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Showing 1 to 12 of 406 entries
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Long-term management of natalizumab discontinuation in a large monocentric cohort of multiple sclerosis patients.

Multiple sclerosis and related disorders

Sangalli F, Moiola L, Ferrè L, Radaelli M, Barcella V, Rodegher M, Colombo B, Martinelli Boneschi F, Martinelli V, Comi G.
PMID: 25877065
Mult Scler Relat Disord. 2014 Jul;3(4):520-6. doi: 10.1016/j.msard.2014.04.003. Epub 2014 Apr 13.

BACKGROUND: Pivotal and post-marketing studies demonstrated the impressive efficacy and the good tolerability profile of natalizumab in Multiple Sclerosis patients. On the other hand long-term safety of natalizumab therapy is burdened by the risk of progressive multifocal leukoencephalopathy, especially...

Effect of prior treatment status and reasons for discontinuation on the efficacy and safety of fingolimod vs. interferon β-1a intramuscular: Subgroup analyses of the Trial Assessing Injectable Interferon vs. Fingolimod Oral in Relapsing-Remitting Multiple Sclerosis (TRANSFORMS).

Multiple sclerosis and related disorders

Khatri BO, Pelletier J, Kappos L, Hartung HP, Comi G, Barkhof F, von Rosenstiel P, Meng X, Grinspan A, Hashmonay R, Cohen JA.
PMID: 25876473
Mult Scler Relat Disord. 2014 May;3(3):355-63. doi: 10.1016/j.msard.2013.11.006. Epub 2013 Dec 12.

BACKGROUND: Fingolimod demonstrated superior efficacy compared with interferon β-1a intramuscular in relapsing multiple sclerosis. The impact of treatment history on fingolimod efficacy is unknown.OBJECTIVES: This post-hoc analysis of phase 3 TRANSFORMS data compared the efficacy and safety of fingolimod...

A randomized trial of teriflunomide added to glatiramer acetate in relapsing multiple sclerosis.

Multiple sclerosis journal - experimental, translational and clinical

Freedman MS, Wolinsky JS, Truffinet P, Comi G, Kappos L, Miller AE, Olsson TP, Benamor M, Chambers S, O'Connor PW.
PMID: 28607708
Mult Scler J Exp Transl Clin. 2015 Dec 07;1:2055217315618687. doi: 10.1177/2055217315618687. eCollection 2015.

BACKGROUND: Teriflunomide is a once-daily oral immunomodulator for the treatment of relapsing-remitting MS.OBJECTIVE: To evaluate the safety and tolerability of teriflunomide as add-on therapy to a stable dose of glatiramer acetate (GA) in patients with relapsing forms of MS...

Gene therapy rescues disease phenotype in a spinal muscular atrophy with respiratory distress type 1 (SMARD1) mouse model.

Science advances

Nizzardo M, Simone C, Rizzo F, Salani S, Dametti S, Rinchetti P, Del Bo R, Foust K, Kaspar BK, Bresolin N, Comi GP, Corti S.
PMID: 26601156
Sci Adv. 2015 Mar 13;1(2):e1500078. doi: 10.1126/sciadv.1500078. eCollection 2015 Mar.

Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is an autosomal recessive motor neuron disease affecting children. It is caused by mutations in the IGHMBP2 gene (11q13) and presently has no cure. Recently, adeno-associated virus serotype 9 (AAV9)-mediated...

The efficacy of cladribine tablets in CIS patients retrospectively assigned the diagnosis of MS using modern criteria: Results from the ORACLE-MS study.

Multiple sclerosis journal - experimental, translational and clinical

Freedman MS, Leist TP, Comi G, Cree BA, Coyle PK, Hartung HP, Vermersch P, Damian D, Dangond F.
PMID: 29051829
Mult Scler J Exp Transl Clin. 2017 Oct 09;3(4):2055217317732802. doi: 10.1177/2055217317732802. eCollection 2017.

BACKGROUND: Multiple sclerosis (MS) diagnostic criteria have changed since the ORACLE-MS study was conducted; 223 of 616 patients (36.2%) would have met the diagnosis of MS vs clinically isolated syndrome (CIS) using the newer criteria.OBJECTIVE: The objective of this...

HPV Infection in a Cohort of HIV-Positive Men and Women: Prevalence of Oncogenic Genotypes and Predictors of Mucosal Damage at Genital and Oral Sites.

Journal of sexually transmitted diseases

Marchetti G, Comi L, Bini T, Rovati M, Bai F, Cassani B, Ravizza M, Tarozzi M, Pandolfo A, Dalzero S, Opocher E, Romagnoli S, Carrassi A, Bosari S, d'Arminio Monforte A.
PMID: 26316967
J Sex Transm Dis. 2013;2013:915169. doi: 10.1155/2013/915169. Epub 2013 Mar 05.

The aim of this study was to assess the prevalence of HPV infection and determinants of abnormal cytology in HIV-positive patients. In a cross-sectional study, patients of both sexes, asymptomatic for HPV, underwent anorectal (men)/cervical (women) and oral swabs....

Self-management and psychological-sexological interventions in patients with endometriosis: strategies, outcomes, and integration into clinical care.

International journal of women's health

Buggio L, Barbara G, Facchin F, Frattaruolo MP, Aimi G, Berlanda N.
PMID: 28496368
Int J Womens Health. 2017 May 02;9:281-293. doi: 10.2147/IJWH.S119724. eCollection 2017.

Endometriosis has a multifactorial etiology. The onset and progression of the disease are believed to be related to different pathogenic mechanisms. Among them, the environment and lifestyle may play significant roles. Diet, dietary supplements, physical exercise, osteopathy, massage, acupuncture,...

Automatic Learning of Fine Operating Rules for Online Power System Security Control.

IEEE transactions on neural networks and learning systems

Sun H, Zhao F, Wang H, Wang K, Jiang W, Guo Q, Zhang B, Wehenkel L.
PMID: 25680217
IEEE Trans Neural Netw Learn Syst. 2016 Aug;27(8):1708-19. doi: 10.1109/TNNLS.2015.2390621. Epub 2015 Feb 09.

Fine operating rules for security control and an automatic system for their online discovery were developed to adapt to the development of smart grids. The automatic system uses the real-time system state to determine critical flowgates, and then a...

Myeloid cells as target of fingolimod action in multiple sclerosis.

Neurology(R) neuroimmunology & neuroinflammation

Di Dario M, Colombo E, Govi C, De Feo D, Messina MJ, Romeo M, Sangalli F, Moiola L, Rodegher M, Martino G, Martinelli V, Comi G, Farina C.
PMID: 26587553
Neurol Neuroimmunol Neuroinflamm. 2015 Nov 04;2(6):e157. doi: 10.1212/NXI.0000000000000157. eCollection 2015 Dec.

OBJECTIVE: To track the effects of fingolimod, an approved drug for multiple sclerosis (MS), on the activation of myeloid cells from the periphery to the CNS.METHODS: In vitro and ex vivo immunologic studies coupled with flow cytometry were performed...

Residual short-range order in the heavy fermion compound CeInCu2.

Acta crystallographica. Section B, Structural science

Takahashi I, Kagayama A, Oomi G, Onuki Y, Komatsubara T.
PMID: 10927336
Acta Crystallogr B. 1999 Feb 01;55:31-34. doi: 10.1107/s0108768198009860.

By using the X-ray diffraction technique, residual short-range order was detected in CeInCu(2), cerium dicopper indium, which is known to be a heavy fermion compound. In spite of the long-range order of this substance, diffuse scattering exhibiting short-range order...

[Congenital cardiopathy in a data-based population].

Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma

Magnani C, Bussolati G, Gambini L, Garani GP, Bosi G, Cocchi G, Garavelli L, Calzolari E.
PMID: 11424793
Acta Biomed Ateneo Parmense. 2000;71:483-6.

Altogether 429.139 consecutive births were surveyed during the eighteen years study period by the Emilia-Romagna Registry. Among these, 2147 newborns with congenital heart defects (CHD) (prevalence 5 per 1000) were detected within the first week of life. There were...

Measurements of fetal limb bones in early pregnancy.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

Zorzoli A, Kustermann A, Caravelli E, Corso FE, Fogliani R, Aimi G, Nicolini U.
PMID: 12797223
Ultrasound Obstet Gynecol. 1994 Jan 01;4(1):29-33. doi: 10.1046/j.1469-0705.1994.04010029.x.

The fetal humerus, radius/ulna, femur, tibia/fibula and foot were measured in 296 pregnant women at 64-108 days' menstrual age, using vaginal sonography. All limb measurements correlated significantly with gestational age and biparietal diameter independently. Ratios of limb segment lengths...

Showing 1 to 12 of 406 entries