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Showing 1 to 12 of 14 entries
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Gene-Editing Technologies Paired With Viral Vectors for Translational Research Into Neurodegenerative Diseases.

Frontiers in molecular neuroscience

Rittiner JE, Moncalvo M, Chiba-Falek O, Kantor B.
PMID: 32903507
Front Mol Neurosci. 2020 Aug 12;13:148. doi: 10.3389/fnmol.2020.00148. eCollection 2020.

Diseases of the central nervous system (CNS) have historically been among the most difficult to treat using conventional pharmacological approaches. This is due to a confluence of factors, including the limited regenerative capacity and overall complexity of the brain,...

Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer's disease brains.

Molecular neurodegeneration

Barrera J, Song L, Gamache JE, Garrett ME, Safi A, Yun Y, Premasinghe I, Sprague D, Chipman D, Li J, Fradin H, Soldano K, Gordân R, Ashley-Koch AE, Crawford GE, Chiba-Falek O.
PMID: 34429139
Mol Neurodegener. 2021 Aug 24;16(1):58. doi: 10.1186/s13024-021-00481-0.

BACKGROUND: In the post-GWAS era, there is an unmet need to decode the underpinning genetic etiologies of late-onset Alzheimer's disease (LOAD) and translate the associations to causation.METHODS: We conducted ATAC-seq profiling using NeuN sorted-nuclei from 40 frozen brain tissues...

Gene Expression Analysis of Neurons and Astrocytes Isolated by Laser Capture Microdissection from Frozen Human Brain Tissues.

Frontiers in molecular neuroscience

Tagliafierro L, Bonawitz K, Glenn OC, Chiba-Falek O.
PMID: 27587997
Front Mol Neurosci. 2016 Aug 18;9:72. doi: 10.3389/fnmol.2016.00072. eCollection 2016.

Different cell types and multiple cellular connections characterize the human brain. Gene expression analysis using a specific population of cells is more accurate than conducting analysis of the whole tissue homogenate, particularly in the context of neurodegenerative diseases, where...

Cell-Type Specific Changes in DNA Methylation of .

Frontiers in neuroscience

Gu J, Barrera J, Yun Y, Murphy SK, Beach TG, Woltjer RL, Serrano GE, Kantor B, Chiba-Falek O.
PMID: 33994928
Front Neurosci. 2021 Apr 28;15:652226. doi: 10.3389/fnins.2021.652226. eCollection 2021.

Parkinson's disease (PD) and dementia with Lewy body (DLB) are the most common synucleinopathies.

Interpreting Gene Expression Effects of Disease-Associated Variants: A Lesson from .

Frontiers in genetics

Glenn OC, Tagliafierro L, Beach TG, Woltjer RL, Chiba-Falek O.
PMID: 28979294
Front Genet. 2017 Sep 20;8:133. doi: 10.3389/fgene.2017.00133. eCollection 2017.

The

Towards precision medicine in Alzheimer's disease: deciphering genetic data to establish informative biomarkers.

Expert review of precision medicine and drug development

Chiba-Falek O, Lutz MW.
PMID: 28944295
Expert Rev Precis Med Drug Dev. 2017;2(1):47-55. doi: 10.1080/23808993.2017.1286227. Epub 2017 Feb 01.

EXPERT COMMENTARY: Deciphering the precise causal genetic-variants within LOAD-GWAS regions will advance the development of genetic-biomarkers to complement and refine the

Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

Nature communications

Davies G, Lam M, Harris SE, Trampush JW, Luciano M, Hill WD, Hagenaars SP, Ritchie SJ, Marioni RE, Fawns-Ritchie C, Liewald DCM, Okely JA, Ahola-Olli AV, Barnes CLK, Bertram L, Bis JC, Burdick KE, Christoforou A, DeRosse P, Djurovic S, Espeseth T, Giakoumaki S, Giddaluru S, Gustavson DE, Hayward C, Hofer E, Ikram MA, Karlsson R, Knowles E, Lahti J, Leber M, Li S, Mather KA, Melle I, Morris D, Oldmeadow C, Palviainen T, Payton A, Pazoki R, Petrovic K, Reynolds CA, Sargurupremraj M, Scholz M, Smith JA, Smith AV, Terzikhan N, Thalamuthu A, Trompet S, van der Lee SJ, Ware EB, Windham BG, Wright MJ, Yang J, Yu J, Ames D, Amin N, Amouyel P, Andreassen OA, Armstrong NJ, Assareh AA, Attia JR, Attix D, Avramopoulos D, Bennett DA, Böhmer AC, Boyle PA, Brodaty H, Campbell H, Cannon TD, Cirulli ET, Congdon E, Conley ED, Corley J, Cox SR, Dale AM, Dehghan A, Dick D, Dickinson D, Eriksson JG, Evangelou E, Faul JD, Ford I, Freimer NA, Gao H, Giegling I, Gillespie NA, Gordon SD, Gottesman RF, Griswold ME, Gudnason V, Harris TB, Hartmann AM, Hatzimanolis A, Heiss G, Holliday EG, Joshi PK, Kähönen M, Kardia SLR, Karlsson I, Kleineidam L, Knopman DS, Kochan NA, Konte B, Kwok JB, Le Hellard S, Lee T, Lehtimäki T, Li SC, Lill CM, Liu T, Koini M, London E, Longstreth WT, Lopez OL, Loukola A, Luck T, Lundervold AJ, Lundquist A, Lyytikäinen LP, Martin NG, Montgomery GW, Murray AD, Need AC, Noordam R, Nyberg L, Ollier W, Papenberg G, Pattie A, Polasek O, Poldrack RA, Psaty BM, Reppermund S, Riedel-Heller SG, Rose RJ, Rotter JI, Roussos P, Rovio SP, Saba Y, Sabb FW, Sachdev PS, Satizabal CL, Schmid M, Scott RJ, Scult MA, Simino J, Slagboom PE, Smyrnis N, Soumaré A, Stefanis NC, Stott DJ, Straub RE, Sundet K, Taylor AM, Taylor KD, Tzoulaki I, Tzourio C, Uitterlinden A, Vitart V, Voineskos AN, Kaprio J, Wagner M, Wagner H, Weinhold L, Wen KH, Widen E, Yang Q, Zhao W, Adams HHH, Arking DE, Bilder RM, Bitsios P, Boerwinkle E, Chiba-Falek O, Corvin A, De Jager PL, Debette S, Donohoe G, Elliott P, Fitzpatrick AL, Gill M, Glahn DC, Hägg S, Hansell NK, Hariri AR, Ikram MK, Jukema JW, Vuoksimaa E, Keller MC, Kremen WS, Launer L, Lindenberger U, Palotie A, Pedersen NL, Pendleton N, Porteous DJ, Räikkönen K, Raitakari OT, Ramirez A, Reinvang I, Rudan I, Dan Rujescu, Schmidt R, Schmidt H, Schofield PW, Schofield PR, Starr JM, Steen VM, Trollor JN, Turner ST, Van Duijn CM, Villringer A, Weinberger DR, Weir DR, Wilson JF, Malhotra A, McIntosh AM, Gale CR, Seshadri S, Mosley TH, Bressler J, Lencz T, Deary IJ.
PMID: 31043617
Nat Commun. 2019 May 01;10(1):2068. doi: 10.1038/s41467-019-10160-w.

Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article.

The Landscape of .

Frontiers in genetics

Tseng E, Rowell WJ, Glenn OC, Hon T, Barrera J, Kujawa S, Chiba-Falek O.
PMID: 31338105
Front Genet. 2019 Jul 09;10:584. doi: 10.3389/fgene.2019.00584. eCollection 2019.

Dysregulation of alpha-synuclein expression has been implicated in the pathogenesis of synucleinopathies, in particular Parkinson's Disease (PD) and Dementia with Lewy bodies (DLB). Previous studies have shown that the alternatively spliced isoforms of the SNCA gene are differentially expressed...

Cell-Type Specific Changes in DNA Methylation of .

Frontiers in neuroscience

Gu J, Barrera J, Yun Y, Murphy SK, Beach TG, Woltjer RL, Serrano GE, Kantor B, Chiba-Falek O.
PMID: 33994928
Front Neurosci. 2021 Apr 28;15:652226. doi: 10.3389/fnins.2021.652226. eCollection 2021.

Parkinson's disease (PD) and dementia with Lewy body (DLB) are the most common synucleinopathies.

Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer's disease brains.

Molecular neurodegeneration

Barrera J, Song L, Gamache JE, Garrett ME, Safi A, Yun Y, Premasinghe I, Sprague D, Chipman D, Li J, Fradin H, Soldano K, Gordân R, Ashley-Koch AE, Crawford GE, Chiba-Falek O.
PMID: 34429139
Mol Neurodegener. 2021 Aug 24;16(1):58. doi: 10.1186/s13024-021-00481-0.

BACKGROUND: In the post-GWAS era, there is an unmet need to decode the underpinning genetic etiologies of late-onset Alzheimer's disease (LOAD) and translate the associations to causation.METHODS: We conducted ATAC-seq profiling using NeuN sorted-nuclei from 40 frozen brain tissues...

The Role of Upregulated APOE in Alzheimer's Disease Etiology.

Journal of Alzheimer's disease & Parkinsonism

Gottschalk WK, Mihovilovic M, Roses AD, Chiba-Falek O.
PMID: 27104063
J Alzheimers Dis Parkinsonism. 2016 Mar;6(1). doi: 10.4172/2161-0460.1000209. Epub 2016 Feb 09.

No abstract available.

The Broad Impact of TOM40 on Neurodegenerative Diseases in Aging.

Journal of Parkinson's disease and Alzheimer's disease

Gottschalk WK, Lutz MW, He YT, Saunders AM, Burns DK, Roses AD, Chiba-Falek O.
PMID: 25745640
J Parkinsons Dis Alzheimers Dis. 2014 Nov;1(1). doi: 10.13188/2376-922X.1000003.

Mitochondrial dysfunction is an important factor in the pathogenesis of age-related diseases, including neurodegenerative diseases like Alzheimer's and Parkinson's spectrum disorders. A polymorphism in Translocase of the Outer Mitochondrial Membrane - 40 kD (

Showing 1 to 12 of 14 entries