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Showing 1 to 12 of 146 entries
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The effects of tetrahydrobiopterin (BH4) treatment on brain function in individuals with phenylketonuria.

NeuroImage. Clinical

Christ SE, Moffitt AJ, Peck D, White DA.
PMID: 24371792
Neuroimage Clin. 2013 Aug 30;3:539-47. doi: 10.1016/j.nicl.2013.08.012. eCollection 2013.

Phenylketonuria (PKU) is a rare genetic condition characterized by an absence or mutation of the PAH enzyme, which is necessary for the metabolism of the amino acid phenylalanine into tyrosine. Recently, sapropterin dihydrochloride, a synthetic form of tetrahydrobiopterin (BH4),...

Impact of Melatonin on Zeitgeber Time-Dependent Changes in Cell Proliferation and Apoptosis in the Adult Murine Hypothalamic-Hypophyseal System.

Neuroendocrinology

Fredrich M, Christ E, Derouiche A, Korf HW.
PMID: 26044072
Neuroendocrinology. 2015;102(4):311-326. doi: 10.1159/000433440. Epub 2015 May 29.

BACKGROUND/AIMS: Cell proliferation and apoptosis are known to adjust neuroendocrine circuits to the photoperiod. The latter is communicated by melatonin, the hormone secreted by the pineal organ. The present study investigated zeitgeber time (ZT)-dependent changes in cell proliferation and...

A Unimodal Model for Double Observer Distance Sampling Surveys.

PloS one

Becker EF, Christ AM.
PMID: 26317984
PLoS One. 2015 Aug 28;10(8):e0136403. doi: 10.1371/journal.pone.0136403. eCollection 2015.

Distance sampling is a widely used method to estimate animal population size. Most distance sampling models utilize a monotonically decreasing detection function such as a half-normal. Recent advances in distance sampling modeling allow for the incorporation of covariates into...

Correction to Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity.

Journal of medicinal chemistry

Bruncko M, Wang L, Sheppard GS, Phillips DC, Tahir SK, Xue J, Erickson S, Fidanze S, Fry E, Hasvold L, Jenkins GJ, Jin S, Judge RA, Kovar PJ, Madar D, Nimmer P, Park C, Petros AM, Rosenberg SH, Smith ML, Song X, Sun C, Tao ZF, Wang X, Xiao Y, Zhang H, Tse C, Leverson JD, Elmore SW, Souers AJ.
PMID: 25933255
J Med Chem. 2015 May 14;58(9):4089. doi: 10.1021/acs.jmedchem.5b00616. Epub 2015 May 01.

No abstract available.

Chemical potential of water from measurements of optic axial angle of zeolites.

Science (New York, N.Y.)

Eberlein GD, Christ CL.
PMID: 17746822
Science. 1968 Dec 06;162(3858):1145-6. doi: 10.1126/science.162.3858.1145.

Values of the uncorrected optic axial angle (2H(alpha)) of a crystal of the calcium zeolite stellerite (CaAl(2)Si(7)O(l8) . 7H(2)0) immersed in calcium chloride solutions of known activity of water (a(w)) are directly proportional to log a(w). A general relationship...

Role of flavanols in yellowing beech trees of the Black Forest.

Tree physiology

Feucht W, Treutter D, Christ E.
PMID: 14759857
Tree Physiol. 1997 May;17(5):335-40. doi: 10.1093/treephys/17.5.335.

Beech leaves were sampled at the end of a prolonged hot dry period at a tree decline site in the Black Forest, Germany to investigate the potential role of flavanols in defense mechanisms against environmental stress. Green and yellowing...

Effects of Speed, Hip and Knee Angle, and Gravity-on Hamstring to Quadriceps Torque Ratios.

The Journal of orthopaedic and sports physical therapy

Figoni SF, Christ CB, Massey BH.
PMID: 18796996
J Orthop Sports Phys Ther. 1988;9(8):287-91. doi: 10.2519/jospt.1988.9.8.287.

The purpose of this study was to determine the effects of speed, hip angle, knee angle, and gravity on hamstring to quadriceps (H/Q) torque ratios. Eighteen healthy college-aged men performed three maximal-effort knee extension and flexion repetitions on a...

Activity coefficients of aqueous potassium chloride measured with a potassium-sensitive glass electrode.

Science (New York, N.Y.)

Hostetler PB, Truesdell AH, Christ CL.
PMID: 17830046
Science. 1967 Mar 24;155(3769):1537-9. doi: 10.1126/science.155.3769.1537.

Values of gamma(+/-KCl) over temperature and molality ranges of 10 degrees to 50 degrees C and 0.01 to 1.0 molal were determined with an electromotive-force cell: potas sium-sensitive glass electrode, KCl (molality), Ag-AgCl. A more satisfactory method than is...

Multiple free energies from a single simulation: extending enveloping distribution sampling to nonoverlapping phase-space distributions.

The Journal of chemical physics

Christ CD, van Gunsteren WF.
PMID: 18465915
J Chem Phys. 2008 May 07;128(17):174112. doi: 10.1063/1.2913050.

A recently proposed method to obtain free energy differences for multiple end states from a single simulation of a reference state which was called enveloping distribution sampling (EDS) [J. Chem. Phys. 126, 184110 (2007)] is expanded to situations where...

Dyslipidaemia in Adult Growth Hormone (GH) Deficiency and the Effect of GH Replacement Therapy: A Review.

Trends in endocrinology and metabolism: TEM

Christ ER, Cummings MH, Russell-Jones DL.
PMID: 18406266
Trends Endocrinol Metab. 1998 Jul;9(5):200-6. doi: 10.1016/s1043-2760(98)00050-2.

Adult growth hormone (GH) deficiency is associated with a lipid profile known to be related to atherosclerosis. GH replacement therapy improves the lipid profile with the exception of lipoprotein (a) concentrations, which tend to increase after GH therapy. Plasma...

Advances in Patellofemoral Arthroplasty.

Current reviews in musculoskeletal medicine

Strickland SM, Bird ML, Christ AB.
PMID: 29721690
Curr Rev Musculoskelet Med. 2018 Jun;11(2):221-230. doi: 10.1007/s12178-018-9477-0.

PURPOSE OF REVIEW: To describe current indications, implants, economic benefits, comparison to TKA, and functional and patient-reported outcomes of patellofemoral arthroplasty.RECENT FINDINGS: Modern onlay implants and improved patient selection have allowed for recent improvements in short- and long-term outcomes...

Both Reaction Time and Accuracy Measures of Intraindividual Variability Predict Cognitive Performance in Alzheimer's Disease.

Frontiers in human neuroscience

Christ BU, Combrinck MI, Thomas KGF.
PMID: 29686610
Front Hum Neurosci. 2018 Apr 09;12:124. doi: 10.3389/fnhum.2018.00124. eCollection 2018.

Dementia researchers around the world prioritize the urgent need for sensitive measurement tools that can detect cognitive and functional change at the earliest stages of Alzheimer's disease (AD). Sensitive indicators of underlying neural pathology assist in the early detection...

Showing 1 to 12 of 146 entries