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Showing 1 to 12 of 27 entries
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Data on spray-drying processing to optimize the yield of materials sensitive to heat and moisture content.

Data in brief

Magri G, Franzé S, Musazzi UM, Selmin F, Cilurzo F.
PMID: 31372438
Data Brief. 2019 Feb 28;23:103792. doi: 10.1016/j.dib.2019.103792. eCollection 2019 Apr.

Full dataset used to evaluate the spray-drying process parameters on the preparation of a micronized powder made of maltodextrin (MDX) is herein reported. The process parameters (namely, feed flow rate (FFR); inlet temperature (T

Simulation data for an estimation of the maximum theoretical value and confidence interval for the correlation coefficient.

Data in brief

Rocco P, Cilurzo F, Minghetti P, Vistoli G, Pedretti A.
PMID: 28795106
Data Brief. 2017 Jul 23;14:291-294. doi: 10.1016/j.dib.2017.07.045. eCollection 2017 Oct.

The data presented in this article are related to the article titled "Molecular Dynamics as a tool for in silico screening of skin permeability" (Rocco et al., 2017) [1]. Knowledge of the confidence interval and maximum theoretical value of...

Lyophilization of Liposomal Formulations: Still Necessary, Still Challenging.

Pharmaceutics

Franzé S, Selmin F, Samaritani E, Minghetti P, Cilurzo F.
PMID: 30154315
Pharmaceutics. 2018 Aug 28;10(3). doi: 10.3390/pharmaceutics10030139.

Nowadays, the freeze-drying of liposome dispersions is still necessary to provide a solid dosage form intended for different routes of administration (i.e., parenteral, oral, nasal and/or pulmonary). However, after decades of studies the optimization of process conditions remains still...

Pharmacovigilance and drug safety 2011 in Calabria (Italy): Adverse events analysis.

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

Scicchitano F, Giofrè C, Palleria C, Mazzitello C, Ciriaco M, Gallelli L, Paletta L, Marrazzo G, De Fazio S, Menniti M, Curia R, Arena C, Chimirri S, Patanè M, Esposito S, Cilurzo F, Staltari O, Russo E, De Sarro G.
PMID: 23826016
J Res Med Sci. 2012 Sep;17(9):872-5.

BACKGROUND: Pharmacovigilance assesses the safety profile of drugs. Its main aim is the increase of spontaneous reporting of adverse drug reactions (ADRs). The Italian Drug Agency (AIFA; Agenzia Italiana del Farmaco) is financing several projects to the aim of...

Mathematical Models as Tools to Predict the Release Kinetic of Fluorescein from Lyotropic Colloidal Liquid Crystals.

Materials (Basel, Switzerland)

Paolino D, Tudose A, Celia C, Di Marzio L, Cilurzo F, Mircioiu C.
PMID: 30813650
Materials (Basel). 2019 Feb 26;12(5). doi: 10.3390/ma12050693.

In this study, we investigated the release kinetic of fluorescein from colloidal liquid crystals made from monoglyceride and different non-ionic surfactants. The crystals were physicochemically characterized and the release experiments were carried out under the sink conditions, while mathematical...

In Vitro Anticancer Activity of Extracellular Vesicles (EVs) Secreted by Gingival Mesenchymal Stromal Cells Primed with Paclitaxel.

Pharmaceutics

Coccè V, Franzè S, Brini AT, Giannì AB, Pascucci L, Ciusani E, Alessandri G, Farronato G, Cavicchini L, Sordi V, Paroni R, Dei Cas M, Cilurzo F, Pessina A.
PMID: 30717104
Pharmaceutics. 2019 Feb 01;11(2). doi: 10.3390/pharmaceutics11020061.

Interdental papilla are an interesting source of mesenchymal stromal cells (GinPaMSCs), which are easy to isolate and expand in vitro. In our laboratory, GinPaMSCs were isolated, expanded, and characterized by studying their secretome before and after priming with paclitaxel...

Trends in the Characterization Methods of Orodispersible Films.

Current drug delivery

Khalid GM, Selmin F, Musazzi UM, Gennari CGM, Minghetti P, Cilurzo F.
PMID: 33305704
Curr Drug Deliv. 2021 Dec 10;18(7):935-946. doi: 10.2174/1567201818999201210212557.

The recent increased interest in orodispersible films (ODF) stems from their ideal potential to circumvent several pharmacotherapy-related problems, such as improved medication compliance and adherence, especially in children, elderly and uncooperative patients. Their administration is well accepted by the...

Data on the stability of darunavir/cobicistat suspension after tablet manipulation.

Data in brief

Zanon D, Manca A, De Nicolò A, D'Avolio A, Musazzi UM, Cilurzo F, Maximova N, Tomasello C, Minghetti P.
PMID: 32292805
Data Brief. 2020 Apr 12;30:105552. doi: 10.1016/j.dib.2020.105552. eCollection 2020 Jun.

The COVID-19 outbreak is now one of the most critical crises to manage for most of the national healthcare systems in the world. In the absence of authorised pharmacological treatments, many antiretrovirals, including darunavir/cobicistat fixed combination, are used off-label...

Pharmaceutics

Hasa D, Žakelj S, Grabnar I, Cilurzo F, Dall'Acqua S, Riva A, Perissutti B, Voinovich D.
PMID: 33207557
Pharmaceutics. 2020 Nov 16;12(11). doi: 10.3390/pharmaceutics12111096.

Dodeca-2

Preserving the Integrity of Liposomes Prepared by Ethanol Injection upon Freeze-Drying: Insights from Combined Molecular Dynamics Simulations and Experimental Data.

Pharmaceutics

Franzè S, Selmin F, Rocco P, Colombo G, Casiraghi A, Cilurzo F.
PMID: 32526935
Pharmaceutics. 2020 Jun 09;12(6). doi: 10.3390/pharmaceutics12060530.

The freeze-drying of complex formulations, such as liposomes, is challenging, particularly if dispersions contain residual organic solvents. This work aimed to investigate the effects of possible protectants, namely sucrose, trehalose and/or poly(vinyl pyrrolidone) (PVP), on the main features of...

Nexavar(®)-related adverse reactions: Calabrian (Italy) experience for sorafenib exposition in 2012.

Journal of pharmacology & pharmacotherapeutics

Cilurzo F, Staltari O, Patanè M, Ammendola M, Garaffo C, Di Paola ED.
PMID: 24347990
J Pharmacol Pharmacother. 2013 Dec;4:S86-9. doi: 10.4103/0976-500X.120971.

Hepatocellular carcinoma (HCC) remains a major global health problem and Calabria in the south of Italy is not an exception. Sorafenib is the first and only Food and Drug Administration approved drug for the treatment of advanced HCC and...

Tendon Tissue Repair in Prospective of Drug Delivery, Regenerative Medicines, and Innovative Bioscaffolds.

Stem cells international

Hafeez MN, d'Avanzo N, Russo V, Di Marzio L, Cilurzo F, Paolino D, Fresta M, Barboni B, Santos HA, Celia C.
PMID: 34824586
Stem Cells Int. 2021 Nov 16;2021:1488829. doi: 10.1155/2021/1488829. eCollection 2021.

The natural healing capacity of the tendon tissue is limited due to the hypovascular and cellular nature of this tissue. So far, several conventional approaches have been tested for tendon repair to accelerate the healing process, but all these...

Showing 1 to 12 of 27 entries