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Showing 1 to 12 of 27 entries
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Add-on cannabidiol in patients with Dravet syndrome: Results of a long-term open-label extension trial.

Epilepsia

Scheffer IE, Halford JJ, Miller I, Nabbout R, Sanchez-Carpintero R, Shiloh-Malawsky Y, Wong M, Zolnowska M, Checketts D, Dunayevich E, Devinsky O.
PMID: 34406656
Epilepsia. 2021 Oct;62(10):2505-2517. doi: 10.1111/epi.17036. Epub 2021 Aug 18.

OBJECTIVE: Add-on cannabidiol (CBD) reduced seizures associated with Dravet syndrome (DS) in two randomized, double-blind, placebo-controlled trials: GWPCARE1 Part B (NCT02091375) and GWPCARE2 (NCT02224703). Patients who completed GWPCARE1 Part A (NCT02091206) or Part B, or GWPCARE2, were enrolled in...

Evaluation of spin in the abstracts of orthopedic trauma literature: A cross-sectional review.

Injury

Shepard S, Checketts J, Eash C, Austin J, Arthur W, Wayant C, Johnson M, Norris B, Vassar M.
PMID: 34020782
Injury. 2021 May 06;1709-1714. doi: 10.1016/j.injury.2021.04.060. Epub 2021 May 06.

OBJECTIVES: A cross-sectional analysis of orthopedic trauma randomized controlled trial (RCT) abstracts to assess the frequency and manifestations of spin, the misrepresentation or distortion of research findings, in orthopedic trauma clinical trials.METHODS: The top 5 orthopedic trauma journals were...

Long-term safety and efficacy of add-on cannabidiol in patients with Lennox-Gastaut syndrome: Results of a long-term open-label extension trial.

Epilepsia

Patel AD, Mazurkiewicz-Bełdzińska M, Chin RF, Gil-Nagel A, Gunning B, Halford JJ, Mitchell W, Scott Perry M, Thiele EA, Weinstock A, Dunayevich E, Checketts D, Devinsky O.
PMID: 34287833
Epilepsia. 2021 Sep;62(9):2228-2239. doi: 10.1111/epi.17000. Epub 2021 Jul 20.

OBJECTIVE: Lennox-Gastaut syndrome (LGS) is an epileptic encephalopathy that is often treatment resistant. Efficacy and safety of add-on cannabidiol (CBD) to treat seizures associated with LGS was demonstrated in two randomized controlled trials (RCTs). Patients who completed the RCTs...

An Analysis of the Evidence Underpinning the American Academy Orthopaedic Surgery Pediatrics Clinical Practice Guidelines.

Journal of pediatric orthopedics

Batioja KLE, Nguyen T, Anderson JM, Detweiler B, Checketts J, Torgerson T, Hartwell M, Vassar M.
PMID: 34739437
J Pediatr Orthop. 2021 Nov 04; doi: 10.1097/BPO.0000000000002002. Epub 2021 Nov 04.

BACKGROUND: Randomized control trials (RCTs) serve as evidentiary support for recommendations underpinning clinical practice guidelines (CPGs) with the goal of optimizing patient care. A knowledge gap exists within scientific literature when evaluating the quality of RCTs used as evidence...

Evaluation of spin in the abstracts of systematic reviews and meta-analyses related to the treatment of proximal humerus fractures.

Journal of shoulder and elbow surgery

Jones C, Rulon Z, Arthur W, Ottwell R, Checketts J, Detweiler B, Calder M, Adil A, Hartwell M, Wright DN, Vassar M.
PMID: 33482369
J Shoulder Elbow Surg. 2021 Jan 19;2197-2205. doi: 10.1016/j.jse.2020.11.026. Epub 2021 Jan 19.

BACKGROUND: Research has shown that many physicians rely solely on abstracts to make clinical decisions. However, many abstracts have been shown to be misleading. The primary objective of this study was to identify the prevalence of spin - bias...

Analyzing Spin in Abstracts of Orthopaedic Randomized Controlled Trials with Statistically Insignificant Primary Endpoints.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

Arthur W, Zaaza Z, Checketts JX, Johnson AL, Middlemist K, Basener C, Jellison S, Wayant C, Vassar M.
PMID: 31954806
Arthroscopy. 2020 Jan 16;1443-1450.e1. doi: 10.1016/j.arthro.2019.12.025. Epub 2020 Jan 16.

PURPOSE: Our primary aim of our study is to evaluate the prevalence of spin among abstracts in orthopaedic randomized controlled trials (RCTs) with nonsignificant primary endpoints.METHODS: This study was conducted in accordance with a previously written protocol publicly available...

Intraneural Synovial Cyst of the Common Peroneal Nerve: An Unusual Cause of Foot Drop with Four-Year Follow-Up.

Case reports in orthopedics

Adil A, Basener C, Checketts J.
PMID: 31467755
Case Rep Orthop. 2019 Aug 05;2019:8045252. doi: 10.1155/2019/8045252. eCollection 2019.

In our case report, we describe a 55-year-old male patient with isolated foot drop due to an intraneural synovial ganglion. We successfully treated the lesion with decompression via epineurotomy combined with primary division of the recurrent articular branch of...

Ten years later: a review of the US 2009 institute of medicine report on conflicts of interest and solutions for further reform.

BMJ evidence-based medicine

Torgerson T, Wayant C, Cosgrove L, Akl EA, Checketts J, Dal Re R, Gill J, Grover SC, Khan N, Khan R, Marušić A, McCoy MS, Mitchell A, Prasad V, Vassar M.
PMID: 33177167
BMJ Evid Based Med. 2020 Nov 11; doi: 10.1136/bmjebm-2020-111503. Epub 2020 Nov 11.

Conflicts of interest (COIs) in healthcare are increasingly discussed in the literature, yet these relationships continue to influence healthcare. Research has consistently shown that financial COIs shape prescribing practices, medical education and guideline recommendations. In 2009, the Institute of...

Increased Bite Distance From the Edge Lowers Risk of Pullout of Simple Sutures from Acellular Dermal Allograft.

Arthroscopy, sports medicine, and rehabilitation

Hanson CD, Thompson JC, Checketts JX, Beason DP, Pille C, Lemak L.
PMID: 34712988
Arthrosc Sports Med Rehabil. 2021 Aug 27;3(5):e1513-e1516. doi: 10.1016/j.asmr.2021.06.015. eCollection 2021 Oct.

PURPOSE: To investigate whether pullout strength in the acellular dermal allograft matrix (ADM) used for superior capsule reconstruction depends on the distance from the edge of the graft.METHODS: ADM used for superior capsule reconstruction was obtained and cut into...

Time to onset of cannabidiol treatment effects in Dravet syndrome: Analysis from two randomized controlled trials.

Epilepsia

Madan Cohen J, Checketts D, Dunayevich E, Gunning B, Hyslop A, Madhavan D, Villanueva V, Zolnowska M, Zuberi SM.
PMID: 34265088
Epilepsia. 2021 Sep;62(9):2218-2227. doi: 10.1111/epi.16974. Epub 2021 Jul 15.

OBJECTIVE: We conducted a post hoc analysis of two randomized controlled trials, GWPCARE1 (NCT02091375) and GWPCARE2 (NCT02224703), to estimate the time to onset of cannabidiol (CBD) treatment effects (seizure reduction and adverse events [AEs]) in patients with Dravet syndrome...

Add-on Cannabidiol Treatment for Drug-Resistant Seizures in Tuberous Sclerosis Complex: A Placebo-Controlled Randomized Clinical Trial.

JAMA neurology

Thiele EA, Bebin EM, Bhathal H, Jansen FE, Kotulska K, Lawson JA, O'Callaghan FJ, Wong M, Sahebkar F, Checketts D, Knappertz V.
PMID: 33346789
JAMA Neurol. 2021 Mar 01;78(3):285-292. doi: 10.1001/jamaneurol.2020.4607.

IMPORTANCE: Efficacy of cannabidiol has been demonstrated in seizures associated with Lennox-Gastaut and Dravet syndromes but appears not yet to have been established in conditions with primarily focal seizures, such as tuberous sclerosis complex (TSC).OBJECTIVE: To evaluate efficacy and...

An Analysis of the Evidence Underpinning the American Academy Orthopaedic Surgery Pediatrics Clinical Practice Guidelines.

Journal of pediatric orthopedics

Batioja KLE, Nguyen T, Anderson JM, Detweiler B, Checketts J, Torgerson T, Hartwell M, Vassar M.
PMID: 34739437
J Pediatr Orthop. 2022 Feb 01;42(2):e218-e223. doi: 10.1097/BPO.0000000000002002.

BACKGROUND: Randomized control trials (RCTs) serve as evidentiary support for recommendations underpinning clinical practice guidelines (CPGs) with the goal of optimizing patient care. A knowledge gap exists within scientific literature when evaluating the quality of RCTs used as evidence...

Showing 1 to 12 of 27 entries