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White matter changes in psychosis risk relate to development and are not impacted by the transition to psychosis.

Molecular psychiatry

Di Biase MA, Cetin-Karayumak S, Lyall AE, Zalesky A, Cho KIK, Zhang F, Kubicki M, Rathi Y, Lyons MG, Bouix S, Billah T, Anticevic A, Schleifer C, Adkinson BD, Ji JL, Tamayo Z, Addington J, Bearden CE, Cornblatt BA, Keshavan MS, Mathalon DH, McGlashan TH, Perkins DO, Cadenhead KS, Tsuang MT, Woods SW, Stone WS, Shenton ME, Cannon TD, Pasternak O.
PMID: 34024906
Mol Psychiatry. 2021 Nov;26(11):6833-6844. doi: 10.1038/s41380-021-01128-8. Epub 2021 May 24.

Subtle alterations in white matter microstructure are observed in youth at clinical high risk (CHR) for psychosis. However, the timing of these changes and their relationships to the emergence of psychosis remain unclear. Here, we track the evolution of...

White matter changes in psychosis risk relate to development and are not impacted by the transition to psychosis.

Molecular psychiatry

Di Biase MA, Cetin-Karayumak S, Lyall AE, Zalesky A, Cho KIK, Zhang F, Kubicki M, Rathi Y, Lyons MG, Bouix S, Billah T, Anticevic A, Schleifer C, Adkinson BD, Ji JL, Tamayo Z, Addington J, Bearden CE, Cornblatt BA, Keshavan MS, Mathalon DH, McGlashan TH, Perkins DO, Cadenhead KS, Tsuang MT, Woods SW, Stone WS, Shenton ME, Cannon TD, Pasternak O.
PMID: 34024906
Mol Psychiatry. 2021 Nov;26(11):6833-6844. doi: 10.1038/s41380-021-01128-8. Epub 2021 May 24.

Subtle alterations in white matter microstructure are observed in youth at clinical high risk (CHR) for psychosis. However, the timing of these changes and their relationships to the emergence of psychosis remain unclear. Here, we track the evolution of...

Negative symptoms: associations with defeatist beliefs, self-efficacy, and maladaptive schemas in youth and young adults at-risk for psychosis.

Behavioural and cognitive psychotherapy

Devoe DJ, Cadenhead KS, Cornblatt B, Granholm E, Addington J.
PMID: 34784991
Behav Cogn Psychother. 2021 Nov 17;1-14. doi: 10.1017/S1352465821000461. Epub 2021 Nov 17.

BACKGROUND: Investigations into possible mechanisms that may contribute to the development, maintenance, and exacerbation of negative symptoms are needed. Defeatist beliefs, self-efficacy, and early maladaptive schemas have been shown to contribute to negative symptoms in schizophrenia. Likewise, negative symptoms...

North American Prodrome Longitudinal Study (NAPLS 3): Methods and baseline description.

Schizophrenia research

Addington J, Liu L, Brummitt K, Bearden CE, Cadenhead KS, Cornblatt BA, Keshavan M, Mathalon DH, McGlashan TH, Perkins DO, Seidman LJ, Stone W, Tsuang MT, Walker EF, Woods SW, Cannon TD.
PMID: 32317224
Schizophr Res. 2020 Apr 18; doi: 10.1016/j.schres.2020.04.010. Epub 2020 Apr 18.

The North American Prodrome Longitudinal Study (NAPLS) is a consortium of nine programs focusing on youth at clinical high risk (CHR) for psychosis. Funded by the National Institute of Mental Health (NIMH), the sites are located at Emory University,...

Association between residential instability at individual and area levels and future psychosis in adolescents at clinical high risk from the North American Prodrome Longitudinal Study (NAPLS) consortium.

Schizophrenia research

Ku BS, Addington J, Bearden CE, Cadenhead KS, Cannon TD, Compton MT, Cornblatt BA, Keshavan M, Mathalon DH, Perkins DO, Stone WS, Tsuang MT, Walker EF, Woods SW, Druss BG.
PMID: 34673386
Schizophr Res. 2021 Dec;238:137-144. doi: 10.1016/j.schres.2021.09.025. Epub 2021 Oct 19.

OBJECTIVE: Accumulating evidence supports an association between residential instability and increased risk for psychosis, but the association between residential instability and conversion to psychosis among adolescents at clinical high risk (CHR) is unclear. In this study, we determined whether...

PERSONALITY FEATURES AND DISORDER IN THE SUBJECTS IN THE NEW YORK HIGH-RISK PROJECT.

Journal of psychiatric research

Squires-Wheeler E, Skodol AE, Adamo UH, Bassett AS, Gewirtz GR, Honer WG, Cornblatt BA, Roberts SA, Erlenmeyer-Kimling L.
PMID: 22287799
J Psychiatr Res. 1993;27(4):379-393. doi: 10.1016/0022-3956(93)90065-a.

One hundred and seventy-five offspring of parents in two psychiatrically ill groups and of normal controls in the New York High-Risk Project (NYHRP) were assessed for Axis II personality traits and disorders as defined by the Diagnostic and Statistical...

The timing of neurodevelopmental abnormality in schizophrenia: an integrative review of the neuroimaging literature.

CNS spectrums

Lencz T, Bilder RM, Cornblatt B.
PMID: 16951658
CNS Spectr. 2001 Mar;6(3):233-55. doi: 10.1017/s1092852900008610.

In this paper we will review recent neuroimaging research in schizophrenia, with an aim to critically evaluate several recent proposals concerning the nature and the timing of the neuroanatomic abnormalities underlying the disorder. Specifically, enlargement of cerebrospinal fluid spaces,...

Prodromal Symptom Severity Predicts Accelerated Gray Matter Reduction and Third Ventricle Expansion Among Clinically High Risk Youth Developing Psychotic Disorders.

Molecular neuropsychiatry

Chung Y, Jacobson A, He G, van Erp TG, McEwen S, Addington J, Bearden CE, Cadenhead K, Cornblatt B, Mathalon DH, McGlashan T, Perkins D, Seidman LJ, Tsuang M, Walker E, Woods SW, Heinssen R, Cannon TD.
PMID: 26005673
Mol Neuropsychiatry. 2015 May 01;1(1):13-22. doi: 10.1159/000371887.

A recent prospective longitudinal neuroimaging study of 274 prodromal risk syndrome subjects revealed that those who later developed full-blown psychotic symptoms exhibited accelerated gray matter loss and third ventricle expansion around the time of onset of psychosis. Previous studies...

Theory of Mind, Emotion Recognition and Social Perception in Individuals at Clinical High Risk for Psychosis: findings from the NAPLS-2 cohort.

Schizophrenia research. Cognition

Barbato M, Liu L, Cadenhead KS, Cannon TD, Cornblatt BA, McGlashan TH, Perkins DO, Seidman LJ, Tsuang MT, Walker EF, Woods SW, Bearden CE, Mathalon DH, Heinssen R, Addington J.
PMID: 27695675
Schizophr Res Cogn. 2015 Sep;2(3):133-139. doi: 10.1016/j.scog.2015.04.004. Epub 2015 May 16.

Social cognition, the mental operations that underlie social interactions, is a major construct to investigate in schizophrenia. Impairments in social cognition are present before the onset of psychosis, and even in unaffected first-degree relatives, suggesting that social cognition may...

Evidence of Slow Neural Processing, Developmental Differences and Sensitivity to Cannabis Effects in a Sample at Clinical High Risk for Psychosis From the NAPLS Consortium Assessed With the Human Startle Paradigm.

Frontiers in psychiatry

Cadenhead KS, Duncan E, Addington J, Bearden C, Cannon TD, Cornblatt BA, Mathalon D, McGlashan TH, Perkins DO, Seidman LJ, Tsuang M, Walker EF, Woods SW, Bauchman P, Belger A, Carrión RE, Donkers F, Johannesen J, Light G, Niznikiewicz M, Nunag J, Roach B.
PMID: 33005152
Front Psychiatry. 2020 Aug 25;11:833. doi: 10.3389/fpsyt.2020.00833. eCollection 2020.

ABSTRACT: Biomarkers are important in the study of the prodromal period of psychosis because they can help to identify individuals at greatest risk for future psychotic illness and provide insights into disease mechanism underlying neurodevelopmental abnormalities. The biomarker abnormalities...

DSM-5 Attenuated Psychosis Syndrome in Adolescents Hospitalized With Non-psychotic Psychiatric Disorders.

Frontiers in psychiatry

Salazar de Pablo G, Guinart D, Cornblatt BA, Auther AM, Carrión RE, Carbon M, Jiménez-Fernández S, Vernal DL, Walitza S, Gerstenberg M, Saba R, Lo Cascio N, Brandizzi M, Arango C, Moreno C, Van Meter A, Fusar-Poli P, Correll CU.
PMID: 33192693
Front Psychiatry. 2020 Oct 21;11:568982. doi: 10.3389/fpsyt.2020.568982. eCollection 2020.

No abstract available.

Cognitive behavioural social skills training: Methods of a randomized controlled trial for youth at risk of psychosis.

Early intervention in psychiatry

Addington J, Liu L, Santesteban-Echarri O, Brummitt K, Braun A, Cadenhead KS, Cornblatt BA, Holden JL, Granholm E.
PMID: 33398922
Early Interv Psychiatry. 2021 Dec;15(6):1626-1636. doi: 10.1111/eip.13102. Epub 2021 Jan 04.

AIM: Poor functioning has become a hallmark of many youth at clinical high-risk (CHR) of psychosis. Even for those who do not make the transition to psychosis remain troubled by functional deficits and a decline in functioning increases the...

Showing 1 to 12 of 29 entries