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Showing 1 to 12 of 129 entries
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An AAV9 coding for frataxin clearly improved the symptoms and prolonged the life of Friedreich ataxia mouse models.

Molecular therapy. Methods & clinical development

Gérard C, Xiao X, Filali M, Coulombe Z, Arsenault M, Couet J, Li J, Drolet MC, Chapdelaine P, Chikh A, Tremblay JP.
PMID: 26015982
Mol Ther Methods Clin Dev. 2014 Oct 08;1:14044. doi: 10.1038/mtm.2014.44. eCollection 2014.

Friedreich ataxia (FRDA) is a genetic disease due to increased repeats of the GAA trinucleotide in intron 1 of the frataxin gene. This mutation leads to a reduced expression of frataxin. We have produced an adeno-associated virus (AAV)9 coding...

Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV.

ACS medicinal chemistry letters

Fader LD, Carson R, Morin S, Bilodeau F, Chabot C, Halmos T, Bailey MD, Kawai SH, Coulombe R, Laplante S, Mekhssian K, Jakalian A, Garneau M, Duan J, Mason SW, Simoneau B, Fenwick C, Tsantrizos Y, Yoakim C.
PMID: 24944749
ACS Med Chem Lett. 2014 Apr 16;5(6):711-6. doi: 10.1021/ml500110j. eCollection 2014 Jun 12.

A scaffold replacement approach was used to identifying the pyridine series of noncatalytic site integrase inhibitors. These molecules bind with higher affinity to a tetrameric form compared to a dimeric form of integrase. Optimization of the C6 and C4...

Differential RNA expression of the pS2 gene in the human benign and malignant prostatic tissue.

Prostate cancer and prostatic diseases

Colombel M, Dante R, Bouvier R, Ribieras S, Pangaud C, Marechal JM, Lasne Y.
PMID: 12496791
Prostate Cancer Prostatic Dis. 1999 Nov;2:S11. doi: 10.1038/sj.pcan.4500337.

No abstract available.

Sleep-Related Issues in Children and Adolescents Presenting at Community Mental Health Clinics.

Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent

Quon EC, Ellis AT, Coulombe A.
PMID: 30038655
J Can Acad Child Adolesc Psychiatry. 2018 Aug;27(3):175-181. Epub 2018 Jul 01.

OBJECTIVE: To examine sleep-related issues in children and adolescents presenting at community clinics with diverse mental health concerns using a brief sleep questionnaire and to examine whether sleep issues would improve with mental health interventions.METHOD: Study 1: A questionnaire-based...

Altered Cerebellar Biochemical Profiles in Infants Born Prematurely.

Scientific reports

Brossard-Racine M, Murnick J, Bouyssi-Kobar M, Coulombe J, Chang T, Limperopoulos C.
PMID: 28811513
Sci Rep. 2017 Aug 15;7(1):8143. doi: 10.1038/s41598-017-08195-4.

This study aims to compare the cerebellar biochemical profiles in preterm (PT) infants evaluated at term equivalent age (TEA) and healthy full-term newborns using proton magnetic resonance spectroscopy (

Wetting behavior of multi-walled carbon nanotube nanofluids.

Nanotechnology

Karthikeyan A, Coulombe S, Kietzig AM.
PMID: 28106004
Nanotechnology. 2017 Mar 10;28(10):105706. doi: 10.1088/1361-6528/aa5a5f. Epub 2017 Jan 19.

Nanofluids-engineered colloidal suspensions in base liquids-have captivated the interest of researchers over the last two decades for various existing as well as emerging technological applications. The main impetus for the synthesis of such novel nanocomposite liquids is the potential...

Holmium Laser Enucleation of the Prostate versus Laparoscopic Transcapsular Prostatectomy: Perioperative Results and Three-Month Follow-Up.

Current urology

Baldini A, Fassi-Fehri H, Duarte RC, Crouzet S, Ecochard R, Abid N, Martin X, Badet L, Colombel M.
PMID: 28785192
Curr Urol. 2017 Jul;10(2):81-86. doi: 10.1159/000447156. Epub 2017 May 30.

PURPOSE: Symptomatic benign prostatic hypertrophy greater than 70 cc used to be treated by invasive procedures. Holmium laser enucleation of prostate (HoLEP) and laparoscopic transcapsular prostatectomy (LTP) are two techniques whose efficacy has been demonstrated compared to standard onesmore...

Mango allergic contact dermatitis.

Contact dermatitis

Alipour Tehrany Y, Coulombe J.
PMID: 33609039
Contact Dermatitis. 2021 Feb 20; doi: 10.1111/cod.13818. Epub 2021 Feb 20.

No abstract available.

Combined model-based and deep learning-based automated 3D zonal segmentation of the prostate on T2-weighted MR images: clinical evaluation.

European radiology

Rouvière O, Moldovan PC, Vlachomitrou A, Gouttard S, Riche B, Groth A, Rabotnikov M, Ruffion A, Colombel M, Crouzet S, Weese J, Rabilloud M.
PMID: 35001157
Eur Radiol. 2022 Jan 10; doi: 10.1007/s00330-021-08408-5. Epub 2022 Jan 10.

OBJECTIVE: To train and to test for prostate zonal segmentation an existing algorithm already trained for whole-gland segmentation.METHODS: The algorithm, combining model-based and deep learning-based approaches, was trained for zonal segmentation using the NCI-ISBI-2013 dataset and 70 T2-weighted datasets...

[Training needs for educators and nurses using the individualized services plan in mental health].

Sante mentale au Quebec

Coulombe R, Boisvert D, Parent G.
PMID: 9052269
Sante Ment Que. 1996;21(2):181-99.
Free Article

With the help of the method elaborated by Herskowitz (1977), this study examines the training needs of 42 workers (19 educators and 23 nurses) using when needed, the individualized services plan in a context of external services (deinstitutionalization) in...

Experiences of Transgender Participants in Emergency Departments: Findings from the OutLook Study.

Transgender health

Thompson-Blum DN, Coleman TA, Phillips NE, Richardson S, Travers R, Coulombe S, Wilson C, Woodford M, Cameron R, Davis C.
PMID: 34993307
Transgend Health. 2021 Dec 02;6(6):358-368. doi: 10.1089/trgh.2020.0112. eCollection 2021 Dec.

No abstract available.

Prurigo pigmentosa with new-onset diabetic ketoacidosis.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

Coulombe J, Lim D, Geoffroy L.
PMID: 34844940
CMAJ. 2021 Nov 29;193(47):E1815. doi: 10.1503/cmaj.210723.

No abstract available.

Showing 1 to 12 of 129 entries