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Showing 1 to 12 of 24 entries
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Donor HLA-DR Drives the Development of De Novo Autoimmunity Following Lung and Heart Transplantation.

Transplantation direct

Jankowska Gan E, Agashe VV, Lema DA, Zhou Y, Gonzalez Bosc L, Sullivan JA, Greenspan DS, Burlingham WJ.
PMID: 33062840
Transplant Direct. 2020 Sep 24;6(10):e607. doi: 10.1097/TXD.0000000000001062. eCollection 2020 Oct.

Individuals harbor preexisting HLA-DR/DQ-restricted responses to collagen type V (ColV) mediated by Th17 cells under Treg control, both specific to peptides that bind to inherited HLA class II antigens. Yet after transplant, the donor-DR type somehow influences graft outcome....

Complement Blockade in Recipients Prevents Delayed Graft Function and Delays Antibody-mediated Rejection in a Nonhuman Primate Model of Kidney Transplantation.

Transplantation

Eerhart MJ, Reyes JA, Blanton CL, Danobeitia JS, Chlebeck PJ, Zitur LJ, Springer M, Polyak E, Coonen J, Capuano S, D'Alessandro AM, Torrealba J, van Amersfoort E, Ponstein Y, van Kooten C, Burlingham W, Sullivan J, Pozniak M, Zhong W, Yankol Y, Fernandez LA.
PMID: 34905763
Transplantation. 2022 Jan 01;106(1):60-71. doi: 10.1097/TP.0000000000003754.

BACKGROUND: Complement activation in kidney transplantation is implicated in the pathogenesis of delayed graft function (DGF). This study evaluated the therapeutic efficacy of high-dose recombinant human C1 esterase inhibitor (rhC1INH) to prevent DGF in a nonhuman primate model of...

Kinetics of Alloantigen-Specific Regulatory CD4 T Cell Development and Tissue Distribution After Donor-Specific Transfusion and Costimulatory Blockade.

Transplantation direct

Tomita Y, Satomi M, Bracamonte-Baran W, Jankowska Gan E, Workman AS, Workman CJ, Vignali DA, Burlingham WJ.
PMID: 27500263
Transplant Direct. 2016 Apr 21;2(5):e73. doi: 10.1097/TXD.0000000000000580. eCollection 2016 May.

BACKGROUND: The influence of donor-side regulation toward recipient antigens on graft outcome is poorly understood.METHODS: Because this influence might be due in part to the accumulation of tissue-resident memory T cells in the donor organ, we used a standard...

Complement Blockade in Recipients Prevents Delayed Graft Function and Delays Antibody-mediated Rejection in a Nonhuman Primate Model of Kidney Transplantation.

Transplantation

Eerhart MJ, Reyes JA, Blanton CL, Danobeitia JS, Chlebeck PJ, Zitur LJ, Springer M, Polyak E, Coonen J, Capuano S, D'Alessandro AM, Torrealba J, van Amersfoort E, Ponstein Y, van Kooten C, Burlingham W, Sullivan J, Pozniak M, Zhong W, Yankol Y, Fernandez LA.
PMID: 34905763
Transplantation. 2022 Jan 01;106(1):60-71. doi: 10.1097/TP.0000000000003754.

BACKGROUND: Complement activation in kidney transplantation is implicated in the pathogenesis of delayed graft function (DGF). This study evaluated the therapeutic efficacy of high-dose recombinant human C1 esterase inhibitor (rhC1INH) to prevent DGF in a nonhuman primate model of...

Vessel diameter and close surveillance helps predict early patency in native arteriovenous fistulas.

The journal of vascular access

Kirkham EN, Fallon J, Foy C, Harris S, Birch G, Bullingham J, Pickett TM, Kulkarni SR, Paravastu SC, Cooper DG.
PMID: 34763540
J Vasc Access. 2021 Nov 11;11297298211058034. doi: 10.1177/11297298211058034. Epub 2021 Nov 11.

INTRODUCTION: Arteriovenous fistulas are the preferred method of vascular access for haemodialysis. Data suggests patency rates can be low and may be related to vessel diameters prior to creation. We use specific size criteria for fistula selection. We aimed...

Tomotherapy Applied Total Lymphoid Irradiation and Allogeneic Hematopoietic Cell Transplantation Generates Mixed Chimerism in the Rhesus Macaque Model.

Radiation research

Forrest L, Fechner J, Post J, Van Asselt N, Kvasnica K, Haynes LD, Coonen J, Brunner K, Haynes WJ, Little C, Burlingham WJ, Hematti P, Strober S, Kaufman DB.
PMID: 34388816
Radiat Res. 2021 Dec 01;196(6):623-632. doi: 10.1667/RADE-20-00246.1.

Development of a new methodology to induce immunological chimerism after allogeneic hematopoietic cell (HC) transplantation in a rhesus macaque model is described. The chimeric state was achieved using a non-myeloablative, helical tomotherapy-based total lymphoid irradiation (TomoTLI) conditioning regimen followed...

Tomotherapy Applied Total Lymphoid Irradiation and Allogeneic Hematopoietic Cell Transplantation Generates Mixed Chimerism in the Rhesus Macaque Model.

Radiation research

Forrest L, Fechner J, Post J, Van Asselt N, Kvasnica K, Haynes LD, Coonen J, Brunner K, Haynes WJ, Little C, Burlingham WJ, Hematti P, Strober S, Kaufman DB.
PMID: 34388816
Radiat Res. 2021 Dec 01;196(6):623-632. doi: 10.1667/RADE-20-00246.1.

Development of a new methodology to induce immunological chimerism after allogeneic hematopoietic cell (HC) transplantation in a rhesus macaque model is described. The chimeric state was achieved using a non-myeloablative, helical tomotherapy-based total lymphoid irradiation (TomoTLI) conditioning regimen followed...

Complement Blockade in Recipients Prevents Delayed Graft Function and Delays Antibody-mediated Rejection in a Nonhuman Primate Model of Kidney Transplantation.

Transplantation

Eerhart MJ, Reyes JA, Blanton CL, Danobeitia JS, Chlebeck PJ, Zitur LJ, Springer M, Polyak E, Coonen J, Capuano S, D'Alessandro AM, Torrealba J, van Amersfoort E, Ponstein Y, van Kooten C, Burlingham W, Sullivan J, Pozniak M, Zhong W, Yankol Y, Fernandez LA, Jeong JS, González-Gómez D.
PMID: 34905763
Transplantation. 2022 Jan 01;106(1):60-71. doi: 10.1097/TP.0000000000003754.

BACKGROUND: Complement activation in kidney transplantation is implicated in the pathogenesis of delayed graft function (DGF). This study evaluated the therapeutic efficacy of high-dose recombinant human C1 esterase inhibitor (rhC1INH) to prevent DGF in a nonhuman primate model of...

Complement Blockade in Recipients Prevents Delayed Graft Function and Delays Antibody-mediated Rejection in a Nonhuman Primate Model of Kidney Transplantation.

Transplantation

Eerhart MJ, Reyes JA, Blanton CL, Danobeitia JS, Chlebeck PJ, Zitur LJ, Springer M, Polyak E, Coonen J, Capuano S, D'Alessandro AM, Torrealba J, van Amersfoort E, Ponstein Y, van Kooten C, Burlingham W, Sullivan J, Pozniak M, Zhong W, Yankol Y, Fernandez LA.
PMID: 34905763
Transplantation. 2022 Jan 01;106(1):60-71. doi: 10.1097/TP.0000000000003754.

BACKGROUND: Complement activation in kidney transplantation is implicated in the pathogenesis of delayed graft function (DGF). This study evaluated the therapeutic efficacy of high-dose recombinant human C1 esterase inhibitor (rhC1INH) to prevent DGF in a nonhuman primate model of...

Extended lung preservation with UW solution does not adversely affect graft outcome.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Woolley DS, Devito-Haynes LD, Ulschmid S, Leverson G, Welter DL, Hoffmann A, Cornwell RD, Burlingham WJ, Meyer KC, Love RB.
PMID: 11250372
J Heart Lung Transplant. 2001 Feb;20(2):207. doi: 10.1016/s1053-2498(00)00445-9.

No abstract available.

Correlation between post transplant maternal microchimerism and tolerance across MHC barriers in mice.

Chimerism

Dutta P, Burlingham WJ.
PMID: 22163065
Chimerism. 2011 Jul;2(3):78-83. doi: 10.4161/chim.2.3.18083. Epub 2011 Jul 01.

UNLABELLED: Exposure to non-inherited maternal antigens (NIMA) during fetal and neonatal life can result in lifelong maternal microchimerism (MMc) and tolerance to NIMA(+) allografts. We have previously shown that 40-50% of BDF1 female x B6 male offspring have multi-organ...

Mycophenolate Monotherapy in HLA-Matched Kidney Transplant Recipients: A Case Series of 20 Patients.

Transplantation direct

Hennes AJ, Holdener KE, Burlingham WJ, Mandelbrot DA, Parajuli S, Mohamed MA, Garg N, Aziz F, Astor BC, Djamali A.
PMID: 32095512
Transplant Direct. 2020 Jan 17;6(2):e526. doi: 10.1097/TXD.0000000000000961. eCollection 2020 Feb.

The ideal minimizing strategy for maintenance immunosuppression in HLA-matched kidney transplant recipients (KTR) is unknown. We hypothesized that mycophenolate (MPA) monotherapy is a safe and effective approach for maintenance therapy in this group of KTR.METHODS: Data were abstracted for...

Showing 1 to 12 of 24 entries