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Showing 1 to 12 of 303 entries
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Benzydamine oral spray inhibiting parasympathetic function of tracheal smooth muscle.

Clinical and experimental otorhinolaryngology

Wang HW, Chao PZ, Lee FP, Wang JY.
PMID: 25729498
Clin Exp Otorhinolaryngol. 2015 Mar;8(1):65-8. doi: 10.3342/ceo.2015.8.1.65. Epub 2015 Feb 03.

OBJECTIVES: Benzydamine is a nonsteroidal anti-inflammatory agents agent with anti-inflammatory and local anesthesia properties that is available in the entire world as an oral spray for oral mucositis patients who are suffering from radiation effects. The effect of benzydamine...

Genome Sequence of Parvimonas micra Strain A293, Isolated from an Abdominal Abscess from a Patient in the United Kingdom.

Genome announcements

Ang MY, Dymock D, Tan JL, Thong MH, Tan QK, Wong GJ, Paterson IC, Choo SW.
PMID: 24309744
Genome Announc. 2013 Dec 05;1(6). doi: 10.1128/genomeA.01025-13.

Parvimonas micra is an important oral microbe that has the ability to grow and proliferate within oral biofilms and is involved in periodontal disease, leading to gingival bleeding, gingival recession, alveolar bone loss, and tooth mobility. However, occasionally these...

Erratum: Overexpression of neuropeptide Y in the dorsomedial hypothalamus causes hyperphagia and obesity in rats.

Obesity (Silver Spring, Md.)

Zheng F, Kim YJ, Chao PT, Bi S.
PMID: 27028285
Obesity (Silver Spring). 2016 Apr;24(4):977. doi: 10.1002/oby.21469. Epub 2016 Mar 14.

No abstract available.

Synthesis of 1,4-amino alcohols by Grignard reagent addition to THF and N-tosyliminobenzyliodinane.

Organic & biomolecular chemistry

Tejo C, See YF, Mathiew M, Chan PW.
PMID: 26626538
Org Biomol Chem. 2016 Jan 21;14(3):844-8. doi: 10.1039/c5ob02302e. Epub 2015 Dec 02.

The synthesis of 1,4-amino alcohols from THF treated with N-tosyliminobenzyliodinane (PhINTs) followed by a Grignard reagent under mild reaction conditions at room temperature is described herein. Various Grignard reagents were shown to be compatible, furnishing the corresponding 4-substituted-N-1,4-tosylamino alcohols...

Silver-Catalyzed 1,3-Acyloxy Migration/Diels-Alder Reaction of 1,9-Dien-4-yne Esters to Partially Hydrogenated Isoquinolines.

The Journal of organic chemistry

Zhao Y, Jin J, Boyle JW, Lee BR, Day DP, Susanti D, Clarkson GJ, Chan PW.
PMID: 28225621
J Org Chem. 2017 Mar 17;82(6):2826-2834. doi: 10.1021/acs.joc.7b00048. Epub 2017 Mar 07.

A synthetic method to prepare partially hydrogenated isoquinolines efficiently from silver-mediated [3,3]-sigmatropic rearrangement/Diels-Alder reaction of 1,9-dien-4-yne esters is described. The reactions were shown to be robust with a wide variety of substitution patterns tolerated to provide the corresponding nitrogen-containing...

Inhibitive effects of mulberry leaf-related extracts on cell adhesion and inflammatory response in human aortic endothelial cells.

Evidence-based complementary and alternative medicine : eCAM

Chao PY, Lin KH, Chiu CC, Yang YY, Huang MY, Yang CM.
PMID: 24371453
Evid Based Complement Alternat Med. 2013;2013:267217. doi: 10.1155/2013/267217. Epub 2013 Nov 28.

Effects of mulberry leaf-related extracts (MLREs) on hydrogen peroxide-induced DNA damage in human lymphocytes and on inflammatory signaling pathways in human aortic endothelial cells (HAECs) were studied. The tested MLREs were rich in flavonols, especially bombyx faces tea (BT)...

Gold-catalyzed cycloisomerization of 1,6,8-dienyne carbonates and esters to cis-cyclohepta-4,8-diene-fused pyrrolidines.

Chemistry (Weinheim an der Bergstrasse, Germany)

Rao W, Sally, Berry SN, Chan PW.
PMID: 25113644
Chemistry. 2014 Oct 06;20(41):13174-80. doi: 10.1002/chem.201402500. Epub 2014 Aug 11.

A synthetic approach that provides access to cis-cyclohepta-4,8-diene-fused pyrrolidines efficiently through Au(I) -catalyzed cycloisomerization of 1,6,8-dienyne carbonates and esters at a low catalyst loading of 2 mol % is reported. Starting carbonates and esters with a pendant alkyl group...

NeisseriaBase: a specialised Neisseria genomic resource and analysis platform.

PeerJ

Zheng W, Mutha NV, Heydari H, Dutta A, Siow CC, Jakubovics NS, Wee WY, Tan SY, Ang MY, Wong GJ, Choo SW.
PMID: 27017950
PeerJ. 2016 Mar 17;4:e1698. doi: 10.7717/peerj.1698. eCollection 2016.

Background. The gram-negative Neisseria is associated with two of the most potent human epidemic diseases: meningococcal meningitis and gonorrhoea. In both cases, disease is caused by bacteria colonizing human mucosal membrane surfaces. Overall, the genus shows great diversity and...

Thrombolytic Therapy Using Urokinase for Management of Central Venous Catheter Thrombosis.

Vascular specialist international

Son JT, Min SY, Kim JI, Choi PW, Heo TG, Lee MS, Kim CN, Kim HY, Yi SY, Lee HR, Roh YN.
PMID: 26217634
Vasc Specialist Int. 2014 Dec;30(4):144-50. doi: 10.5758/vsi.2014.30.4.144. Epub 2014 Dec 31.

PURPOSE: The management of central venous catheters (CVCs) and catheter thrombosis vary among centers, and the efficacy of the methods of management of catheter thrombosis in CVCs is rarely reported. We investigated the efficacy of bedside thrombolysis with urokinase...

Study of substrate dependence on the chemoselectivity of the gold-catalysed cycloisomerisation of aryl substituted 1,7-enynes.

Organic & biomolecular chemistry

Huang C, Kothandaraman P, Koh BQ, Chan PW.
PMID: 23086455
Org Biomol Chem. 2012 Dec 07;10(45):9067-78. doi: 10.1039/c2ob26458g. Epub 2012 Oct 22.

The effects of starting material substitution patterns on reaction selectivity for the gold(I)-catalysed cycloisomerisations of aryl substituted 1,7-enynes were investigated. The results indicated the chemoselectivity of the reaction to be highly substrate and catalyst dependent. Either the piperidine or...

Roles of cofactors and chromatin accessibility in Hox protein target specificity.

Epigenetics & chromatin

Beh CY, El-Sharnouby S, Chatzipli A, Russell S, Choo SW, White R.
PMID: 26753000
Epigenetics Chromatin. 2016 Jan 08;9:1. doi: 10.1186/s13072-015-0049-x. eCollection 2016.

BACKGROUND: The regulation of specific target genes by transcription factors is central to our understanding of gene network control in developmental and physiological processes yet how target specificity is achieved is still poorly understood. This is well illustrated by...

Gold(III) porphyrin-catalyzed cycloisomerization of allenones.

Organic letters

Zhou CY, Chan PW, Che CM.
PMID: 16408906
Org Lett. 2006 Jan 19;8(2):325-8. doi: 10.1021/ol052696c.

[reaction: see text] Gold(III) porphyrin-catalyzed cycloisomerization of allenones gave the corresponding furans in good to excellent yields (up to 98%) and with quantitative substrate conversions. By recovering the Au(III) catalyst, a recyclable catalytic system is developed with over 8300...

Showing 1 to 12 of 303 entries