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A microRNA Cluster Controls Fat Cell Differentiation and Adipose Tissue Expansion By Regulating SNCG.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Rodríguez-Barrueco R, Latorre J, Devis-Jáuregui L, Lluch A, Bonifaci N, Llobet FJ, Olivan M, Coll-Iglesias L, Gassner K, Davis ML, Moreno-Navarrete JM, Castells-Nobau A, Plata-Peña L, Dalmau-Pastor M, Höring M, Liebisch G, Olkkonen VM, Arnoriaga-Rodríguez M, Ricart W, Fernández-Real JM, Silva JM, Ortega FJ, Llobet-Navas D.
PMID: 34898027
Adv Sci (Weinh). 2021 Dec 13;e2104759. doi: 10.1002/advs.202104759. Epub 2021 Dec 13.

The H19X-encoded miR-424(322)/503 cluster regulates multiple cellular functions. Here, it is reported for the first time that it is also a critical linchpin of fat mass expansion. Deletion of this miRNA cluster in mice results in obesity, while increasing...

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Rodríguez-Barrueco R, Latorre J, Devis-Jáuregui L, et al. A microRNA Cluster Controls Fat Cell Differentiation and Adipose Tissue Expansion By Regulating SNCG. Adv Sci (Weinh). 2021;e2104759doi: 10.1002/advs.202104759.
Rodríguez-Barrueco, R., Latorre, J., Devis-Jáuregui, L., Lluch, A., Bonifaci, N., Llobet, F. J., Olivan, M., Coll-Iglesias, L., Gassner, K., Davis, M. L., Moreno-Navarrete, J. M., Castells-Nobau, A., Plata-Peña, L., Dalmau-Pastor, M., Höring, M., Liebisch, G., Olkkonen, V. M., Arnoriaga-Rodríguez, M., Ricart, W., Fernández-Real, J. M., Silva, J. M., Ortega, F. J., & Llobet-Navas, D. (2021). A microRNA Cluster Controls Fat Cell Differentiation and Adipose Tissue Expansion By Regulating SNCG. Advanced science (Weinheim, Baden-Wurttemberg, Germany), e2104759. https://doi.org/10.1002/advs.202104759
Rodríguez-Barrueco, Ruth, et al. "A microRNA Cluster Controls Fat Cell Differentiation and Adipose Tissue Expansion By Regulating SNCG." Advanced science (Weinheim, Baden-Wurttemberg, Germany) vol. (2021): e2104759. doi: https://doi.org/10.1002/advs.202104759
Rodríguez-Barrueco R, Latorre J, Devis-Jáuregui L, Lluch A, Bonifaci N, Llobet FJ, Olivan M, Coll-Iglesias L, Gassner K, Davis ML, Moreno-Navarrete JM, Castells-Nobau A, Plata-Peña L, Dalmau-Pastor M, Höring M, Liebisch G, Olkkonen VM, Arnoriaga-Rodríguez M, Ricart W, Fernández-Real JM, Silva JM, Ortega FJ, Llobet-Navas D. A microRNA Cluster Controls Fat Cell Differentiation and Adipose Tissue Expansion By Regulating SNCG. Adv Sci (Weinh). 2021 Dec 13;e2104759. doi: 10.1002/advs.202104759. Epub 2021 Dec 13. PMID: 34898027.
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Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways.

Gut

Arnoriaga-Rodríguez M, Mayneris-Perxachs J, Contreras-Rodríguez O, Burokas A, Ortega-Sanchez JA, Blasco G, Coll C, Biarnés C, Castells-Nobau A, Puig J, Garre-Olmo J, Ramos R, Pedraza S, Brugada R, Vilanova JC, Serena J, Barretina J, Gich J, Pérez-Brocal V, Moya A, Fernández-Real X, Ramio-Torrentà L, Pamplona R, Sol J, Jové M, Ricart W, Portero-Otin M, Maldonado R, Fernández-Real JM.
PMID: 33514598
Gut. 2021 Dec;70(12):2283-2296. doi: 10.1136/gutjnl-2020-323371. Epub 2021 Jan 29.

BACKGROUND: Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits.METHODS: We studied gut microbiome composition and functionality, and plasma and faecal...

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Arnoriaga-Rodríguez M, Mayneris-Perxachs J, Contreras-Rodríguez O, et al. Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways. Gut. 2021;70(12):2283-2296doi: 10.1136/gutjnl-2020-323371.
Arnoriaga-Rodríguez, M., Mayneris-Perxachs, J., Contreras-Rodríguez, O., Burokas, A., Ortega-Sanchez, J. A., Blasco, G., Coll, C., Biarnés, C., Castells-Nobau, A., Puig, J., Garre-Olmo, J., Ramos, R., Pedraza, S., Brugada, R., Vilanova, J. C., Serena, J., Barretina, J., Gich, J., Pérez-Brocal, V., Moya, A., Fernández-Real, X., Ramio-Torrentà, L., Pamplona, R., Sol, J., Jové, M., Ricart, W., Portero-Otin, M., Maldonado, R., & Fernández-Real, J. M. (2021). Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways. Gut, 70(12), 2283-2296. https://doi.org/10.1136/gutjnl-2020-323371
Arnoriaga-Rodríguez, María, et al. "Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways." Gut vol. 70,12 (2021): 2283-2296. doi: https://doi.org/10.1136/gutjnl-2020-323371
Arnoriaga-Rodríguez M, Mayneris-Perxachs J, Contreras-Rodríguez O, Burokas A, Ortega-Sanchez JA, Blasco G, Coll C, Biarnés C, Castells-Nobau A, Puig J, Garre-Olmo J, Ramos R, Pedraza S, Brugada R, Vilanova JC, Serena J, Barretina J, Gich J, Pérez-Brocal V, Moya A, Fernández-Real X, Ramio-Torrentà L, Pamplona R, Sol J, Jové M, Ricart W, Portero-Otin M, Maldonado R, Fernández-Real JM. Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways. Gut. 2021 Dec;70(12):2283-2296. doi: 10.1136/gutjnl-2020-323371. Epub 2021 Jan 29. PMID: 33514598; PMCID: PMC8588299.
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Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways.

Gut

Arnoriaga-Rodríguez M, Mayneris-Perxachs J, Contreras-Rodríguez O, Burokas A, Ortega-Sanchez JA, Blasco G, Coll C, Biarnés C, Castells-Nobau A, Puig J, Garre-Olmo J, Ramos R, Pedraza S, Brugada R, Vilanova JC, Serena J, Barretina J, Gich J, Pérez-Brocal V, Moya A, Fernández-Real X, Ramio-Torrentà L, Pamplona R, Sol J, Jové M, Ricart W, Portero-Otin M, Maldonado R, Fernández-Real JM.
PMID: 33514598
Gut. 2021 Dec;70(12):2283-2296. doi: 10.1136/gutjnl-2020-323371. Epub 2021 Jan 29.

BACKGROUND: Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits.METHODS: We studied gut microbiome composition and functionality, and plasma and faecal...

Cite
Arnoriaga-Rodríguez M, Mayneris-Perxachs J, Contreras-Rodríguez O, et al. Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways. Gut. 2021;70(12):2283-2296doi: 10.1136/gutjnl-2020-323371.
Arnoriaga-Rodríguez, M., Mayneris-Perxachs, J., Contreras-Rodríguez, O., Burokas, A., Ortega-Sanchez, J. A., Blasco, G., Coll, C., Biarnés, C., Castells-Nobau, A., Puig, J., Garre-Olmo, J., Ramos, R., Pedraza, S., Brugada, R., Vilanova, J. C., Serena, J., Barretina, J., Gich, J., Pérez-Brocal, V., Moya, A., Fernández-Real, X., Ramio-Torrentà, L., Pamplona, R., Sol, J., Jové, M., Ricart, W., Portero-Otin, M., Maldonado, R., & Fernández-Real, J. M. (2021). Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways. Gut, 70(12), 2283-2296. https://doi.org/10.1136/gutjnl-2020-323371
Arnoriaga-Rodríguez, María, et al. "Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways." Gut vol. 70,12 (2021): 2283-2296. doi: https://doi.org/10.1136/gutjnl-2020-323371
Arnoriaga-Rodríguez M, Mayneris-Perxachs J, Contreras-Rodríguez O, Burokas A, Ortega-Sanchez JA, Blasco G, Coll C, Biarnés C, Castells-Nobau A, Puig J, Garre-Olmo J, Ramos R, Pedraza S, Brugada R, Vilanova JC, Serena J, Barretina J, Gich J, Pérez-Brocal V, Moya A, Fernández-Real X, Ramio-Torrentà L, Pamplona R, Sol J, Jové M, Ricart W, Portero-Otin M, Maldonado R, Fernández-Real JM. Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways. Gut. 2021 Dec;70(12):2283-2296. doi: 10.1136/gutjnl-2020-323371. Epub 2021 Jan 29. PMID: 33514598; PMCID: PMC8588299.
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Converging evidence does not support GIT1 as an ADHD risk gene.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

Klein M, van der Voet M, Harich B, van Hulzen KJ, Onnink AM, Hoogman M, Guadalupe T, Zwiers M, Groothuismink JM, Verberkt A, Nijhof B, Castells-Nobau A, Faraone SV, Buitelaar JK, Schenck A, Arias-Vasquez A, Franke B.
PMID: 26061966
Am J Med Genet B Neuropsychiatr Genet. 2015 Sep;168(6):492-507. doi: 10.1002/ajmg.b.32327. Epub 2015 Jun 10.

Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neuropsychiatric disorder with a complex genetic background. The G protein-coupled receptor kinase interacting ArfGAP 1 (GIT1) gene was previously associated with ADHD. We aimed at replicating the association of GIT1 with ADHD and...

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Klein M, van der Voet M, Harich B, et al. Converging evidence does not support GIT1 as an ADHD risk gene. Am J Med Genet B Neuropsychiatr Genet. 2015;168(6):492-507doi: 10.1002/ajmg.b.32327.
Klein, M., van der Voet, M., Harich, B., van Hulzen, K. J., Onnink, A. M., Hoogman, M., Guadalupe, T., Zwiers, M., Groothuismink, J. M., Verberkt, A., Nijhof, B., Castells-Nobau, A., Faraone, S. V., Buitelaar, J. K., Schenck, A., Arias-Vasquez, A., Franke, B. (2015). Converging evidence does not support GIT1 as an ADHD risk gene. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 168(6), 492-507. https://doi.org/10.1002/ajmg.b.32327
Klein, Marieke, et al. "Converging evidence does not support GIT1 as an ADHD risk gene." American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics vol. 168,6 (2015): 492-507. doi: https://doi.org/10.1002/ajmg.b.32327
Klein M, van der Voet M, Harich B, van Hulzen KJ, Onnink AM, Hoogman M, Guadalupe T, Zwiers M, Groothuismink JM, Verberkt A, Nijhof B, Castells-Nobau A, Faraone SV, Buitelaar JK, Schenck A, Arias-Vasquez A, Franke B. Converging evidence does not support GIT1 as an ADHD risk gene. Am J Med Genet B Neuropsychiatr Genet. 2015 Sep;168(6):492-507. doi: 10.1002/ajmg.b.32327. Epub 2015 Jun 10. PMID: 26061966; PMCID: PMC7164571.
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Showing 1 to 4 of 4 entries