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Alkylation and Carbamylation Effects of Lomustine and Its Major Metabolites and MGMT Expression in Canine Cells.

Veterinary sciences

Chakkath T, Lavergne S, Fan TM, Bunick D, Dirikolu L.
PMID: 29061931
Vet Sci. 2015 Apr 24;2(2):52-68. doi: 10.3390/vetsci2020052.

DNA Alkylation is thought to be the reason for the efficacy of lomustine while carbamylation has been implicated as the cause for the side effects seen with lomustine treatment such as hepatotoxicity. In the alkylation study we show that...

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