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Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors.

OncoTargets and therapy

Creelan BC, Gabrilovich DI, Gray JE, Williams CC, Tanvetyanon T, Haura EB, Weber JS, Gibney GT, Markowitz J, Proksch JW, Reisman SA, McKee MD, Chin MP, Meyer CJ, Antonia SJ.
PMID: 28919776
Onco Targets Ther. 2017 Aug 29;10:4239-4250. doi: 10.2147/OTT.S136992. eCollection 2017.

BACKGROUND: Omaveloxolone is a semisynthetic oleanane triterpenoid that potently activates Nrf2 with subsequent antioxidant function. We conducted a first-in-human Phase I clinical trial (NCT02029729) with the primary objectives to determine the appropriate dose for Phase II studies, characterize pharmacokinetic...

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Creelan BC, Gabrilovich DI, Gray JE, et al. Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors. Onco Targets Ther. 2017;10:4239-4250doi: 10.2147/OTT.S136992.
Creelan, B. C., Gabrilovich, D. I., Gray, J. E., Williams, C. C., Tanvetyanon, T., Haura, E. B., Weber, J. S., Gibney, G. T., Markowitz, J., Proksch, J. W., Reisman, S. A., McKee, M. D., Chin, M. P., Meyer, C. J., & Antonia, S. J. (2017). Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors. OncoTargets and therapy, 104239-4250. https://doi.org/10.2147/OTT.S136992
Creelan, Ben C, et al. "Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors." OncoTargets and therapy vol. 10 (2017): 4239-4250. doi: https://doi.org/10.2147/OTT.S136992
Creelan BC, Gabrilovich DI, Gray JE, Williams CC, Tanvetyanon T, Haura EB, Weber JS, Gibney GT, Markowitz J, Proksch JW, Reisman SA, McKee MD, Chin MP, Meyer CJ, Antonia SJ. Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors. Onco Targets Ther. 2017 Aug 29;10:4239-4250. doi: 10.2147/OTT.S136992. eCollection 2017. PMID: 28919776; PMCID: PMC5587199.
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Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci.

Neurology. Genetics

Chan G, White CC, Winn PA, Cimpean M, Replogle JM, Glick LR, Cuerdon NE, Ryan KJ, Johnson KA, Schneider JA, Bennett DA, Chibnik LB, Sperling RA, De Jager PL, Bradshaw EM.
PMID: 27504496
Neurol Genet. 2016 Jul 26;2(4):e90. doi: 10.1212/NXG.0000000000000090. eCollection 2016 Aug.

OBJECTIVE: Given evidence from genetic studies, we hypothesized that there may be a shared component to the role of myeloid function in Parkinson and Alzheimer disease (PD and AD) and assessed whether PD susceptibility variants influenced protein expression of...

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Chan G, White CC, Winn PA, et al. Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci. Neurol Genet. 2016;2(4):e90doi: 10.1212/NXG.0000000000000090.
Chan, G., White, C. C., Winn, P. A., Cimpean, M., Replogle, J. M., Glick, L. R., Cuerdon, N. E., Ryan, K. J., Johnson, K. A., Schneider, J. A., Bennett, D. A., Chibnik, L. B., Sperling, R. A., De Jager, P. L., & Bradshaw, E. M. (2016). Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci. Neurology. Genetics, 2(4), e90. https://doi.org/10.1212/NXG.0000000000000090
Chan, Gail, et al. "Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci." Neurology. Genetics vol. 2,4 (2016): e90. doi: https://doi.org/10.1212/NXG.0000000000000090
Chan G, White CC, Winn PA, Cimpean M, Replogle JM, Glick LR, Cuerdon NE, Ryan KJ, Johnson KA, Schneider JA, Bennett DA, Chibnik LB, Sperling RA, De Jager PL, Bradshaw EM. Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci. Neurol Genet. 2016 Jul 26;2(4):e90. doi: 10.1212/NXG.0000000000000090. eCollection 2016 Aug. PMID: 27504496; PMCID: PMC4962525.
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From repulsive to attractive glass: A rheological investigation.

The Journal of chemical physics

Zhou Z, Jia D, Hollingsworth JV, Cheng H, Han CC.
PMID: 26696073
J Chem Phys. 2015 Dec 21;143(23):234901. doi: 10.1063/1.4937796.

Linear rheological properties and yielding behavior of polystyrene core and poly (N-isopropylacrylamide) (PNIPAM) shell microgels were investigated to understand the transition from repulsive glass (RG) to attractive glass (AG) and the A3 singularity. Due to the volume phase transition...

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Zhou Z, Jia D, Hollingsworth JV, et al. From repulsive to attractive glass: A rheological investigation. J Chem Phys. 2015;143(23):234901doi: 10.1063/1.4937796.
Zhou, Z., Jia, D., Hollingsworth, J. V., Cheng, H., & Han, C. C. (2015). From repulsive to attractive glass: A rheological investigation. The Journal of chemical physics, 143(23), 234901. https://doi.org/10.1063/1.4937796
Zhou, Zhi, et al. "From repulsive to attractive glass: A rheological investigation." The Journal of chemical physics vol. 143,23 (2015): 234901. doi: https://doi.org/10.1063/1.4937796
Zhou Z, Jia D, Hollingsworth JV, Cheng H, Han CC. From repulsive to attractive glass: A rheological investigation. J Chem Phys. 2015 Dec 21;143(23):234901. doi: 10.1063/1.4937796. PMID: 26696073.
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Diabetic Retinopathy: A Position Statement by the American Diabetes Association.

Diabetes care

Solomon SD, Chew E, Duh EJ, Sobrin L, Sun JK, VanderBeek BL, Wykoff CC, Gardner TW.
PMID: 28223445
Diabetes Care. 2017 Mar;40(3):412-418. doi: 10.2337/dc16-2641.

No abstract available.

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Solomon SD, Chew E, Duh EJ, et al. Diabetic Retinopathy: A Position Statement by the American Diabetes Association. Diabetes Care. 2017;40(3):412-418doi: 10.2337/dc16-2641.
Solomon, S. D., Chew, E., Duh, E. J., Sobrin, L., Sun, J. K., VanderBeek, B. L., Wykoff, C. C., & Gardner, T. W. (2017). Diabetic Retinopathy: A Position Statement by the American Diabetes Association. Diabetes care, 40(3), 412-418. https://doi.org/10.2337/dc16-2641
Solomon, Sharon D, et al. "Diabetic Retinopathy: A Position Statement by the American Diabetes Association." Diabetes care vol. 40,3 (2017): 412-418. doi: https://doi.org/10.2337/dc16-2641
Solomon SD, Chew E, Duh EJ, Sobrin L, Sun JK, VanderBeek BL, Wykoff CC, Gardner TW. Diabetic Retinopathy: A Position Statement by the American Diabetes Association. Diabetes Care. 2017 Mar;40(3):412-418. doi: 10.2337/dc16-2641. PMID: 28223445; PMCID: PMC5402875.
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Asymmetrical phase separation and gelation in binary mixtures of oppositely charged colloids.

The Journal of chemical physics

Zong Y, Yuan G, Han CC.
PMID: 27394122
J Chem Phys. 2016 Jul 07;145(1):014904. doi: 10.1063/1.4954993.

Two types of colloidal particles, which are nearly the same in chemical composition but carry opposite surface charges, are mixed in water. Depending on the relative proportion of the oppositely charged particles, the process of aggregation leads to the...

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Zong Y, Yuan G, Han CC. Asymmetrical phase separation and gelation in binary mixtures of oppositely charged colloids. J Chem Phys. 2016;145(1):014904doi: 10.1063/1.4954993.
Zong, Y., Yuan, G., & Han, C. C. (2016). Asymmetrical phase separation and gelation in binary mixtures of oppositely charged colloids. The Journal of chemical physics, 145(1), 014904. https://doi.org/10.1063/1.4954993
Zong, Yiwu, et al. "Asymmetrical phase separation and gelation in binary mixtures of oppositely charged colloids." The Journal of chemical physics vol. 145,1 (2016): 014904. doi: https://doi.org/10.1063/1.4954993
Zong Y, Yuan G, Han CC. Asymmetrical phase separation and gelation in binary mixtures of oppositely charged colloids. J Chem Phys. 2016 Jul 07;145(1):014904. doi: 10.1063/1.4954993. PMID: 27394122.
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Effects of particle softness on shear thickening of microgel suspensions.

Soft matter

Zhou Z, Hollingsworth JV, Hong S, Wei G, Shi Y, Lu X, Cheng H, Han CC.
PMID: 25028061
Soft Matter. 2014 Sep 07;10(33):6286-93. doi: 10.1039/c4sm01181c. Epub 2014 Jul 16.

A series of microgel particles composed of a polystyrene (PS) core and a thermo-sensitive poly(N-isopropylacrylamide) (PNIPAM) shell with different shell thicknesses were investigated to elucidate the effect of microgel softness on its shear thickening behavior. Since the softness of...

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Zhou Z, Hollingsworth JV, Hong S, et al. Effects of particle softness on shear thickening of microgel suspensions. Soft Matter. 2014;10(33):6286-93doi: 10.1039/c4sm01181c.
Zhou, Z., Hollingsworth, J. V., Hong, S., Wei, G., Shi, Y., Lu, X., Cheng, H., & Han, C. C. (2014). Effects of particle softness on shear thickening of microgel suspensions. Soft matter, 10(33), 6286-93. https://doi.org/10.1039/c4sm01181c
Zhou, Zhi, et al. "Effects of particle softness on shear thickening of microgel suspensions." Soft matter vol. 10,33 (2014): 6286-93. doi: https://doi.org/10.1039/c4sm01181c
Zhou Z, Hollingsworth JV, Hong S, Wei G, Shi Y, Lu X, Cheng H, Han CC. Effects of particle softness on shear thickening of microgel suspensions. Soft Matter. 2014 Sep 07;10(33):6286-93. doi: 10.1039/c4sm01181c. Epub 2014 Jul 16. PMID: 25028061.
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From Exhaustion to Disengagement via Self-Efficacy Change: Findings from Two Longitudinal Studies among Human Services Workers.

Frontiers in psychology

Rogala A, Shoji K, Luszczynska A, Kuna A, Yeager C, Benight CC, Cieslak R.
PMID: 26779114
Front Psychol. 2016 Jan 08;6:2032. doi: 10.3389/fpsyg.2015.02032. eCollection 2015.

This longitudinal research examined the relationship direction between burnout components (exhaustion and disengagement) within the context of personal resources measured by self-efficacy and social support. In line with the conservation of resources theory we hypothesized that exhaustion may trigger...

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Rogala A, Shoji K, Luszczynska A, et al. From Exhaustion to Disengagement via Self-Efficacy Change: Findings from Two Longitudinal Studies among Human Services Workers. Front Psychol. 2016;6:2032doi: 10.3389/fpsyg.2015.02032.
Rogala, A., Shoji, K., Luszczynska, A., Kuna, A., Yeager, C., Benight, C. C., & Cieslak, R. (2015). From Exhaustion to Disengagement via Self-Efficacy Change: Findings from Two Longitudinal Studies among Human Services Workers. Frontiers in psychology, 62032. https://doi.org/10.3389/fpsyg.2015.02032
Rogala, Anna, et al. "From Exhaustion to Disengagement via Self-Efficacy Change: Findings from Two Longitudinal Studies among Human Services Workers." Frontiers in psychology vol. 6 (2015): 2032. doi: https://doi.org/10.3389/fpsyg.2015.02032
Rogala A, Shoji K, Luszczynska A, Kuna A, Yeager C, Benight CC, Cieslak R. From Exhaustion to Disengagement via Self-Efficacy Change: Findings from Two Longitudinal Studies among Human Services Workers. Front Psychol. 2016 Jan 08;6:2032. doi: 10.3389/fpsyg.2015.02032. eCollection 2015. PMID: 26779114; PMCID: PMC4705225.
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Morphology of hydrothermally synthesized ZnO nanoparticles tethered to carbon nanotubes affects electrocatalytic activity for H.

Electrochimica acta

Wayu MB, Spidle RT, Devkota T, Deb AK, Delong RK, Ghosh KC, Wanekaya AK, Chusuei CC.
PMID: 25684785
Electrochim Acta. 2013 May 01;97:99-104. doi: 10.1016/j.electacta.2013.02.028.

We describe the synthesis of zinc oxide (ZnO) nanoparticles and demonstrate their attachment to multiwalled carbon tubes, resulting in a composite with a unique synergistic effect. Morphology and size of ZnO nanostructures were controlled using hydrothermal synthesis, varying the...

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Wayu MB, Spidle RT, Devkota T, et al. Morphology of hydrothermally synthesized ZnO nanoparticles tethered to carbon nanotubes affects electrocatalytic activity for H. Electrochim Acta. 2013;97:99-104doi: 10.1016/j.electacta.2013.02.028.
Wayu, M. B., Spidle, R. T., Devkota, T., Deb, A. K., Delong, R. K., Ghosh, K. C., Wanekaya, A. K., & Chusuei, C. C. (2013). Morphology of hydrothermally synthesized ZnO nanoparticles tethered to carbon nanotubes affects electrocatalytic activity for H. Electrochimica acta, 9799-104. https://doi.org/10.1016/j.electacta.2013.02.028
Wayu, Mulugeta B, et al. "Morphology of hydrothermally synthesized ZnO nanoparticles tethered to carbon nanotubes affects electrocatalytic activity for H." Electrochimica acta vol. 97 (2013): 99-104. doi: https://doi.org/10.1016/j.electacta.2013.02.028
Wayu MB, Spidle RT, Devkota T, Deb AK, Delong RK, Ghosh KC, Wanekaya AK, Chusuei CC. Morphology of hydrothermally synthesized ZnO nanoparticles tethered to carbon nanotubes affects electrocatalytic activity for H. Electrochim Acta. 2013 May 01;97:99-104. doi: 10.1016/j.electacta.2013.02.028. PMID: 25684785; PMCID: PMC4326222.
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Generation of Escher Arts with Dual Perception.

IEEE transactions on visualization and computer graphics

Lin SS, Morace CC, Lin CH, Hsu LF, Lee TY.
PMID: 28141524
IEEE Trans Vis Comput Graph. 2018 Feb;24(2):1103-1113. doi: 10.1109/TVCG.2017.2660488. Epub 2017 Jan 27.

Escher transmutation is a graphic art that smoothly transforms one tile pattern into another tile pattern with dual perception. A classic example is the artwork called Sky and Water, in which a compelling figure-ground arrangement is applied to portray...

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Lin SS, Morace CC, Lin CH, et al. Generation of Escher Arts with Dual Perception. IEEE Trans Vis Comput Graph. 2017;24(2):1103-1113doi: 10.1109/TVCG.2017.2660488.
Lin, S. S., Morace, C. C., Lin, C. H., Hsu, L. F., & Lee, T. Y. (2018). Generation of Escher Arts with Dual Perception. IEEE transactions on visualization and computer graphics, 24(2), 1103-1113. https://doi.org/10.1109/TVCG.2017.2660488
Lin, Shih-Syun, et al. "Generation of Escher Arts with Dual Perception." IEEE transactions on visualization and computer graphics vol. 24,2 (2018): 1103-1113. doi: https://doi.org/10.1109/TVCG.2017.2660488
Lin SS, Morace CC, Lin CH, Hsu LF, Lee TY. Generation of Escher Arts with Dual Perception. IEEE Trans Vis Comput Graph. 2018 Feb;24(2):1103-1113. doi: 10.1109/TVCG.2017.2660488. Epub 2017 Jan 27. PMID: 28141524.
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Evaluating more naturalistic outcome measures: A 1-year smartphone study in multiple sclerosis.

Neurology(R) neuroimmunology & neuroinflammation

Bove R, White CC, Giovannoni G, Glanz B, Golubchikov V, Hujol J, Jennings C, Langdon D, Lee M, Legedza A, Paskavitz J, Prasad S, Richert J, Robbins A, Roberts S, Weiner H, Ramachandran R, Botfield M, De Jager PL.
PMID: 26516627
Neurol Neuroimmunol Neuroinflamm. 2015 Oct 15;2(6):e162. doi: 10.1212/NXI.0000000000000162. eCollection 2015 Dec.

OBJECTIVE: In this cohort of individuals with and without multiple sclerosis (MS), we illustrate some of the novel approaches that smartphones provide to monitor patients with chronic neurologic disorders in their natural setting.METHODS: Thirty-eight participant pairs (MS and cohabitant)...

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Bove R, White CC, Giovannoni G, et al. Evaluating more naturalistic outcome measures: A 1-year smartphone study in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2015;2(6):e162doi: 10.1212/NXI.0000000000000162.
Bove, R., White, C. C., Giovannoni, G., Glanz, B., Golubchikov, V., Hujol, J., Jennings, C., Langdon, D., Lee, M., Legedza, A., Paskavitz, J., Prasad, S., Richert, J., Robbins, A., Roberts, S., Weiner, H., Ramachandran, R., Botfield, M., & De Jager, P. L. (2015). Evaluating more naturalistic outcome measures: A 1-year smartphone study in multiple sclerosis. Neurology(R) neuroimmunology & neuroinflammation, 2(6), e162. https://doi.org/10.1212/NXI.0000000000000162
Bove, Riley, et al. "Evaluating more naturalistic outcome measures: A 1-year smartphone study in multiple sclerosis." Neurology(R) neuroimmunology & neuroinflammation vol. 2,6 (2015): e162. doi: https://doi.org/10.1212/NXI.0000000000000162
Bove R, White CC, Giovannoni G, Glanz B, Golubchikov V, Hujol J, Jennings C, Langdon D, Lee M, Legedza A, Paskavitz J, Prasad S, Richert J, Robbins A, Roberts S, Weiner H, Ramachandran R, Botfield M, De Jager PL. Evaluating more naturalistic outcome measures: A 1-year smartphone study in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2015 Oct 15;2(6):e162. doi: 10.1212/NXI.0000000000000162. eCollection 2015 Dec. PMID: 26516627; PMCID: PMC4608760.
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Genotype/Phenotype Correlations in X-Linked Dominant Charcot-Marie-Tooth Disease.

Annals of the New York Academy of Sciences

Hahn AF, Bolton CF, White CM, Brown WF, Tuuha SE, Tan CC, Ainsworth PJ.
PMID: 29086963
Ann N Y Acad Sci. 1999 Oct;883(1):366-382. doi: 10.1111/j.1749-6632.1999.tb08598.x.

We have studied the relationship between genotype, clinical phenotype, and pathology in 13 families with dominant X-linked Charcot-Marie-Tooth (CMT) neuropathy. Connexin32 (Cx32) gene mutations were spread throughout the coding region and included eight missense mutations, one 8-bp deletion/4-bp insertion...

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Hahn AF, Bolton CF, White CM, et al. Genotype/Phenotype Correlations in X-Linked Dominant Charcot-Marie-Tooth Disease. Ann N Y Acad Sci. 1999;883(1):366-382doi: 10.1111/j.1749-6632.1999.tb08598.x.
Hahn, A. F., Bolton, C. F., White, C. M., Brown, W. F., Tuuha, S. E., Tan, C. C., & Ainsworth, P. J. (1999). Genotype/Phenotype Correlations in X-Linked Dominant Charcot-Marie-Tooth Disease. Annals of the New York Academy of Sciences, 883(1), 366-382. https://doi.org/10.1111/j.1749-6632.1999.tb08598.x
Hahn, Angelika F, et al. "Genotype/Phenotype Correlations in X-Linked Dominant Charcot-Marie-Tooth Disease." Annals of the New York Academy of Sciences vol. 883,1 (1999): 366-382. doi: https://doi.org/10.1111/j.1749-6632.1999.tb08598.x
Hahn AF, Bolton CF, White CM, Brown WF, Tuuha SE, Tan CC, Ainsworth PJ. Genotype/Phenotype Correlations in X-Linked Dominant Charcot-Marie-Tooth Disease. Ann N Y Acad Sci. 1999 Oct;883(1):366-382. doi: 10.1111/j.1749-6632.1999.tb08598.x. PMID: 29086963.
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Zebrafish small molecule screens: Taking the phenotypic plunge.

Computational and structural biotechnology journal

Williams CH, Hong CC.
PMID: 27721960
Comput Struct Biotechnol J. 2016 Sep 18;14:350-356. doi: 10.1016/j.csbj.2016.09.001. eCollection 2016.

Target based chemical screens are a mainstay of modern drug discovery, but the effectiveness of this reductionist approach is being questioned in light of declines in pharmaceutical R & D efficiency. In recent years, phenotypic screens have gained increasing...

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Williams CH, Hong CC. Zebrafish small molecule screens: Taking the phenotypic plunge. Comput Struct Biotechnol J. 2016;14:350-356doi: 10.1016/j.csbj.2016.09.001.
Williams, C. H., & Hong, C. C. (2016). Zebrafish small molecule screens: Taking the phenotypic plunge. Computational and structural biotechnology journal, 14350-356. https://doi.org/10.1016/j.csbj.2016.09.001
Williams, Charles H, and Hong, Charles C. "Zebrafish small molecule screens: Taking the phenotypic plunge." Computational and structural biotechnology journal vol. 14 (2016): 350-356. doi: https://doi.org/10.1016/j.csbj.2016.09.001
Williams CH, Hong CC. Zebrafish small molecule screens: Taking the phenotypic plunge. Comput Struct Biotechnol J. 2016 Sep 18;14:350-356. doi: 10.1016/j.csbj.2016.09.001. eCollection 2016. PMID: 27721960; PMCID: PMC5050293.
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Showing 1 to 12 of 936 entries