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Showing 1 to 12 of 132 entries
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An AAV9 coding for frataxin clearly improved the symptoms and prolonged the life of Friedreich ataxia mouse models.

Molecular therapy. Methods & clinical development

Gérard C, Xiao X, Filali M, Coulombe Z, Arsenault M, Couet J, Li J, Drolet MC, Chapdelaine P, Chikh A, Tremblay JP.
PMID: 26015982
Mol Ther Methods Clin Dev. 2014 Oct 08;1:14044. doi: 10.1038/mtm.2014.44. eCollection 2014.

Friedreich ataxia (FRDA) is a genetic disease due to increased repeats of the GAA trinucleotide in intron 1 of the frataxin gene. This mutation leads to a reduced expression of frataxin. We have produced an adeno-associated virus (AAV)9 coding...

Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV.

ACS medicinal chemistry letters

Fader LD, Carson R, Morin S, Bilodeau F, Chabot C, Halmos T, Bailey MD, Kawai SH, Coulombe R, Laplante S, Mekhssian K, Jakalian A, Garneau M, Duan J, Mason SW, Simoneau B, Fenwick C, Tsantrizos Y, Yoakim C.
PMID: 24944749
ACS Med Chem Lett. 2014 Apr 16;5(6):711-6. doi: 10.1021/ml500110j. eCollection 2014 Jun 12.

A scaffold replacement approach was used to identifying the pyridine series of noncatalytic site integrase inhibitors. These molecules bind with higher affinity to a tetrameric form compared to a dimeric form of integrase. Optimization of the C6 and C4...

Foliage physiology and biochemistry in response to light gradients in conifers with varying shade tolerance.

Oecologia

Bond BJ, Farnsworth BT, Coulombe RA, Winner WE.
PMID: 28308078
Oecologia. 1999 Aug;120(2):183-192. doi: 10.1007/s004420050847.

To examine the predictability of leaf physiology and biochemistry from light gradients within canopies, we measured photosynthetic light-response curves, leaf mass per area (LMA) and concentrations of nitrogen, phosphorus and chlorophyll at 15-20 positions within canopies of three conifer...

Ellipsometric Scatterometry for the Metrology of Sub-0.1- num-Linewidth Structures.

Applied optics

Minhas BK, Coulombe SA, Naqvi SS, McNeil JR.
PMID: 18285983
Appl Opt. 1998 Aug 01;37(22):5112-5. doi: 10.1364/ao.37.005112.

We describe a modification to our existing scatterometry technique for extracting the relative phase and amplitude of the electric field diffracted from a grating. This modification represents a novel combination of aspects of ellipsometry and scatterometry to provide improved...

Frequency stabilization of a single mode terahertz quantum cascade laser to the kilohertz level.

Optics express

Danylov AA, Goyette TM, Waldman J, Coulombe MJ, Gatesman AJ, Giles RH, Goodhue WD, Qian X, Nixon WE.
PMID: 19399130
Opt Express. 2009 Apr 27;17(9):7525-32. doi: 10.1364/oe.17.007525.

A simple analog locking circuit was shown to stabilize the beat signal between a 2.408 THz quantum cascade laser and a CH(2)DOH THz CO(2) optically pumped molecular laser to 3-4 kHz (FWHM). This is approximately a tenth of the...

Sleep-Related Issues in Children and Adolescents Presenting at Community Mental Health Clinics.

Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent

Quon EC, Ellis AT, Coulombe A.
PMID: 30038655
J Can Acad Child Adolesc Psychiatry. 2018 Aug;27(3):175-181. Epub 2018 Jul 01.

OBJECTIVE: To examine sleep-related issues in children and adolescents presenting at community clinics with diverse mental health concerns using a brief sleep questionnaire and to examine whether sleep issues would improve with mental health interventions.METHOD: Study 1: A questionnaire-based...

Altered Cerebellar Biochemical Profiles in Infants Born Prematurely.

Scientific reports

Brossard-Racine M, Murnick J, Bouyssi-Kobar M, Coulombe J, Chang T, Limperopoulos C.
PMID: 28811513
Sci Rep. 2017 Aug 15;7(1):8143. doi: 10.1038/s41598-017-08195-4.

This study aims to compare the cerebellar biochemical profiles in preterm (PT) infants evaluated at term equivalent age (TEA) and healthy full-term newborns using proton magnetic resonance spectroscopy (

Wetting behavior of multi-walled carbon nanotube nanofluids.

Nanotechnology

Karthikeyan A, Coulombe S, Kietzig AM.
PMID: 28106004
Nanotechnology. 2017 Mar 10;28(10):105706. doi: 10.1088/1361-6528/aa5a5f. Epub 2017 Jan 19.

Nanofluids-engineered colloidal suspensions in base liquids-have captivated the interest of researchers over the last two decades for various existing as well as emerging technological applications. The main impetus for the synthesis of such novel nanocomposite liquids is the potential...

Mango allergic contact dermatitis.

Contact dermatitis

Alipour Tehrany Y, Coulombe J.
PMID: 33609039
Contact Dermatitis. 2021 Feb 20; doi: 10.1111/cod.13818. Epub 2021 Feb 20.

No abstract available.

[Training needs for educators and nurses using the individualized services plan in mental health].

Sante mentale au Quebec

Coulombe R, Boisvert D, Parent G.
PMID: 9052269
Sante Ment Que. 1996;21(2):181-99.
Free Article

With the help of the method elaborated by Herskowitz (1977), this study examines the training needs of 42 workers (19 educators and 23 nurses) using when needed, the individualized services plan in a context of external services (deinstitutionalization) in...

Tysserand - Fast and accurate reconstruction of spatial networks from bioimages.

Bioinformatics (Oxford, England)

Coullomb A, Pancaldi V.
PMID: 34213523
Bioinformatics. 2021 Jul 02; doi: 10.1093/bioinformatics/btab490. Epub 2021 Jul 02.

SUMMARY: Networks provide a powerful framework to analyze spatial omics experiments. However, we lack tools that integrate several methods to easily reconstruct networks for further analyses with dedicated libraries. In addition, choosing the appropriate method and parameters can be...

Experiences of Transgender Participants in Emergency Departments: Findings from the OutLook Study.

Transgender health

Thompson-Blum DN, Coleman TA, Phillips NE, Richardson S, Travers R, Coulombe S, Wilson C, Woodford M, Cameron R, Davis C.
PMID: 34993307
Transgend Health. 2021 Dec 02;6(6):358-368. doi: 10.1089/trgh.2020.0112. eCollection 2021 Dec.

No abstract available.

Showing 1 to 12 of 132 entries