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Evaluation of teratogenicity and genotoxicity induced by kramecyne (KACY).

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Cristóbal-Luna JM, Paniagua-Castro N, Escalona-Cardoso GN, Pérez-Gutiérrez MS, Álvarez-González I, Madrigal-Bujaidar E, Chamorro-Cevallos G.
PMID: 30202224
Saudi Pharm J. 2018 Sep;26(6):829-838. doi: 10.1016/j.jsps.2018.03.016. Epub 2018 Mar 29.

Kramecyne (KACY), a polymer isolated from

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Cristóbal-Luna JM, Paniagua-Castro N, Escalona-Cardoso GN, et al. Evaluation of teratogenicity and genotoxicity induced by kramecyne (KACY). Saudi Pharm J. 2018;26(6):829-838doi: 10.1016/j.jsps.2018.03.016.
Cristóbal-Luna, J. M., Paniagua-Castro, N., Escalona-Cardoso, G. N., Pérez-Gutiérrez, M. S., Álvarez-González, I., Madrigal-Bujaidar, E., & Chamorro-Cevallos, G. (2018). Evaluation of teratogenicity and genotoxicity induced by kramecyne (KACY). Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 26(6), 829-838. https://doi.org/10.1016/j.jsps.2018.03.016
Cristóbal-Luna, J M, et al. "Evaluation of teratogenicity and genotoxicity induced by kramecyne (KACY)." Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society vol. 26,6 (2018): 829-838. doi: https://doi.org/10.1016/j.jsps.2018.03.016
Cristóbal-Luna JM, Paniagua-Castro N, Escalona-Cardoso GN, Pérez-Gutiérrez MS, Álvarez-González I, Madrigal-Bujaidar E, Chamorro-Cevallos G. Evaluation of teratogenicity and genotoxicity induced by kramecyne (KACY). Saudi Pharm J. 2018 Sep;26(6):829-838. doi: 10.1016/j.jsps.2018.03.016. Epub 2018 Mar 29. PMID: 30202224; PMCID: PMC6128725.
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Morphological and biochemical effects of weekend alcohol consumption in rats: Role of concentration and gender.

World journal of hepatology

Morales-González JA, Sernas-Morales ML, Morales-González Á, González-López LL, Madrigal-Santillán EO, Vargas-Mendoza N, Fregoso-Aguilar TA, Anguiano-Robledo L, Madrigal-Bujaidar E, Álvarez-González I, Chamorro-Cevallos G.
PMID: 29527265
World J Hepatol. 2018 Feb 27;10(2):297-307. doi: 10.4254/wjh.v10.i2.297.

AIM: To examine the association between weekend alcohol consumption and the biochemical and histological alterations at two different concentrations of alcohol in both genders in rats.METHODS: Wistar rats weighing 170-200 g were divided into groups as follows: (1) Control...

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Morales-González JA, Sernas-Morales ML, Morales-González Á, et al. Morphological and biochemical effects of weekend alcohol consumption in rats: Role of concentration and gender. World J Hepatol. 2018;10(2):297-307doi: 10.4254/wjh.v10.i2.297.
Morales-González, J. A., Sernas-Morales, M. L., Morales-González, �. �., González-López, L. L., Madrigal-Santillán, E. O., Vargas-Mendoza, N., Fregoso-Aguilar, T. A., Anguiano-Robledo, L., Madrigal-Bujaidar, E., Álvarez-González, I., & Chamorro-Cevallos, G. (2018). Morphological and biochemical effects of weekend alcohol consumption in rats: Role of concentration and gender. World journal of hepatology, 10(2), 297-307. https://doi.org/10.4254/wjh.v10.i2.297
Morales-González, José A, et al. "Morphological and biochemical effects of weekend alcohol consumption in rats: Role of concentration and gender." World journal of hepatology vol. 10,2 (2018): 297-307. doi: https://doi.org/10.4254/wjh.v10.i2.297
Morales-González JA, Sernas-Morales ML, Morales-González Á, González-López LL, Madrigal-Santillán EO, Vargas-Mendoza N, Fregoso-Aguilar TA, Anguiano-Robledo L, Madrigal-Bujaidar E, Álvarez-González I, Chamorro-Cevallos G. Morphological and biochemical effects of weekend alcohol consumption in rats: Role of concentration and gender. World J Hepatol. 2018 Feb 27;10(2):297-307. doi: 10.4254/wjh.v10.i2.297. PMID: 29527265; PMCID: PMC5838448.
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Inhibitory Effect of Spirulina maxima on the Azoxymethane-induced Aberrant Colon Crypts and Oxidative Damage in Mice.

Pharmacognosy magazine

Álvarez-González I, Islas-Islas V, Chamorro-Cevallos G, Barrios JP, Paniagua N, Vásquez-Garzón VR, Villa-Treviño S, Osiris-Madrigal-Santillán, Morales-González JA, Madrigal-Bujaidar E.
PMID: 27013804
Pharmacogn Mag. 2015 Oct;11:S619-24. doi: 10.4103/0973-1296.172973.

BACKGROUND: Spirulina maxima (Sm) is a cyanobacterium well known because of its high nutritive value, as well as its anti-inflammatory, anti-hyperlipidemic, antioxidant, and anti-genotoxic activities.OBJECTIVE: To determine the capacity of Sm to inhibit the induction of aberrant colon crypts...

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Álvarez-González I, Islas-Islas V, Chamorro-Cevallos G, et al. Inhibitory Effect of Spirulina maxima on the Azoxymethane-induced Aberrant Colon Crypts and Oxidative Damage in Mice. Pharmacogn Mag. 2015;11:S619-24doi: 10.4103/0973-1296.172973.
Álvarez-González, I., Islas-Islas, V., Chamorro-Cevallos, G., Barrios, J. P., Paniagua, N., Vásquez-Garzón, V. R., Villa-Treviño, S., Osiris-Madrigal-Santillán, Morales-González, J. A., & Madrigal-Bujaidar, E. (2015). Inhibitory Effect of Spirulina maxima on the Azoxymethane-induced Aberrant Colon Crypts and Oxidative Damage in Mice. Pharmacognosy magazine, 11S619-24. https://doi.org/10.4103/0973-1296.172973
Álvarez-González, Isela, et al. "Inhibitory Effect of Spirulina maxima on the Azoxymethane-induced Aberrant Colon Crypts and Oxidative Damage in Mice." Pharmacognosy magazine vol. 11 (2015): S619-24. doi: https://doi.org/10.4103/0973-1296.172973
Álvarez-González I, Islas-Islas V, Chamorro-Cevallos G, Barrios JP, Paniagua N, Vásquez-Garzón VR, Villa-Treviño S, Osiris-Madrigal-Santillán, Morales-González JA, Madrigal-Bujaidar E. Inhibitory Effect of Spirulina maxima on the Azoxymethane-induced Aberrant Colon Crypts and Oxidative Damage in Mice. Pharmacogn Mag. 2015 Oct;11:S619-24. doi: 10.4103/0973-1296.172973. PMID: 27013804; PMCID: PMC4787098.
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Development, Characterization, Optimization, and In Vivo Evaluation of Methacrylic Acid-Ethyl Acrylate Copolymer Nanoparticles Loaded with Glibenclamide in Diabetic Rats for Oral Administration.

Pharmaceutics

Guadarrama-Escobar OR, Sánchez-Vázquez I, Serrano-Castañeda P, Chamorro-Cevallos GA, Rodríguez-Cruz IM, Sánchez-Padrón AY, Anguiano-Almazán E, Peña-Juárez MC, Méndez-Albores A, Domínguez-Delgado CL, Mercado-Márquez C, Rodríguez-Pérez B, Escobar-Chávez JJ.
PMID: 34959305
Pharmaceutics. 2021 Nov 27;13(12). doi: 10.3390/pharmaceutics13122023.

The methacrylic acid-ethyl acrylate copolymer nanoparticles were prepared using the solvent displacement method. The independent variables were the drug/polymer ratio, surfactant concentration, Polioxyl 40 hydrogenated castor oil, the added water volume, time, and stirring speed, while size, PDI, zeta...

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Guadarrama-Escobar OR, Sánchez-Vázquez I, Serrano-Castañeda P, et al. Development, Characterization, Optimization, and In Vivo Evaluation of Methacrylic Acid-Ethyl Acrylate Copolymer Nanoparticles Loaded with Glibenclamide in Diabetic Rats for Oral Administration. Pharmaceutics. 2021;13(12)doi: 10.3390/pharmaceutics13122023.
Guadarrama-Escobar, O. R., Sánchez-Vázquez, I., Serrano-Castañeda, P., Chamorro-Cevallos, G. A., Rodríguez-Cruz, I. M., Sánchez-Padrón, A. Y., Anguiano-Almazán, E., Peña-Juárez, M. C., Méndez-Albores, A., Domínguez-Delgado, C. L., Mercado-Márquez, C., Rodríguez-Pérez, B., & Escobar-Chávez, J. J. (2021). Development, Characterization, Optimization, and In Vivo Evaluation of Methacrylic Acid-Ethyl Acrylate Copolymer Nanoparticles Loaded with Glibenclamide in Diabetic Rats for Oral Administration. Pharmaceutics, 13(12), . https://doi.org/10.3390/pharmaceutics13122023
Guadarrama-Escobar, Omar Rodrigo, et al. "Development, Characterization, Optimization, and In Vivo Evaluation of Methacrylic Acid-Ethyl Acrylate Copolymer Nanoparticles Loaded with Glibenclamide in Diabetic Rats for Oral Administration." Pharmaceutics vol. 13,12 (2021). doi: https://doi.org/10.3390/pharmaceutics13122023
Guadarrama-Escobar OR, Sánchez-Vázquez I, Serrano-Castañeda P, Chamorro-Cevallos GA, Rodríguez-Cruz IM, Sánchez-Padrón AY, Anguiano-Almazán E, Peña-Juárez MC, Méndez-Albores A, Domínguez-Delgado CL, Mercado-Márquez C, Rodríguez-Pérez B, Escobar-Chávez JJ. Development, Characterization, Optimization, and In Vivo Evaluation of Methacrylic Acid-Ethyl Acrylate Copolymer Nanoparticles Loaded with Glibenclamide in Diabetic Rats for Oral Administration. Pharmaceutics. 2021 Nov 27;13(12). doi: 10.3390/pharmaceutics13122023. PMID: 34959305.
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Development, Characterization, Optimization, and In Vivo Evaluation of Methacrylic Acid-Ethyl Acrylate Copolymer Nanoparticles Loaded with Glibenclamide in Diabetic Rats for Oral Administration.

Pharmaceutics

Guadarrama-Escobar OR, Sánchez-Vázquez I, Serrano-Castañeda P, Chamorro-Cevallos GA, Rodríguez-Cruz IM, Sánchez-Padrón AY, Anguiano-Almazán E, Peña-Juárez MC, Méndez-Albores A, Domínguez-Delgado CL, Mercado-Márquez C, Rodríguez-Pérez B, Escobar-Chávez JJ.
PMID: 34959305
Pharmaceutics. 2021 Nov 27;13(12). doi: 10.3390/pharmaceutics13122023.

The methacrylic acid-ethyl acrylate copolymer nanoparticles were prepared using the solvent displacement method. The independent variables were the drug/polymer ratio, surfactant concentration, Polioxyl 40 hydrogenated castor oil, the added water volume, time, and stirring speed, while size, PDI, zeta...

Cite
Guadarrama-Escobar OR, Sánchez-Vázquez I, Serrano-Castañeda P, et al. Development, Characterization, Optimization, and In Vivo Evaluation of Methacrylic Acid-Ethyl Acrylate Copolymer Nanoparticles Loaded with Glibenclamide in Diabetic Rats for Oral Administration. Pharmaceutics. 2021;13(12)doi: 10.3390/pharmaceutics13122023.
Guadarrama-Escobar, O. R., Sánchez-Vázquez, I., Serrano-Castañeda, P., Chamorro-Cevallos, G. A., Rodríguez-Cruz, I. M., Sánchez-Padrón, A. Y., Anguiano-Almazán, E., Peña-Juárez, M. C., Méndez-Albores, A., Domínguez-Delgado, C. L., Mercado-Márquez, C., Rodríguez-Pérez, B., & Escobar-Chávez, J. J. (2021). Development, Characterization, Optimization, and In Vivo Evaluation of Methacrylic Acid-Ethyl Acrylate Copolymer Nanoparticles Loaded with Glibenclamide in Diabetic Rats for Oral Administration. Pharmaceutics, 13(12), . https://doi.org/10.3390/pharmaceutics13122023
Guadarrama-Escobar, Omar Rodrigo, et al. "Development, Characterization, Optimization, and In Vivo Evaluation of Methacrylic Acid-Ethyl Acrylate Copolymer Nanoparticles Loaded with Glibenclamide in Diabetic Rats for Oral Administration." Pharmaceutics vol. 13,12 (2021). doi: https://doi.org/10.3390/pharmaceutics13122023
Guadarrama-Escobar OR, Sánchez-Vázquez I, Serrano-Castañeda P, Chamorro-Cevallos GA, Rodríguez-Cruz IM, Sánchez-Padrón AY, Anguiano-Almazán E, Peña-Juárez MC, Méndez-Albores A, Domínguez-Delgado CL, Mercado-Márquez C, Rodríguez-Pérez B, Escobar-Chávez JJ. Development, Characterization, Optimization, and In Vivo Evaluation of Methacrylic Acid-Ethyl Acrylate Copolymer Nanoparticles Loaded with Glibenclamide in Diabetic Rats for Oral Administration. Pharmaceutics. 2021 Nov 27;13(12). doi: 10.3390/pharmaceutics13122023. PMID: 34959305; PMCID: PMC8704609.
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Oxidative Stress, Mitochondrial Function and Adaptation to Exercise: New Perspectives in Nutrition.

Life (Basel, Switzerland)

Vargas-Mendoza N, Angeles-Valencia M, Morales-González Á, Madrigal-Santillán EO, Morales-Martínez M, Madrigal-Bujaidar E, Álvarez-González I, Gutiérrez-Salinas J, Esquivel-Chirino C, Chamorro-Cevallos G, Cristóbal-Luna JM, Morales-González JA.
PMID: 34833151
Life (Basel). 2021 Nov 22;11(11). doi: 10.3390/life11111269.

Cells have the ability to adapt to stressful environments as a part of their evolution. Physical exercise induces an increase of a demand for energy that must be met by mitochondria as the main (ATP) provider. However, this process...

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Vargas-Mendoza N, Angeles-Valencia M, Morales-González Á, et al. Oxidative Stress, Mitochondrial Function and Adaptation to Exercise: New Perspectives in Nutrition. Life (Basel). 2021;11(11)doi: 10.3390/life11111269.
Vargas-Mendoza, N., Angeles-Valencia, M., Morales-González, �. �., Madrigal-Santillán, E. O., Morales-Martínez, M., Madrigal-Bujaidar, E., Álvarez-González, I., Gutiérrez-Salinas, J., Esquivel-Chirino, C., Chamorro-Cevallos, G., Cristóbal-Luna, J. M., & Morales-González, J. A. (2021). Oxidative Stress, Mitochondrial Function and Adaptation to Exercise: New Perspectives in Nutrition. Life (Basel, Switzerland), 11(11), . https://doi.org/10.3390/life11111269
Vargas-Mendoza, Nancy, et al. "Oxidative Stress, Mitochondrial Function and Adaptation to Exercise: New Perspectives in Nutrition." Life (Basel, Switzerland) vol. 11,11 (2021). doi: https://doi.org/10.3390/life11111269
Vargas-Mendoza N, Angeles-Valencia M, Morales-González Á, Madrigal-Santillán EO, Morales-Martínez M, Madrigal-Bujaidar E, Álvarez-González I, Gutiérrez-Salinas J, Esquivel-Chirino C, Chamorro-Cevallos G, Cristóbal-Luna JM, Morales-González JA. Oxidative Stress, Mitochondrial Function and Adaptation to Exercise: New Perspectives in Nutrition. Life (Basel). 2021 Nov 22;11(11). doi: 10.3390/life11111269. PMID: 34833151; PMCID: PMC8624755.
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Amelioration of Cadmium-Produced Teratogenicity and Genotoxicity in Mice Given Arthrospira maxima (Spirulina) Treatment.

Evidence-based complementary and alternative medicine : eCAM

Argüelles-Velázquez N, Alvarez-González I, Madrigal-Bujaidar E, Chamorro-Cevallos G.
PMID: 24369479
Evid Based Complement Alternat Med. 2013;2013:604535. doi: 10.1155/2013/604535. Epub 2013 Nov 28.

Evaluation of the effects of Arthrospira maxima (AM) was made, otherwise known as Spirulina, on the teratogenicity, genotoxicity, and DNA oxidation processes induced by cadmium (Cd). Pregnant ICR mice were divided into groups and administered water, Cd only, AM...

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Argüelles-Velázquez N, Alvarez-González I, Madrigal-Bujaidar E, et al. Amelioration of Cadmium-Produced Teratogenicity and Genotoxicity in Mice Given Arthrospira maxima (Spirulina) Treatment. Evid Based Complement Alternat Med. 2013;2013:604535doi: 10.1155/2013/604535.
Argüelles-Velázquez, N., Alvarez-González, I., Madrigal-Bujaidar, E., & Chamorro-Cevallos, G. (2013). Amelioration of Cadmium-Produced Teratogenicity and Genotoxicity in Mice Given Arthrospira maxima (Spirulina) Treatment. Evidence-based complementary and alternative medicine : eCAM, 2013604535. https://doi.org/10.1155/2013/604535
Argüelles-Velázquez, Nancy, et al. "Amelioration of Cadmium-Produced Teratogenicity and Genotoxicity in Mice Given Arthrospira maxima (Spirulina) Treatment." Evidence-based complementary and alternative medicine : eCAM vol. 2013 (2013): 604535. doi: https://doi.org/10.1155/2013/604535
Argüelles-Velázquez N, Alvarez-González I, Madrigal-Bujaidar E, Chamorro-Cevallos G. Amelioration of Cadmium-Produced Teratogenicity and Genotoxicity in Mice Given Arthrospira maxima (Spirulina) Treatment. Evid Based Complement Alternat Med. 2013;2013:604535. doi: 10.1155/2013/604535. Epub 2013 Nov 28. PMID: 24369479; PMCID: PMC3863560.
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Protective effects of Spirulina (Arthrospira maxima) against toxicity induced by cadmium in Xenopus laevis.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

Pérez-Alvarez I, Islas-Flores H, Gómez-Oliván LM, Sánchez-Aceves LM, Chamorro-Cevallos G.
PMID: 34102331
Comp Biochem Physiol C Toxicol Pharmacol. 2021 Oct;248:109099. doi: 10.1016/j.cbpc.2021.109099. Epub 2021 Jun 05.

Spirulina (Arthrospira maxima) has been recognized as a superfood and nutraceutical by its high nutritional value and the benefits of its consumption; it is an important source of lipids, proteins, vitamins, minerals, and antioxidants. It is known that spirulina...

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Pérez-Alvarez I, Islas-Flores H, Gómez-Oliván LM, et al. Protective effects of Spirulina (Arthrospira maxima) against toxicity induced by cadmium in Xenopus laevis. Comp Biochem Physiol C Toxicol Pharmacol. 2021;248:109099doi: 10.1016/j.cbpc.2021.109099.
Pérez-Alvarez, I., Islas-Flores, H., Gómez-Oliván, L. M., Sánchez-Aceves, L. M., & Chamorro-Cevallos, G. (2021). Protective effects of Spirulina (Arthrospira maxima) against toxicity induced by cadmium in Xenopus laevis. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 248109099. https://doi.org/10.1016/j.cbpc.2021.109099
Pérez-Alvarez, Itzayana, et al. "Protective effects of Spirulina (Arthrospira maxima) against toxicity induced by cadmium in Xenopus laevis." Comparative biochemistry and physiology. Toxicology & pharmacology : CBP vol. 248 (2021): 109099. doi: https://doi.org/10.1016/j.cbpc.2021.109099
Pérez-Alvarez I, Islas-Flores H, Gómez-Oliván LM, Sánchez-Aceves LM, Chamorro-Cevallos G. Protective effects of Spirulina (Arthrospira maxima) against toxicity induced by cadmium in Xenopus laevis. Comp Biochem Physiol C Toxicol Pharmacol. 2021 Oct;248:109099. doi: 10.1016/j.cbpc.2021.109099. Epub 2021 Jun 05. PMID: 34102331.
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Anticonvulsive profile of two GABA.

Epilepsy research

Pagès N, Maurois P, Bac P, Meza-Toledo S, Peralta-Cruz J, Chamorro-Cevallos G, Cristóbal-Luna JM, Vamecq J.
PMID: 33932748
Epilepsy Res. 2021 Aug;174:106644. doi: 10.1016/j.eplepsyres.2021.106644. Epub 2021 Apr 20.

INTRODUCTION: DL-3-hydroxy-3-phenylpentanamide (HEPP) and DL-3-hydroxy-3-(4'chlorophenyl)-pentanamide (Cl-HEPP) are phenyl-alcohol-amides that are metabotropic GABAB receptor (MGBR) antagonists and protective against absence seizures. This study aims to further characterize the anticonvulsant profile of these drugs.METHODS: HEPP and Cl-HEPP were evaluated in various...

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Pagès N, Maurois P, Bac P, et al. Anticonvulsive profile of two GABA. Epilepsy Res. 2021;174:106644doi: 10.1016/j.eplepsyres.2021.106644.
Pagès, N., Maurois, P., Bac, P., Meza-Toledo, S., Peralta-Cruz, J., Chamorro-Cevallos, G., Cristóbal-Luna, J. M., & Vamecq, J. (2021). Anticonvulsive profile of two GABA. Epilepsy research, 174106644. https://doi.org/10.1016/j.eplepsyres.2021.106644
Pagès, Nicole, et al. "Anticonvulsive profile of two GABA." Epilepsy research vol. 174 (2021): 106644. doi: https://doi.org/10.1016/j.eplepsyres.2021.106644
Pagès N, Maurois P, Bac P, Meza-Toledo S, Peralta-Cruz J, Chamorro-Cevallos G, Cristóbal-Luna JM, Vamecq J. Anticonvulsive profile of two GABA. Epilepsy Res. 2021 Aug;174:106644. doi: 10.1016/j.eplepsyres.2021.106644. Epub 2021 Apr 20. PMID: 33932748.
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Phycobiliproteins extract from Spirulina protects against single-dose cadmium-induced reproductive toxicity in male mice.

Environmental science and pollution research international

Montaño-González RI, Gutiérrez-Salmeán G, Mojica-Villegas MA, Cristóbal-Luna JM, Briseño-Bugarín J, Chamorro-Cevallos G.
PMID: 34664174
Environ Sci Pollut Res Int. 2021 Oct 19; doi: 10.1007/s11356-021-16668-3. Epub 2021 Oct 19.

Cadmium (Cd) is known for its many toxic effects on male population such as hypogonadism and fertility difficulties, which are oftenly associated with oxidative stress. As beneficial food, Spirulina(Sp) has been proved efficient against the heavy metal toxicity. This...

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Montaño-González RI, Gutiérrez-Salmeán G, Mojica-Villegas MA, et al. Phycobiliproteins extract from Spirulina protects against single-dose cadmium-induced reproductive toxicity in male mice. Environ Sci Pollut Res Int. 2021;doi: 10.1007/s11356-021-16668-3.
Montaño-González, R. I., Gutiérrez-Salmeán, G., Mojica-Villegas, M. A., Cristóbal-Luna, J. M., Briseño-Bugarín, J., & Chamorro-Cevallos, G. (2021). Phycobiliproteins extract from Spirulina protects against single-dose cadmium-induced reproductive toxicity in male mice. Environmental science and pollution research international, . https://doi.org/10.1007/s11356-021-16668-3
Montaño-González, Ricardo Iván, et al. "Phycobiliproteins extract from Spirulina protects against single-dose cadmium-induced reproductive toxicity in male mice." Environmental science and pollution research international vol. (2021). doi: https://doi.org/10.1007/s11356-021-16668-3
Montaño-González RI, Gutiérrez-Salmeán G, Mojica-Villegas MA, Cristóbal-Luna JM, Briseño-Bugarín J, Chamorro-Cevallos G. Phycobiliproteins extract from Spirulina protects against single-dose cadmium-induced reproductive toxicity in male mice. Environ Sci Pollut Res Int. 2021 Oct 19; doi: 10.1007/s11356-021-16668-3. Epub 2021 Oct 19. PMID: 34664174.
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