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Showing 1 to 12 of 13 entries
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Pharmacodynamics, Pharmacokinetics, and Antiviral Activity of BAY 81-8781, a Novel NF-κB Inhibiting Anti-influenza Drug.

Frontiers in microbiology

Droebner K, Haasbach E, Dudek SE, Scheuch G, Nocker K, Canisius S, Ehrhardt C, von Degenfeld G, Ludwig S, Planz O.
PMID: 29163418
Front Microbiol. 2017 Nov 02;8:2130. doi: 10.3389/fmicb.2017.02130. eCollection 2017.

Influenza is a respiratory disease that causes annual epidemics. Antiviral treatment options targeting the virus exist, but their efficiency is limited and influenza virus strains easily develop resistance. Thus, new treatment strategies are urgently needed. In the present study,...

Presence and distribution of mosquito larvae predators and factors influencing their abundance along the Mara River, Kenya and Tanzania.

SpringerPlus

Dida GO, Gelder FB, Anyona DN, Abuom PO, Onyuka JO, Matano AS, Adoka SO, Kanangire CK, Owuor PO, Ouma C, Ofulla AV.
PMID: 25830082
Springerplus. 2015 Mar 20;4:136. doi: 10.1186/s40064-015-0905-y. eCollection 2015.

Among all the malaria controlling measures, biological control of mosquito larvae may be the cheapest and easiest to implement. This study investigated baseline predation of immature mosquitoes by macroinvertebrate predators along the Mara River, determined the diversity of predators...

Contralateral parenchymal enhancement on MRI is associated with tumor proteasome pathway gene expression and overall survival of early ER+/HER2-breast cancer patients.

Breast (Edinburgh, Scotland)

Ragusi MAA, Bismeijer T, van der Velden BHM, Loo CE, Canisius S, Wesseling J, Wessels LFA, Elias SG, Gilhuijs KGA.
PMID: 34763270
Breast. 2021 Dec;60:230-237. doi: 10.1016/j.breast.2021.11.002. Epub 2021 Nov 02.

PURPOSE: To assess whether contralateral parenchymal enhancement (CPE) on MRI is associated with gene expression pathways in ER+/HER2-breast cancer, and if so, whether such pathways are related to survival.METHODS: Preoperative breast MRIs were analyzed of early ER+/HER2-breast cancer patients...

Distribution and abundance of schistosomiasis and fascioliasis host snails along the Mara River in Kenya and Tanzania.

Infection ecology & epidemiology

Dida GO, Gelder FB, Anyona DN, Matano AS, Abuom PO, Adoka SO, Ouma C, Kanangire CK, Owuor PO, Ofulla AV.
PMID: 25405008
Infect Ecol Epidemiol. 2014 Oct 24;4. doi: 10.3402/iee.v4.24281. eCollection 2014.

We purposively selected 39 sampling sites along the Mara River and its two perennial tributaries of Amala and Nyangores and sampled snails. In addition, water physicochemical parameters (temperature, turbidity, dissolved oxygen, conductivity, alkalinity, salinity and pH) were taken to...

The Mechanism of 1,4- and 1,6-Cuprate Additions: The First Determination of Activation Parameters.

Angewandte Chemie (International ed. in English)

Canisius J, Gerold A, Krause N.
PMID: 29710999
Angew Chem Int Ed Engl. 1999 Jun 01;38(11):1644-1646. doi: 10.1002/(SICI)1521-3773(19990601)38:11<1644::AID-ANIE1644>3.0.CO;2-A.

With a direct kinetic study, activation parameters for the 1,4-cuprate addition to enones (see the Arrhenius plot,▴) and the 1,6-addition to acceptor-substituted enynes (█) were determined for the first time. Both reactions might involve σ copper(III) species which are...

Sponge-supported cultures of primary head and neck tumors for an optimized preclinical model.

Oncotarget

Dohmen AJC, Sanders J, Canisius S, Jordanova ES, Aalbersberg EA, van den Brekel MWM, Neefjes J, Zuur CL.
PMID: 29861851
Oncotarget. 2018 May 18;9(38):25034-25047. doi: 10.18632/oncotarget.25244. eCollection 2018 May 18.

Treatment of advanced head and neck cancer is associated with low survival, high toxicity and a widely divergent individual response. The sponge-gel-supported histoculture model was previously developed to serve as a preclinical model for predicting individual treatment responses. We...

Mechanism of 1,6-addition reactions of organocuprates: detailed NMR spectroscopic study of a cuprate-enyne pi complex.

Chemistry (Weinheim an der Bergstrasse, Germany)

Canisius J, Mobley TA, Berger S, Krause N.
PMID: 11465458
Chemistry. 2001 Jun 18;7(12):2671-5. doi: 10.1002/1521-3765(20010618)7:12<2671::aid-chem26710>3.0.co;2-s.

A detailed NMR-spectroscopic study of the multiply 13C-labeled cuprate pi complexes 2, 2a and 2b was carried out. The 13C,13C coupling constants observed were interpreted in terms of a deformation of the cuprate-alkene complex from the expected idealized square...

The allyl complex di-&mgr;-chloro-bis.

Acta crystallographica. Section C, Crystal structure communications

Spek AL, Canisius J, Preut H, Krause N.
PMID: 10986482
Acta Crystallogr C. 2000 Sep;56:1065-6. doi: 10.1107/s0108270100008799.

The title compound, di-&mgr;-chloro-bis[(2,3,4-eta)-ethyl 6, 6-dimethyl-5-oxohept-2-enoato]palladium(II), [Pd(2)Cl(2)(C(11)H(17)O(3))(2)], is a binuclear chloro-bridged palladium allyl complex that was obtained serendipitously From the reaction of 6,6-dimethyl-2-hepten-4-ynoate with Na(2)PdCl(4) in water-containing alcohol. The allyl group is substituted with an ester and a tert-butylcarboxy...

Efficacy of decitabine in malignant meningioma cells: relation to promoter demethylation of distinct tumor suppressor and oncogenes and independence from TERT.

Journal of neurosurgery

Stögbauer L, Thomas C, Wagner A, Warneke N, Bunk EC, Grauer O, Canisius J, Paulus W, Stummer W, Senner V, Brokinkel B.
PMID: 33307532
J Neurosurg. 2020 Dec 11;1-10. doi: 10.3171/2020.7.JNS193097. Epub 2020 Dec 11.

OBJECTIVE: Chemotherapeutic options for meningiomas refractory to surgery or irradiation are largely unknown. Human telomerase reverse transcriptase (hTERT) promoter methylation with subsequent TERT expression and telomerase activity, key features in oncogenesis, are found in most high-grade meningiomas. Therefore, the...

Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment.

Breast cancer research : BCR

Morra A, Escala-Garcia M, Beesley J, Keeman R, Canisius S, Ahearn TU, Andrulis IL, Anton-Culver H, Arndt V, Auer PL, Augustinsson A, Beane Freeman LE, Becher H, Beckmann MW, Behrens S, Bojesen SE, Bolla MK, Brenner H, Brüning T, Buys SS, Caan B, Campa D, Canzian F, Castelao JE, Chang-Claude J, Chanock SJ, Cheng TD, Clarke CL, Colonna SV, Couch FJ, Cox A, Cross SS, Czene K, Daly MB, Dennis J, Dörk T, Dossus L, Dunning AM, Dwek M, Eccles DM, Ekici AB, Eliassen AH, Eriksson M, Evans DG, Fasching PA, Flyger H, Fritschi L, Gago-Dominguez M, García-Sáenz JA, Giles GG, Grip M, Guénel P, Gündert M, Hahnen E, Haiman CA, Håkansson N, Hall P, Hamann U, Hart SN, Hartikainen JM, Hartmann A, He W, Hooning MJ, Hoppe R, Hopper JL, Howell A, Hunter DJ, Jager A, Jakubowska A, Janni W, John EM, Jung AY, Kaaks R, Keupers M, Kitahara CM, Koutros S, Kraft P, Kristensen VN, Kurian AW, Lacey JV, Lambrechts D, Le Marchand L, Lindblom A, Linet M, Luben RN, Lubiński J, Lush M, Mannermaa A, Manoochehri M, Margolin S, Martens JWM, Martinez ME, Mavroudis D, Michailidou K, Milne RL, Mulligan AM, Muranen TA, Nevanlinna H, Newman WG, Nielsen SF, Nordestgaard BG, Olshan AF, Olsson H, Orr N, Park-Simon TW, Patel AV, Peissel B, Peterlongo P, Plaseska-Karanfilska D, Prajzendanc K, Prentice R, Presneau N, Rack B, Rennert G, Rennert HS, Rhenius V, Romero A, Roylance R, Ruebner M, Saloustros E, Sawyer EJ, Schmutzler RK, Schneeweiss A, Scott C, Shah M, Smichkoska S, Southey MC, Stone J, Surowy H, Swerdlow AJ, Tamimi RM, Tapper WJ, Teras LR, Terry MB, Tollenaar RAEM, Tomlinson I, Troester MA, Truong T, Vachon CM, Wang Q, Hurson AN, Winqvist R, Wolk A, Ziogas A, Brauch H, García-Closas M, Pharoah PDP, Easton DF, Chenevix-Trench G, Schmidt MK.
PMID: 34407845
Breast Cancer Res. 2021 Aug 18;23(1):86. doi: 10.1186/s13058-021-01450-7.

BACKGROUND: Given the high heterogeneity among breast tumors, associations between common germline genetic variants and survival that may exist within specific subgroups could go undetected in an unstratified set of breast cancer patients.METHODS: We performed genome-wide association analyses within...

Contralateral parenchymal enhancement on MRI is associated with tumor proteasome pathway gene expression and overall survival of early ER+/HER2-breast cancer patients.

Breast (Edinburgh, Scotland)

Ragusi MAA, Bismeijer T, van der Velden BHM, Loo CE, Canisius S, Wesseling J, Wessels LFA, Elias SG, Gilhuijs KGA.
PMID: 34763270
Breast. 2021 Nov 02;60:230-237. doi: 10.1016/j.breast.2021.11.002. Epub 2021 Nov 02.

PURPOSE: To assess whether contralateral parenchymal enhancement (CPE) on MRI is associated with gene expression pathways in ER+/HER2-breast cancer, and if so, whether such pathways are related to survival.METHODS: Preoperative breast MRIs were analyzed of early ER+/HER2-breast cancer patients...

Differential survival and therapy benefit of breast cancer patients are characterized by distinct epithelial and immune cell microenvironments.

Clinical cancer research : an official journal of the American Association for Cancer Research

Kester L, Seinstra D, van Rossum AGJ, Vennin C, Hoogstraat M, van der Velden D, Opdam M, van Werkhoven E, Hahn K, Nederlof I, Lips EH, Mandjes IAM, van Leeuwen-Stok AE, Canisius S, van Tinteren H, Imholz ALT, Portielje JEA, Bos MEMM, Bakker SD, Rutgers EJ, Horlings HM, Wesseling J, Voest EE, Wessels LFA, Kok M, Oosterkamp HM, van Oudenaarden A, Linn SC, van Rheenen J.
PMID: 34965952
Clin Cancer Res. 2021 Dec 29; doi: 10.1158/1078-0432.CCR-21-1442. Epub 2021 Dec 29.

PURPOSE: Extensive work in pre-clinical models has shown that microenvironmental cells influence many aspects of cancer cell behavior, including metastatic potential and their sensitivity to therapeutics. In the human setting, this behavior is mainly correlated with the presence of...

Showing 1 to 12 of 13 entries