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The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems.

The Journal of organic chemistry

Smith AC, Cabral S, Kung DW, Rose CR, Southers JA, García-Irizarry CN, Damon DB, Bagley SW, Griffith DA.
PMID: 27056793
J Org Chem. 2016 May 06;81(9):3509-19. doi: 10.1021/acs.joc.5b02890. Epub 2016 Apr 25.

The synthesis of a series of pharmaceutically important N-protected methyl-substituted spirocyclic piperidine-azetidine (2,7-diazaspiro[3.5]nonane) and spirocyclic piperidine-pyrrolidine (2,8-diazaspiro[4.5]decane) ring systems was developed. These motifs contain two differentiated sites (protected secondary amines) to allow for further functionalization via reductive amination, amidation,...

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Smith AC, Cabral S, Kung DW, et al. The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems. J Org Chem. 2016;81(9):3509-19doi: 10.1021/acs.joc.5b02890.
Smith, A. C., Cabral, S., Kung, D. W., Rose, C. R., Southers, J. A., García-Irizarry, C. N., Damon, D. B., Bagley, S. W., & Griffith, D. A. (2016). The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems. The Journal of organic chemistry, 81(9), 3509-19. https://doi.org/10.1021/acs.joc.5b02890
Smith, Aaron C, et al. "The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems." The Journal of organic chemistry vol. 81,9 (2016): 3509-19. doi: https://doi.org/10.1021/acs.joc.5b02890
Smith AC, Cabral S, Kung DW, Rose CR, Southers JA, García-Irizarry CN, Damon DB, Bagley SW, Griffith DA. The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems. J Org Chem. 2016 May 06;81(9):3509-19. doi: 10.1021/acs.joc.5b02890. Epub 2016 Apr 25. PMID: 27056793.
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"Two-step" technique with OsiriX™ to evaluate feasibility of C2 pedicle for surgical fixation.

Journal of craniovertebral junction & spine

Marques LM, d'Almeida GN, Cabral J.
PMID: 27217652
J Craniovertebr Junction Spine. 2016 Apr-Jun;7(2):75-81. doi: 10.4103/0974-8237.181826.

BACKGROUND: Surgical treatment of craniovertebral junction pathology has evolved considerably in recent decades with the implementation of short atlanto-axial fixation techniques, notwhithstanding increasing neurovascular risks. Also, there is strong evidence that fixation of C2 anatomical pedicle has the best...

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Marques LM, d'Almeida GN, Cabral J. "Two-step" technique with OsiriX™ to evaluate feasibility of C2 pedicle for surgical fixation. J Craniovertebr Junction Spine. 2016;7(2):75-81doi: 10.4103/0974-8237.181826.
Marques, L. M., d'Almeida, G. N., & Cabral, J. (2016). "Two-step" technique with OsiriX™ to evaluate feasibility of C2 pedicle for surgical fixation. Journal of craniovertebral junction & spine, 7(2), 75-81. https://doi.org/10.4103/0974-8237.181826
Marques, Luis Miguel Sousa, et al. ""Two-step" technique with OsiriX™ to evaluate feasibility of C2 pedicle for surgical fixation." Journal of craniovertebral junction & spine vol. 7,2 (2016): 75-81. doi: https://doi.org/10.4103/0974-8237.181826
Marques LM, d'Almeida GN, Cabral J. "Two-step" technique with OsiriX™ to evaluate feasibility of C2 pedicle for surgical fixation. J Craniovertebr Junction Spine. 2016 Apr-Jun;7(2):75-81. doi: 10.4103/0974-8237.181826. PMID: 27217652; PMCID: PMC4872566.
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Research projects in the Surgeon-Scientist and Clinician-Investigator programs at the University of Toronto (1987-2016): a cohort study.

CMAJ open

Goldenberg NM, Steinberg BE, Rutka JT, Chen R, Cabral V, Rosenblum ND, Kapus A, Lee WL.
PMID: 27730108
CMAJ Open. 2016 Aug 22;4(3):E444-E447. doi: 10.9778/cmajo.20160062. eCollection 2016.

BACKGROUND: Physicians have traditionally been at the forefront of medical research, bringing clinical questions to the laboratory and returning with ideas for treatment. However, we have anecdotally observed a decline in the popularity of basic science research among trainees....

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Goldenberg NM, Steinberg BE, Rutka JT, et al. Research projects in the Surgeon-Scientist and Clinician-Investigator programs at the University of Toronto (1987-2016): a cohort study. CMAJ Open. 2016;4(3):E444-E447doi: 10.9778/cmajo.20160062.
Goldenberg, N. M., Steinberg, B. E., Rutka, J. T., Chen, R., Cabral, V., Rosenblum, N. D., Kapus, A., & Lee, W. L. (2016). Research projects in the Surgeon-Scientist and Clinician-Investigator programs at the University of Toronto (1987-2016): a cohort study. CMAJ open, 4(3), E444-E447. https://doi.org/10.9778/cmajo.20160062
Goldenberg, Neil M, et al. "Research projects in the Surgeon-Scientist and Clinician-Investigator programs at the University of Toronto (1987-2016): a cohort study." CMAJ open vol. 4,3 (2016): E444-E447. doi: https://doi.org/10.9778/cmajo.20160062
Goldenberg NM, Steinberg BE, Rutka JT, Chen R, Cabral V, Rosenblum ND, Kapus A, Lee WL. Research projects in the Surgeon-Scientist and Clinician-Investigator programs at the University of Toronto (1987-2016): a cohort study. CMAJ Open. 2016 Aug 22;4(3):E444-E447. doi: 10.9778/cmajo.20160062. eCollection 2016. PMID: 27730108; PMCID: PMC5047840.
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Diagnosis of severe fetal anemia based on perinatal outcomes: a comparative analysis of the current reference values.

Anemia

Reis ZS, Osanan GC, Coelho TL, Rezende CA, Leite HV, Cabral AC.
PMID: 24349768
Anemia. 2013;2013:351258. doi: 10.1155/2013/351258. Epub 2013 Nov 20.

Objectives. To compare current criteria for severe fetal anemia diagnosis. Methodology. A cohort study analyzed 105 alloimmunized fetuses that underwent cordocentesis due to risk of anemia. Concordance among the diagnostic criteria for severe fetal anemia, hemoglobin deficit >7 g/dL,...

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Reis ZS, Osanan GC, Coelho TL, et al. Diagnosis of severe fetal anemia based on perinatal outcomes: a comparative analysis of the current reference values. Anemia. 2013;2013:351258doi: 10.1155/2013/351258.
Reis, Z. S., Osanan, G. C., Coelho, T. L., Rezende, C. A., Leite, H. V., & Cabral, A. C. (2013). Diagnosis of severe fetal anemia based on perinatal outcomes: a comparative analysis of the current reference values. Anemia, 2013351258. https://doi.org/10.1155/2013/351258
Reis, Zilma Silveira Nogueira, et al. "Diagnosis of severe fetal anemia based on perinatal outcomes: a comparative analysis of the current reference values." Anemia vol. 2013 (2013): 351258. doi: https://doi.org/10.1155/2013/351258
Reis ZS, Osanan GC, Coelho TL, Rezende CA, Leite HV, Cabral AC. Diagnosis of severe fetal anemia based on perinatal outcomes: a comparative analysis of the current reference values. Anemia. 2013;2013:351258. doi: 10.1155/2013/351258. Epub 2013 Nov 20. PMID: 24349768; PMCID: PMC3854004.
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Nonfunctioning giant pituitary adenomas: Invasiveness and recurrence.

Surgical neurology international

Landeiro JA, Fonseca EO, Monnerat AL, Taboada GF, Cabral GA, Antunes F.
PMID: 26674325
Surg Neurol Int. 2015 Nov 26;6:179. doi: 10.4103/2152-7806.170536. eCollection 2015.

BACKGROUND: We report our surgical series of 35 patients with giant nonfunctioning pituitary adenomas (GNFPA). We analyzed the rule of Ki-67 antigen expression in predicting recurrence.METHODS: Thirty-five patients were operated between 2000 and 2010. Suprassellar extension of the tumors...

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Landeiro JA, Fonseca EO, Monnerat AL, et al. Nonfunctioning giant pituitary adenomas: Invasiveness and recurrence. Surg Neurol Int. 2015;6:179doi: 10.4103/2152-7806.170536.
Landeiro, J. A., Fonseca, E. O., Monnerat, A. L., Taboada, G. F., Cabral, G. A., & Antunes, F. (2015). Nonfunctioning giant pituitary adenomas: Invasiveness and recurrence. Surgical neurology international, 6179. https://doi.org/10.4103/2152-7806.170536
Landeiro, José Alberto, et al. "Nonfunctioning giant pituitary adenomas: Invasiveness and recurrence." Surgical neurology international vol. 6 (2015): 179. doi: https://doi.org/10.4103/2152-7806.170536
Landeiro JA, Fonseca EO, Monnerat AL, Taboada GF, Cabral GA, Antunes F. Nonfunctioning giant pituitary adenomas: Invasiveness and recurrence. Surg Neurol Int. 2015 Nov 26;6:179. doi: 10.4103/2152-7806.170536. eCollection 2015. PMID: 26674325; PMCID: PMC4665135.
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Evidence from a rare case study for Hebbian-like changes in structural connectivity induced by long-term deep brain stimulation.

Frontiers in behavioral neuroscience

van Hartevelt TJ, Cabral J, Møller A, FitzGerald JJ, Green AL, Aziz TZ, Deco G, Kringelbach ML.
PMID: 26175675
Front Behav Neurosci. 2015 Jun 30;9:167. doi: 10.3389/fnbeh.2015.00167. eCollection 2015.

It is unclear whether Hebbian-like learning occurs at the level of long-range white matter connections in humans, i.e., where measurable changes in structural connectivity (SC) are correlated with changes in functional connectivity. However, the behavioral changes observed after deep...

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van Hartevelt TJ, Cabral J, Møller A, et al. Evidence from a rare case study for Hebbian-like changes in structural connectivity induced by long-term deep brain stimulation. Front Behav Neurosci. 2015;9:167doi: 10.3389/fnbeh.2015.00167.
van Hartevelt, T. J., Cabral, J., Møller, A., FitzGerald, J. J., Green, A. L., Aziz, T. Z., Deco, G., & Kringelbach, M. L. (2015). Evidence from a rare case study for Hebbian-like changes in structural connectivity induced by long-term deep brain stimulation. Frontiers in behavioral neuroscience, 9167. https://doi.org/10.3389/fnbeh.2015.00167
van Hartevelt, Tim J, et al. "Evidence from a rare case study for Hebbian-like changes in structural connectivity induced by long-term deep brain stimulation." Frontiers in behavioral neuroscience vol. 9 (2015): 167. doi: https://doi.org/10.3389/fnbeh.2015.00167
van Hartevelt TJ, Cabral J, Møller A, FitzGerald JJ, Green AL, Aziz TZ, Deco G, Kringelbach ML. Evidence from a rare case study for Hebbian-like changes in structural connectivity induced by long-term deep brain stimulation. Front Behav Neurosci. 2015 Jun 30;9:167. doi: 10.3389/fnbeh.2015.00167. eCollection 2015. PMID: 26175675; PMCID: PMC4485173.
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Prediction of early and late preeclampsia by flow-mediated dilation of the brachial artery.

Radiologia brasileira

Brandão AH, Evangelista AA, Martins RM, Leite HV, Cabral AC.
PMID: 25741086
Radiol Bras. 2014 Jul-Aug;47(4):206-9. doi: 10.1590/0100-3984.2013.1894.

OBJECTIVE: To assess the accuracy in the prediction of both early and late preeclampsia by flow-mediated dilation of the brachial artery (FMD), a biophysical marker for endothelial dysfunction.MATERIALS AND METHODS: A total of 91 patients, considered at high risk...

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Brandão AH, Evangelista AA, Martins RM, et al. Prediction of early and late preeclampsia by flow-mediated dilation of the brachial artery. Radiol Bras. 2014;47(4):206-9doi: 10.1590/0100-3984.2013.1894.
Brandão, A. H., Evangelista, A. A., Martins, R. M., Leite, H. V., & Cabral, A. C. (2014). Prediction of early and late preeclampsia by flow-mediated dilation of the brachial artery. Radiologia brasileira, 47(4), 206-9. https://doi.org/10.1590/0100-3984.2013.1894
Brandão, Augusto Henriques Fulgêncio, et al. "Prediction of early and late preeclampsia by flow-mediated dilation of the brachial artery." Radiologia brasileira vol. 47,4 (2014): 206-9. doi: https://doi.org/10.1590/0100-3984.2013.1894
Brandão AH, Evangelista AA, Martins RM, Leite HV, Cabral AC. Prediction of early and late preeclampsia by flow-mediated dilation of the brachial artery. Radiol Bras. 2014 Jul-Aug;47(4):206-9. doi: 10.1590/0100-3984.2013.1894. PMID: 25741086; PMCID: PMC4337122.
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Brain circuits mediating the orexigenic action of peripheral ghrelin: narrow gates for a vast kingdom.

Frontiers in endocrinology

Cabral A, De Francesco PN, Perello M.
PMID: 25870587
Front Endocrinol (Lausanne). 2015 Mar 30;6:44. doi: 10.3389/fendo.2015.00044. eCollection 2015.

No abstract available.

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Cabral A, De Francesco PN, Perello M. Brain circuits mediating the orexigenic action of peripheral ghrelin: narrow gates for a vast kingdom. Front Endocrinol (Lausanne). 2015;6:44doi: 10.3389/fendo.2015.00044.
Cabral, A., De Francesco, P. N., & Perello, M. (2015). Brain circuits mediating the orexigenic action of peripheral ghrelin: narrow gates for a vast kingdom. Frontiers in endocrinology, 644. https://doi.org/10.3389/fendo.2015.00044
Cabral, Agustina, et al. "Brain circuits mediating the orexigenic action of peripheral ghrelin: narrow gates for a vast kingdom." Frontiers in endocrinology vol. 6 (2015): 44. doi: https://doi.org/10.3389/fendo.2015.00044
Cabral A, De Francesco PN, Perello M. Brain circuits mediating the orexigenic action of peripheral ghrelin: narrow gates for a vast kingdom. Front Endocrinol (Lausanne). 2015 Mar 30;6:44. doi: 10.3389/fendo.2015.00044. eCollection 2015. PMID: 25870587; PMCID: PMC4378314.
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Prenatal diagnosis of congenital syngnathia by 3D ultrasound and pathological correlation.

Journal of medical ultrasonics (2001)

Rezende Gde C, Pereira AK, Reis ZS, Parola AR, Bastos FM, Araujo Júnior E, Nardozza LM, Cabral AC.
PMID: 27276933
J Med Ultrason (2001). 2013 Jan;40(1):85-7. doi: 10.1007/s10396-012-0389-0. Epub 2012 Aug 10.

Congenital syngnathia is a maxillomandibular fusion, and it can vary in severity from single mucosal bands (synechiae) to complete bony fusion (synostosis). Cases of combinations of bony or soft tissue adhesions between the mandible and maxilla with cleft of...

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Rezende Gde C, Pereira AK, Reis ZS, et al. Prenatal diagnosis of congenital syngnathia by 3D ultrasound and pathological correlation. J Med Ultrason (2001). 2012;40(1):85-7doi: 10.1007/s10396-012-0389-0.
Rezende, G. d. e. . C., Pereira, A. K., Reis, Z. S., Parola, A. R., Bastos, F. M., Araujo Júnior, E., Nardozza, L. M., & Cabral, A. C. (2013). Prenatal diagnosis of congenital syngnathia by 3D ultrasound and pathological correlation. Journal of medical ultrasonics (2001), 40(1), 85-7. https://doi.org/10.1007/s10396-012-0389-0
Rezende, Guilherme de Castro, et al. "Prenatal diagnosis of congenital syngnathia by 3D ultrasound and pathological correlation." Journal of medical ultrasonics (2001) vol. 40,1 (2013): 85-7. doi: https://doi.org/10.1007/s10396-012-0389-0
Rezende Gde C, Pereira AK, Reis ZS, Parola AR, Bastos FM, Araujo Júnior E, Nardozza LM, Cabral AC. Prenatal diagnosis of congenital syngnathia by 3D ultrasound and pathological correlation. J Med Ultrason (2001). 2013 Jan;40(1):85-7. doi: 10.1007/s10396-012-0389-0. Epub 2012 Aug 10. PMID: 27276933.
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Incidence of lagophthalmos after aponeurotic ptosis repair.

Orbit (Amsterdam, Netherlands)

Tucker SM, Cabral H.
PMID: 12045949
Orbit. 2000 Jun;19(2):61-66.

This study was designed to determine the incidence of lagophthalmos following aponeurotic ptosis repair, and to establish any predictive factors for its development. Data from a prospective, interventional, non-comparative case series was reviewed. Of these 164 eyelids with acquired...

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Tucker SM, Cabral H. Incidence of lagophthalmos after aponeurotic ptosis repair. Orbit. 2000;19(2):61-66
Tucker, S. M., & Cabral, H. (2000). Incidence of lagophthalmos after aponeurotic ptosis repair. Orbit (Amsterdam, Netherlands), 19(2), 61-66.
Tucker, Susan M., and Cabral, Howard. "Incidence of lagophthalmos after aponeurotic ptosis repair." Orbit (Amsterdam, Netherlands) vol. 19,2 (2000): 61-66.
Tucker SM, Cabral H. Incidence of lagophthalmos after aponeurotic ptosis repair. Orbit. 2000 Jun;19(2):61-66. PMID: 12045949.
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Kids' perception about epilepsy.

Epilepsy & behavior : E&B

Fernandes PT, Cabral P, Araújo U, Noronha AL, Li LM.
PMID: 15907755
Epilepsy Behav. 2005 Jun;6(4):601-3. doi: 10.1016/j.yebeh.2005.02.011.

PURPOSE: Epilepsy remains a stigmatized condition. Lack of information has been pointed to as a cause of the perpetuation of stigma. Our goal was to survey children's perception of epilepsy.METHODS: We used a questionnaire to determine if the children...

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Fernandes PT, Cabral P, Araújo U, et al. Kids' perception about epilepsy. Epilepsy Behav. 2005;6(4):601-3doi: 10.1016/j.yebeh.2005.02.011.
Fernandes, P. T., Cabral, P., Araújo, U., Noronha, A. L., & Li, L. M. (2005). Kids' perception about epilepsy. Epilepsy & behavior : E&B, 6(4), 601-3. https://doi.org/10.1016/j.yebeh.2005.02.011
Fernandes, Paula T, et al. "Kids' perception about epilepsy." Epilepsy & behavior : E&B vol. 6,4 (2005): 601-3. doi: https://doi.org/10.1016/j.yebeh.2005.02.011
Fernandes PT, Cabral P, Araújo U, Noronha AL, Li LM. Kids' perception about epilepsy. Epilepsy Behav. 2005 Jun;6(4):601-3. doi: 10.1016/j.yebeh.2005.02.011. PMID: 15907755.
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Hydrogen in chemical vapour deposited carbon nanotubes: an active site for functionalization.

Journal of nanoscience and nanotechnology

Titus E, Cabral G, Madaleno JC, Coelho MC, Babu PR, Blau WJ, Misra DS, Gracio J.
PMID: 19049170
J Nanosci Nanotechnol. 2008 Aug;8(8):4017-22. doi: 10.1166/jnn.2008.an34.

The presence of hydrogen in as-grown carbon nanotubes (CNTs) synthesized by microwave plasma (MP) chemical vapour deposition (CVD) technique is demonstrated. Our results showed that the MPCVD, as-grown CNTs were hydrogenated consisting of C-H bonds; whereas, the tubes synthesized...

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Titus E, Cabral G, Madaleno JC, et al. Hydrogen in chemical vapour deposited carbon nanotubes: an active site for functionalization. J Nanosci Nanotechnol. 2008;8(8):4017-22doi: 10.1166/jnn.2008.an34.
Titus, E., Cabral, G., Madaleno, J. C., Coelho, M. C., Babu, P. R., Blau, W. J., Misra, D. S., & Gracio, J. (2008). Hydrogen in chemical vapour deposited carbon nanotubes: an active site for functionalization. Journal of nanoscience and nanotechnology, 8(8), 4017-22. https://doi.org/10.1166/jnn.2008.an34
Titus, E, et al. "Hydrogen in chemical vapour deposited carbon nanotubes: an active site for functionalization." Journal of nanoscience and nanotechnology vol. 8,8 (2008): 4017-22. doi: https://doi.org/10.1166/jnn.2008.an34
Titus E, Cabral G, Madaleno JC, Coelho MC, Babu PR, Blau WJ, Misra DS, Gracio J. Hydrogen in chemical vapour deposited carbon nanotubes: an active site for functionalization. J Nanosci Nanotechnol. 2008 Aug;8(8):4017-22. doi: 10.1166/jnn.2008.an34. PMID: 19049170.
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Showing 1 to 12 of 443 entries