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Showing 1 to 12 of 29 entries
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Type 1 diabetes and coronary artery disease.

Diabetes care

Orchard TJ, Costacou T, Kretowski A, Nesto RW.
PMID: 17065698
Diabetes Care. 2006 Nov;29(11):2528-38. doi: 10.2337/dc06-1161.

No abstract available.

Recent trends over time in vascular disease in type 1 diabetes: insights from the Pittsburgh Epidemiology of Diabetes Complications study.

Cardiovascular endocrinology & metabolism

Costacou T, Orchard TJ.
PMID: 31531415
Cardiovasc Endocrinol Metab. 2019 Mar;8(1):3-13. doi: 10.1097/XCE.0000000000000164.

AIMS: To evaluate recent trends, by diagnosis year, in the cumulative incidence of vascular type 1 diabetes (T1D) complications and their risk factors up to 35 years duration.METHODS: Participants from the Epidemiology of Diabetes Complications study of childhood-onset T1D...

Elemental Analysis and In Vitro Evaluation of Antibacterial and Antifungal Activities of .

Plants (Basel, Switzerland)

Popovici V, Bucur L, Calcan SI, Cucolea EI, Costache T, Rambu D, Schröder V, Gîrd CE, Gherghel D, Vochita G, Caraiane A, Badea V.
PMID: 35009036
Plants (Basel). 2021 Dec 23;11(1). doi: 10.3390/plants11010032.

This study aims to complete our research on

Insulin resistance-associated genetic variants in type 1 diabetes.

Journal of diabetes and its complications

Miller RG, McGurnaghan SJ, Onengut-Gumuscu S, Chen WM, Colhoun HM, Rich SS, Orchard TJ, Costacou T.
PMID: 33468396
J Diabetes Complications. 2021 Apr;35(4):107842. doi: 10.1016/j.jdiacomp.2020.107842. Epub 2021 Jan 09.

AIMS: To examine candidate insulin resistance single nucleotide polymorphisms (SNPs) for associations with glycemic control, insulin resistance, BMI, and complications in an observational type 1 diabetes (T1D) cohort: the Pittsburgh Epidemiology of Diabetes Complications (EDC) study.METHODS: In 422 European-ancestry...

Perfluoroalkyl substances and kidney function in chronic kidney disease, anemia, and diabetes.

Diabetes, metabolic syndrome and obesity : targets and therapy

Conway BN, Badders AN, Costacou T, Arthur JM, Innes KE.
PMID: 30532572
Diabetes Metab Syndr Obes. 2018 Nov 15;11:707-716. doi: 10.2147/DMSO.S173809. eCollection 2018.

BACKGROUND: Anemia often complicates chronic kidney disease (CKD), leading to insufficient tissue oxygenation and hypoxic injury, the factor thought to underlie progression from CKD to renal failure. Perfluorocarbons are potent oxygen transporters used in organ preservation and synthetic blood...

Usnic Acid and .

Antioxidants (Basel, Switzerland)

Popovici V, Matei E, Cozaru GC, Aschie M, Bucur L, Rambu D, Costache T, Cucolea IE, Vochita G, Gherghel D, Caraiane A, Badea V.
PMID: 34439420
Antioxidants (Basel). 2021 Jul 23;10(8). doi: 10.3390/antiox10081171.

Nowadays, numerous biomedical studies performed on natural compounds and plant extracts aim to obtain highly selective pharmacological activities without unwanted toxic effects. In the big world of medicinal plants,

Association of Coding Variants in Hydroxysteroid 17-beta Dehydrogenase 14 (.

Journal of the American Society of Nephrology : JASN

Mychaleckyj JC, Valo E, Ichimura T, Ahluwalia TS, Dina C, Miller RG, Shabalin IG, Gyorgy B, Cao J, Onengut-Gumuscu S, Satake E, Smiles AM, Haukka JK, Tregouet DA, Costacou T, O'Neil K, Paterson AD, Forsblom C, Keenan HA, Pezzolesi MG, Pragnell M, Galecki A, Rich SS, Sandholm N, Klein R, Klein BE, Susztak K, Orchard TJ, Korstanje R, King GL, Hadjadj S, Rossing P, Bonventre JV, Groop PH, Warram JH, Krolewski AS.
PMID: 34261756
J Am Soc Nephrol. 2021 Oct;32(10):2634-2651. doi: 10.1681/ASN.2020101457. Epub 2021 Jul 14.

No abstract available.

A Fatty Acid Fraction Purified From Sea Buckthorn Seed Oil Has Regenerative Properties on Normal Skin Cells.

Frontiers in pharmacology

Dudau M, Codrici E, Tarcomnicu I, Mihai S, Popescu ID, Albulescu L, Constantin N, Cucolea I, Costache T, Rambu D, Enciu AM, Hinescu ME, Tanase C.
PMID: 34712136
Front Pharmacol. 2021 Oct 08;12:737571. doi: 10.3389/fphar.2021.737571. eCollection 2021.

In recent years, natural product's research gained momentum, fueled by technological advancement and open availability of research data. To date, sea buckthorn (

Antioxidant and Cytotoxic Activities of .

Plants (Basel, Switzerland)

Popovici V, Bucur L, Popescu A, Schröder V, Costache T, Rambu D, Cucolea IE, Gîrd CE, Caraiane A, Gherghel D, Vochita G, Badea V.
PMID: 34062835
Plants (Basel). 2021 May 01;10(5). doi: 10.3390/plants10050909.

Lichens represent a significant source of antioxidants due to numerous metabolites that can reduce free radicals.

30-Year Cardiovascular Disease in Type 1 Diabetes: Risk and Risk Factors Differ by Long-term Patterns of Glycemic Control.

Diabetes care

Miller RG, Orchard TJ, Costacou T.
PMID: 34782353
Diabetes Care. 2022 Jan 01;45(1):142-150. doi: 10.2337/dc21-1381.

OBJECTIVE: We hypothesized that there is heterogeneity in long-term patterns of glycemic control with respect to cardiovascular disease (CVD) development in type 1 diabetes and that risk factors for CVD differ by glycemic control pattern. Thus, we estimated associations...

Persistent polypharmacy and fall injury risk: the Health, Aging and Body Composition Study.

BMC geriatrics

Xue L, Boudreau RM, Donohue JM, Zgibor JC, Marcum ZA, Costacou T, Newman AB, Waters TM, Strotmeyer ES.
PMID: 34911467
BMC Geriatr. 2021 Dec 15;21(1):710. doi: 10.1186/s12877-021-02695-9.

BACKGROUND: Older adults receive treatment for fall injuries in both inpatient and outpatient settings. The effect of persistent polypharmacy (i.e. using multiple medications over a long period) on fall injuries is understudied, particularly for outpatient injuries. We examined the...

30-Year Cardiovascular Disease in Type 1 Diabetes: Risk and Risk Factors Differ by Long-Term Patterns of Glycemic Control.

Diabetes care

Miller RG, Orchard TJ, Costacou T.
PMID: 34782353
Diabetes Care. 2021 Nov 15; doi: 10.2337/dc21-1381. Epub 2021 Nov 15.

OBJECTIVE: We hypothesized that there is heterogeneity in long-term patterns of glycemic control with respect to cardiovascular disease (CVD) development in type 1 diabetes and that risk factors for CVD differ by glycemic control pattern. Thus, we estimated associations...

Showing 1 to 12 of 29 entries