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Novel Multitarget Hydroxamic Acids with a Natural Origin CAP Group against Alzheimer's Disease: Synthesis, Docking and Biological Evaluation.

Pharmaceutics

Neganova M, Aleksandrova Y, Suslov E, Mozhaitsev E, Munkuev A, Tsypyshev D, Chicheva M, Rogachev A, Sukocheva O, Volcho K, Klochkov S.
PMID: 34834312
Pharmaceutics. 2021 Nov 08;13(11). doi: 10.3390/pharmaceutics13111893.

Hydroxamic acids are one of the most promising and actively studied classes of chemical compounds in medicinal chemistry. In this study, we describe the directed synthesis and effects of HDAC6 inhibitors. Fragments of adamantane and natural terpenes camphane and...

Impact of Restrictive Measures during the Covid-19 Pandemic on Aerosol Pollution of the Atmosphere of the Moscow Megalopolis.

Herald of the Russian Academy of Sciences

Popovicheva OB, Chichaeva MA, Kasimov NS.
PMID: 34131373
Her Russ Acad Sci. 2021;91(2):213-222. doi: 10.1134/S1019331621020131. Epub 2021 Jun 10.

The COVID-19 pandemic has led to self-isolation and business interruptions around the world. On the basis of measurements of concentrations of an indicator of aerosol emissions from fuel combustion products-black carbon-it is shown that the decrease in economic activity...

Mitochondrial diseases caused by mtDNA mutations: a mini-review.

Therapeutics and clinical risk management

Ryzhkova AI, Sazonova MA, Sinyov VV, Galitsyna EV, Chicheva MM, Melnichenko AA, Grechko AV, Postnov AY, Orekhov AN, Shkurat TP.
PMID: 30349272
Ther Clin Risk Manag. 2018 Oct 09;14:1933-1942. doi: 10.2147/TCRM.S154863. eCollection 2018.

There are several types of mitochondrial cytopathies, which cause a set of disorders, arise as a result of mitochondria's failure. Mitochondria's functional disruption leads to development of physical, growing and cognitive disabilities and includes multiple organ pathologies, essentially disturbing...

Showing 1 to 3 of 3 entries