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Showing 1 to 12 of 54 entries
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Studies on the frequency and clinical manifestations of epilepsy in infancy and early childhood.

Folia medica

Chakova L.
PMID: 9002365
Folia Med (Plovdiv). 1996;38(2):75-80.

The frequency, clinical manifestations and prognosis of epileptic seizures were analysed in 149 epileptic children aged up to three years. The frequency of epileptic seizures was found to have increased four-fold for the period of study. The generalised forms...

Erythrocyte membrane fluidity and haemoglobin haemoporphyrin conformation: features revealed in patients with heart failure.

Pathophysiology : the official journal of the International Society for Pathophysiology

Rodnenkov OV, Luneva OG, Ulyanova NA, Maksimov GV, Rubin AB, Orlov SN, Chazov EI.
PMID: 15837166
Pathophysiology. 2005 May;11(4):209-213. doi: 10.1016/j.pathophys.2004.12.001.

This study examined the possible involvement of abnormal erythrocyte oxygen (O(2)) transport in the pathogenesis of heart failure. Haemoglobin (Hb) haemoporphyrin conformation was assessed by Raman spectroscopy (RS) of blood samples, whereas membrane fluidity was estimated at depths of...

Efficient spin injector scheme based on Heusler materials.

Physical review letters

Chadov S, Graf T, Chadova K, Dai X, Casper F, Fecher GH, Felser C.
PMID: 21867035
Phys Rev Lett. 2011 Jul 22;107(4):047202. doi: 10.1103/PhysRevLett.107.047202. Epub 2011 Jul 18.

We present a rational design scheme intended to provide stable high spin polarization at the interfaces of the magnetoresistive junctions by fulfilling the criteria of structural and chemical compatibilities at the interface. This can be realized by joining the...

Challenges of diagnostic exome sequencing in an inbred founder population.

Molecular genetics & genomic medicine

Azmanov DN, Chamova T, Tankard R, Gelev V, Bynevelt M, Florez L, Tzoneva D, Zlatareva D, Guergueltcheva V, Bahlo M, Tournev I, Kalaydjieva L.
PMID: 24498604
Mol Genet Genomic Med. 2013 Jul;1(2):71-6. doi: 10.1002/mgg3.7. Epub 2013 Apr 22.

Exome sequencing was used as a diagnostic tool in a Roma/Gypsy family with three subjects (one deceased) affected by lissencephaly with cerebellar hypoplasia (LCH), a clinically and genetically heterogeneous diagnostic category. Data analysis identified high levels of unreported inbreeding,...

Foaming properties of acid-soluble protein-rich ingredient obtained from industrial rapeseed meal.

Journal of food science and technology

Ivanova P, Kalaydzhiev H, Dessev TT, Silva CLM, Rustad T, Chalova VI.
PMID: 30150839
J Food Sci Technol. 2018 Sep;55(9):3792-3798. doi: 10.1007/s13197-018-3311-y. Epub 2018 Aug 09.

The use of the rapeseed meal as a source for preparation of protein-rich ingredients for the food industry is an alternative to the current limited application as a feed additive. The aim of this study was to evaluate foaming...

Vaso-occlusive crisis in sickle cell disease: current paradigm on pain management.

Journal of pain research

Uwaezuoke SN, Ayuk AC, Ndu IK, Eneh CI, Mbanefo NR, Ezenwosu OU.
PMID: 30588066
J Pain Res. 2018 Dec 11;11:3141-3150. doi: 10.2147/JPR.S185582. eCollection 2018.

This narrative review aims to highlight the current paradigm on pain management in sickle cell vaso-occlusive crisis. It specifically examines the pathophysiologic mechanisms of sickle cell pain as well as the pharmacologic and nonpharmacologic methods of pain management. Recurrent...

[A therapeutic approach to treating arterial hypertension in patients with insulin resistance].

Problemy endokrinologii

Mychka VВ, Masenko VP, Chazova IY.
PMID: 31627603
Probl Endokrinol (Mosk). 2006 Oct 15;52(5):5-11. doi: 10.14341/probl20065255-11.

The purpose of the study was to evaluate moxonidme therapy on the daily profde of blood pressure (BP), insulin sensitivity, glucose tolerance, carbohydrate and lipid metabolic parameters, and vascular endothelial function in patients with metabolic syndrome (MS) and grade...

Truncating Mutations in UBAP1 Cause Hereditary Spastic Paraplegia.

American journal of human genetics

Farazi Fard MA, Rebelo AP, Buglo E, Nemati H, Dastsooz H, Gehweiler I, Reich S, Reichbauer J, Quintáns B, Ordóñez-Ugalde A, Cortese A, Courel S, Abreu L, Powell E, Danzi MC, Martuscelli NB, Bis-Brewer DM, Tao F, Zarei F, Habibzadeh P, Yavarian M, Modarresi F, Silawi M, Tabatabaei Z, Yousefi M, Farpour HR, Kessler C, Mangold E, Kobeleva X, Tournev I, Chamova T, Mueller AJ, Haack TB, Tarnopolsky M, Gan-Or Z, Rouleau GA, Synofzik M, Sobrido MJ, Jordanova A, Schüle R, Zuchner S, Faghihi MA.
PMID: 31173719
Am J Hum Genet. 2019 Jun 06;104(6):1251. doi: 10.1016/j.ajhg.2019.05.009.

No abstract available.

Characterization of population genetic structure of hereditary transthyretin amyloidosis in Bulgaria.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

Pavlova Z, Sarafov S, Todorov T, Kirov A, Chamova T, Gospodinova M, Tournev I, Mitev V, Todorova A.
PMID: 34076545
Amyloid. 2021 Dec;28(4):219-225. doi: 10.1080/13506129.2021.1935230. Epub 2021 Jun 02.

The hereditary transthyretin amyloidosis (ATTRv amyloidosis) is an autosomal dominant genetic disease characterized by amyloid formation in different tissues due to pathogenic variants in the

MYH7-related disorders in two Bulgarian families: Novel variants in the same region associated with different clinical manifestation and disease penetrance.

Neuromuscular disorders : NMD

Atemin S, Todorov T, Maver A, Chamova T, Georgieva B, Tincheva S, Pacheva I, Ivanov I, Taneva A, Zlatareva D, Tournev I, Guergueltcheva V, Gospodinova M, Chochkova L, Peterlin B, Mitev V, Todorova A.
PMID: 34053846
Neuromuscul Disord. 2021 Jul;31(7):633-641. doi: 10.1016/j.nmd.2021.04.004. Epub 2021 Apr 26.

Pathogenic variants in MYH7 cause a wide range of cardiac and skeletal muscle diseases with childhood or adult onset. These include dilated and/or hypertrophic cardiomyopathy, left ventricular non-compaction cardiomyopathy, congenital myopathies with multi-minicores and myofiber type disproportion, myosin storage...

Implementation of Health Technology Assessment in the Middle East and North Africa: Comparison Between the Current and Preferred Status.

Frontiers in pharmacology

Fasseeh A, Karam R, Jameleddine M, George M, Kristensen FB, Al-Rabayah AA, Alsaggabi AH, El Rabbat M, Alowayesh MS, Chamova J, Ismail A, Abaza S, Kaló Z.
PMID: 32153393
Front Pharmacol. 2020 Feb 21;11:15. doi: 10.3389/fphar.2020.00015. eCollection 2020.

INTRODUCTION: Implementation of health technology assessment (HTA) is still in an early stage with some heterogeneity in the Middle East and North Africa (MENA). Our objective was to assess the current and future status of HTA implementation in the...

Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways.

Journal of lipid research

Bugajev V, Paulenda T, Utekal P, Mrkacek M, Halova I, Kuchar L, Kuda O, Vavrova P, Schuster B, Fuentes-Liso S, Potuckova L, Smrz D, Cernohouzova S, Draberova L, Bambouskova M, Draber P.
PMID: 34560079
J Lipid Res. 2021 Sep 21;100121. doi: 10.1016/j.jlr.2021.100121. Epub 2021 Sep 21.

Leukotrienes and sphingolipids are critical lipid mediators participating in numerous cellular signal transduction events and developing various disorders, such as bronchial hyperactivity leading to asthma. Enzymatic reactions initiating production of these lipid mediators involve 5-lipoxygenase (5-LO)-mediated conversion of arachidonic...

Showing 1 to 12 of 54 entries