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Showing 1 to 12 of 384 entries
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A comparison of targetting of neuroblastoma with mIBG and anti L1-CAM antibody mAb chCE7: therapeutic efficacy in a neuroblastoma xenograft model and imaging of neuroblastoma patients.

European journal of nuclear medicine

Hoefnagel CA, Rutgers M, Buitenhuis CK, Smets LA, Kraker Jd, Meli M, Carrel F, Amstutz H, Schubiger PA, Novak-Hofer I.
PMID: 24623005
Eur J Nucl Med. 2001 Mar;28(3):359-68. doi: 10.1007/s002590000454.

Iodine-131 labelled anti L1-CAM antibody mAb chCE7 was compared with the effective neuroblastoma-seeking agent (131)I-labelled metaiodobenzylguanidine (MIBG) with regard to (a) its therapeutic efficacy in treating nude mice with neuroblastoma xenografts and (b) its tumour targetting ability in neuroblastoma...

The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems.

The Journal of organic chemistry

Smith AC, Cabral S, Kung DW, Rose CR, Southers JA, García-Irizarry CN, Damon DB, Bagley SW, Griffith DA.
PMID: 27056793
J Org Chem. 2016 May 06;81(9):3509-19. doi: 10.1021/acs.joc.5b02890. Epub 2016 Apr 25.

The synthesis of a series of pharmaceutically important N-protected methyl-substituted spirocyclic piperidine-azetidine (2,7-diazaspiro[3.5]nonane) and spirocyclic piperidine-pyrrolidine (2,8-diazaspiro[4.5]decane) ring systems was developed. These motifs contain two differentiated sites (protected secondary amines) to allow for further functionalization via reductive amination, amidation,...

Stability-Indicating HPLC Assay for Determination of Idebenone in Pharmaceutical Forms.

Journal of analytical methods in chemistry

Kombath S, Balde IB, Carret S, Kabiche S, Cisternino S, Fontan JE, Schlatter J.
PMID: 26605105
J Anal Methods Chem. 2015;2015:835986. doi: 10.1155/2015/835986. Epub 2015 Oct 29.

A stability-indicating method was validated for the determination in pharmaceutical forms of idebenone a coenzyme Q10-like compound. The assay was achieved by liquid chromatography analysis using a reversed-phase C18 column and a detector set at 480 nm. The optimized...

Remote Cerebellar Hemorrhage after Revision Lumbar Spine Surgery.

Global spine journal

Haller JM, Calvert G, Spiker WR, Brodke DS, Lawrence BD.
PMID: 26682108
Global Spine J. 2015 Dec;5(6):535-7. doi: 10.1055/s-0035-1567839.

Study Design Case report. Objective To report a case of remote cerebellar hemorrhage (RCH) without intraoperative dural tear after revision lumbar spine surgery. RCH is a rare postoperative complication following spine surgery. RCH has previously been reported only in...

Theranostic mercury: (197(m))Hg with high specific activity for imaging and therapy.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

Walther M, Preusche S, Bartel S, Wunderlich G, Freudenberg R, Steinbach J, Pietzsch HJ.
PMID: 25588997
Appl Radiat Isot. 2015 Mar;97:177-181. doi: 10.1016/j.apradiso.2015.01.001. Epub 2015 Jan 05.

The no carrier added (NCA) radionuclide (197(m))Hg is accessible through proton induced nuclear reactions on gold. The decay properties of both simultaneous produced nuclear isomers (197m)Hg and (197)Hg like convenient half life, low energy gamma radiations for imaging, Auger...

Management of vascular graft and endoprosthetic infection of the thoracic and thoraco-abdominal aorta.

Multimedia manual of cardiothoracic surgery : MMCTS

Carrel T, Schmidli J.
PMID: 24413747
Multimed Man Cardiothorac Surg. 2011 Jan 01;2011(1101):mmcts.2010.004705. doi: 10.1510/mmcts.2010.004705.

Infection of a vascular prosthesis or endovascular stent-graft is probably the most serious complication that may occur after implantation and dramatically affects the patient's outcome. Surgical treatment is almost always required but even after surgery, morbidity can be significant....

Blood Pressure Management After Intracerebral Hemorrhage.

Current treatment options in neurology

Sato S, Carcel C, Anderson CS.
PMID: 26478247
Curr Treat Options Neurol. 2015 Dec;17(12):49. doi: 10.1007/s11940-015-0382-1.

OPINION STATEMENT: Elevated blood pressure (BP), which presents in approximately 80 % of patients with acute intracerebral hemorrhage (ICH), is associated with increased risk of poor outcome. The Second Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2)...

Trends, Costs, and Complications of Anterior Cervical Discectomy and Fusion With and Without Bone Morphogenetic Protein in the United States Medicare Population.

Global spine journal

Lord EL, Cohen JR, Buser Z, Meisel HJ, Brodke DS, Yoon ST, Youssef JA, Wang JC, Park JB.
PMID: 28989837
Global Spine J. 2017 Oct;7(7):603-608. doi: 10.1177/2192568217699207. Epub 2017 Aug 17.

STUDY DESIGN: Retrospective database review.OBJECTIVES: After the Food and Drug Administration approved bone morphogenetic protein-2 (BMP) in 2002, BMP was used off-label in the cervical spine to increase bone growth and bony fusion. Since then, concerns have been raised...

Trends Analysis of rhBMP Utilization in Single-Level Posterior Lumbar Interbody Fusion in the United States.

Global spine journal

Lao L, Cohen JR, Buser Z, Brodke DS, Youssef JA, Park JB, Yoon ST, Wang JC, Meisel HJ.
PMID: 28989840
Global Spine J. 2017 Oct;7(7):624-628. doi: 10.1177/2192568217699387. Epub 2017 Jun 30.

STUDY DESIGN: Retrospective study.OBJECTIVES: Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been widely used in spinal fusion surgery, but there is little information on rhBMP-2 utilization in single-level posterior lumbar interbody fusion (PLIF). The purpose of our study was...

Building a family network from genetic testing.

Molecular genetics & genomic medicine

Leppig KA, Thiese HA, Carrel D, Crosslin DR, Dorschner MO, Gordon AS, Hartzler A, Ralston J, Scrol A, Larson EB, Jarvik GP.
PMID: 28361098
Mol Genet Genomic Med. 2016 Dec 29;5(2):122-129. doi: 10.1002/mgg3.259. eCollection 2017 Mar.

BACKGROUND: Genetic testing has multigenerational and familial repercussions. However, the "trickle-down effect" of providing genetic counseling and testing to family members at risk after an initial identification of a pathogenic variant in a medically actionable gene has been poorly...

Historical change in fish species distribution: shifting reference conditions and global warming effects.

Aquatic sciences

Pont D, Logez M, Carrel G, Rogers C, Haidvogl G.
PMID: 26257502
Aquat Sci. 2015;77(3):441-453. doi: 10.1007/s00027-014-0386-z. Epub 2015 Jan 03.

Species distributions models (SDM) that rely on estimated relationships between present environmental conditions and species presence-absence are widely used to forecast changes of species distributions caused by global warming but far less to reconstruct historical assemblages. By compiling historical...

Periaortic pedicle screw removal with endovascular control of the aorta and intraoperative aortography: a case report and review of the literature.

Evidence-based spine-care journal

Potter MQ, Lawrence BD, Kinikini DV, Brodke DS.
PMID: 24436714
Evid Based Spine Care J. 2013 Oct;4(2):149-53. doi: 10.1055/s-0033-1357358.

Study Design  Case report and review of the literature. Objective The objective of the article is to report the case of a 20-year-old patient with a threatened aortic injury from pedicle screw instrumentation successfully managed without aortic grafting. Methods...

Showing 1 to 12 of 384 entries