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Showing 1 to 12 of 46 entries
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Pancreatic carcinoma, pancreatitis, and healthy controls: metabolite models in a three-class diagnostic dilemma.

Metabolomics : Official journal of the Metabolomic Society

Leichtle AB, Ceglarek U, Weinert P, Nakas CT, Nuoffer JM, Kase J, Conrad T, Witzigmann H, Thiery J, Fiedler GM.
PMID: 23678345
Metabolomics. 2013 Jun;9(3):677-687. doi: 10.1007/s11306-012-0476-7. Epub 2012 Nov 06.

Metabolomics as one of the most rapidly growing technologies in the "-omics" field denotes the comprehensive analysis of low molecular-weight compounds and their pathways. Cancer-specific alterations of the metabolome can be detected by high-throughput mass-spectrometric metabolite profiling and serve...

The plasma lipidome in acute myeloid leukemia at diagnosis in relation to clinical disease features.

BBA clinical

Pabst T, Kortz L, Fiedler GM, Ceglarek U, Idle JR, Beyoğlu D.
PMID: 28331812
BBA Clin. 2017 Mar 08;7:105-114. doi: 10.1016/j.bbacli.2017.03.002. eCollection 2017 Jun.

BACKGROUND: Early studies established that certain lipids were lower in acute myeloid leukemia (AML) cells than normal leukocytes. Because lipids are now known to play an important role in cell signaling and regulation of homeostasis, and are often perturbed...

The effect of a high-polyphenol Mediterranean diet (GREEN-MED) combined with physical activity on age-related brain atrophy: the DIRECT PLUS randomized controlled trial.

The American journal of clinical nutrition

Kaplan A, Zelicha H, Meir AY, Rinott E, Tsaban G, Levakov G, Prager O, Salti M, Yovell Y, Ofer J, Huhn S, Beyer F, Witte V, Villringer A, Meiran N, Emesh TB, Kovacs P, von Bergen M, Ceglarek U, Blüher M, Stumvoll M, Hu FB, Stampfer MJ, Friedman A, Shelef I, Avidan G, Shai I.
PMID: 35021194
Am J Clin Nutr. 2022 Jan 11; doi: 10.1093/ajcn/nqac001. Epub 2022 Jan 11.

BACKGROUND: The effect of diet on age-related brain atrophy is largely unproven.OBJECTIVE: To explore the effect of a Mediterranean diet higher in polyphenols and lower in red/processed meat (Green-MED diet) on age-related brain atrophy.METHODS: This 18-month clinical trial longitudinally...

Diet-induced fasting ghrelin elevation reflects the recovery of insulin sensitivity and visceral adiposity regression.

The Journal of clinical endocrinology and metabolism

Tsaban G, Yaskolka Meir A, Zelicha H, Rinott E, Kaplan A, Shalev A, Katz A, Brikner D, Blüher M, Ceglarek U, Stumvoll M, Stampfer MJ, Shai I.
PMID: 34643713
J Clin Endocrinol Metab. 2021 Oct 13; doi: 10.1210/clinem/dgab681. Epub 2021 Oct 13.

AIMS: Lower fasting-ghrelin-levels (FGL) are associated with obesity and metabolic syndrome. We aimed to explore the dynamics of FGL during weight-loss and its metabolic and adiposity-related manifestations beyond weight-loss.METHODS: A secondary analysis of a clinical trial where we randomized...

Time-Frequency Characterization of Resting Brain in Bipolar Disorder during Euthymia-A Preliminary Study.

Brain sciences

Chrobak AA, Bohaterewicz B, Sobczak AM, Marszał-Wiśniewska M, Tereszko A, Krupa A, Ceglarek A, Fafrowicz M, Bryll A, Marek T, Dudek D, Siwek M.
PMID: 34067189
Brain Sci. 2021 May 07;11(5). doi: 10.3390/brainsci11050599.

The goal of this paper is to investigate the baseline brain activity in euthymic bipolar disorder (BD) patients by comparing it to healthy controls (HC) with the use of a variety of resting state functional magnetic resonance imaging (rs-fMRI)...

Non-linear Functional Brain Co-activations in Short-Term Memory Distortion Tasks.

Frontiers in neuroscience

Ceglarek A, Ochab JK, Cifre I, Fafrowicz M, Sikora-Wachowicz B, Lewandowska K, Bohaterewicz B, Marek T, Chialvo DR.
PMID: 34924944
Front Neurosci. 2021 Dec 03;15:778242. doi: 10.3389/fnins.2021.778242. eCollection 2021.

Recent works shed light on the neural correlates of true and false recognition and the influence of time of day on cognitive performance. The current study aimed to investigate the modulation of the false memory formation by the time...

Plant Sterol-Poor Diet Is Associated with Pro-Inflammatory Lipid Mediators in the Murine Brain.

International journal of molecular sciences

Reinicke M, Leyh J, Zimmermann S, Chey S, Brkovic IB, Wassermann C, Landmann J, Lütjohann D, Isermann B, Bechmann I, Ceglarek U.
PMID: 34948003
Int J Mol Sci. 2021 Dec 08;22(24). doi: 10.3390/ijms222413207.

Plant sterols (PSs) cannot be synthesized in mammals and are exclusively diet-derived. PSs cross the blood-brain barrier and may have anti-neuroinflammatory effects. Obesity is linked to lower intestinal uptake and blood levels of PSs, but its effects in terms...

Associations Between Anxiety, Body Mass Index, and Sex Hormones in Women.

Frontiers in psychiatry

Stanikova D, Luck T, Pabst A, Bae YJ, Hinz A, Glaesmer H, Stanik J, Sacher J, Engel C, Enzenbach C, Wirkner K, Ceglarek U, Thiery J, Kratzsch J, Riedel-Heller SG.
PMID: 31333520
Front Psychiatry. 2019 Jul 04;10:479. doi: 10.3389/fpsyt.2019.00479. eCollection 2019.

No abstract available.

Correction: Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3.

PLoS genetics

Peters A, Krumbholz P, Jäger E, Heintz-Buschart A, Çakir MV, Rothemund S, Gaudl A, Ceglarek U, Schöneberg T, Stäubert C.
PMID: 31323042
PLoS Genet. 2019 Jul 19;15(7):e1008283. doi: 10.1371/journal.pgen.1008283. eCollection 2019 Jul.

[This corrects the article DOI: 10.1371/journal.pgen.1008145.].

Screening for Type 1 Diabetes Risk in Newborns: The Freder1k Pilot Study in Saxony.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

Hommel A, Haupt F, Delivani P, Winkler C, Stopsack M, Wimberger P, Nitzsche K, Heinke S, Naeke A, Ceglarek U, Thiery J, Bergert R, Stadthaus D, Groeger K, Heubner G, Schramm U, Dziambor U, Zirkel A, Kiess W, Mueller I, Lange K, Berner R, Bonifacio E, Ziegler AG.
PMID: 29121687
Horm Metab Res. 2018 Jan;50(1):44-49. doi: 10.1055/s-0043-120921. Epub 2017 Nov 09.

An increased risk for type 1 diabetes can be identified using genetic and immune markers. The Freder1k study introduces genetic testing for type 1 diabetes risk within the context of the newborn screening in order to identify newborns with...

Sex-Specific Causal Relations between Steroid Hormones and Obesity-A Mendelian Randomization Study.

Metabolites

Pott J, Horn K, Zeidler R, Kirsten H, Ahnert P, Kratzsch J, Loeffler M, Isermann B, Ceglarek U, Scholz M.
PMID: 34822396
Metabolites. 2021 Oct 28;11(11). doi: 10.3390/metabo11110738.

Steroid hormones act as important regulators of physiological processes including gene expression. They provide possible mechanistic explanations of observed sex-dimorphisms in obesity and coronary artery disease (CAD). Here, we aim to unravel causal relationships between steroid hormones, obesity, and...

Circulating sterols as predictors of early allograft dysfunction and clinical outcome in patients undergoing liver transplantation.

Metabolomics : Official journal of the Metabolomic Society

Ceglarek U, Kresse K, Becker S, Fiedler GM, Thiery J, Quante M, Wieland R, Bartels M, Aust G.
PMID: 27840599
Metabolomics. 2016;12(12):182. doi: 10.1007/s11306-016-1129-z. Epub 2016 Oct 24.

INTRODUCTION: Sensitive and specific assessment of the hepatic graft metabolism after liver transplantation (LTX) is essential for early detection of postoperative dysfunction implying the need for consecutive therapeutic interventions.OBJECTIVES: Here, we assessed circulating liver metabolites of the cholesterol pathway,...

Showing 1 to 12 of 46 entries