic and Phosphoproteomic Analysis of Patient Samples with Acute Myeloid Leukemia. Proteomes. 2016;4(3)doi: 10.3390/proteomes4030024.
Hernandez-Valladares, M., Aasebø, E., Selheim, F., Berven, F. S., & Bruserud, �. �. (2016). Selecting Sample Preparation Workflows for Mass Spectrometry-Based Proteomic and Phosphoproteomic Analysis of Patient Samples with Acute Myeloid Leukemia. Proteomes, 4(3), . https://doi.org/10.3390/proteomes4030024
Hernandez-Valladares, Maria, et al. "Selecting Sample Preparation Workflows for Mass Spectrometry-Based Proteomic and Phosphoproteomic Analysis of Patient Samples with Acute Myeloid Leukemia." Proteomes vol. 4,3 (2016). doi: https://doi.org/10.3390/proteomes4030024
Hernandez-Valladares M, Aasebø E, Selheim F, Berven FS, Bruserud Ø. Selecting Sample Preparation Workflows for Mass Spectrometry-Based Proteomic and Phosphoproteomic Analysis of Patient Samples with Acute Myeloid Leukemia. Proteomes. 2016 Aug 22;4(3). doi: 10.3390/proteomes4030024. PMID: 28248234; PMCID: PMC5217354.
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Oral microbiota in autoimmune polyendocrine syndrome type 1.

Journal of oral microbiology

Bruserud Ø, Siddiqui H, Marthinussen MC, Chen T, Jonsson R, Oftedal BE, Olsen I, Husebye ES, Wolff AB.
PMID: 29503707
J Oral Microbiol. 2018 Feb 26;10(1):1442986. doi: 10.1080/20002297.2018.1442986. eCollection 2018.

No abstract available.

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Bruserud Ø, Siddiqui H, Marthinussen MC, et al. Oral microbiota in autoimmune polyendocrine syndrome type 1. J Oral Microbiol. 2018;10(1):1442986doi: 10.1080/20002297.2018.1442986.
Bruserud, �. �., Siddiqui, H., Marthinussen, M. C., Chen, T., Jonsson, R., Oftedal, B. E., Olsen, I., Husebye, E. S., & Wolff, A. B. (2018). Oral microbiota in autoimmune polyendocrine syndrome type 1. Journal of oral microbiology, 10(1), 1442986. https://doi.org/10.1080/20002297.2018.1442986
Bruserud, Øyvind, et al. "Oral microbiota in autoimmune polyendocrine syndrome type 1." Journal of oral microbiology vol. 10,1 (2018): 1442986. doi: https://doi.org/10.1080/20002297.2018.1442986
Bruserud Ø, Siddiqui H, Marthinussen MC, Chen T, Jonsson R, Oftedal BE, Olsen I, Husebye ES, Wolff AB. Oral microbiota in autoimmune polyendocrine syndrome type 1. J Oral Microbiol. 2018 Feb 26;10(1):1442986. doi: 10.1080/20002297.2018.1442986. eCollection 2018. PMID: 29503707; PMCID: PMC5827717.
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Clonal Heterogeneity Reflected by PI3K-AKT-mTOR Signaling in Human Acute Myeloid Leukemia Cells and Its Association with Adverse Prognosis.

Cancers

Nepstad I, Hatfield KJ, Tvedt THA, Reikvam H, Bruserud Ø.
PMID: 30223538
Cancers (Basel). 2018 Sep 14;10(9). doi: 10.3390/cancers10090332.

Clonal heterogeneity detected by karyotyping is a biomarker associated with adverse prognosis in acute myeloid leukemia (AML). Constitutive activation of the phosphatidylinositol-3-kinase-Akt-mechanistic target of rapamycin (PI3K-Akt-mTOR) pathway is present in AML cells, and this pathway integrates signaling from several...

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Nepstad I, Hatfield KJ, Tvedt THA, et al. Clonal Heterogeneity Reflected by PI3K-AKT-mTOR Signaling in Human Acute Myeloid Leukemia Cells and Its Association with Adverse Prognosis. Cancers (Basel). 2018;10(9)doi: 10.3390/cancers10090332.
Nepstad, I., Hatfield, K. J., Tvedt, T. H. A., Reikvam, H., & Bruserud, �. �. (2018). Clonal Heterogeneity Reflected by PI3K-AKT-mTOR Signaling in Human Acute Myeloid Leukemia Cells and Its Association with Adverse Prognosis. Cancers, 10(9), . https://doi.org/10.3390/cancers10090332
Nepstad, Ina, et al. "Clonal Heterogeneity Reflected by PI3K-AKT-mTOR Signaling in Human Acute Myeloid Leukemia Cells and Its Association with Adverse Prognosis." Cancers vol. 10,9 (2018). doi: https://doi.org/10.3390/cancers10090332
Nepstad I, Hatfield KJ, Tvedt THA, Reikvam H, Bruserud Ø. Clonal Heterogeneity Reflected by PI3K-AKT-mTOR Signaling in Human Acute Myeloid Leukemia Cells and Its Association with Adverse Prognosis. Cancers (Basel). 2018 Sep 14;10(9). doi: 10.3390/cancers10090332. PMID: 30223538; PMCID: PMC6162751.
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The association between cytokines and psychomotor speed in a spectrum of psychotic disorders: A longitudinal study.

Brain, behavior, & immunity - health

Larsen JB, Reitan SK, Løberg EM, Rettenbacher M, Bruserud Ø, Larsen TK, Anda L, Bartz-Johannessen C, Johnsen E, Kroken RA.
PMID: 34877553
Brain Behav Immun Health. 2021 Nov 23;18:100392. doi: 10.1016/j.bbih.2021.100392. eCollection 2021 Dec.

BACKGROUND: In schizophrenia, impaired psychomotor speed is a common symptom predicting worse functional outcome. Inflammation causes changes in white matter integrity, which may lead to reduced psychomotor speed. Therefore, we wanted to investigate if peripheral inflammation assessed with cytokines...

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Larsen JB, Reitan SK, Løberg EM, et al. The association between cytokines and psychomotor speed in a spectrum of psychotic disorders: A longitudinal study. Brain Behav Immun Health. 2021;18:100392doi: 10.1016/j.bbih.2021.100392.
Larsen, J. B., Reitan, S. K., Løberg, E. M., Rettenbacher, M., Bruserud, �. �., Larsen, T. K., Anda, L., Bartz-Johannessen, C., Johnsen, E., & Kroken, R. A. (2021). The association between cytokines and psychomotor speed in a spectrum of psychotic disorders: A longitudinal study. Brain, behavior, & immunity - health, 18100392. https://doi.org/10.1016/j.bbih.2021.100392
Larsen, Jeanette Brun, et al. "The association between cytokines and psychomotor speed in a spectrum of psychotic disorders: A longitudinal study." Brain, behavior, & immunity - health vol. 18 (2021): 100392. doi: https://doi.org/10.1016/j.bbih.2021.100392
Larsen JB, Reitan SK, Løberg EM, Rettenbacher M, Bruserud Ø, Larsen TK, Anda L, Bartz-Johannessen C, Johnsen E, Kroken RA. The association between cytokines and psychomotor speed in a spectrum of psychotic disorders: A longitudinal study. Brain Behav Immun Health. 2021 Nov 23;18:100392. doi: 10.1016/j.bbih.2021.100392. eCollection 2021 Dec. PMID: 34877553; PMCID: PMC8633579.
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21-Hydroxylase-Specific CD8+ T Cells in Autoimmune Addison's Disease Are Restricted by HLA-A2 and HLA-C7 Molecules.

Frontiers in immunology

Hellesen A, Aslaksen S, Breivik L, Røyrvik EC, Bruserud Ø, Edvardsen K, Brokstad KA, Wolff ASB, Husebye ES, Bratland E.
PMID: 34721410
Front Immunol. 2021 Oct 14;12:742848. doi: 10.3389/fimmu.2021.742848. eCollection 2021.

OBJECTIVES: CD8+ T cells targeting 21-hydroxylase (21OH) are presumed to play a central role in the destruction of adrenocortical cells in autoimmune Addison's disease (AAD). Earlier reports have suggested two immunodominant CD8+ T cell epitopes within 21OH: LLNATIAEV (21OHMETHODS:...

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Hellesen A, Aslaksen S, Breivik L, et al. 21-Hydroxylase-Specific CD8+ T Cells in Autoimmune Addison's Disease Are Restricted by HLA-A2 and HLA-C7 Molecules. Front Immunol. 2021;12:742848doi: 10.3389/fimmu.2021.742848.
Hellesen, A., Aslaksen, S., Breivik, L., Røyrvik, E. C., Bruserud, �. �., Edvardsen, K., Brokstad, K. A., Wolff, A. S. B., Husebye, E. S., & Bratland, E. (2021). 21-Hydroxylase-Specific CD8+ T Cells in Autoimmune Addison's Disease Are Restricted by HLA-A2 and HLA-C7 Molecules. Frontiers in immunology, 12742848. https://doi.org/10.3389/fimmu.2021.742848
Hellesen, Alexander, et al. "21-Hydroxylase-Specific CD8+ T Cells in Autoimmune Addison's Disease Are Restricted by HLA-A2 and HLA-C7 Molecules." Frontiers in immunology vol. 12 (2021): 742848. doi: https://doi.org/10.3389/fimmu.2021.742848
Hellesen A, Aslaksen S, Breivik L, Røyrvik EC, Bruserud Ø, Edvardsen K, Brokstad KA, Wolff ASB, Husebye ES, Bratland E. 21-Hydroxylase-Specific CD8+ T Cells in Autoimmune Addison's Disease Are Restricted by HLA-A2 and HLA-C7 Molecules. Front Immunol. 2021 Oct 14;12:742848. doi: 10.3389/fimmu.2021.742848. eCollection 2021. PMID: 34721410; PMCID: PMC8551825.
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The Beighton scoring system.

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

Høiseth TCJ, Tsykunova G, Bruserud Ø, Tvedt THA.
PMID: 32238962
Tidsskr Nor Laegeforen. 2020 Mar 30;140(5). doi: 10.4045/tidsskr.19.0487. Print 2020 Mar 31.

No abstract available.

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Høiseth TCJ, Tsykunova G, Bruserud Ø, et al. Beighton-skår. The Beighton scoring system. Tidsskr Nor Laegeforen. 2020;140(5)doi: 10.4045/tidsskr.19.0487.
Høiseth, T. C. J., Tsykunova, G., Bruserud, �. �., & Tvedt, T. H. A. (2020). Beighton-skår. The Beighton scoring system. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 140(5), . https://doi.org/10.4045/tidsskr.19.0487
Høiseth, Thea Cecilie Johnsen, et al. "Beighton-skår." The Beighton scoring system. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke vol. 140,5 (2020). doi: https://doi.org/10.4045/tidsskr.19.0487
Høiseth TCJ, Tsykunova G, Bruserud Ø, Tvedt THA. Beighton-skår. The Beighton scoring system. Tidsskr Nor Laegeforen. 2020 Mar 30;140(5). doi: 10.4045/tidsskr.19.0487. Print 2020 Mar 31. Norwegian. PMID: 32238962.
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High Constitutive Cytokine Release by Primary Human Acute Myeloid Leukemia Cells Is Associated with a Specific Intercellular Communication Phenotype.

Journal of clinical medicine

Reikvam H, Aasebø E, Brenner AK, Bartaula-Brevik S, Grønningsæter IS, Forthun RB, Hovland R, Bruserud Ø.
PMID: 31277464
J Clin Med. 2019 Jul 04;8(7). doi: 10.3390/jcm8070970.

Acute myeloid leukemia (AML) is a heterogeneous disease, and this heterogeneity includes the capacity of constitutive release of extracellular soluble mediators by AML cells. We investigated whether this capacity is associated with molecular genetic abnormalities, and we compared the...

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Reikvam H, Aasebø E, Brenner AK, et al. High Constitutive Cytokine Release by Primary Human Acute Myeloid Leukemia Cells Is Associated with a Specific Intercellular Communication Phenotype. J Clin Med. 2019;8(7)doi: 10.3390/jcm8070970.
Reikvam, H., Aasebø, E., Brenner, A. K., Bartaula-Brevik, S., Grønningsæter, I. S., Forthun, R. B., Hovland, R., & Bruserud, �. �. (2019). High Constitutive Cytokine Release by Primary Human Acute Myeloid Leukemia Cells Is Associated with a Specific Intercellular Communication Phenotype. Journal of clinical medicine, 8(7), . https://doi.org/10.3390/jcm8070970
Reikvam, Håkon, et al. "High Constitutive Cytokine Release by Primary Human Acute Myeloid Leukemia Cells Is Associated with a Specific Intercellular Communication Phenotype." Journal of clinical medicine vol. 8,7 (2019). doi: https://doi.org/10.3390/jcm8070970
Reikvam H, Aasebø E, Brenner AK, Bartaula-Brevik S, Grønningsæter IS, Forthun RB, Hovland R, Bruserud Ø. High Constitutive Cytokine Release by Primary Human Acute Myeloid Leukemia Cells Is Associated with a Specific Intercellular Communication Phenotype. J Clin Med. 2019 Jul 04;8(7). doi: 10.3390/jcm8070970. PMID: 31277464; PMCID: PMC6678419.
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The Progression of Acute Myeloid Leukemia from First Diagnosis to Chemoresistant Relapse: A Comparison of Proteomic and Phosphoproteomic Profiles.

Cancers

Aasebø E, Berven FS, Hovland R, Døskeland SO, Bruserud Ø, Selheim F, Hernandez-Valladares M.
PMID: 32512867
Cancers (Basel). 2020 Jun 04;12(6). doi: 10.3390/cancers12061466.

Acute myeloid leukemia (AML) is an aggressive hematological malignancy. Nearly 50% of the patients who receive the most intensive treatment develop chemoresistant leukemia relapse. Although the leukemogenic events leading to relapse seem to differ between patients (i.e., regrowth from...

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Aasebø E, Berven FS, Hovland R, et al. The Progression of Acute Myeloid Leukemia from First Diagnosis to Chemoresistant Relapse: A Comparison of Proteomic and Phosphoproteomic Profiles. Cancers (Basel). 2020;12(6)doi: 10.3390/cancers12061466.
Aasebø, E., Berven, F. S., Hovland, R., Døskeland, S. O., Bruserud, �. �., Selheim, F., & Hernandez-Valladares, M. (2020). The Progression of Acute Myeloid Leukemia from First Diagnosis to Chemoresistant Relapse: A Comparison of Proteomic and Phosphoproteomic Profiles. Cancers, 12(6), . https://doi.org/10.3390/cancers12061466
Aasebø, Elise, et al. "The Progression of Acute Myeloid Leukemia from First Diagnosis to Chemoresistant Relapse: A Comparison of Proteomic and Phosphoproteomic Profiles." Cancers vol. 12,6 (2020). doi: https://doi.org/10.3390/cancers12061466
Aasebø E, Berven FS, Hovland R, Døskeland SO, Bruserud Ø, Selheim F, Hernandez-Valladares M. The Progression of Acute Myeloid Leukemia from First Diagnosis to Chemoresistant Relapse: A Comparison of Proteomic and Phosphoproteomic Profiles. Cancers (Basel). 2020 Jun 04;12(6). doi: 10.3390/cancers12061466. PMID: 32512867; PMCID: PMC7352627.
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The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles.

Biomedicines

Aarstad HH, Moe SEE, Bruserud Ø, Lybak S, Aarstad HJ, Tvedt THA.
PMID: 33066437
Biomedicines. 2020 Oct 14;8(10). doi: 10.3390/biomedicines8100418.

C-reactive protein (CRP) has a prognostic impact in head and neck squamous cell carcinoma (HNSCC). However, the acute phase reaction involves many other proteins depending on its inducing events, including various cytokines that can function as reaction inducers. In...

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Aarstad HH, Moe SEE, Bruserud Ø, et al. The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles. Biomedicines. 2020;8(10)doi: 10.3390/biomedicines8100418.
Aarstad, H. H., Moe, S. E. E., Bruserud, �. �., Lybak, S., Aarstad, H. J., & Tvedt, T. H. A. (2020). The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles. Biomedicines, 8(10), . https://doi.org/10.3390/biomedicines8100418
Aarstad, Helene Hersvik, et al. "The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles." Biomedicines vol. 8,10 (2020). doi: https://doi.org/10.3390/biomedicines8100418
Aarstad HH, Moe SEE, Bruserud Ø, Lybak S, Aarstad HJ, Tvedt THA. The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles. Biomedicines. 2020 Oct 14;8(10). doi: 10.3390/biomedicines8100418. PMID: 33066437; PMCID: PMC7602291.
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The pretransplant systemic metabolic profile reflects a risk of acute graft versus host disease after allogeneic stem cell transplantation.

Metabolomics : Official journal of the Metabolomic Society

Reikvam H, Hatfield K, Bruserud Ø.
PMID: 27829829
Metabolomics. 2016;12(1):12. doi: 10.1007/s11306-015-0880-x. Epub 2015 Nov 16.

Allogeneic stem cell transplantation is used in the treatment of younger patients with severe hematological diseases, especially hematological malignancies, and acute graft versus host disease (GVHD) is then an important immune-mediated posttransplant complication. Several risk factors for acute GVHD...

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Reikvam H, Hatfield K, Bruserud Ø. The pretransplant systemic metabolic profile reflects a risk of acute graft versus host disease after allogeneic stem cell transplantation. Metabolomics. 2015;12(1):12doi: 10.1007/s11306-015-0880-x.
Reikvam, H., Hatfield, K., & Bruserud, �. �. (2016). The pretransplant systemic metabolic profile reflects a risk of acute graft versus host disease after allogeneic stem cell transplantation. Metabolomics : Official journal of the Metabolomic Society, 12(1), 12. https://doi.org/10.1007/s11306-015-0880-x
Reikvam, Håkon, et al. "The pretransplant systemic metabolic profile reflects a risk of acute graft versus host disease after allogeneic stem cell transplantation." Metabolomics : Official journal of the Metabolomic Society vol. 12,1 (2016): 12. doi: https://doi.org/10.1007/s11306-015-0880-x
Reikvam H, Hatfield K, Bruserud Ø. The pretransplant systemic metabolic profile reflects a risk of acute graft versus host disease after allogeneic stem cell transplantation. Metabolomics. 2016;12(1):12. doi: 10.1007/s11306-015-0880-x. Epub 2015 Nov 16. PMID: 27829829; PMCID: PMC5080330.
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