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Showing 1 to 12 of 37 entries
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Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-Encoded Library Technology (ELT).

ACS medicinal chemistry letters

Ding Y, O'Keefe H, DeLorey JL, Israel DI, Messer JA, Chiu CH, Skinner SR, Matico RE, Murray-Thompson MF, Li F, Clark MA, Cuozzo JW, Arico-Muendel C, Morgan BA.
PMID: 26288689
ACS Med Chem Lett. 2015 Jul 07;6(8):888-93. doi: 10.1021/acsmedchemlett.5b00138. eCollection 2015 Aug 13.

The aggrecan degrading metalloprotease ADAMTS-4 has been identified as a novel therapeutic target for osteoarthritis. Here, we use DNA-encoded Library Technology (ELT) to identify novel ADAMTS-4 inhibitors from a DNA-encoded triazine library by affinity selection. Structure-activity relationship studies based...

Cleft lip and palate in a Brazilian subpopulation.

Journal of international oral health : JIOH

Cuozzo FD, Espinosa MM, da Silva KT, de Barros YB, Bandeca MC, Aranha AM, Borges AH, Volpato LE.
PMID: 24155614
J Int Oral Health. 2013 Aug;5(4):15-20. Epub 2013 Aug 28.

BACKGROUND: This work aimed to access the profile of cleft lip and palate patients of a sub-population in Mid-West Brazil.MATERIALS & METHODS: Research was carried out through a cross-sectional study at the Craniofacial Rehabilitation Center of the University General...

Discovery of Novel UDP-.

Journal of medicinal chemistry

Ryan MD, Parkes AL, Corbett D, Dickie AP, Southey M, Andersen OA, Stein DB, Barbeau OR, Sanzone A, Thommes P, Barker J, Cain R, Compper C, Dejob M, Dorali A, Etheridge D, Evans S, Faulkner A, Gadouleau E, Gorman T, Haase D, Holbrow-Wilshaw M, Krulle T, Li X, Lumley C, Mertins B, Napier S, Odedra R, Papadopoulos K, Roumpelakis V, Spear K, Trimby E, Williams J, Zahn M, Keefe AD, Zhang Y, Soutter HT, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Deng B, Hunt A, Sigel EA, Troast DM, DeJonge BLM.
PMID: 34569791
J Med Chem. 2021 Oct 14;64(19):14377-14425. doi: 10.1021/acs.jmedchem.1c00888. Epub 2021 Sep 27.

This study describes a novel series of UDP-

Effects of Chronic Oral Probiotic Treatment in Paclitaxel-Induced Neuropathic Pain.

Biomedicines

Cuozzo M, Castelli V, Avagliano C, Cimini A, d'Angelo M, Cristiano C, Russo R.
PMID: 33808052
Biomedicines. 2021 Mar 30;9(4). doi: 10.3390/biomedicines9040346.

Chemotherapy-induced peripheral neuropathy (CIPN) represents one of the most prevalent and potentially disabling side effects due to the use of anticancer drugs, one of the primary neuropathies detected is peripheral neuropathy induced by administration of taxanes, including paclitaxel. It...

Ascospore Infection and .

The plant pathology journal

Alaniz S, Cuozzo V, Martínez V, Stadnik MJ, Mondino P.
PMID: 31007640
Plant Pathol J. 2019 Apr;35(2):100-111. doi: 10.5423/PPJ.OA.07.2018.0145. Epub 2019 Apr 01.

Glomerella leaf spot (GLS) caused by

Extracellular Polymeric Substances (EPS) produced by Streptomyces sp. biofilms: Chemical composition and anticancer properties.

Microbiological research

Homero U, Tortella G, Sandoval E, Cuozzo SA.
PMID: 34644673
Microbiol Res. 2021 Dec;253:126877. doi: 10.1016/j.micres.2021.126877. Epub 2021 Sep 24.

The extracellular polymeric substances (EPS) have shown free radical scavenging and antitumor activity against both breast and colon cell lines. In this regard, actinobacteria have become an increasingly popular sources of EPS. Therefore, in this study four Streptomyces strains...

Quantum-Limited Squeezed Light Detection with a Camera.

Physical review letters

Matekole ES, Cuozzo SL, Prajapati N, Bhusal N, Lee H, Novikova I, Mikhailov EE, Dowling JP, Cohen L.
PMID: 32975994
Phys Rev Lett. 2020 Sep 11;125(11):113602. doi: 10.1103/PhysRevLett.125.113602.

We present a technique for squeezed light detection based on direct imaging of the displaced-squeezed-vacuum state using a CCD camera. We show that the squeezing parameter can be accurately estimated using only the first two moments of the recorded...

Isoform-specific Roles of Prolyl Hydroxylases in the Regulation of Pancreatic β-Cell Function.

Endocrinology

Hoang M, Jentz E, Janssen SM, Nasteska D, Cuozzo F, Hodson DJ, Tupling AR, Fong GH, Joseph JW.
PMID: 34718519
Endocrinology. 2022 Jan 01;163(1). doi: 10.1210/endocr/bqab226.

Pancreatic β-cells can secrete insulin via 2 pathways characterized as KATP channel -dependent and -independent. The KATP channel-independent pathway is characterized by a rise in several potential metabolic signaling molecules, including the NADPH/NADP+ ratio and α-ketoglutarate (αKG). Prolyl hydroxylases...

Genetic population structure of endangered ring-tailed lemurs (.

Ecology and evolution

Chandrashekar A, Knierim JA, Khan S, Raboin DL, Venkatesh S, Clarke TA, Cuozzo FP, LaFleur M, Lawler RR, Parga JA, Rasamimanana HR, Reuter KE, Sauther ML, Baden AL.
PMID: 32788959
Ecol Evol. 2020 Jul 16;10(15):8030-8043. doi: 10.1002/ece3.6337. eCollection 2020 Aug.

Madagascar's ring-tailed lemurs (

Distinct Metabolic Signals Underlie Clone by Environment Interplay in "Nebbiolo" Grapes Over Ripening.

Frontiers in plant science

Pagliarani C, Boccacci P, Chitarra W, Cosentino E, Sandri M, Perrone I, Mori A, Cuozzo D, Nerva L, Rossato M, Zuccolotto P, Pezzotti M, Delledonne M, Mannini F, Gribaudo I, Gambino G.
PMID: 31867031
Front Plant Sci. 2019 Dec 04;10:1575. doi: 10.3389/fpls.2019.01575. eCollection 2019.

Several research studies were focused to understand how grapevine cultivars respond to environment; nevertheless, the biological mechanisms tuning this phenomenon need to be further deepened. Particularly, the molecular processes underlying the interplay between clones of the same cultivar and...

Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.

ACS medicinal chemistry letters

Johannes JW, Bates S, Beigie C, Belmonte MA, Breen J, Cao S, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Ferguson AD, Habeshian S, Hargreaves D, Joubran C, Kazmirski S, Keefe AD, Lamb ML, Lan H, Li Y, Ma H, Mlynarski S, Packer MJ, Rawlins PB, Robbins DW, Shen H, Sigel EA, Soutter HH, Su N, Troast DM, Wang H, Wickson KF, Wu C, Zhang Y, Zhao Q, Zheng X, Hird AW.
PMID: 28197319
ACS Med Chem Lett. 2016 Dec 27;8(2):239-244. doi: 10.1021/acsmedchemlett.6b00464. eCollection 2017 Feb 09.

Mcl-1 is a pro-apoptotic BH3 protein family member similar to Bcl-2 and Bcl-xL. Overexpression of Mcl-1 is often seen in various tumors and allows cancer cells to evade apoptosis. Here we report the discovery and optimization of a series...

Elastocaloric Effect in Carbon Nanotubes and Graphene.

Nano letters

Lisenkov S, Herchig R, Patel S, Vaish R, Cuozzo J, Ponomareva I.
PMID: 27709965
Nano Lett. 2016 Nov 09;16(11):7008-7012. doi: 10.1021/acs.nanolett.6b03155. Epub 2016 Oct 11.

Carbon nanotubes are famous for their many extraordinary properties. We use a thermodynamical approach, experimental data from the literature, and atomistic simulations to reveal one more remarkable property of the carbon nanotubes that has so far been overlooked. Namely,...

Showing 1 to 12 of 37 entries