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Showing 1 to 12 of 635 entries
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PACE project: object-orientated modelling of paediatric practice.

Medical informatics = Medecine et informatique

Horslen S, Capey A, Casey A, Helms P.
PMID: 1405839
Med Inform (Lond). 1992 Jul-Sep;17(3):179-86. doi: 10.3109/14639239209096533.

The need for useful clinical support based on integrated computerized systems is now well recognized. To build systems desired by busy clinicians requires accurate specifications. These specifications in turn require rigorous descriptions of the processes to be automated in...

RRx-001-Induced Tumor Necrosis and Immune Cell Infiltration in an EGFR Mutation-Positive NSCLC with Resistance to EGFR Tyrosine Kinase Inhibitors: A Case Report.

Case reports in oncology

Brzezniak C, Schmitz BA, Peterson PG, Degesys A, Oronsky BT, Scicinski JJ, Caroen SZ, Carter CA.
PMID: 26933418
Case Rep Oncol. 2016 Jan 15;9(1):45-50. doi: 10.1159/000443605. eCollection 2016.

We present the case of a 49-year-old male with metastatic epidermal growth factor receptor (EGFR) mutation-positive adenocarcinoma of the lung that continues to outlive stage IV diagnosis of non-small cell lung cancer after treatment with RRx-001, an experimental anticancer...

A psychologically informed, audiologist-delivered, manualised intervention for tinnitus: protocol for a randomised controlled feasibility trial (Tin Man study).

Pilot and feasibility studies

Taylor JA, Hall DA, Walker DM, McMurran M, Casey A, Stockdale D, Featherstone D, Thompson DM, MacDonald C, Hoare DJ.
PMID: 28515957
Pilot Feasibility Stud. 2017 May 15;3:24. doi: 10.1186/s40814-017-0137-8. eCollection 2017.

BACKGROUND: Chronic tinnitus is a common incurable condition often associated with depression, anxiety, insomnia and reduced quality of life. Within National Health Service (NHS) audiology in the United Kingdom (UK), no standard protocol currently exists for the treatment of...

Estimation of Time Period for Effective Human Inhalational Anthrax Treatment Including Antitoxin Therapy.

PLoS currents

Rubinson L, Corey A, Hanfling D.
PMID: 28856066
PLoS Curr. 2017 Jul 28;9. doi: 10.1371/currents.outbreaks.7896c43f69838f17ce1c2c372e79d55d.

INTRODUCTION: Infrequent natural human inhalational anthrax cases coupled with high bioterrorism risk have brought about use of animal models to serve as the basis for approval of novel treatments. For inhalational anthrax, protective antigen (PA) drives much of the...

Comparative studies of cellular viability levels on 2D and 3D in vitro culture matrices.

Cytotechnology

Gargotti M, Lopez-Gonzalez U, Byrne HJ, Casey A.
PMID: 28924965
Cytotechnology. 2018 Feb;70(1):261-273. doi: 10.1007/s10616-017-0139-7. Epub 2017 Sep 18.

In this study, the cellular viability and function of immortalized human cervical and dermal cells are monitored and compared in conventional 2D and two commercial 3D membranes, Collagen and Geltrex, of varying working concentration and volume. Viability was monitored...

Aerobic Capacity is Related to Repeated Sprint Ability with Sprint Distances Less Than 40 Meters.

International journal of exercise science

Sanders GJ, Turner Z, Boos B, Peacock CA, Peveler W, Lipping A.
PMID: 28344734
Int J Exerc Sci. 2017 Mar 01;10(2):197-204. eCollection 2017.

Research is inconclusive regarding the association between aerobic fitness (objectively measured VO

Layered Bi2Se3 nanoplate/polyvinylidene fluoride composite based n-type thermoelectric fabrics.

ACS applied materials & interfaces

Dun C, Hewitt CA, Huang H, Xu J, Montgomery DS, Nie W, Jiang Q, Carroll DL.
PMID: 25798653
ACS Appl Mater Interfaces. 2015 Apr 08;7(13):7054-9. doi: 10.1021/acsami.5b00514. Epub 2015 Mar 27.

In this study, we report the fabrication of n-type flexible thermoelectric fabrics using layered Bi2Se3 nanoplate/polyvinylidene fluoride (PVDF) composites as the thermoelectric material. These composites exhibit room temperature Seebeck coefficient and electrical conductivity values of -80 μV K(-1) and...

Ig Constant Region Effects on Variable Region Structure and Function.

Frontiers in microbiology

Janda A, Bowen A, Greenspan NS, Casadevall A.
PMID: 26870003
Front Microbiol. 2016 Feb 04;7:22. doi: 10.3389/fmicb.2016.00022. eCollection 2016.

The adaptive humoral immune response is responsible for the generation of antimicrobial proteins known as immunoglobulin molecules or antibodies. Immunoglobulins provide a defense system against pathogenic microbes and toxins by targeting them for removal and/or destruction. Historically, antibodies have...

The AMP-Dependent Protein Kinase (AMPK) Activator A-769662 Causes Arterial Relaxation by Reducing Cytosolic Free Calcium Independently of an Increase in AMPK Phosphorylation.

Frontiers in pharmacology

Huang Y, Smith CA, Chen G, Sharma B, Miner AS, Barbee RW, Ratz PH.
PMID: 29093683
Front Pharmacol. 2017 Oct 18;8:756. doi: 10.3389/fphar.2017.00756. eCollection 2017.

Although recent studies reveal that activation of the metabolic and Ca

Effect of an herbal/botanical supplement on recovery from delayed onset muscle soreness: a randomized placebo-controlled trial.

Journal of the International Society of Sports Nutrition

Rynders CA, Weltman JY, Rynders SD, Patrie J, McKnight J, Katch FI, Hertel J, Weltman A.
PMID: 24966805
J Int Soc Sports Nutr. 2014 Jun 13;11:27. doi: 10.1186/1550-2783-11-27. eCollection 2014.

BACKGROUND: We examined the effects of a proprietary herbal/botanical supplement (StemSport, Stemtech, San Clemente, CA.) suggested to increase circulating stem cells, decrease inflammation, and attenuate exercise induced muscle damage on recovery from delayed onset muscle soreness (DOMS).METHODS: Sixteen subjects...

Novel segmental proxy measures for estimating weight and height in healthy school children aged 11-18 years.

Clinical nutrition ESPEN

Carey A, McCarthy H, Gill J, Thompson A, McNulty H.
PMID: 28531548
Clin Nutr ESPEN. 2015 Oct;10(5):e211. doi: 10.1016/j.clnesp.2015.03.078. Epub 2015 Aug 28.

No abstract available.

Immune Reactivity and Pseudoprogression or Tumor Flare in a Serially Biopsied Neuroendocrine Patient Treated with the Epigenetic Agent RRx-001.

Case reports in oncology

Carter CA, Schmitz B, Peterson PG, Quinn M, Degesys A, Jenkins J, Oronsky B, Scicinski J, Caroen S, Reid TR, Cabrales P, Brzezniak C.
PMID: 27065848
Case Rep Oncol. 2016 Mar 10;9(1):164-70. doi: 10.1159/000444633. eCollection 2016.

Neuroendocrine tumors (NETs) are grouped together as a single class on the basis of histologic appearance, immunoreactivity for the neuroendocrine markers chromogranin A and synaptophysin, and potential secretion of hormones, neurotransmitters, neuromodulators and neuropeptides. Nevertheless, despite these common characteristics,...

Showing 1 to 12 of 635 entries