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Potential role for pyruvate kinase M2 in the regulation of murine cardiac glycolytic flux during in vivo chronic hypoxia.

Bioscience reports

Handzlik MK, Tooth DJ, Constantin-Teodosiu D, Greenhaff PL, Cole MA.
PMID: 33973628
Biosci Rep. 2021 Jun 25;41(6). doi: 10.1042/BSR20203170.

Carbohydrate metabolism in heart failure shares similarities to that following hypoxic exposure, and is thought to maintain energy homoeostasis in the face of reduced O2 availability. As part of these in vivo adaptations during sustained hypoxia, the heart up-regulates...

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Handzlik MK, Tooth DJ, Constantin-Teodosiu D, et al. Potential role for pyruvate kinase M2 in the regulation of murine cardiac glycolytic flux during in vivo chronic hypoxia. Biosci Rep. 2021;41(6)doi: 10.1042/BSR20203170.
Handzlik, M. K., Tooth, D. J., Constantin-Teodosiu, D., Greenhaff, P. L., & Cole, M. A. (2021). Potential role for pyruvate kinase M2 in the regulation of murine cardiac glycolytic flux during in vivo chronic hypoxia. Bioscience reports, 41(6), . https://doi.org/10.1042/BSR20203170
Handzlik, Michal K, et al. "Potential role for pyruvate kinase M2 in the regulation of murine cardiac glycolytic flux during in vivo chronic hypoxia." Bioscience reports vol. 41,6 (2021). doi: https://doi.org/10.1042/BSR20203170
Handzlik MK, Tooth DJ, Constantin-Teodosiu D, Greenhaff PL, Cole MA. Potential role for pyruvate kinase M2 in the regulation of murine cardiac glycolytic flux during in vivo chronic hypoxia. Biosci Rep. 2021 Jun 25;41(6). doi: 10.1042/BSR20203170. PMID: 33973628; PMCID: PMC8173528.
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PPARα, δ and FOXO1 Gene Silencing Overturns Palmitate-Induced Inhibition of Pyruvate Oxidation Differentially in C2C12 Myotubes.

Biology

Chien HC, Constantin D, Greenhaff PL, Constantin-Teodosiu D.
PMID: 34827089
Biology (Basel). 2021 Oct 25;10(11). doi: 10.3390/biology10111098.

The molecular mechanisms by which free fatty acids (FFA) inhibit muscle glucose oxidation is still elusive. We recently showed that C2C12 myotubes treated with palmitate (PAL) presented with greater protein expression levels of PDK4 and transcription factors

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Chien HC, Constantin D, Greenhaff PL, et al. PPARα, δ and FOXO1 Gene Silencing Overturns Palmitate-Induced Inhibition of Pyruvate Oxidation Differentially in C2C12 Myotubes. Biology (Basel). 2021;10(11)doi: 10.3390/biology10111098.
Chien, H. C., Constantin, D., Greenhaff, P. L., & Constantin-Teodosiu, D. (2021). PPARα, δ and FOXO1 Gene Silencing Overturns Palmitate-Induced Inhibition of Pyruvate Oxidation Differentially in C2C12 Myotubes. Biology, 10(11), . https://doi.org/10.3390/biology10111098
Chien, Hung-Che, et al. "PPARα, δ and FOXO1 Gene Silencing Overturns Palmitate-Induced Inhibition of Pyruvate Oxidation Differentially in C2C12 Myotubes." Biology vol. 10,11 (2021). doi: https://doi.org/10.3390/biology10111098
Chien HC, Constantin D, Greenhaff PL, Constantin-Teodosiu D. PPARα, δ and FOXO1 Gene Silencing Overturns Palmitate-Induced Inhibition of Pyruvate Oxidation Differentially in C2C12 Myotubes. Biology (Basel). 2021 Oct 25;10(11). doi: 10.3390/biology10111098. PMID: 34827089; PMCID: PMC8614693.
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Degenerin channel activation causes caspase-mediated protein degradation and mitochondrial dysfunction in adult C. elegans muscle.

Journal of cachexia, sarcopenia and muscle

Gaffney CJ, Shephard F, Chu J, Baillie DL, Rose A, Constantin-Teodosiu D, Greenhaff PL, Szewczyk NJ.
PMID: 27493871
J Cachexia Sarcopenia Muscle. 2016 May;7(2):181-92. doi: 10.1002/jcsm.12040. Epub 2015 Jun 04.

BACKGROUND: Declines in skeletal muscle structure and function are found in various clinical populations, but the intramuscular proteolytic pathways that govern declines in these individuals remain relatively poorly understood. The nematode Caenorhabditis elegans has been developed into a model...

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Gaffney CJ, Shephard F, Chu J, et al. Degenerin channel activation causes caspase-mediated protein degradation and mitochondrial dysfunction in adult C. elegans muscle. J Cachexia Sarcopenia Muscle. 2015;7(2):181-92doi: 10.1002/jcsm.12040.
Gaffney, C. J., Shephard, F., Chu, J., Baillie, D. L., Rose, A., Constantin-Teodosiu, D., Greenhaff, P. L., & Szewczyk, N. J. (2016). Degenerin channel activation causes caspase-mediated protein degradation and mitochondrial dysfunction in adult C. elegans muscle. Journal of cachexia, sarcopenia and muscle, 7(2), 181-92. https://doi.org/10.1002/jcsm.12040
Gaffney, Christopher J, et al. "Degenerin channel activation causes caspase-mediated protein degradation and mitochondrial dysfunction in adult C. elegans muscle." Journal of cachexia, sarcopenia and muscle vol. 7,2 (2016): 181-92. doi: https://doi.org/10.1002/jcsm.12040
Gaffney CJ, Shephard F, Chu J, Baillie DL, Rose A, Constantin-Teodosiu D, Greenhaff PL, Szewczyk NJ. Degenerin channel activation causes caspase-mediated protein degradation and mitochondrial dysfunction in adult C. elegans muscle. J Cachexia Sarcopenia Muscle. 2016 May;7(2):181-92. doi: 10.1002/jcsm.12040. Epub 2015 Jun 04. PMID: 27493871; PMCID: PMC4864282.
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Regulation of muscle pyruvate dehydrogenase complex in insulin resistance: effects of exercise and dichloroacetate.

Diabetes & metabolism journal

Constantin-Teodosiu D.
PMID: 24199158
Diabetes Metab J. 2013 Oct;37(5):301-14. doi: 10.4093/dmj.2013.37.5.301.

Since the mitochondrial pyruvate dehydrogenase complex (PDC) controls the rate of carbohydrate oxidation, impairment of PDC activity mediated by high-fat intake has been advocated as a causative factor for the skeletal muscle insulin resistance, metabolic syndrome, and the onset...

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Constantin-Teodosiu D. Regulation of muscle pyruvate dehydrogenase complex in insulin resistance: effects of exercise and dichloroacetate. Diabetes Metab J. 2013;37(5):301-14doi: 10.4093/dmj.2013.37.5.301.
Constantin-Teodosiu, D. (2013). Regulation of muscle pyruvate dehydrogenase complex in insulin resistance: effects of exercise and dichloroacetate. Diabetes & metabolism journal, 37(5), 301-14. https://doi.org/10.4093/dmj.2013.37.5.301
Constantin-Teodosiu, Dumitru. "Regulation of muscle pyruvate dehydrogenase complex in insulin resistance: effects of exercise and dichloroacetate." Diabetes & metabolism journal vol. 37,5 (2013): 301-14. doi: https://doi.org/10.4093/dmj.2013.37.5.301
Constantin-Teodosiu D. Regulation of muscle pyruvate dehydrogenase complex in insulin resistance: effects of exercise and dichloroacetate. Diabetes Metab J. 2013 Oct;37(5):301-14. doi: 10.4093/dmj.2013.37.5.301. PMID: 24199158; PMCID: PMC3816130.
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Whole-body & muscle responses to aerobic exercise training and withdrawal in ageing & COPD.

The European respiratory journal

Latimer LE, Constantin-Teodosiu D, Popat B, Constantin D, Houchen-Wolloff L, Bolton CE, Steiner MC, Greenhaff PL, Harrison JR, Bunford N, Evans SW.
PMID: 34588196
Eur Respir J. 2021 Sep 29; doi: 10.1183/13993003.01507-2021. Epub 2021 Sep 29.

COPD patients exhibit lower peak oxygen consumption (V̇O

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Latimer LE, Constantin-Teodosiu D, Popat B, et al. Whole-body & muscle responses to aerobic exercise training and withdrawal in ageing & COPD. Eur Respir J. 2021;doi: 10.1183/13993003.01507-2021.
Latimer, L. E., Constantin-Teodosiu, D., Popat, B., Constantin, D., Houchen-Wolloff, L., Bolton, C. E., Steiner, M. C., Greenhaff, P. L., Harrison, J. R., Bunford, N., & Evans, S. W. (2021). Whole-body & muscle responses to aerobic exercise training and withdrawal in ageing & COPD. The European respiratory journal, . https://doi.org/10.1183/13993003.01507-2021
Latimer, Lorna E, et al. "Whole-body & muscle responses to aerobic exercise training and withdrawal in ageing & COPD." The European respiratory journal vol. (2021). doi: https://doi.org/10.1183/13993003.01507-2021
Latimer LE, Constantin-Teodosiu D, Popat B, Constantin D, Houchen-Wolloff L, Bolton CE, Steiner MC, Greenhaff PL, Harrison JR, Bunford N, Evans SW. Whole-body & muscle responses to aerobic exercise training and withdrawal in ageing & COPD. Eur Respir J. 2021 Sep 29; doi: 10.1183/13993003.01507-2021. Epub 2021 Sep 29. PMID: 34588196.
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Showing 1 to 5 of 5 entries